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Praseodymium metal nanorods as a 5-fluorouracil carrier

Journal of Rare Earths 2024年第7期42卷 1328-1336,I0005页

作者： Varnitha manikantan govindaraj Sri Varalakshmi Ujma Ashapak Tamboli Archana Sumohan Pillai Aleyamma Alexander Anushka Lucas Bose Allben Akash Israel V.m.V.Enoch Centre for Nanoscience and Genomics Karunya Institute of Technology and Sciences(Deemed University)Coimbatore641114Tamil NaduIndia Department of Applied Chemistry Karunya Institute of Technology and Sciences(Deemed University)Coimbatore641114Tamil NaduIndia

Interest in metal nanoparticles as nanoscale drug-carrying vehicles has been *** such an aspect,lanthanide metal nanoparticles are particularly ***,we report praseodymium nanoparticles as a novel anticancer therapeutic transporting *** material was made as a composite with the supramolecular host polymer,poly-β-*** praseodymium nanorods were characterized using standard analytical techniques,including X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),and thermogravimetric analysis(TGA).In addition,they were imaged using transmission electron *** nanostructures are a long rod-shaped material with 2.0±0.1μm in length and 230±10 nm in *** material shows a saturation magnetization value above 30 emu/g with a coercivity value of 130 *** nanocarrier is freighted with the drug 5-fluorouracil,and the encapsulation efficiency is 76.09%.The drug release is continuous from the nanocarrier(polymer-containing praseodymium nanoparticles)and proceeds for above 250 *** in vitro cytotoxicities of the blank nanocarrier and the 5-fluorouracil-loaded one are deduced by testing them on mCF-7 and Vero(non-cancerous)cell *** cytotoxicity on the cancerous cell lines is observed,whereas the non-cancerous cells are *** IC_(50)values on the cell lines are reported.

关键词： metal nanoparticles Praseodymium Poly-cyclodextrin Drug delivery Anticancer activity Rare earths

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molecular dynamics of amorphous pharmaceutical fenofibrate studied by broadband dielectric spectroscopy

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Journal of Pharmaceutical Analysis 2016年第3期6卷 165-170页

作者： U. Sailaja m. Shahin Thayyil N.S. Krishna Kumar G. govindaraj Department of Physics M.E.S Keveeyam College. Valanchery 676552 Malappuram Kerala India Department of Physics University of Calicut 673635 Kerala. India Department of Physics School of Physical Chemical and Applied Sciences Pondicherry University Puducherry 605014 India

Fenofibrate is mainly used to reduce cholesterol level in patients at risk of cardiovascular disease. Thermal transition study with the help of differential scanning calorimetry （DSC） shows that the aforesaid active pharmaceutical ingredient （API） is a good glass former. Based on our DSC study, the molecular dynamics of this API has been carried out by broadband dielectric spectroscopy （BDS） covering wide temperature and frequency ranges. Dielectric measurements of amorphous fenofibrate were per- formed after its vitrification by fast cooling from a few degrees above the melting point （Tm=354.11 K） to deep glassy state. The sample does not show any crystallization tendency during cooling and reaches the glassy state. The temperature dependence of the structural relaxation has been fitted by single Vogel- Fulcher-Tamman （VFT） equation. From VFT fit, glass transition temperature （Tg） was estimated as 250.56 K and fragility （m） was determined as 94.02. This drug is classified as a fragile glass former. Deviations of experimental data from Kohlrausch-Williams-Watts （KWW） fits on high-frequency flank of α-peak indicate the presence of an excess wing in fenofibrate. Based on Ngai＇s coupling model, we identified the excess wing as true Johari-Goldstein （JG） process. Below the glass transition temperature one can clearly see a secondary relaxation （γ） with an activation energy of 32.67 kJ/mol.

关键词： Amorphous fenofibrate Bioavailability Broadband dielectric spectroscopy Glass transition molecular dynamics

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Structural behaviour of carbon single wall nanotubes under high pressure

Structural behaviour of carbon single wall nanotubes under h...

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18th International Conference on High Pressure Science and Technology

作者： Surinder m Sharma S.Karmakar S.K.Sikka Pallavi V.Teredesai A.K.Sood A.govindaraj C.N.R.Rao High Pressure Physics Division Bhabha Atomic Research CenterMumbai 400085India High Pressure Physics Division Bhabha Atomic Research CenterMumbai 400085India High Pressure Physics Division Bhabha Atomic Research CenterMumbai 400085India Department of Physics Indian Institute of ScienceBangalore 560012India Department of Physics Indian Institute of ScienceBangalore 560012India Chemistry and Physics of Materials UnitJawaharlal Nehru Centre for Advanced Scientific ResearchJakkur CampusJakkur P.O.Bangalore 560064India Chemistry and Physics of materials Unit Jawaharlal Nehru Centre for Advanced Scientific ResearchJakkur CampusJakkur P.O.Bangalore 560064India Chemistry and Physics of materials Unit Jawaharlal Nehru Centre for Advanced Scientific ResearchJakkur CampusJakkur P.O.Bangalore 560064India

＜正＞Single walled carbon nanotubes （SWNTs） can be viewed as tubes formed by the conformal mapping of graphite strips onto cylindrical surfaces. When stacked in bundles, these tubes form a two dimensional triangular lattice. In addition to many interesting and useful physical properties1 of SWNTs, these have been predicted to have remarkable mechanical resilience, such as reversible bending of isolated tubes to -110° 2. Recently several high pressure Raman studies have been carried out to understand the behaviour under high pressure. Based on these studies, existence of a structural phase transformation at 1.7 GPa3 and polygonization of tubes at - 2.5 GPa4 has been suggested. Another Raman investigation indicates a reversible phase transformation at 10 GPa5. To investigate the nature of structural changes under pressure, we have carried out in-situ high pressure x-ray diffraction study on SWNTs up to 13 GPa. These experiments were carried out at the SPringS synchrotron facility. Observed variation of the d-spacings as a function of pressure is shown in Fig. 1. Vanishing of the strongest and only recorded diffraction line （100） of the SWNTs show that the carbon nanotube bundles loose the triangular translational order beyond 10 GPa. However, before losing its translational coherence, the two-dimensional lattice softens substantially as is displayed by an upward jump of dioo of SWNTs in Fig. 1. This is rationalizable in terms of the formation of heterogeneous fins like structures, which may help reduce the average basal strain. These results also provide an explanation for the unusual downward jump of tangential mode of the Raman results at this pressure.5 On release of pressure, the tubes regain the triangular lattice structure. These experimental observations validate the predicted remarkable mechanical resilience of the carbon nanotubes. Our data, which represents hydrostatic environment, gives the bulk modulus to be 34 GPa, which is more than a

关键词： High pressure Single Wall carbon NanoTubes (SWNTs) X-ray diffraction

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