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急性脑卒中后CT动脉高密度征与血管取栓术中的阿替普酶效果

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国际医学放射学杂志 2023年第1期46卷 106-106页

作者： Y.Zhou Y.Jing J.Ospel m.goyal R.mcDonough X.Yue 胡金玥

摘要最近研究提示平扫CT上出现动脉高密度征(HAS)的颅内动脉血栓病人,对于阿替普酶静脉溶栓有更好的反应。HAS病人联合静脉阿替普酶与血管内介入治疗

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急性缺血性脑卒中血管内治疗流程和时间及其对治疗效果的影响分析:SWIFT PRImE随机对照试验的结果

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国际医学放射学杂志 2016年第4期 442-442页

作者： m.goyal A.P.Jadhav A.Bonafe H.Diener V.m.Pereira E.Levy 戴群瑶 Departments of Radiology and Clinical Neuro-sciences University of Calgary

摘要目的研究急性缺血性脑卒中病人Solitaire支架机械取栓作为急性缺血性梗死(AIS)血管内主要治疗(SWIFT PRImE)试验中功能独立性和再灌注时间的关系,一组病人进行联合血管内治疗和静脉组织纤溶酶原激活物(t PA)治疗,另外一组进行单纯t... 详细信息

摘要目的研究急性缺血性脑卒中病人Solitaire支架机械取栓作为急性缺血性梗死(AIS)血管内主要治疗(SWIFT PRImE)试验中功能独立性和再灌注时间的关系,一组病人进行联合血管内治疗和静脉组织纤溶酶原激活物(t PA)治疗,另外一组进行单纯t PA治疗。研究影响不连续步骤间隔时间的变量。材料与方法分析SWIFT PRImE试验的

关键词：急性缺血性脑卒中再灌注血管内

脑卒中III期介入治疗临床试验中基线CT血管成像所见血栓闭塞点的再通和临床结果

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国际医学放射学杂志 2014年第6期 588-588页

作者： A.m.Demchuk m.goyal S.D.Yeatts J.Carrozzella L.D.Foster E.Qazi 张扬 Calgary Stroke Program Dept of Clinical Neurosciences and RadiologyHotchkiss Brain InstUniv of Calg.ary1403 29 St NWRoom 112CalgaryABCanada T2N 2T9

摘要目的使用基线CT(CT)血管成像分析影像表现和脑卒中Ⅲ期介入治疗中临床终点来确定将从血管内卒中治疗中获益的病人。材料与方法主要临床终点为90 d二分改

关键词：血管成像 III 基线脑卒中介入治疗 CT

Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients

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Stroke & Vascular Neurology 2022年第2期7卷 124-131页

作者： Deepthi Rajashekar matthias Wilms m Ethan macDonald Serena Schimert michael D Hill Andrew Demchuk mayank goyal Sean P Dukelow Nils Daniel Forkert Biomedical Engineering Graduate Program Hotchkiss Brain InstituteUniversity of CalgaryCalgaryAlbertaCanada Department of Radiology Cumming School of MedicineUniversity of CalgaryCalgaryAlbertaCanada Hotchkiss Brain Institute University of CalgaryCalgaryAlbertaCanada Department of Clinical Neurosciences University of CalgaryCalgaryAlbertaCanada Department of Electrical and Computer Engineering University of CalgaryCalgaryAlbertaCanada Department of Community Health Sciences Cumming School of MedicineUniversity of CalgaryCalgaryAlbertaCanada Department of medicine Cumming School of MedicineUniversity of CalgaryCalgaryAlbertaCanada Alberta Children's Hospital Research Institute University of CalgaryCalgaryABCanada

Background Lesion-symptom mapping(LSm)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical *** clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to *** far,LSm studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS ***,the aim of this work was to investigate the feasibility to perform LSm analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not *** Employing a multivariate technique,LSm analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE *** NIHSS domains were grouped into six categories using two *** was conducted for each category of the two groupings and the total NIHSS *** Sub-score LSms not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised *** These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging.

关键词： patients score category

Cardiometabolic risk factors in young Indian men and their association with parameters of insulin resistance and beta-cell function

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World Journal of Cardiology 2022年第8期14卷 462-472页

作者： Yashdeep Gupta Alpesh goyal mani Kalaivani Nikhil Tandon Department of Endocrinology and metabolism All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of Biostatistics All India Institute of Medical SciencesNew Delhi 110029DelhiIndia

BACKGROUND There is an unmet need to evaluate the burden of cardiometabolic risk factors in young South Asian adults,who are not preselected for *** To evaluate young North Indian men(aged 20-50 years)for burden of cardiometabolic risk factors,in relation to parameters of homeostatic model assessment for insulin resistance(HOmA-IR)and beta-cell function(oral disposition index[oDI]).mETHODS Study participants were invited in a fasting ***,anthropometric,and medical data were collected,and 75 g oral glucose tolerance test was performed with serum insulin and plasma glucose estimation at 0,30,and 120 *** were divided into quartiles for HOmA-IR and oDI(category 1:Best HOmA-IR/oDI quartile;category 3:Worst HOmA-IR/oDI quartile)and composite HOmA-IR/oDI phenotypes(phenotype 1:Best quartile for both HOmA-IR and oDI;phenotype 4:Worst quartile for both HOmA-IR and oDI)were *** We evaluated a total of 635 men at a mean(±SD)age of 33.9±5.1 years and body mass index of 26.0±3.9 kg/m^(2).Diabetes and prediabetes were present in 34(5.4%)and 297(46.8%)participants,***/obesity,metabolic syndrome,and hypertension were present in 388(61.1%),258(40.6%),and 123(19.4%)participants,*** prevalence of dysglycaemia,metabolic syndrome,and hypertension was significantly higher in participants belonging to the worst HOmA-IR and oDI quartiles,either alone(category 3 vs 1)or in combination(phenotype 4 vs 1).The adjusted odds ratios for dysglycaemia(6.5 to 7.0-fold),hypertension(2.9 to 3.6-fold),and metabolic syndrome(4.0 to 12.2-fold)were significantly higher in individuals in the worst quartile of HOmA-IR and oDI(category 3),compared to those in the best quartile(category 1).The adjusted odds ratios further increased to 21.1,5.6,and 13.7,respectively,in individuals with the worst,compared to the best composite HOmA-IR/oDI phenotypes(phenotype 4 vs 1).CONCLUSION The burden of cardiometabolic risk factors is hi

关键词： Cardiometabolic Insulin resistance Asian Disposition index men Young

Repetitive Sequences in Plant Nuclear DNA:Types, Distribution, Evolution and Function

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Genomics, Proteomics & Bioinformatics 2014年第4期12卷 164-171页

作者： Shweta mehrotra Vinod goyal Department of Botany University of Delhi

Repetitive DNA sequences are a major component of eukaryotic genomes and may account for up to 90% of the genome size. They can be divided into minisatellite, microsatellite and satellite sequences. Satellite DNA sequences are considered to be a liist-evolving component of eukaryotic genomes, comprising tandemly-arrayed, highly-repetitive and highly-conserved monomer sequences. The monomer unit of satellite DNA is 150m00 base pairs （bp） in length. Repetitive sequences may be species- or genus-specific, and may be centromeric or subtelomeric in nature. They exhibit cohesive and concerted evolution caused by molecular drive, leading to high sequence homogeneity. Repetitive sequences accumulate variations in sequence and copy number during evolution, hence they are important tools for taxonomic and phylogenetic studies, and are known as ＂tuning knobs＂ in the evolution. Therefore, knowledge of repetitive sequences assists our understanding of the organization, evolution and behavior of eukaryotic genomes. Repetitive sequences have cytoplasmic, cellular and developmental effects and play a role in chromosomal recombination. In the post-genomics era, with the introduction of next-generation sequencing tech- nology, it is possible to evaluate complex genomes for analyzing repetitive sequences and decipher- ing the yet unknown functional potential of repetitive sequences.

关键词： Repetitive Satellites Tandem Dispersed Concertedsequences evolution Next-generation sequencing

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Extreme ultraviolet and x-ray transition wavelengths in Rb XXIV

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Chinese Physics B 2015年第10期24卷 115-126页

作者： Indu Khatri Arun goyal Sunny Aggarwal A.K.Singh man mohan Department of Physics and Astrophysics University of Delhi Department of Physics Shyamlal CollegeUniversity of Delhi Department of Physics D.D.U.CollegeUniversity of Delhi

Energy levels, radiative rates, oscillator strengths and line strengths are reported for transitions among the lowest 97 levels of the（1s22s22p6） 3s23p2, 3s23p3 d, 3s3p3, 3p4, 3s3p23 d, and 3s23d2 configurations of Rb XXIV. A multiconfiguration Dirac-Fock（mCDF） method is adopted for the calculations. Radiative rates, oscillator strengths, and line strengths are provided for all electric dipole（E1）, magnetic dipole（m1）, electric quadrupole（E2）, and magnetic quadrupole（m2）transitions from the ground level to all 97 levels, although calculations are performed for a much larger number of *** achieve the accuracy of the data, comparisons are provided with similar data obtained from the Flexible Atomic Code（FAC） and also with the available theoretical and experimental results. Our energy levels are found to be accurate to better than 1.2%. Wavelengths calculated are found to lie in EUV（extreme ultraviolet） and x-ray regions. Additionally, lifetimes for all 97 levels are obtained for the first time.

关键词： atomic data energy levels transition probability

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Emergence of non-albicans Candida species and antifungal resistance in intensive care unit patients

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 455-460页

作者： Ravinder Kaur megh Singh Dhakad Ritu goyal Rakesh Kumar Department of microbiology Lady Hardinge Medical College and Associated Hospitals Department of microbiology Maulana Azad Medical College and Associated Lok Nayak Hospitals Department of Obstetrics and Gynaecology Maulana Azad Medical College and Associated Lok Nayak Hospitals Department of Anaesthesiology Maulana Azad Medical College and Associated Lok Nayak Hospitals

Objective: To evaluate the epidemiology of candidiasis and the antifungal susceptibility profile of Candida species isolated from the intensive care unit(ICU) ***: The study used a qualitative descriptive design. Relevant samples depending on organ system involvement from 100 ICU patients were collected and *** and speciation of the isolates was conducted by the biochemical *** susceptibility testing was carried out as per CLSI-m27-A3 ***: Ninety Candida isolates were isolated from the different clinical samples: urine(43.3%), tracheal aspirate(31.1%), urinary catheter(12.2%), endotracheal tube(7.8%),abdominal drains(3.3%), sputum(2.2%). The incidence of candidiasis caused by nonalbicans Candida(NAC) species(63.3%) was higher than Candida albicans(36.7%).The various NAC species were isolated as: Candida tropicalis(41.1%), Candida glabrata(10%), Candida parapsilosis(6.7%), Candida krusei(3.3%) and Candida kefyr(2.2%). The overall isolation rate of Candida species from samples was 53.3%. Antifungal susceptibility indicated that 37.8% and 7.8% of the Candida isolates were resistant to fluconazole and amphotericin B, ***: Predominance of NAC species in ICU patients along with the increasing resistance being recorded to fluconazole which has a major bearing on the morbidity and management of these patients and needs to be further worked upon.

关键词： Antifungal resistance Candida species Colonization Intensive care unit patients

Psychogenic Polydipsia- management challenges

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上海精神医学 2017年第3期29卷 180-183页

作者： m.S.BHATIA Aparna goyal Rashmita SAHA Nimisha DOVAL Department of Psychiatry University College of Medical Sciences & Guru TegB ahadur Hospital

强迫性饮水或心因性多渴越来越多见。过度水分摄入会导致低钠血症引起恶心、呕吐、癫痫、谵妄等症状,如不及早发现和处理,甚至可能会危及生命。这里报告的病例是一例35岁心因性多渴症男性患者,通过药物、限制摄水量和心理等整合治疗手... 详细信息

强迫性饮水或心因性多渴越来越多见。过度水分摄入会导致低钠血症引起恶心、呕吐、癫痫、谵妄等症状,如不及早发现和处理,甚至可能会危及生命。这里报告的病例是一例35岁心因性多渴症男性患者,通过药物、限制摄水量和心理等整合治疗手段获成功治愈。

关键词：精神性管理精神疾病药物治疗饮水量成年人

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