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Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

Action of ZDY101 on passive avoidance test and brain m-receptor density after intracranial co-injection of Aβ plus ibotenic acid

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Nuclear Science and Techniques 2001年第4期12卷 250-255页

作者： HUYa－er XIAZong－Qin 等 ResearchLaboratoryofCellRegulation ShanghaiSecondMedicalUniversityShanghai200025

The aim of this study was to establish a model by single injection of Aβ1-40+IA into rat brain basal ganglion and examine the effect of ZDY101, an active component of a Yin tonic from Chinese traditional medicinal herb. The results showed that the amnestic effect of co-injection of Aβ and IA lasted for at least 2 months. At same time, the total m-receptor density in model brain was significantly lower than blank control, indicating the change is profound enough for long term pathological studies or drug screening. It can be clearly seen that the decreased brain m-receptor density caused by Aβ was significantly increased by ZDY101. Such an elevation effect was significantly correlated with dose of ZDY101 when the dose was examined in a certain reasonable range. It can also he clearly seen that such an elevation of m-cholinergic receptor density was significantly correlated with the improvement of memory which indicated that the increase of m-cholinergic receptor density was an important factor in improving the memory of such animal model.

关键词：放射医学 Alzeimer病动物模型

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Brain-penetrating neurotrophic factor mimetics: Her-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Sequential occurrence of T790m mutation and small cell lung cancer transformation in EGFR-positive lung adenocarcinoma:A case report

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World Journal of Clinical Cases 2022年第9期10卷 2836-2843页

作者： er Hong Xi-er Chen Jia mao Jing-Jing Zhou Ling Chen Jia-Yi Xu Wei Tao Department of Respiratory Ningbo Municipal Hospital of Traditional Chinese MedicineAffiliated to Zhejiang Chinese Medical UniversityNingbo 315000Zhejiang ProvinceChina Department of Radiology Ningbo Municipal Hospital of Traditional Chinese MedicineAffiliated to Zhejiang Chinese Medical UniversityNingbo 315000Zhejiang ProvinceChina

BACKGROUND The emergence of secondary drug resistance when treating epidermal growth factor receptor(EGFR)mutated non-small cell lung cancer(NSCLC)using EGFRtyrosine kinase inhibitors(EGFR-TKIs),seriously affects the therapeutic efficacy and survival of ***,we report a case of advanced NSCLC focusing on the application of multiple biopsy modalities to reveal the development of multiple resistance mechanisms during targeted *** SUmmARY A 54-year-old male patient presented with EGFR 19Del-mutated advanced lung adenocarcinoma,and exhibited the development of a T790m mutation during initial TKI *** 3 mo of Osimertinib treatment,a mixed response was *** biopsy of the progressive lesion showed transformation to small cell lung cancer(SCLC)harboring RB1 and TP53 mutations,with loss of the original T790m mutation.A standard chemotherapy regimen with Anlotinib for SCLC was *** biopsy revealed adenocarcinoma combined with SCLC after tumor *** patient’s overall survival was 24 *** multiple biopsy modalities can reveal the development of multiple resistance mechanisms which help with treatment *** treatment regimens according to the drug resistance mechanism significantly improved the prognosis of such patients.

关键词： Adenocarcinoma Epidermal growth factor receptor-tyrosine kinase inhibitor Epidermal growth factor receptor-T790m mutation Small cell lung cancer transformation Chemotherapy Case report

Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

SBL-JP-0004: A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology research 2025年第1期33卷 235-243页

作者： Hassan m Otifi Department of Pathology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Background:Gastric cancer (GC) remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, making them attractive targets for therapeutic interventions.methods:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and SNU-5 GC cells were used for evaluation.Results:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases, as evidenced by molecular docking scores and molecular dynamics simulations. Binding interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target proteins. SBL-JP-0004 displayed an half-maximal inhibitory concentration (IC) value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD enzymes. SBL-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells, with half-maximal growth inhibitory concentration (GI) values of 250.8 and 516.3 nm, respectively. A significant elevation in the early phase apoptosis (28.53% in KATOIII cells and 26.85% in SNU-5 cells) and late phase apoptosis (17.37% in KATOIII cells and 10.05% in SNU-5 cells) were observed with SBL-JP-0004 treatment compared to 2.1% and 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Dual inhibition Gastric cancer (GC) JAK2 molecular docking molecular dynamics simulation PI3KCD SBL-JP-0004

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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STUDY ON REACTION OF (μ_3-CCO_2Et)CO_2m(CO)_8(Cpme)(m=mo,W) WITH Na_2[Fe(CO)_4].SYNTHESIS OF TWO KINDS OF THE NOVEL CLUSTerS EtO_2CCFeCom(CO)_8(Cpme)H AND (OCC)FeCom(CO)_8(Cpme)

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Chinese Chemical Letters 1996年第4期7卷 381-384页

作者： Wu, HP Ding, er Yin, YQ Huang, XY Yu, KB CHINESE ACAD SCI LANZHOU INST CHEM PHYSLANZHOU 730000PEOPLES R CHINA FUZHOU INST STRUCT mATTer STN KEY LAB STRUCT CHEMFUZHOU 350002PEOPLES R CHINA CHINESE ACAD SCI CHENGDU CTR ANAL & MEASUREMENTCHENGDU 610041PEOPLES R CHINA

The reactions of dusters (μ3- CCO2Et)Co2m (CO)8(meCp)[m = mo(2a),W(2b)], derived from the reaction of (μ3-CCO2Et)Co3(CO)9 with Na[m(CO)3(meCp)], with Na2[Fe(CO)4] in THF at reflux not only gave the expected metal fragment exchange products (μ3-CCO2Et) FeCom (CO)6(me-Cp )H [m=mo(3a), W(3b)] but also produced the unexpected compounds (μ3-CCO)FeCom (CO)5(meCp) [m=mO(4a), W(4b)]. It is suggested that the formation of two kinds of compounds resulted from two competitive reactions of the intermediates [(μ3-CCO2Et) FeCo m(CO)8,(meCp)] with 11+: the one is the Protonic reaction of the intermediate giving the cluster 3a,b; the another one is the intermolecular nucleophilic substitution reaction of the intermediate under the H+ catalytic action giving the cluster 4a,b.

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