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Dietary glycine supplementation enhances syntheses of creatine and glutathione by tissues of hybrid striped bass(morone saxatilis ♀ × morone chrysops ♂) fed soybean meal-based diets

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1996-2011页

作者： Wenliang he Xinyu Li Guoyao Wu Department of Animal Science Texas A&M UniversityCollege StationTX 77843USA

Background We recently reported that supplementing glycine to soybean meal-based diets is necessary for the optimum growth of 5-to 40-g(Phase-I)and 110-to 240-g(Phase-II)hybrid striped bass(HSB),as well as their intestinal *** glycine serves as an essential substrate for syntheses of creatine and glutathione(GSH)in mammals(e.g.,pigs),little is known about these metabolic pathways or their nutritional regulation in *** study tested the hypothesis that glycine supplementation enhances the activities of creatine-and GSH-forming enzymes as well as creatine and GSH availabilities in tissues of hybrid striped bass(HSB;morone saxatilis♀×morone chrysops♂).methods Phase-I and Phase-II HSB were fed a soybean meal-based diet supplemented with 0%,1%,or 2%glycine for 8 *** the end of the 56-d feeding,tissues(liver,intestine,skeletal muscle,kidneys,and pancreas)were collected for biochemical *** In contrast to terrestrial mammals and birds,creatine synthesis occurred primarily in skeletal muscle from all *** liver was most active in GSH synthesis among the HSB tissues *** Phase-I HSB,supplementation with 1%or 2%glycine increased(Pmuscular creatine(15%–19%)and hepatic GSH(8%–11%),while reducing(Phepatic GSH sulfide(GSSG)/GSH ratios by 14%–15%,compared with the 0-glycine group;there were no differences(P>0.05)in these variables between the 1%and 2%glycine *** Phase-II HSB,supplementation with 1%and 2%glycine increased(Phe muscle(15%–27%)and liver(11%–20%)in a dose-dependent manner,with reduced ratios of hepatic GSSG/GSH in the 1%or 2%glycine *** all HSB,supplementation with 1%and 2%glycine dose-dependently increased(Pmuscular arginine:glycine amidinotransferase(22%–41%)and hepaticγ-glutamylcysteine synthetase(17%–37%),with elevated activities of intramuscular guanidinoacetate methyltransferase and hepatic GSH synthetase a

关键词： Amino acids Creatine Fish Glutathione Glycine Nutrition

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From traditional Chinese medicine formulations to effective anticancer agents:Insights from Calculus bovis

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World Journal of Gastroenterology 2024年第35期30卷 4011-4013页

作者： he-Tong Zhao Department of Traditional Chinese medicine Navy No.905 HospitalShanghai 200050China

This editorial examines the therapeutic potential of traditional Chinese medicine(TCm)for aggressive cancers,particularly liver *** highlights the study by Huang et al,which shows how Calculus bovis,a component of the TCm Pien Tze Huang,suppresses liver cancer by inhibiting m2 macrophage polarization via the Wnt/β-catenin *** research emphasizes the importance of transitioning from effective TCm formulations to isolating active components and understanding their *** the study provides valuable insights,it primarily focuses on the Wnt/β-catenin pathway and does not delve deeply into the mechanisms of individual *** research should aim to comprehensively study these components,explore their interactions,and validate findings through clinical *** approach will integrate traditional wisdom with modern scientific validation,advancing the development of innovative cancer treatments based on TCm formulations.

关键词： Calculus bovis Traditional Chinese medicine Liver cancer Tumor microenvironment m2 tumor-associated macrophages Wnt/β-catenin pathway

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Hydrocarbon gas huff-n-puff optimization of multiple horizontal wells with complex fracture networks in the m unconventional reservoir

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Petroleum Science 2024年第2期21卷 1018-1031页

作者： Hao-Chuan Zhang Yong Tang You-Wei he Yong Qin Jian-Hong Luo Yu Sun Ning Wang De-Qiang Wang State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina CNPC Research Institute of Petroleum Exploration&Development Beijing100083China Southwest Oil&Gas Field Company PetroChinaChengdu610051SichuanChina State Key Laboratory of Offshore Oil Exploitation CNOOC Research Institute Co.LtdBeijing100027China

The oil production of the multi-fractured horizontal wells(mFHWs) declines quickly in unconventional oil reservoirs due to the fast depletion of natural energy. Gas injection has been acknowledged as an effective method to improve oil recovery factor from unconventional oil reservoirs. Hydrocarbon gas huff-n-puff becomes preferable when the CO_(2) source is limited. However, the impact of complex fracture networks and well interference on the EOR performance of multiple mFHWs is still unclear. The optimal gas huff-n-puff parameters are significant for enhancing oil recovery. This work aims to optimize the hydrocarbon gas injection and production parameters for multiple mFHWs with complex fracture networks in unconventional oil reservoirs. Firstly, the numerical model based on unstructured grids is developed to characterize the complex fracture networks and capture the dynamic fracture ***, the PVT phase behavior simulation was carried out to provide the fluid model for numerical simulation. Thirdly, the optimal parameters for hydrocarbon gas huff-n-puff were obtained. Finally, the dominant factors of hydrocarbon gas huff-n-puff under complex fracture networks are obtained by fuzzy mathematical method. Results reveal that the current pressure of hydrocarbon gas injection can achieve miscible displacement. The optimal injection and production parameters are obtained by single-factor analysis to analyze the effect of individual parameter. Gas injection time is the dominant factor of hydrocarbon gas huff-n-puff in unconventional oil reservoirs with complex fracture networks. This work can offer engineers guidance for hydrocarbon gas huff-n-puff of multiple mFHWs considering the complex fracture networks.

关键词： Unconventional oil reservoir Complex fracture network Hydrocarbon gas huff-n-puff Parameter optimization Numerical simulation

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TGF-βsignaling in health,disease,and therapeutics

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1466-1505页

作者： Ziqin Deng Tao Fan Chu Xiao he Tian Yujia Zheng Chunxiang Li Jie he Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

ransforming growth factor(TGF)-βis a multifunctional cytokine expressed by almost every tissue and cell *** signal transduction of TGF-βcan stimulate diverse cellular responses and is particularly critical to embryonic development,wound healing,tissue homeostasis,and immune homeostasis in *** dysfunction of TGF-βcan play key roles in many diseases,and numerous targeted therapies have been developed to rectify its pathogenic *** the past decades,a large number of studies on TGF-βsignaling have been carried out,covering a broad spectrum of topics in health,disease,and ***,a comprehensive overview of TGF-βsignaling is required for a general picture of the studies in this *** this review,we retrace the research history of TGF-βand introduce the molecular mechanisms regarding its biosynthesis,activation,and signal *** also provide deep insights into the functions of TGF-βsignaling in physiological conditions as well as in pathological ***-β-targeting therapies which have brought fresh hope to the treatment of relevant diseases are *** the summary of previous knowledge and recent updates,this review aims to provide a systematic understanding of TGF-βsignaling and to attract more attention and interest to this research area.

关键词： homeostasis healing wound

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Regulating melting Process in the Energy Storage of Solid-Liquid PCm based on Double mRT-LBm Simulation

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Journal of Thermal Science 2024年第5期33卷 1688-1700页

作者： CheN Weiqi SONG Zhichao QUAN Dongliang he Yurong School of Energy Science&Engineering Harbin Institute of TechnologyHarbin 150001China heilongjiang Key Laboratory of New Energy Storage materials and Processes Harbin 150001China Zhengzhou Research Institute of Harbin Institute of Technology Zhengzhou 450000China Innovation&Research Institute of Hiwing Technology Academy Beijing 100074China

The melting process of solid-liquid phase change materials(PCm)has a significant impact on their energy storage *** more effectively apply solid-liquid PCm for energy storage,it is crucial to study the regulation of melting process of solid-liquid PCm,which is numerically investigated based on double multiple relaxation time lattice Boltzmann method(mRT-LBm)in this *** this work we pay more attention to the effects of different Stefan numbers(Ste)and Rayleigh numbers(Ra)on the melting *** results indicate that the PCm melting is greatly influenced by the Ste number and Ra number,which can be divided into the heat conduction dominant stage and the convection dominant stage,according to the onset time of convection Fo_(C).In order to describe the contribution of the heat conduction dominant stage to the whole melting process quantitatively,we firstly propose the ratio of the heat conduction dominant stage R_(pc),which can be defined as the ratio of Fo_(C)to the complete melting time Fo_(m).R_(pc)gradually decreases as the Ra number increases,and when the Ste number rises:R_(pc)=90.0%when Ste=1.0 and Ra=1×10^(5),R_(pc)=39.6%when Ste=0.1 and Ra=1×10^(5),and R_(pc)=14.0%when Ste=1.0 and Ra=1×10~7.A regime map about the effects of different Ste numbers and Ra numbers on R_(pc)has been further *** discovered findings would be helpful in regulating melting process in the energy storage of solid-liquid PCm.

关键词： latent thermal energy storage solid-liquid phase change double mRT-LBm dominant melting mechanism

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OIP5 Interacts with NCK2 to mediate Human Spermatogonial Stem Cell Self-Renewal and Apoptosis through Cell Cyclins and Cycle Progression and Its Abnormality Is Correlated with male Infertility

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Research 2024年第1期2023卷 455-469页

作者： Yinghong Cui Wei Chen Li Du Zuping he The Key Laboratory of model Animals and Stem Cell Biology in Hunan Province The Research Center of Reproduction and Translational Medicine of Hunan ProvinceHunan Normal University School of MedicineChangsha 410013HunanChina

Spermatogonial stem cells(SSCs)have important applications in both reproduction and regenerative ***,specific genes and signaling transduction pathways in mediating fate decisions of human SSCs remain ***,we have demonstrated for the first time that OIP5(Opa interacting protein 5)controlled the self-renewal and apoptosis of human *** sequencing identified that NCK2 was a target for OIP5 in human SSCs,and interestingly,OIP5 could interact with NCK2 as shown by Co-IP(co-immunoprecipitation),IP-mS(mass spectrometry),and GST pulldown ***2 silencing decreased human SSC proliferation and DNA synthesis but enhanced their ***,NCK2 knockdown reversed the influence of OIP5 overexpression on human ***,OIP5 inhibition decreased the numbers of human SSCs at S and G2/m phases,while the levels of numerous cell cycle proteins,including cyclins A2,B1,D1,E1 and H,especially cyclin D1,were remarkably ***,whole-exome sequencing of 777 patients with nonobstructive azoospermia(NOA)revealed 54 singlenucleotide polymorphism mutations of the OIP5 gene(6.95%),while the level of OIP5 protein was obviously lower in testes of NOA patients compared to fertile ***,these results implicate that OIP5 interacts with NCK2 to modulate human SSC self-renewal and apoptosis via cell cyclins and cell cycle progression and that its mutation and/or lower expression is correlated with *** such,this study offers novel insights into molecular mechanisms underlying the fate determinations of human SSCs and the pathogenesis of NOA,and it provides new targets for treating male infertility.

关键词： OIP5 Apoptosis reversed

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Design of a Novel Exoskeleton with Passive magnetic Spring Self-locking and Spine Lateral Balancing

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Journal of Bionic Engineering 2024年第1期21卷 236-255页

作者： Jhon F.Rodríguez-león Betsy D.m.Chaparro-Rico Daniele Cafolla Francesco Lago Eduardo Castillo-Castañeda Giuseppe Carbone Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada Unidad Querétaro MecatronicaInstituto Politécnico NacionalCerro Blanco 14176090 Colinas del CimatarioQuerétaroMexico Department of mechanical Energy and Management EngineeringUniversity of CalabriaVia P.Bucci Cubo 46 C87036 RendeItaly Faculty of Science and Engineering Department of Computer ScienceSwansea UniversitySwanseaUK CESTER University of Cluj-NapocaCluj-NapocaRomania

This paper proposes a new upper-limb exoskeleton to reduce worker physical *** proposed design is based on a novel PRRRP(P-Prismatic;R-Revolute)kinematic chain with 5 passive Degrees of Freedom(DoF).Utilizing a magnetic spring,the proposed mechanism includes a specially designed locking mechanism that maintains any desired task *** proposed exoskeleton incorporates a balancing mechanism to alleviate discomfort and spinal torsional effects also helping in limb weight *** paper reports specific models and simulations to demonstrate the feasibility and effectiveness of the proposed *** experimental characterization is performed to validate the performance of the mechanism in terms of forces and physical strain during a specific application consisting of ceiling-surface drilling *** obtained results preliminarily validate the engineering feasibility and effectiveness of the proposed exoskeleton in the intended operation task thereby requiring the user to exert significantly less force than when not wearing it.

关键词： Assistive mechanism Exoskeleton Locking mechanism Bionic robot

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Interaction of yttrium barrier and calcium-rich phase on production and properties of WC precursor powders and alloys

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Journal of Rare Earths 2024年第1期42卷 228-236,I0008页

作者： Wen he Dunqiang Tan Zhiqiang Yi Zhiqiang Liu School of materials Science and Engineering Nanchang UniversityNanchang330031China Instrumental Analysis Center of Nanchang Hangkong University Nanchang330063China

In order to reduce or eliminate the adverse effects of calcium impurity,the interaction of Ca and rare earth Y co-doping on the preparation of WC-Co cemented carbides was investigated.X-ray diffraction,scanning electron microscopy and transmission electron microscopy were employed to analyze the phase compositions,particle sizes and morphologies of them,*** results show that the second type of"yttrium barrier effect"is observed and the adverse influence of Ca-rich phase on tungsten powder can be eliminated by *** flexural strength and fracture toughness of YG6-0.01%Ca+0.09%Y alloy are 2199.5 mPa and 11.49 mPa·m^(1/2),showing improvement of 6.5% and 2.7% compared to YG6 alloy,*** evolutions of Ca-rich phase and Y-rich phase at the every alloy preparation stage of WO_(3),W,WC and cemented carbides are ***,the strengthening mechanism of WC-Co cemented carbide with co-addition of Ca and Y is proposed.

关键词： Yttrium barrier effect Ca-rich phase WC-Co cemented Carbide microstructures mechanisms Rare earths

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Accelerated Primal-Dual Projection Neurodynamic Approach With Time Scaling for Linear and Set Constrained Convex Optimization Problems

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1485-1498页

作者： You Zhao Xing he mingliang Zhou Tingwen Huang Chongqing Key Laboratory of Nonlinear Circuits and Intelligent Information Processing College of Electronic and Information EngineeringSouthwest UniversityChongqing 400715China School of Computer Science Chongqing UniversityChongqing 400044China Department of mathematics Texas A&M University at QatarDoha 23874Qatar IEEE

The Nesterov accelerated dynamical approach serves as an essential tool for addressing convex optimization problems with accelerated convergence *** previous studies in this field have primarily concentrated on unconstrained smooth con-vex optimization *** this paper,on the basis of primal-dual dynamical approach,Nesterov accelerated dynamical approach,projection operator and directional gradient,we present two accelerated primal-dual projection neurodynamic approaches with time scaling to address convex optimization problems with smooth and nonsmooth objective functions subject to linear and set constraints,which consist of a second-order ODE(ordinary differential equation)or differential conclusion system for the primal variables and a first-order ODE for the dual *** satisfying specific conditions for time scaling,we demonstrate that the proposed approaches have a faster conver-gence *** only requires assuming convexity of the objective *** validate the effectiveness of our proposed two accel-erated primal-dual projection neurodynamic approaches through numerical experiments.

关键词： Accelerated projection neurodynamic approach lin-ear and set constraints projection operators smooth and nonsmooth convex optimization time scaling.

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Retrieval of high spatial resolution mountainous land surface temperature considering topographic and adjacency effects

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Science China Earth Sciences 2024年第11期67卷 3610-3625页

作者： Zhiwei he Bohui TANG Zhaoliang LI Faculty of Land Resources Engineering Kunming University of Science and Technology Key Laboratory of Plateau Remote Sensing Department of Education of Yunnan Province State Key Lab of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences Key Laboratory of Agricultural Remote Sensing Ministry of Agriculture and Rural Affairs Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences

Land surface temperature(LST) is a key parameter reflecting the interaction between land and atmosphere. Currently,thermal infrared(TIR) quantitative remote sensing technology is the only means to obtain large-scale, high spatial resolution LST. Accurately retrieving high spatial resolution mountainous LST(mLST) plays an important role in the study of mountain climate change. The complex terrain and strong spatial heterogeneity in mountainous areas change the geometric relationship between the surface and satellite sensors, affecting the radiation received by the sensors, and rendering the assumption of planar parallelism invalid. In this study, considering the influence of complex terrain in mountainous areas on atmospheric downward radiation and the thermal radiation contribution of adjacent pixels, a mountainous TIR radiative transfer model based on the sky view factor was developed. Combining with the atmospheric radiative transfer model mODTRAN 5.2, a nonlinear generalized split-window algorithm suitable for high spatial resolution mLST retrieval was constructed and applied to Landsat-9 TIRS-2satellite TIR remote sensing data. The analysis results indicate that neglecting the topographic and adjacency effects would lead to significant discrepancies in LST retrieval, with simulated data showing LST differences of up to 2.5 K. Furthermore, due to the lack of measured mLST in the field, the mLST accuracy obtained by this retrieval method was indirectly validated using the currently recognized highest-accuracy forward 3D radiative transfer model DART. The mLST and emissivity were input into the DART model to simulate the brightness temperature at the top of the atmosphere(TOA) of Landsat-9 band 10, and compared with the brightness temperature at TOA of Landsat-9 band 10. The RmSE(Root mean Square Error) for the two subregions was0.50 and 0.61 K, respectively, indicating that the method proposed can retrieve high-precision mLST.

关键词： mountainous land surface temperature Topographic and adjacency effects Nonlinear generalized split-window algorithm Landsat-9 data DART model

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