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World Journal of Gastrointestinal Surgery 2024年第7期16卷 1956-1959页

作者： meer m Chisthi Department of General Surgery Government Medical College PathanamthittaKonni 689691KeralaIndia

This editorial delves into Peng et al's article,published in the World Journal of Gastrointestinal *** et al's meta-analysis investigates the effectiveness of electrocautery-enhanced lumen-apposing metal stents(ECE-LAmS)in ultrasound-guided biliary drainage for alleviating malignant biliary *** 14 studies encompassing 620 participants,the research underscores a robust technical success rate of 96.7%,highlighting the efficacy of ECE-LAmS,particularly in challenging cases which have failed endoscopic retrograde cholangio pancreatography.A clinical success rate of 91.0% underscores its impact on symptom alleviation,while a reasonably tolerable adverse event rate of 17.5% is ***,the 7.3% re-intervention rate stresses the need for post-procedural *** analyses validate consistent outcomes,bolstering the applicability of *** findings advocate for the adoption of ECELAmS as an appropriate approach for biliary palliation,urging further exploration in real-world clinical *** offer valuable insights for optimizing interventions targeting malignant biliary obstruction management.

关键词： Biliary drainage Electrocautery-enhanced lumen-apposing metal stent Endoscopic retrograde cholangiopancreatography Endoscopic ultrasound malignant biliary obstruction

Emerging role of galectin 3 in neuroinflammation and neurodegeneration

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Neural Regeneration Research 2024年第9期19卷 2004-2009页

作者： Brian m.Lozinski Khanh Ta Yifei Dong Department of Clinical Neuroscience University of CalgaryCalgaryABCanada Deparment of Biochemistry Microbiology&ImmunologyUniversity of SaskatchewanSaskatoonSKCanada

Neuroinflammation and neurodegeneration are key processes that mediate the development and progression of neurological ***,the mechanisms modulating these processes in different diseases remain incompletely *** in single cell based multi-omic analyses have helped to identify distinct molecular signatures such as Lgals3 that is associated with neuroinflammation and neurodegeneration in the central nervous system(CNS).Lgals3 encodes galectin-3(Gal3),aβ-galactoside and glycan binding glycoprotein that is frequently upregulated by reactive microglia/macrophages in the CNS during various neurological *** Gal3 has previously been associated with non-CNS inflammatory and fibrotic diseases,recent studies highlight Gal3 as a prominent regulator of inflammation and neuroaxonal damage in the CNS during diseases such as multiple sclerosis,Alzheimer’s disease,and Parkinson’s *** this review,we summarize the pleiotropic functions of Gal3 and discuss evidence that demonstrates its detrimental role in neuroinflammation and neurodegeneration during different neurological *** also consider the challenges of translating preclinical observations into targeting Gal3 in the human CNS.

关键词： Alzheimer’s disease Galectin 3 microglia multiple sclerosis neurodegeneration neuroinflammation Parkinson’s disease therapeutics

Investigation of material composition,design,and performance of open-graded asphalt mixtures for semi-flexible pavement:A comprehensive experimental study

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 92-116页

作者： mohammad Taghipoor Abolfazl Hassani mohammad m.Karimi Department of Civil and Environmental Engineering Tarbiat Modares UniversityTehranIran

The primary goal of this study is the design and construction of semi-flexible pavement(SFP)mixture in accordance with the engineering and mechanical *** study involves the use of a range of gradation curves,air void contents,cellulose and synthesized fibers,and neat and modified asphalt binders to prepare the open-graded asphalt(OGA)*** analyze the characteristics of these mixtures,a variety of test,namely binder drainage,semi-circular bending(SCB),Cantabro,wheel tracking,indirect tensile strength(ITS),and permeability tests were ***,to analyze the prepared grouting material,flexural strength,compressive strength,and fluidity tests were *** the final stage,SFP was compared to HmA in terms of engineering characteristics and *** to the results,SFP was more resistant to skid,rutting,fire,and moisture damage,while HmA had a better performance in fracture tests,including SCB *** to the results of the mechanical performance tests conducted on OGA mixtures,the highest and lowest values for air void content to achieve the highest mechanical performance level were 30%-35%and 25%,***,based on the laboratory results,it was determined that the required void ratio for constructing OGA mixtures was 24%-26%based on the bitumen type and fibers amount in the ***,SFP mixture can be regarded as a viable alternative to common pavements thanks to its high resistance to rutting and moisture damage,long freezing-thawing fatigue life,and adequate fire and skid resistance.

关键词： Semi-flexible pavement mixture Open-graded asphalt mixture Engineering properties Cantabro test Hot mix asphalt

采用前瞻性触发和心电脉冲降低心脏CT辐射剂量的量化评价:体模研究

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国际医学放射学杂志 2010年第6期 583-583页

作者： L.Lehmkuhl D.Gosch H.D.Nagel P.Stumpp T.Kahn m.gutberlet 郑梅竹 Diagnostische und Interventionelle Radiologie Universitt Leipzig-HerzzentrumStrümpellstrasse 3904289 LeipzigGermany

目的定量评价采用前瞻性触发心脏CT较回顾性心电门控螺旋扫描方式所减少的辐射剂量。材料与方法采用74个热发光剂量计的Alderson模拟男性体模,定量评价64层心脏CT的器官吸收剂量。包括3种成像方案:回顾性

关键词： CT 前瞻门控辐射剂量器官辐射剂量体模

Fire resistance evaluation through synthetic fire tests and generative adversarial networks

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Frontiers of Structural and Civil Engineering 2024年第4期18卷 587-614页

作者： AybikeÖzyükselÇiftçioğlua m.Z.Naser Department of Civil Engineering Manisa Celal Bayar University45140Türkiye School of Civil&Environmental Engineering and Earth Sciences(SCEEES) Clemson UniversityClemsonSC 29631USA Artificial Intelligence Research Institute for Science and Engineering(AIRISE) Clemson UniversityClemsonSC 29631USA

This paper introduces a machine learning approach to address the challenge of limited data resulting from costly and time-consuming fire experiments by enlarging small fire test data sets and predicting the fire resistance of reinforced concrete *** approach begins by creating deep learning models,namely generative adversarial networks and variational autoencoders,to learn the spatial distribution of real fire *** then use these models to generate synthetic tabular samples that closely resemble realistic fire resistance values for reinforced concrete *** generated data are employed to train state-of-the-art machine learning techniques,including Extreme Gradient Boost,Light Gradient Boosting machine,Categorical Boosting Algorithm,Support Vector Regression,Random Forest,Decision Tree,multiple Linear Regression,Polynomial Regression,Support Vector machine,Kernel Support Vector machine,Naive Bayes,and K-Nearest Neighbors,which can predict the fire resistance of the columns through regression and *** learning analyses achieved highly accurate predictions of fire resistance values,outperforming traditional models that relied solely on limited experimental *** study highlights the potential for using machine learning and deep learning analyses to revolutionize the field of structural engineering by improving the accuracy and efficiency of fire resistance evaluations while reducing the reliance on costly and time-consuming experiments.

关键词： deep learning fire resistance generative adversarial networks machine learning

Analysis of synthetic parameters for coating aluminum powders with phenyltriethoxysilane coupling agent and their effects on powder flow behavior

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Particuology 2024年第7期90卷 412-417页

作者： Lillian m.mawby Bellamarie Ludwig Benjamin J.Lear Department of Chemistry The Pennsylvania State UniversityUniversity ParkPA16802USA Applied Research Laboratory The Pennsylvania State UniversityUniversity ParkPA16802USA

Though silanization of aluminum powder is currently used to improve its flow properties,for use as an alternative fuel source,there are a wide range of experimental parameters for the process and not all of them have been thoroughly *** this is complete,it is unknown if the process is optimized in terms of time,efficiency,and ***,we report on a study into the effects of changes in humidity,degree of agitation,reaction temperature,and curing time upon the deposition of phenyl triethoxysilane into 20μm(d50)aluminum *** confirm the deposition of the coating via diffuse reflectance infrared spectroscopy and x-ray photoelectron *** then characterize the coated particles using apparent density measurements and Carney flow *** analysis of variance,we find that,of the parameters explored,only changes in cure time and reaction temperature provide meaningful changes to the apparent density,while none of our parameters produced statistically significant changes in Carney flow ***,we conclude that,when optimizing silanization of aluminum particles,environmental control of humidity is unneeded and that the reaction can be run with minimal *** ability to largely ignore these parameters is a benefit to large-scale processing.

关键词： Aluminum powder Silane Fluidization Apparent density Carney flow

Complexed amino acid minerals ***-glycinate chelated minerals:Impact on the performance of old laying hens

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Animal Nutrition 2024年第1期16卷 395-408页

作者： marcos J.B.Santos maria C.m.m.Ludke Leandro m.Silva Carlos B.V.Rabello mércia R.Barros Fabiano S.Costa Clariana S.Santos Jamille S.S.Wanderley Department of Animal Science Rural Federal University of PernambucoRecifePEBrazil Department of Veterinary Science Rural Federal University of PernambucoRecifePEBrazil

The present study was to evaluate the effect of trace minerals(Zn,mn,and Cu)from complexed amino acid minerals(ZmCAA)and bis-glycinate chelated minerals(ZmCGly)in laying hen diets on performance,internal and external egg quality,yolk mineral deposition,intestinal morphometry,and bone *** 78 to 98 weeks of age,400 White LSL-Lite strain laying hens were distributed in a randomized design with 4 treatments with 10 replicates per *** were distributed in a 2×2 factorial arrangement using either Zn,mn,and Cu of ZmCAA or ZmCGly source at 2 levels:low(20,20,and 3.5 mg/kg of Zn,mn,and Cu,respectively)or high(40,40,and 7 mg/kg of Zn,mn,and Cu,respectively).The analysis of variance was performed,and in cases where differences were observed,the means were compared using Tukey?s test(Pmineral supplementation had a significant impact on the performance of laying *** fed ZmCAA had higher egg production(P=0.01),egg weight(P=0.02),egg mass(P=0.01),and lower feed conversion ratio(P=0.05)compared to those fed *** ZmCAA supplementation showed higher albumen height(P=0.01),albumen weight(P=0.01),and eggshell thickness(Pmn(Pmetry(PmCAA *** the small intestine,ZmCAA resulted in longer villi(P=0.02)and shorter crypt depth(P=0.01)in the *** and ileum measurements were influenced by the level and source of trace minerals(PmCAA exhibited superior performance,egg quality,deposition of trace minerals in the egg yolk,and bone density compared to hens fed *** this study,older laying hens supplemented with ZmCAA at lower levels demonstrated adequate levels of supplementation.

关键词： Bis-glycinates metal-amino acids Radiodensity Trace minerals

Effect of cold-working on corrosion induced damage in lug joints

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Defence Technology（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath m.N Chikmath L. murthy H. Department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

Lug joints are preferred joineries for transferring heavy loads to parent components in aerospace *** experience corrosion due to environmental conditions,improper surface finishes and rubbing displacement between the pin and *** causes damage of different sizes and shapes near the *** degradation due to corrosion-induced damage is modelled as a through-pit at one of the identified critical locations through stress *** effect of this pit on fatigue crack initiation life is ***-hole is pre-stressed by cold-working and the benefits of inducing plastic wake on the intended performance of the lug joint during the damages due to corrosion are brought out and compared with non-cold-worked *** analysis is performed on this lug joint with *** results obtained highlight the benefits of cold-working and the methodology can be extended to damage growth and analyse the effect of surface treatments for better structural integrity of components of aerospace vehicles.

关键词： Lug joint Corrosion Crack initiation Cold-working Structural integrity

Kinematic analysis of flexible bipedal robotic systems

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Applied mathematics and mechanics(English Edition) 2024年第5期45卷 795-818页

作者： R.FAZEL A.m.SHAFEI S.R.NEKOO Department of mechanical Engineering Shahid Bahonar University of KermanKerman ***Iran Departamento de Ingenieria de Sistemas y Automatica Escuela Técnica Superior de IngenieriaUniversidad de SevillaSeville 41092Spain

In spite of its intrinsic complexities,the passive gait of bipedal robots on a sloping ramp is a subject of interest for numerous *** distinguishes the present research from similar works is the consideration of flexibility in the constituent links of this type of robotic *** is not a far-fetched assumption because in the transient(impact)phase,due to the impulsive forces which are applied to the system,the likelihood of exciting the vibration modes increases ***,the human leg bones that are involved in walking are supported by viscoelastic muscles and ***,for achieving more exact results,it is essential to model the robot links with viscoelastic *** this end,the Gibbs-Appell formulation and Newton's kinematic impact law are used to derive the most general form of the system's dynamic equations in the swing and transient phases of *** most important issue in the passive walking motion of bipedal robots is the determination of the initial robot configuration with which the system could accomplish a periodic and stable gait solely under the effect of gravitational *** extremely unstable nature of the system studied in this paper and the vibrations caused by the impulsive forces induced by the impact of robot feet with the inclined surface are some of the very serious challenges encountered for achieving the above-mentioned *** overcome such challenges,an innovative method that uses a combination of the linearized equations of motion in the swing phase and the algebraic motion equations in the transition phase is presented in this paper to obtain an eigenvalue *** solving this problem,the suitable initial conditions that are necessary for the passive gait of this bipedal robot on a sloping surface are *** effects of the characteristic parameters of elastic links including the modulus of elasticity and the Kelvin-Voigt coefficient on the walking stability of this type of

关键词： bipedal robot flexible link swing phase transient phase eigenvalue problem Kelvin-Voigt coefficient

On calculating glacial isostatic adjustment

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Geodesy and Geodynamics 2024年第5期15卷 441-452页

作者： L.m.Cathles Cornell University

modeling the earth's fluid and elastic response to the melting of the glaciers of the last ice age is the most direct way to infer the earth's radial viscosity profile. Here, we compare two methods for calculating the viscoelastic response to surface loading. In one, the elastic equation of motion is converted to a viscoelastic equation using the Correspondence Principle. In the other, elastic deformation is added to the viscous flow as isostatic adjustment proceeds. The two modeling methods predict adjustment histories that are different enough to potentially impact the interpretation of the observed glacial isostatic adjustment(GIA). The differences arise from buoyancy and whether fluid displacements are subjected to hydrostatic pre-stress. The methods agree if they use the same equations and boundary conditions. The origin of the differences is determined by varying the boundary conditions and pre-stress application.

关键词： Correspondence principle Elastic buoyancy Glacial isostatic adjustment Hydrostatic pre-stress Viscoelastic normal modes