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解剖学杂志 2015年第1期38卷 31-34页

作者：钱金泽霍佳钱俊乔李陈莉赵昱樋口京一段惠军河北医科大学病理学教研室石家庄050017 河北医科大学附属第三医院骨病科石家庄050017 河北医科大学口腔医院石家庄050017 河北医科大学组织学与胚胎学教研室石家庄050017 日本信州大学医学部加龄生物学教研室松本390862

目的：探讨载脂蛋龄Ⅱ形成的小鼠老化淀粉样纤维是否可形成并沉积于骨骼肌中。方法：采用R1．P1-Apoa2c小鼠进行淀粉样变诱导实验，诱导实验进行2个月后，通过组织学、免疫组织化学、透射电镜及分子生物学检测骨骼肌中淀粉样纤维的沉积... 详细信息

目的：探讨载脂蛋龄Ⅱ形成的小鼠老化淀粉样纤维是否可形成并沉积于骨骼肌中。方法：采用R1．P1-Apoa2c小鼠进行淀粉样变诱导实验，诱导实验进行2个月后，通过组织学、免疫组织化学、透射电镜及分子生物学检测骨骼肌中淀粉样纤维的沉积程度。结果：通过淀粉样变诱导实验2个月及4个月后，淀粉样纤维主要沉积于小鼠骨骼肌中的结缔组织及肌内膜内。结论：小鼠老化淀粉样纤维可在骨骼肌肌内膜及结缔组织中沉积，并为淀粉样变疾病的发生机制提供了新的理论依据。

关键词：小鼠老化淀粉样纤维骨骼肌免疫组织化学电镜

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隆突下积气/主支气管憩室的特征与CT表现

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国际医学放射学杂志 2010年第2期 191-191页

作者： T.higuchi N.Takahashi m.Shiotani H.maeda N.Yoshimura 金涵弢 Department of Radiology Niigata City General Hospital463-7 Chuo-kuShumokuNiigata CityNiigata-ken950-1197Japan

本研究的目的在于评价隆突下积气在多层螺旋CT(mDCT)薄层影像上的特征及CT表现。200名无肺部疾病史且无症状的成人行mDCT检查。病灶为隆突下区域邻近主支气管的腔外气体,本文回顾性地分析其CT表现及特征。其中81人有隆突下积气,

关键词：支气管憩室隆突 CT 积气

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Nanoencapsulation of Antioxidant-Rich Fraction of Roasted moringa oleiferaL. Leaf Extract: Physico-Chemical Properties and in VitroRelease mechanisms

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Food and Nutrition Sciences 2021年第9期12卷 915-936页

作者： Pierre Nobossé Edith N. Fombang Damanpreet Singh Carl m. F. mbofung Department of Food Science and Nutrition National School of Agro-Industrial Sciences ENSAI University of Ngaoundere Ngaoundere Adamawa Region Cameroon Pharmacology and Toxicology Laboratory CSIR-Institute of Himalayan Bioresource Technology Palampur Himachal Pradesh India

Nanocapsules (NC) of antioxidant rich fraction of roasted moringa leaves were prepared using emulsion coacervation technique with alginate (ALG) and/or chitosan (CTS) as biopolymers. NC were characterized based on par... 详细信息

Nanocapsules (NC) of antioxidant rich fraction of roasted Moringa leaves were prepared using emulsion coacervation technique with alginate (ALG) and/or chitosan (CTS) as biopolymers. NC were characterized based on particle size, polydispersity index (PDI), zeta potential, encapsulation efficiency (EE) and loading capacity (LC). Substituting CTS with ALG in NC caused a reduction in particle size and PDI, and enhanced EE. mean particle size dropped from 1209 nm in 1:3 to 413 nm in 3:1 ALG/CTS-NC;PDI decreased from 0.9% to 0.2% and zeta potential from -5.4 to -28.1 mV. The highest EE (87.6%) and LC (13%) were obtained with ALG-CTS-NC (3:1). ALG-NC were spherical while both CTS and ALG-CTS-NC were ovoid. ALG and ALG-CTS-NC were oil/water emulsions while CTS-NC formed water/oil emulsions. 60% and 70% of bioactives in ALG-CTS-NC (3:1) were released in simulated gastric and intestinal fluids respectively after 400 min. Release of antioxidants from NC is concentration-dependent (First order model) and involves simultaneously diffusion (higuchi model), swelling (korsmeyer-Peppas model) and erosion (Hixson-Crowell model) mechanisms.

关键词： Nanoencapsulation Roasted moringa Leaf Extract Liquid-Liquid Partitioning Antioxidant Activity Phenolic Compounds Physico-Chemical Properties Release mechanisms

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用于瘤内注射的姜黄素热敏水凝胶的制备及表征

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中国医药工业杂志 2013年第10期44卷 1017-1017页

作者： Gao m

采用正交试验，以凝胶化温度、黏度和药物含量为指标优化姜黄素热敏水凝胶（CTH）处方。该处方是一种用于瘤内注射的凝胶注射剂。所得优化的CTH处方为：0．2％姜黄素，20％泊洛沙姆407，4％泊洛沙姆188，8％聚乙二醇400，12％1,2一丙二... 详细信息

采用正交试验，以凝胶化温度、黏度和药物含量为指标优化姜黄素热敏水凝胶（CTH）处方。该处方是一种用于瘤内注射的凝胶注射剂。所得优化的CTH处方为：0．2％姜黄素，20％泊洛沙姆407，4％泊洛沙姆188，8％聚乙二醇400，12％1,2一丙二醇，pH6．0。其体外释放试验数据符合higuchi方程。CTH的pH值应尽量接近瘤内环境（约pH7．2），但该pH值条件下姜黄素的稳定性很差。经试验表明，姜黄素的降解速率符合一级动力学，并在pH6．0时较稳定，故选用。

关键词：热敏水凝胶姜黄素注射剂泊洛沙姆407 聚乙二醇400 表征制备正交试验

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Formulation and In-VitroRelease Pattern Study of Gliclazide matrix Tablet

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Pharmacology & Pharmacy 2015年第3期6卷 125-131页

作者： Tanbir Ahammad marium Begum A. F. m. Towheedur Rahman moynul Hasan Saikat Ranjan Paul Shaila Eamen md. Iftekhar Hussain md. Hazrat Ali md. Ashraful Islam mohammad mizanur Rahman mamunur Rashid Department of Pharmacy BRAC University Dhaka Bangladesh Department of Pharmacy Primeasia University Dhaka Bangladesh Department of Pharmaceutical Sciences North South University Dhaka Bangladesh Department of Pharmacy Dhaka International University Dhaka Bangladesh Department of Pharmacy Southeast University Dhaka Bangladesh Department of Pharmacy Jahangirnagar University Dhaka Bangladesh Department of Pharmacy International Islamic University of Chittagong Chittagong Bang-ladesh Department of Biomedical Imaging Faculty of Bioscience Abo Akademi University Turku Finland Department of Pharmacy University of Rajshshi Rajshahi Bangladesh

In current decade, pharmaceutical industries of Bangladesh are giving much emphasize on the formulation of time release preparation to treat various chronic diseases in order to decrease the frequency of administration and to improve patient compliance. Objectives: The objective of this investigation is to design and evaluate sustained release matrix tablet of Gliclazide by direct compression method employing polymers of hydroxypropylmethyl cellulose (HPmC) derivatives (K15m CR and K4m CR) and to select the optimized formulations and compression process by performing a comparative release kinetic study with a reference product, Diamicron mR (one of the worldwide brand of Gliclazide sustain released tablet manufactured by Servier one of the French pharmaceutical company) tablet. methods: Release kinetics of Gliclazide matrix tablets were determined using USP paddle method at Phosphate buffer (pH 7.4). The release mechanism was explored and explained with zero order, first order, higuchi and Korsmeyer model. Result: It is found that formulation with lower polymeric concentration follows higuchi release kinetics and that the formulation with higher concentration best fits with zero order release kinetics. Among the formulations, F1 and F6 show almost similar dissolution profile with Diamicron mR Tablet, which can be suitable candidates for further in-vivo bioequivalence study. Conclusion: Findings of this investigation suggest that F1 and F6 formulations are potential candidates for further bioequivalence study among other formulations.

关键词： Gliclazide Sustained Release methocel K15m CR methocel K4m CR In-Vitro Bioequivalence

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