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利用mR细胞示踪技术评价由VLA-4归巢受体介导的神经胶质前体细胞对炎症组织趋向性的研究

国际医学放射学杂志 2012年第6期 590-590页

作者： m.gorelik I.Orukari S.Galpoththawela H.Kim m.Levy 史佳培 Department of Radiology and Radiological Science Division of MR ResearchThe Johns Hopkins University School of Medicine733 N BroadwayBroadway Research BuildingRoom 649BaltimoreMD 21205

摘要目的探讨神经胶质前体细胞在超表达的VLA-4介导下对炎症脑组织是否具有趋向性,以及动脉内注射mR细胞示踪技术是否能监测此归巢过程。材料与方法本实验性研究的期限为2010年8月-2012年2月,

关键词：细胞示踪 mR 归巢 VLA-4 前体细胞神经胶质胶质细胞受体介导趋向性

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Competition of Aromatic Bromination and Nitration in Concentrated Sulfuric Acid

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Open Journal of Synthesis Theory and Applications 2013年第1期2卷 46-50页

作者： Alexander m. Andrievsky mikhail V. gorelik Research Institute of Organic Intermediates and Dyes (NIOPIK) Moscow Russia

Composition of bromine and nitric acid in concentrated sulfuric acid is effective for bromination of strongly deactivated aromatic compounds and for nitration and bromination of moderately deactivated compounds in one stage. The question why brominating agent is more reactive than nitrating agent in relation to strongly deactivated aromatic compounds and is less reactive in relation to moderate deactivated ones is discussed.

关键词： Bromination Nitration Aromatic Compounds 5-Bromo-1 3-dinitrobenzene 5-Bromo-2 4 7-trinitrofluorenone 4-Bromo-2 7-dinitrophenanthrenquinone

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Aromatic Bromination in Concentrated Nitric Acid

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Open Journal of Synthesis Theory and Applications 2014年第2期3卷 15-20页

作者： Alexander m. Andrievsky Vera I. Lomzakova mikhail K. Grachev mikhail V. gorelik Departament of Chemistry Moscow State Pedagogical University Moscow Russia Research Institute of Organic Intermediates and Dyes (NIOPIK) Moscow Russia

Action of bromine in concentrated nitric acid allows carrying out mono- and polybromination of moderately deactivated aromatic compounds. 4-Chloronitrobenzene and isophthalic acid turnes into 3-bromo-4-chloronitrobenzene and 5-bromoisophthalic acid at reaction with bromine in concentrated nitric acid at 20°C whereas in absence of bromine in the same conditions 4-chloro-1, 3-dinitrobenzene and 5-nitroisophthalic acid are formed accordingly. Presence of bromine in concentrated nitric acid changes nitrating capacity to brominating one. Terephthalic acid and phthalic anhydride at heating with bromine in concentrated nitric acid can be transformed to appropriating tetrabromo substituted compounds.

关键词： Bromination Nitration Aromatic Compounds 3-Bromo-4-chloronitrobenzene 5 Bromoisophthalic Acid 2 3 5 6-Tetrabromoterephthalic Acid 4 6 Tetrabromophthalic Anhydride

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PI3K-mediated Epithelial Sodium Channel Activity by Regulating the Apical membrane morphology of Renal Epithelial Cells

PI3K-Mediated Epithelial Sodium Channel Activity by Regulati...

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第七届亚太地区医学与生物学工程学术年会

作者： J.gorelik D.Klenerman m.Lab C.Edwards Y.Korchev Division of medicine Imperial College LondonLondon United Kingdom Department of Chemistry Cambridge UniversityCambridge United Kingdom

Continuous high spatial resolution observations of living cells would greatly aid the elucidation of the relation-ship between structure and function and facilitate the study of major physiological processes such as the mechanism of action of aldosterone on the activity regulation of epithelial sodium channel （ENaC）. Unfortunately, observing the micro-structural and functional changes in the membrane of living cells is still a big challenge in current nanomedicine. Scanning ion conductance microscopy （SICm） is such a kind of scanning probe microscopy, which is designed for continuous high-resolution topographic imaging of living cells. Under the help of SICm, we have found that aldosterone stimulates ATP release and the basolateral P2X4-like receptors may be in-volved in the regulation of the activity of ENaC. However, the signaling components linking receptor binding to final ENaC channel regulation remain incompletely characterized. We have now further investigated using SICm and Xenopus A6 kidney epithelial cells that the involvement of the PI3K path-way during the aldosterone action. Three hours continuous SICm observations showed how A6 cells changed their morphology in response to the aldosterone treatment. Patch clamping of individual cells enabled anatomy and function to be correlated, showed that the morphology changed cells with the ENaC channel activity. These morphol-ogy changes and ENaC activities were abolished by the specify Phosphoinositide 3-kinases （PI3K） inhibitor LY294002. SICm has the potential to become a powerful tool for research on living renal cells, and has been used to elucidate how PI3K pathway involved in the aldosterone action on renal epithelial sodium reabsorption.

关键词： SICm PI3K ENaC A6 cells SPm

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Nanoscale mapping of optically inaccessible bound-states-in-the-continuum

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Light(Science & Applications) 2022年第2期11卷 188-196页

作者： Zhaogang Dong Zackaria mahfoud Ramón Paniagua-Domínguez Hongtao Wang Antonio I.Fernández-Domínguez Sergey gorelik Son Tung Ha Febiana Tjiptoharsono Arseniy I.Kuznetsov michel Bosman Joel K.W.Yang Institute of materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)2 Fusionopolis Way#08-03 Innovis138634 SingaporeSingapore Department of materials Science and Engineering National University of Singapore9 Engineering Drive 1117575 SingaporeSingapore Singapore University of Technology and Design 8 Somapah Road487372 SingaporeSingapore Departamento de Física Teórica de la materia Condensada and Condensed matter Physics Center Universidad Autónoma de Madrid28049 MadridSpain Singapore Institute of Food and Biotechnology Innovation A*STAR(Agency for ScienceTechnology and Research)31 Biopolis Way#01-02 Nanos138669 SingaporeSingapore

Bound-states-in-the-continuum(BIC)is an emerging concept in nanophotonics with potential impact in applications,such as hyperspectral imaging,mirror-less lasing,and nonlinear harmonic *** true BIC modes are nonradiative,they cannot be excited by using propagating light to investigate their optical *** this paper,for the 1st time,we map out the strong near-field localization of the true BIC resonance on arrays of silicon nanoantennas,via electron energy loss spectroscopy with a sub-1-nm electron *** systematically breaking the designed antenna symmetry,emissive quasi-BIC resonances become *** gives a unique experimental tool to determine the coherent interaction length,which we show to require at least six neighboring antenna *** importantly,we demonstrate that quasi-BIC resonances are able to enhance localized light emission via the Purcell effect by at least 60 times,as compared to unpatterned *** work is expected to enable practical applications of designed,ultra-compact BIC antennas such as for the controlled,localized excitation of quantum emitters.

关键词： antenna states mapping

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