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Divergent molecular and growth responses of young“Cabernet Sauvignon”(Vitis vinifera)plants to simple and mixed infections with Grapevine rupestris stem pitting-associated virus

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Horticulture Research 2020年第1期7卷 2706-2719页

作者： m.Tobar N.Fiore A.G.Pérez-Donoso R.León I.m.Rosales m.gambardella Pontificia Universidad Católica de Chile Facultad de Agronomía e Ingeniería ForestalVicuña Mackena 4860MaculSantiago 7820436Chile Universidad de Chile Facultad de Ciencias AgronómicasAvenida Santa Rosa 11315La PintanaSantiago 8820808Chile

Grapevine rupestris stem pitting associated virus(GRSPaV)is one of the most widely distributed viruses;even so,little is known about its effect on Vitis *** provide new insights,the effects of single and mixed GRSPaV infections on the *** cultivar“Cabernet Sauvignon”were studied by evaluating growth parameters,such as measurements of the total plant length,the number and distance of internodes and the number of leaves per *** addition,parameters relating to gas exchange,i.e.,the stomatal conductance,net photosynthetic rate,internal CO2 concentration and leaf transpiration,were also *** the measurements were performed in one-and two-yearold plants with a single GRSPaV infection or mixed infections of GRSPaV and Grapevine fanleaf virus(GFLV).The results show that the plant phytosanitary status did not significantly alter the growth and gas exchange parameters in oneyear-old ***,in two-year-old plants,single GRSPaV infections increased shoot elongation,which was accompanied by the overexpression of genes associated with the gibberellic acid response *** gas exchange parameters of these plants were negatively affected,despite exhibiting higher LHCII gene *** with mixed infections did not have modified growth parameters,although they presented a greater reduction in the primary photosynthetic parameters evaluated with no change in LHCII *** results presented here confirm the co-evolution hypothesis for *** and GRSPaV during the early stages of plant development,and they provide new evidence about the effects of GRSPaV and GFLV co-infections on the“Cabernet Sauvignon”cultivar.

关键词： Vitis infections vinifera

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mRI影像组学鉴别前列腺癌包膜外侵犯：系统回顾和荟萃分析

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国际医学放射学杂志 2024年第4期 503-503页

作者： A.Ponsiglione m.gambardella A.Stanzione R.Green V.Cantoni C.Nappi 王笑男

摘要目的结合mRI信息的列线图可能在预测前列腺癌（PCa）的前列腺外侵犯（EPE）上出现重大突破，但敏感性和标准化程度较低是尚未解决的问题。mRI影像组学已被应

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mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer

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World Journal of Gastroenterology 2016年第28期22卷 6345-6361页

作者： Vincenzo Sforza Erika martinelli Fortunato Ciardiello Valentina gambardella Stefania Napolitano Giulia martini Carminia della Corte Claudia Cardone marianna L Ferrara Alfonso Reginelli Giuseppina Liguori Giulio Belli Teresa Troiani Oncologia medica Dipartimento di Medicina Clinica e Sperimentale "F. Magrassi e A. Lanzara" Seconda Università degli Studi di Napoli Department of medical Oncology Biomedical Research Institute INCLIVA University of Valencia Department of Internal and Experimental medicine Magrassi-Lanzara Institute of Radiology Seconda Università di Napoli Department of Pathology Istituto Nazionale Tumori "Fond. Pascale" - IRCCS Department of General and Hepato-Pancreato-Biliary Surgery S. M. Loreto Nuovo Hospital

The prognosis of patients with metastatic colorectal cancer (mCRC) remain poor despite the impressive improvement of treatments observed over the last 20 years that led to an increase in median overall survival from 6 mo, with the only best supportive care, to approximately 30 mo with the introduction of active chemotherapy drugs and targeted agents. The monoclonal antibodies (moAbs) cetuximab and panitumumab, directed against the epidermal growth factor receptor (EGFR), undoubtedly represent a major step forward in the treatment of mCRC, given the relevant efficacy in terms of progression-free survival, overall survival, response rate, and quality of life observed in several phase III clinical trials among different lines of treatment. However, the anti-EGFR moAbs were shown only to be effective in a subset of patients. For instance, KRAS and NRAS mutations have been identified as biomarkers of resistance to these drugs, improving the selection of patients who might derive a benefit from these treatments. Nevertheless, several other alterations might affect the response to these drugs, and unfortunately, even the responders eventually become resistant by developing secondary (or acquired) resistance in approximately 13-18 mo. Several studies highlighted that the landscape of responsible alterations of both primary and acquired resistance to anti-EGFR drugs biochemically converge into mEK-ERK and PIK3CA-AKT pathways. In this review, we describe the currently known mechanisms of primary and acquired resistance to anti-EGFR moAbs together with the various strategies evaluated to prevent, overcame or revert them.

关键词： metastatic colorectal cancer Epidermal growth factor receptor Resistance mutation KRAS NRAS BRAF PIK3CA mET monoclonal antibodies

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