<正>This paper aims to FE nonlinear analysis of thin isotropic and also symmetrical composite plates based on DKT(Discrete Kirchhoff Triangular) *** nonlinear analysis of a plate is a more accurate and complicated...
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<正>This paper aims to FE nonlinear analysis of thin isotropic and also symmetrical composite plates based on DKT(Discrete Kirchhoff Triangular) *** nonlinear analysis of a plate is a more accurate and complicated case than linear analysis and has found significant application in the structural analysis,especially in air-structures,shells and *** many current FEm researches,finding an appropriate structural theory,element with sufficient number of nodes and degrees of freedom,per node,is of interest of *** this article the geometrical nonlinear analysis of thin plates based on Kirchhoff- Love theory is *** DKT element,with 5 DoFs in each node,and nonlinear strains are used *** FEm is used for analyzing and finally,Newton-Raphson method is used for solving the nonlinear *** are compared with the other references(including thin and thick plate theories) and the accuracy of this work is shown in comparison with those valid results.
AImTo describe factors associated with treatment failure and frequency of resistance-associated substitutions (RAS).mEThODShuman immunodefciency virus (hIV)/hepatitis C virus (hCV) coinfected patients starting a...
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AImTo describe factors associated with treatment failure and frequency of resistance-associated substitutions (RAS).mEThODShuman immunodefciency virus (hIV)/hepatitis C virus (hCV) coinfected patients starting a first direct-acting antiviral (DAA) regimen before February 2016 and included in the French ANRS CO13 hEPAVIh cohort were eligible. Failure was defned as: (1) non-response [hCV-RNA remained detectable during treatment, at end of treatment (EOT)]; and (2) relapse (hCV-RNA suppressed at EOT but detectable thereafter). Sequencing analysis was performed to describe prevalence of drug class-specifc RAS. Factors associated with failure were determined using logistic regression *** 559 patients, 77% had suppressed plasmahIV-RNA 〈 50 copies/mL at DAA treatment initiation41% were cirrhotic, and 68% were hCV treatmentexperienced. Virological treatment failures occurred in22 patients and were mainly relapses (17, 77%) thenundefined failures (3, 14%) and non-responses (29%). mean treatment duration was 16 wk overall. Posttreatment NS3, NS5A or NS5B RAS were detected in10/14 patients with samples available for sequencinganalysis. After adjustment for age, sex, ribavirin usehCV genotype and treatment duration, low platelecount was the only factor signifcantly associated with ahigher risk of failure (OR: 6.5; 95%CI: 1.8-22.6). CONCLUSIONOnly 3.9% hIV-hCV coinfected patients failed DAAregimens and RAS were found in 70% of those failingLow platelet count was independently associated withvirological failure.
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