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人胰岛素原C肽单克隆抗体的研究

中国医学科学院学报 1989年第1期11卷 46-51页

作者：吴从愿 N.Yanaihara C.Yanaihara m.hoshino 协和医院 The National Institute for physiological Sciences Okazaki 444 Japan

半抗原人胰岛素原C肽(HCP)对小鼠的免疫原性,以蛔虫蛋白作为载体远比牛或小鼠清蛋白为高。将NS-1瘤细胞与HCP-蛔虫蛋白结合物免疫的BALB/c小鼠脾细胞融合,获得12种抗HCP mcAb,对其中8种的Ig类和亚类,亲和力及特异性等进行了详细鉴定。... 详细信息

半抗原人胰岛素原C肽(HCP)对小鼠的免疫原性,以蛔虫蛋白作为载体远比牛或小鼠清蛋白为高。将NS-1瘤细胞与HCP-蛔虫蛋白结合物免疫的BALB/c小鼠脾细胞融合,获得12种抗HCP mcAb,对其中8种的Ig类和亚类,亲和力及特异性等进行了详细鉴定。不同的HCP片段置换反应结果表明,HCP mcAb的抗原决定簇分别位于HCP分子的23～31.22～31及1～22氨基酸区。20例正常成人空腹血浆HCP测定值,用兔多克隆抗血清RIA(0.47±0.16pmol/ml)明显高于mCAb-1 RIA(0.29±0.13 pmol/ml).

关键词：胰岛素 C肽单克隆抗体放免分析

冠状动脉中度狭窄病人在冠状动脉CT血管成像上微血管功能障碍的特征性表现

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国际医学放射学杂志 2022年第1期 122-123页

作者： m.hoshino S.Yang T.Sugiyama J.Zhang Y.Kanaji R.Hamaya 汤若薇

摘要目的评估冠状动脉中度狭窄病人并发冠状动脉微血管功能障碍（CmD）的患病率，并分析冠状动脉CT血管成像（CCTA）上病灶、血管及心包脂肪与CmD相关的特征性

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冠状动脉CT斑块特征与冠状动脉血流动力学和心血管事件的关系

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国际医学放射学杂志 2023年第1期46卷 109-109页

作者： S.Yang m.hoshino B.K.Koo T.Yonetsu J.Zhang D.Hwang 王天灏

摘要冠状动脉CT血管成像(CCTA)的斑块评估和冠状动脉血流指数具有预后意义。目的评价CCTA的斑块负荷和特征与冠状动脉压力和血流之间相关性及其预后价值。资

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慢性阻塞性肺疾病多层CT吸气相和呼气相的气道大小:与气流受限的相关性

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国际医学放射学杂志 2008年第A6期31卷 494-494页

作者： S.matsuoka Y.Kurihara K.Yagihashi m.hoshino Y.Nakajima 申小明 Department of Radiology St. Marianna University School of Medicine Kanagawa Japan.

目的通过多层CT的吸气相和呼气相分析慢性阻塞性肺疾病(COPD)病人3～5级支气管分支的气道大小与气流受限的关系。

关键词：呼气相用力呼气容积内面积知情同意功能测试气腔相关系数系数比测量结果

Amino acid sequence of BmK AS, a novel polypeptide activator of ryanodine receptor on skeletal muscle

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Chinese Science Bulletin 1997年第11期42卷 952-956页

作者： Ji, YH Liu, Y Xu, K Ohishi, T mochizuki, T hoshino, m Yanaihara, N Shanghai Institute of Physiology Chinese Academy of Sciences Shanghai China School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan Yanaihara 1st. Inc. Fujinomiya-shi Japan

IN ref.[1],we have described a novel activator(BmK AS)of ryanodine receptor on skeletal muscle,which was obtained from the venom of scorpion Buthus martensi *** noteprovides the complete amino acid sequence of the active polypeptide,BmK *** molecularweight ot the polypeptide thus determined was 7 698 u,calculated based on its sequence(to-tally 66 residues),which was coincident with the value of 7 696.26 u determined by electro-

关键词： scorpion Buthus martensi Karsch ryanodine receptor activator amino acid sequence.

monitoring and mathematical modeling of mitochondrial ATP in myotubes at single-cell level reveals two distinct population with different kinetics

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Quantitative Biology 2020年第3期8卷 228-237页

作者： Naoki matsuda Ken-ichi Hironaka masashi Fujii Takumi Wada Katsuyuki Kunida Haruki Inoue miki Eto Daisuke hoshino Yasuro Furuichi Yasuko manabe Nobuharu LFujii Hiroyuki Noji Hiromi Imamura Shinya Kuroda Department of Biological Sciences Graduate School of ScienceUniversity of TokyoTokyo 113-0033Japan molecular Genetics Research Laboratory Graduate School of ScienceUniversity of TokyoTokyo 113-0033Japan Department of mathematical and Life Sciences Graduate School of Integrated Sciences for LifeHiroshima UniversityHiroshima 739-8526Japan Laboratory of Computati onal Biology Graduate School of Biological SciencesNara Institute of Science and Tech no logyNara 630-0192Japan Department of Computational Biology and medical Sciences Graduate School of Frontier SciencesUniversity of TokyoTokyo 113-0033Japan Department of Engineering Science Graduate School of Informatics and EngineeringUniversity of Electro-CommunicationsTokyo 182-8585Japan Department of Health Promotion Sciences Graduate School of Human Health SciencesTokyo Metropolitan UniversityTokyo 192-0397Japan Department of Applied Chemistry Graduate School of EngineeringUniversity of TokyoTokyo 113-8656Japan Department of Functional Biology Graduate School of BiostudiesKyoto UniversityKyoto 606-8501Japan CREST Japan Science and Technology CorporationTokyo 113-0033Japan

Backgrounds ATP is the major energy source for myotube contraction,and is quickly produced to compensate ATP consumption and to maintain sufficient ATP *** is consumed mainly in cytoplasm and produced in mitochondria during myotube *** understand the mechanism of ATP homeostasis during myotube contraction,it is essential to monitor mitochondrial ATP at single-cell level,and examine how ATP is produced and consumed in ***:We established C2C12 cell line stably expressing fluorescent probe of mitochondrial ATP,and induced differentiation into myotubes・We gave electric pulse stimulation to the differentiated myotubes,and measured mitochondrial *** constructed mathematical model of mitochondrial ATP at single-cell level,and analyzed kinetic parameters of ATP production and ***:We performed hierarchical clustering analysis of time course of mitochondrial ATP,which resulted in two *** 1 showed strong transient increase,whereas cluster 2 showed weak transient *** modeling at single-cell level revealed that the ATP production rate of cluster 1 was larger than that of cluster 2,and that both regulatory pathways of ATP production and consumption of cluster 1 were faster than those of cluster *** 1 showed larger mitochondrial mass than cluster 2,suggesting that cluster 1 shows the similar property of slow muscle fibers,and cluster 2 shows the similar property of fast muscle *** Cluster 1 showed the stronger mitochondrial ATP increase by larger ATP production rate,but not smaller *** 1 might reflect the larger oxidative capacity of slow muscle fiber.

关键词： mitocondrial ATP production ATP consumption single-cell analysis mathematical modeling

A System to Depict the Cognitive Process of Trainees Based on multiple Skill Parameters： System Validation Involving Normal Individuals with an Electrician＇s License

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通讯和计算机（中英文版） 2017年第2期14卷 73-83页

作者： Norikatsu Fujita Hiroshi Takeshita Sho Aoki Hirotada Fukae Kazushige matsumoto Tomohiro murakami minoru hoshino Ability Development Dept. Polytechnic University of Japan

Low-molecular-weight dextran for optical coherence tomography may not be protective against kidney injury in patients with renal insufficiency

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World Journal of Nephrology 2021年第2期10卷 8-20页

作者： Toru misawa Tomoyo Sugiyama Yoshihisa Kanaji masahiro hoshino masao Yamaguchi masahiro Hada Tatsuhiro Nagamine Kai Nogami Yumi Yasui Eisuke Usui Tetsumin Lee Taishi Yonetsu Tetsuo Sasano Tsunekazu Kakuta Department of Cardiovascular medicine Tsuchiura Kyodo General HospitalIbaraki 300-0028Japan Department of Interventional Cardiology Tokyo Medical and Dental UniversityTokyo 113-8519Japan Department of Cardiovascular medicine Tokyo Medical and Dental UniversityTokyo 113-8519Japan

BACKGROUND Low-molecular-weight dextran(LmWD)is considered a safe alternative to contrast media for blood displacement during optical coherence tomography(OCT)*** To investigate whether the use of LmWD for OCT is protective against kidney injury in patients with advanced renal *** In this retrospective cohort study,we identified 421 patients with advanced renal insufficiency(estimated glomerular filtration ratemL/min/1.73 m2)who underwent coronary angiography or percutaneous coronary intervention;79 patients who used additional LmWD for OCT imaging(LmWD group)and 342 patients who used contrast medium exclusively(control group).We evaluated the differences between these two groups and performed a propensity score-matched subgroup *** The median total volume of contrast medium was 133.0 mL in the control group vs 140.0 mL in the LmWD *** baseline renal function was not statistically different between these two groups,the LmWD group demonstrated a strong trend toward the progression of renal insufficiency as indicated by the greater change in serum creatinine level during the 1-year follow-up compared with the control *** in the LmWD group experienced worsening renal function more frequently than patients in the control *** score matching adjusted for total contrast media volume consistently indicated a trend toward worsening renal function in the LmWD group at the 1-year *** serum creatinine at 1-year follow-up was significantly greater in the LmWD group than that in the control group[0.06(-0.06,0.29)vs-0.04(-0.23,0.08)mg/dL,P=0.001],despite using similar contrast *** OCT using LmWD may not be protective against worsening renal function in patients with advanced renal insufficiency.

关键词： Coronary artery disease Kidney injury Contrast media Dextran Optical coherence tomography Renal insufficiency

陈国达矿(Ag9FeTe2S4)：胶东地区金矿床中发现的硫碲化物新矿物

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科学通报 2008年第17期53卷 2064-2070页

作者：谷湘平 WATANABE makoto 谢先德彭省临 NAKAmUTA Yoshihiro OHKAWA makio hoshino Kenichi OHSUmI Kazumasa SHIBATA Yasuhiro 中国科学院广州地球化学研究所广州510640 Department of Earth & Planetary Sciences Hiroshima University Hiroshima 739-8526 Japan 中南大学地学与环境工程学院长沙410083 The Kyushu University museum Kyushu University Fukuoka 812-8581 Japan Photon Factory National Laboratory for High Energy Physics (KEK) Oho 1-1 Ibaraki 305 Japan

陈国达矿(Ag9FeTe2S4),产于中国胶东金矿区埠南金矿的含金-银的黄铜矿-石英脉中,呈5～70μm的半自形-他形粒状与方铅矿、黄铜矿、碲银矿、银金矿、自然银、未定名的Ag6TeS2,Ag16FeBiTe3S8共生,并被自然银和螺状硫银矿包围交代.其平均化... 详细信息

陈国达矿(Ag9FeTe2S4),产于中国胶东金矿区埠南金矿的含金-银的黄铜矿-石英脉中,呈5～70μm的半自形-他形粒状与方铅矿、黄铜矿、碲银矿、银金矿、自然银、未定名的Ag6TeS2,Ag16FeBiTe3S8共生,并被自然银和螺状硫银矿包围交代.其平均化学成分(16个EPmA分析值)为Ag8.97Fe1.00Te1.99S4.04,理想化学式Ag9FeTe2S4.利用甘多菲照相及同步辐射迴摆照相技术,获得陈国达矿的67个衍射线,主要衍射强线的d值和相对强度(括号中)为:6.742(69),6.416(39),5.951(33),3.265(100),2.981(24),2.649(22),2.25(24),2.188(71),2.142(22),2.123(31),2.044(23),1.949(33).该衍射数据指标化为斜方晶系,a=12.769(2),b=14.814(2),c=16.233(1),V=3070.63,Z=9,dcal=6.85g/cm3.反光显微镜下,陈国达矿的光学性质与硫银锡矿接近,浅灰色,无明显非均质性,摩氏硬度2～3,颜色指数:x=0.3027,y=0.3076,Y=25.78%,λd=474nm,Pe=3.68%.该矿物以中国地质学家、地洼学说的创立人陈国达教授的姓名命名.该矿物及命名经ImA-CNmmN于2004年投票通过.2005年作者补充数据后,由CNmmN主席正式公布,批准号2004-042a。

关键词：陈国达矿新矿物硫碲化物同步辐射胶东金矿