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Search for the doubly charmed baryon ?cc+

Science China(Physics,mechanics & Astronomy) 2021年第10期Mechanics & Astronomy) .卷 6-17页

作者： R. Aaij C. Abellán Beteta T. Ackernley B. Adeva m. Adinolfi H. Afsharnia C. A. Aidala S. Aiola Z. Ajaltouni S. Akar J. Albrecht F. Alessio m. Alexander A. Alfonso Albero Z. Aliouche G. Alkhazov P. Alvarez Cartelle S. Amato Y. Amhis L. An L. Anderlini A. Andreianov m. Andreotti F. Archilli A. Artamonov m. Artuso K. Arzymatov E. Aslanides m. Atzeni B. Audurier S. Bachmann m. Bachmayer J. J. Back P. Baladron Rodriguez V. Balagura W. Baldini J. Baptista Leite R. J. Barlow S. Barsuk W. Barter m. Bartolini F. Baryshnikov J. m. Basels G. Bassi B. Batsukh A. Battig A. Bay m. Becker F. Bedeschi I. Bediaga A. Beiter V. Belavin S. Belin V. Bellee K. Belous I. Belov I. Belyaev G. Bencivenni E. Ben-Haim A. Berezhnoy R. Bernet D. Berninghoff H. C. Bernstein C. Bertella A. Bertolin C. Betancourt F. Betti I. Bezshyiko S. Bhasin J. Bhom L. Bian m. S. Bieker S. Bifani P. Billoir m. Birch F. C. R. Bishop A. Bitadze A. Bizzeti m. Bj?rn m. P. Blago T. Blake F. Blanc S. Blusk D. Bobulska J. A. Boelhauve O. Boente Garcia T. Boettcher A. Boldyrev A. Bondar N. Bondar S. Borghi m. Borisyak m. Borsato J. T. Borsuk S. A. Bouchiba T. J. V. Bowcock A. Boyer C. Bozzi m. J. Bradley S. Braun A. Brea Rodriguez m. Brodski J. Brodzicka A. Brossa Gonzalo D. Brundu A. Buonaura C. Burr A. Bursche A. Butkevich J. S. Butter J. Buytaert W. Byczynski S. Cadeddu H. Cai R. Calabrese L. Calefice L. Calero Diaz S. Cali R. Calladine m. Calvi m. Calvo Gomez P. Camargo magalhaes P. Campana A. F. Campoverde Quezada S. Capelli L. Capriotti A. Carbone G. Carboni R. Cardinale A. Cardini I. Carli P. Carniti L. Carus K. Carvalho Akiba A. Casais Vidal G. Casse m. Cattaneo G. Cavallero S. Celani J. Cerasoli A. J. Chadwick m. G. Chapman m. Charles P. Charpentier G. Chatzikonstantinidis C. A. Chavez Barajas m. Chefdeville C. Chen S. Chen A. Chernov V. Chobanova S. Cholak m. Chrzaszcz A. Chubykin V. Chulikov P. Ciambrone m. F. Cicala X. Cid Vidal G. Ciezarek P. E. L. Clarke m. Clemencic H. V. Clif J. Closier J. L. Cobbledick V. Coco J. A. B. Coelho J. Cogan E. Cogneras L. Nikhef National Institute for Subatomic Physics Physik-Institut Universit?t Zürich Oliver Lodge Laboratory University of Liverpool Instituto Galego de Física de Altas Enerxías (IGFAE) Universidade de Santiago de Compostela H.H. Wills Physics Laboratory University of Bristol Université Clermont Auvergne University of michigan Ann Arbor United States INFN Sezione di milano University of Cincinnati Fakult?t Physik Technische Universit?t Dortmund European Organization for Nuclear Research (CERN) School of Physics and Astronomy University of Glasgow ICCUB Universitat de Barcelona Department of Physics and Astronomy University of manchester Petersburg Nuclear Physics Institute NRC Kurchatov Institute (PNPI NRC KI) Cavendish Laboratory University of Cambridge Universidade Federal do Rio de Janeiro (UFRJ) Université Paris-Saclay INFN Sezione di Firenze INFN Sezione di Ferrara Physikalisches Institut Ruprecht-Karls-Universit?t Heidelberg Institute for High Energy Physics NRC Kurchatov Institute (IHEP NRC KI) Syracuse University Yandex School of Data Analysis Aix marseille Univ Laboratoire Leprince-Ringuet CNRS/IN2P3 Ecole Polytechnique Institut Polytechnique de Paris Institute of Physics Ecole Polytechnique Fédérale de Lausanne (EPFL) Department of Physics University of Warwick Centro Brasileiro de Pesquisas Físicas (CBPF) Imperial College London INFN Sezione di Genova National University of Science and Technology “mISIS” I. Physikalisches Institut RWTH Aachen University INFN Sezione di Pisa INFN Sezione di Cagliari Institute of Nuclear Physics moscow State University (SINP mSU) Institute of Theoretical and Experimental Physics NRC Kurchatov Institute (ITEP NRC KI) INFN Laboratori Nazionali di Frascati LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité Universita degli Studi di Padova Universita e INFN Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences School of Physics and Technology Wuhan University University of Birmingham Università di modena e Reggio Emilia Department of Physics U

A search for the doubly charmed baryon ?cc+with the decay mode ?cc+→Ξc+K-π+is performed using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the LHCb experiment from 2016 to 2018, corresponding to an integrated luminosity of 5.4 fb-1. No significant signal is observed within the invariant mass range of 3.6 to 4.0 GeV/c2. Upper limits are set on the ratio R of the production cross-section times the total branching fraction of the ?cc+→Ξc+K-π+decay with respect to the Ξcc++→Λc+K-π+π+decay. Upper limits at 95% credibility level for R in the range 0.005 to 0.11 are obtained for diferent hypotheses on the ?cc+mass and lifetime in the rapidity range from 2.0 to 4.5 and transverse momentum range from 4 to 15 GeV/c.

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Role of a probiotic (Saccharomyces boulardii) in management and prevention of diarrhoea

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World Journal of Gastroenterology 2006年第28期12卷 4557-4560页

作者： AG Billoo mA memon SA Khaskheli G murtaza Khalid Iqbal m Saeed Shekhani Ahson Q Siddiqi Department of Pediatrics Aga Khan UniversityKarachiParkistan Department of Pathology Kharadar General HospitalKarachiParkistan Department of Pediatrics Kharadar General HospitalKarachiParkistan Consultant Pediatrician Kharadar General HospitalKarachiParkistan medical Director Kharadar General HospitalKarachiParkistan Assistant Professor of medicine Hamdard UniversityParkistan Director medical and Regulatory Affairs Hilton Pharma (Pvt.) LtdParkistan

AIm： To assess the efficacy and safety of Saccharomyces boulardii （S. boulardii） in acute watery diarrhoea and its role in reducing the frequency of episodes of diarrhoea in subsequent two months. mETHODS： Children from 2 mo to 12 years of age, with acute diarrhoea were selected according to inclusion criteria and randomised in S. boulardii group （treated with ORS, nutritional support and S. boulardii, 250 mg bid） and in control group （treated with ORS and nutritional support only）. Active treatment phase was 5 d and each child was followed for two months afterwards. Frequency and consistency of stools as well as safety of drug was assessed on every visit. A comparison of two groups was done in terms of number of diarrhoeal episode in subsequent two months. RESULTS： There were fifty patients in each group. Baseline characteristics such as mean age and the average frequency of stools were comparable in S. boulardii and control group at the time of inclusion in the trial. By d 3 it reduced to 2.7 and 4.2 stools per d respectively and by d 6 it reduced to 1.6 （5. boulardii Group） and 3.3 （control group）. The duration of diarrhoea was 3.6 d in S. boulardii group whereas it was 4.8 d in control group （P = 0.001）. In the following two months, S. boulardii group had a significantly lower frequency of 0.54 episodes as compared to 1.08 episodes in control group. The drug was well accepted and tolerated. There were no reports of the side effects during treatment period CONCLUSION： S. boulardii significantly reduces the frequency and duration of acute diarrhoea. The consistency of stool also improves. The drug is well-tolerated.

关键词： Acute watery diarrhoea Probiotic Saccharomyces boulardii Frequency of episodes of diarrhoea Weight gain

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In vivo analysis of hybrid hydrogels containing dual growth factor combinations,and skeletal stem cells under mechanical stimulation for bone repair

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mechanobiology in medicine 2024年第4期2卷 97-109页

作者： David Gothard michael Rotherham Emma L.Smith Janos m.Kanczler James Henstock Julia A.Wells Carol A.Roberts Omar Qutachi Heather Peto Hassan Rashidi Luis Rojo Lisa J.White molly m.Stevens Alicia J.El Haj Felicity R.J.ose Richard O.C.Oreffo Bone and Joint Research Group Centre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthamptonSO166YDUK Institute for Science and Technology in medicine Keele UniversityGuy Hilton Research CentreStoke-on-TrentST47BQUK Healthcare Technologies Institute School of Chemical EngineeringInstitute of Translational MedicineUniversity of BirminghamBirminghamB152THUK Department of Applied Sciences Pandon BuildingNorthumbria UniversityNewcastle-upon-TyneNE21XEUK Wolfson Centre for Stem Cells Tissue Engineering and ModellingUniversity of NottinghamCentre for Biomolecular SciencesUniversity ParkNottinghamNG72RDUK Leicester Institute for Pharmaceutical Innovation(LIPI) Leicester School of PharmacyFaculty of Health and Life SciencesDe Montfort UniversityThe GatewayLeicesterLE19BHUnited Kingdom Stem Cells and Regenerative medicine Section UCL Great Ormond Street Institute of Child HealthUniversity College LondonLondonWC1N 1EHUK Department of materials Imperial College LondonRoyal School of MinesLondonSW72AZUK Department of Bioengineering Imperial College LondonSouth Kensington CampusLondonSW72AZUK Instituto de Ciencia y Tecnología de Polímeros(ICTP) CSICCalle Juan de la Cierva328006 MadridSpain Consorcio Centro de Investigacion Biomedica en Red CIBER-BBNInstituto de Salud Carlos IIICalle Monforte de Lemos 3-51128029 PabellonMadridSpain Nottingham Biodiscovery Institute School of PharmacyUniversity of NottinghamNottinghamNG72RDUK Institute for Biomedical Engineering Imperial College London South Kensington CampusLondonSW72AZUK Department of Physiology Anatomy&GeneticsDepartment of Engineering Scienceand Kavli Institute for Nanoscience DiscoveryUniversity of OxfordOxfordOX13QUUK

Bone tissue engineering requires a combination of materials,cells,growth factors and mechanical cues to recapitulate bone *** this study we evaluated hybrid hydrogels for minimally invasive bone formation by combining biomaterials with skeletal stem cells and staged release of growth factors together with *** hydrogels consisting of alginate and decellularized,demineralised bone extracellular matrix(ALG/ECm)were seeded with Stro-1t human bone marrow stromal cells(HBmSCs).Dual combinations of growth factors within staged-release polylactic-co-glycolic acid(PLGA)microparticles were added to hydrogels to mimic,in part,the signalling events in bone regeneration:VEGF,TGF-β_(3),PTHrP(fast release),or BmP-2,vitamin D_(3)(slow release).mechanotransduction was initiated using magnetic fields to remotely actuate superparamagnetic nanoparticles(mNP)targeted to TREK1 ion *** hydrogels were implanted subcutaneously within mice for 28 days,and evaluated for bone formation using micro-CT and *** hydrogels lacking HBmSCs,growth factors,or mNP became mineralised,and neither growth factors,HBmSCs,nor mechanotransduction increased bone ***,structural differences in the newly-formed bone were influenced by growth *** release of BmP-2 induced thick bone trabeculae and PTHrP or VitD_(3)increased bone ***,fast-release of TGF-β_(3)and VEGF resulted in thin *** reversed the trabecular thinning and increased collagen deposition with PTHrP and VitD_(3).Our findings demonstrate the potential of hybrid ALG/ECm hydrogel–cell–growth factor constructs to repair bone in combination with mechanotransduction for fine-tuning bone *** approach may form a minimally invasive reparative strategy for bone tissue engineering applications.

关键词： Growth factors Controlled release Bone ECm Bone formation mechanotransduction Skeletal stem cell

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Lynch综合征患者hmLH1和hmSH2基因数量变化的特征

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世界核心医学期刊文摘（胃肠病学分册） 2006年第2期2卷 35-35页

作者： Baudhuin L.m. Ferber m.J. Winters J.L. S.N. Thibodeau 陈云茹 mayo Clinic Department of Laboratory Medicine and Pathology 920 Hilton Building 200 First Street SW Rochester MN 55905 United States Dr.

Background & Aims: A significant proportion of Lynch syndrome cases are believed to be due to large genomic alterations in the mismatch repair genes hmLH1 and hmSH2. However, previous studies have not adequately identified the frequency and scope of such mutations, and routine clinical Lynch syndrome testing often does not include analysis for these mutations. Our aim was to characterize hmLH1 and hmSH2 genomic rearrangements in a large population of suspected Lynch syndrome patients. methods: A total of 365 samples from probands referred for genetic testing for Lynch syndrome were analyzed for the presence of large genomic alterations in hmLH1 or hmSH2 by using a combination of techniques. Samples with a deletion in exons 1- 6 in hmSH2 were further characterized by polymerase chain reaction to establish the presence of the hmSH2 American founder deletion. Results: An hmLH1 or hmSH2 mutation was identified in 153 cases, and, of these, 12 of 67 (17.9% ) and 39 of 86 (45.3% ) had a large genomic alteration in hmLH1 and hmSH2, respectively. Overall, 6 different hmLH1 and 12 different hmSH2 deletions/ duplications, including 10 novel mutations, were identified. Analysis of the hmSH2 exon 1- 6 deletion samples showed that 13 of 18 (72.2% ) had the American founder deletion. Conclusions: These data show a high frequency and diverse spectrum of large genomic alterations in hmLH1 and hmSH2 in suspected Lynch syndrome patients. Thus, a comprehensive mutation identification strategy that includes the ability to detect large genomic rearrangements is imperative for the clinical genetic identification of Lynch syndrome patients and families.

关键词： Lynch hmLH1 hmSH2 基因数量先证者错配修复基因标本分析聚合酶链反应基因重排

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