检索结果-南通市图书馆

Emerging small-molecule therapeutic approaches for Alzheimer's disease and Parkinson's disease based on targeting microRNAs

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第2期17卷 336-337页

作者： Somaya A.Abdelrahman moustafa T.gabr Department of medicinal Chemistry Faculty of PharmacyMansoura UniversityMansouraEgypt Department of Radiology Stanford University School of MedicineStanfordCAUSA

The role of micro RNAs in the progression of neurodegenerative diseases: micro RNAs(mi RNAs) are endogenous, non-coding and short RNA nucleotides that regulate gene expression through base pairing with the targeted me... 详细信息

关键词： endogenous Alzheimer diseases

Internal electrical fault detection techniques in DFIG-based wind turbines: a review

在线全文

学校读者我要写书评

暂无评论

Protection and Control of modern Power Systems 2022年第1期7卷 265-286页

作者： Abdelwahab D.Bebars Abdelfattah A.Eladl gabr m.Abdulsalam Ebrahim A.Badran Electrical Engineering Department Faculty of EngineeringMansoura UniversityEl-MansouraEgypt

The keys factor in making wind power one of the main power sources to meet the world’s growing energy demands is the reliability improvement of wind turbines(WTs).However,the eventuality of fault occurrence on WT com-ponents cannot be avoided,especially for doubly-fed induction generator(DFIG)based WTs,which are operating in severe environments.The maintenance need increases due to unexpected faults,which in turn leads to higher operating cost and poor reliability.Extensive investigation into DFIG internal fault detection techniques has been carried out in the last decade.This paper presents a detailed review of these techniques.It discusses the methods that can be used to detect internal electrical faults in a DFIG stator,rotor,or both.A novel sorting technique is presented which takes into consideration different parameters such as fault location,detection technique,and DFIG modelling.The main mathematical representation used to detect these faults is presented to allow an easier and faster under-standing of each method.In addition,a comparison is carried out in every section to illustrate the main differences,advantages,and disadvantages of every method and/or model.Some real monitoring systems available in the market are presented.Finally,recommendations for the challenges,future work,and main gaps in the field of internal faults in a DFIG are presented.This review is organized in a tutorial manner,to be an effective guide for future research for enhancing the reliability of DFIG-based WTs.

关键词： DFIG Wind turbines Internal fault detection Reliability improvement

Comparative framework for AC-microgrid protection schemes: challenges, solutions, real applications, and future trends

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protection and Control of modern Power Systems 2023年第2期8卷 99-138页

作者： Ahmed N.Sheta gabr m.Abdulsalam Bishoy E.Sedhom Abdelfattah A.Eladl Electrical Engineering Department Faculty of EngineeringMansoura UniversityEl-MansouraEgypt

With the rapid development of electrical power systems in recent years,microgrids(mGs)have become increasingly prevalent.mGs improve network efficiency and reduce operating costs and emissions because of the integration of distributed renewable energy sources(RESs),energy storage,and source-load management systems.Despite these advances,the decentralized architecture of mGs impacts the functioning patterns of the entire system,including control strategy,energy management philosophy,and protection scheme.In this context,developing a convenient protection strategy for mGs is challenging because of various obstacles,such as the significant variance in short-circuit values under different operating modes,two-way power flow,asynchronous reclosing,protection blinding,sympathetic tripping,and loss of coordination.In light of these challenges,this paper reviews prior research on proposed protection schemes for AC-mGs to thoroughly evaluate network protection’s potential issues.The paper also provides a comprehensive overview of the mG structure and the associated protection challenges,solutions,real applications,and future trends.

关键词： microgrid Active distribution network microgrid protection Renewable energy sources Smart grids Distributed energy resources Energy storage

Application model of Energy management and Emissions Control to Limit Environmental Risks of Fossil Fuel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Applied Sciences 2022年第5期12卷 672-687页

作者： Eman m. gabr Processes Development Egyptian Petroleum Research Institute EPRI Cairo Egypt

Around the world energy sustainability and environment protection face many challenges due to the continuously increasing population and energy demands, where the demanding rate of energy increases by at least 2.3% per year. According to statistical data, until 2035, fossil fuels still are the main source of energy consumption. Burning fossil fuels produces the greenhouse gas of carbon dioxide as a byproduct. CO2 emissions have a dangerous effect on both human health and the natural environmental balance. There are many types of clean energy like solar, biofuel, and wind energy. The major limitations of using these types, their availability depends on climate conditions and their production rate is inadequate for energy demand. For any country, energy resources’ availability and economic conditions imposed on projects’ prioritization. Application of energy management and emissions control techniques for industrial unit can limit fuel combustion environmental effects and transfer this fossil fuel to an eco-friendly type. In this work, we applied Green Energy model GEm to the Hydrotreater Unit of the refinery, GEm is composed of four techniques. Which are Heat Exchangers Networks Synthesis [HENS], Fuel Switching, Thermal Insulation application, and Carbon Captures Storage [CCS]. Where they reduce energy consumption by the rate of 3% - 34% and control CO2 emissions by the rate of 26% - 90%. This model is a radical way to face climate change challenges and practical solutions for both energy and environmental crises.

关键词： Energy management Greenhouse Gases Heat Exchangers Networks Fuel Switching Thermal Insulation Carbon Capture

multitarget therapeutic strategies for Alzheimer's disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第3期14卷 437-440页

作者： mostafa m.Ibrahim moustafa T.gabr Department of Pharmacognosy Faculty of Pharmacy Mansoura University Department of Basic Pharmaceutical and Toxicological Sciences College of Pharmacy University of Louisiana at Monroe Department of medicinal Chemistry Faculty of Pharmacy Mansoura University Department of Chemistry University of Iowa

Neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's diseases have multifaceted nature because of the different factors contributing to their progression. The complex nature of neurodegenerative diseases has developed a pressing need to design multitarget-directed ligands to address the complementary pathways involved in these diseases. The major enzyme targets for development of therapeutics for Alzheimer's disease are cholinesterase and β-secretase enzymes. In this review, we discuss recent advances in profiling single target inhibitors based on these enzymes to multitarget-directed ligands as potential therapeutics for this devastating disease. In addition, therapeutics based on iron chelation strategy are discussed as well.

关键词： multitarget-directed ligands acetylcholinesterase β-secretase Alzheimer's disease hybridization neurodegenerative diseases tacrine brain permeability

Structural and Tectonic Evolution of El-Faiyum Depression,North Western Desert,Egypt Based on Analysis of Landsat ETm+,and SRTm Data

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2011年第1期22卷 75-100页

作者： Timothy m Kusky Talaat m Ramadan mahmoud m Hassaan Safwat gabr Three Gorges Research Center for Geo-hazard State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences The Geological Applications and mineral Resources Division National Authority for Remote Sensing and Space Sciences (NARSS) Cairo Egypt

False color Landsat ETm＋（bands 7, 4, 2 in RGB） and SRTm images of the EI-Faiyum depression, Egypt, highlights major NE-SW faults and other lineaments trending NW-SE and N-S. Airborne magnetic data reveal some E-W subsurface faults which are not recognized on Landsat ETm＋ and SRTm images. Ratio images （5/7, 3/1, 4/3） and （5/7, 5/1, 4） were used for lithological discrimination of different rock types. The EI-Faiyum area is occupied by sedimentary rocks of middle Eocene, Upper Eocene, Oligocene, Lower miocene, Pliocene, Pleistocene and Holocene. Understanding the structural regime of EI-Faiyum depression in the Western Desert of Egypt is significant in relation to the neotectonics of the Nile Delta and to the development of new communities west of the delta. The area is covered by Late Cretaceous, middle to Late Eocene deposits, Oligocene deposits （comprising fluviatile sediments and basalt sheets） and Pliocene and Quaternary alluvium and sand deposits. New geological and structural maps were prepared at a scale of 1 ： 100 000 using Landsat ETm＋ and SRTm images coupled with extensive field work. The major structural trends are E-W, ENE, NS and NW--the same trends observed elsewhere in North Africa from NW Sudan to NE Egypt including north and central Sinai. EI-Faiyum depression is a structurally-controlled tectonic basin, marked by northeast-striking faults along its northern margin. These faults are parallel to similar faults of the Syrian arc fold belt, which includes a group of related faults, folds, push-up structures, and basins. Qarun Lake is located in the northern part of EI-Faiyum depression, at a right-step between two strands of the NE striking fault system. We have suggested elsewhere that EI-Faiyum depression is a pull-apart basin related to extension between these mismatched strands of strike-slip faults. The E-W structures are probably related to the relative motion between south Europe and north Egypt and closure of the Neotethys. The continuation of these faults in the present area is only detected

关键词： Egypt EI-Faiyum Syrian arc fold belt pull-apart basin Western Desert of Egypt.

Predicting resilient modulus of recycled concrete and clay masonry blends for pavement applications using soft computing techniques

在线全文

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2019年第6期13卷 1379-1392页

作者： mosbeh R.KALOOP Alaa R.gabr Sherif m.EL-BADAWY Ali ARISHA Sayed SHWALLY Jong Wan HU Department of Civil and Environmental Engineering Incheon National UniversityIncheon 22012South Korea Incheon Disaster Prevention Research Center Incheon National UniversityIncheon 22012South Korea Department of Public Works and Civil Engineering Mansoura UniversityMansoura 35516Egypt

To date,very few researchers employed the Least Square Support Vector machine(LSSVm)in predicting the resilient modulus(mr)of Unbound Granular materials(UGms).This paper focused on the development of a LSSVm model to predict the mT of recycled materials for pavement applications and comparison with other different models such as Regression,and Artificial Neural Network(ANN).Blends of Recycled Concrete Aggregate(RCA)with Recycled Clay masonry(RCm)with proportions of 100/0,90/10,80/20,70/30,55/45,40/60,20/80,and 0/100 by the total aggregate mass were evaluated for use as UGms.RCA/RCm materials were collected from dumps on the sides of roads around mansoura city,Egypt.The investigated blends were evaluated experimentally by routine and advanced tests and the mr values were detennined by Repeated Load Triaxial Test(RLTT).Regression,ANN,and LSSVm models were utilized and compared in predicting the mr of the investigated blends optimizing the best design model.Results showed that the mx values of the investigated RCA/RCm blends were generally increased with the decrease in RCm proportion.Statistical analyses were utilized for evaluating the performance of the developed models and the inputs sensitivity parameters.Eventually,the results approved that the LSSVm model can be used as a novel tool to estimate the mx of the investigated RCA/RCm blends.

关键词： Least Square Support Vector machine Artificial Neural Network resilient modulus Recycled Concrete Aggregate Recycled Clay masonry

microRNA-502-3p regulates GABAergic synapse function in hippocampal neurons

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第12期19卷 2698-2707页

作者： Bhupender Sharma melissa mTorres Sheryl Rodriguez Laxman Gangwani Subodh Kumar Center of Emphasis in Neuroscience Department of Molecular and Translational MedicinePaul L.Foster School of MedicineTexas Tech University Health Sciences CenterEl PasoTXUSA Bond Life Sciences Center and Department of Veterinary Pathobiology University of MissouriColumbiaMOUSA L.Frederick Francis Graduate School of Biomedical Sciences Texas Tech University Health Sciences CenterEl PasoTXUSA

Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurological disorders,including Alzheimer's disease and Alzheimer's disease-related dementia.Our previous study identified the upregulation of microRNA-502-3p(miR-502-3p)and downregulation of GABA type A receptor subunitα-1 in Alzheimer's disease synapses.This study investigated a new molecular relationship between miR-502-3p and GABAergic synapse function.In vitro studies were perfo rmed using the mouse hippocampal neuronal cell line HT22 and miR-502-3p agomiRs and antagomiRs.In silico analysis identified multiple binding sites of miR-502-3p at GABA type A receptor subunitα-1 mRNA.Luciferase assay confirmed that miR-502-3p targets the GABA type A receptor subunitα-1 gene and suppresses the luciferase activity.Furthermore,quantitative reve rse transcription-polymerase chain reaction,miRNA in situ hybridization,immunoblotting,and immunostaining analysis confirmed that overexpression of miR-502-3p reduced the GABA type A receptor subunitα-1 level,while suppression of miR-502-3p increased the level of GABA type A receptor subunitα-1 protein.Notably,as a result of the overexpression of miR-502-3p,cell viability was found to be reduced,and the population of necrotic cells was found to be increased.The whole cell patch-clamp analysis of human-GABA receptor A-α1/β3/γ2L human embryonic kidney(HEK)recombinant cell line also showed that overexpression of miR-502-3p reduced the GABA current and overall GABA function,suggesting a negative correlation between miR-502-3p levels and GABAergic synapse function.Additionally,the levels of proteins associated with Alzheimer s disease were high with miR-502-3p overexpression and reduced with miR-502-3p suppression.The present study provides insight into the molecular mechanism of regulation of GABAergic synapses by miR-502-3p.We propose that micro-RNA,in particular miR-502-3p,could be a potential therapeutic to rget to modulate GABAergic synapse f

关键词： Alzheimer's disease GABAergic synapse gamma-aminobutyric acid type A receptor subunitα-1(gabrα1) microRNA-502-3p(miR-502-3p) miRNA in situ hybridization Patch-clamp

Synthesis, in vitro antitumor activity and molecular modeling studies of a new series of benzothiazole Schiff bases

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2016年第3期27卷 380-386页

作者： moustafa T.gabr Nadia S.El-Gohary Eman R.El-Bendary mohamed m.El-Kerdawy Nanting Ni Department of medicinal Chemistry Faculty of Pharmacy Mansoura University Mansoura 35516 Egypt Department of Chemistry Ceorgia State University Atlanta CA 30303 USA

A new series of benzothiazole Schiff bases 3–29 was synthesized and screened for antitumor activity against cervical cancer（Hela） and kidney fibroblast cancer（COS-7） cell lines. Results indicated that compounds 3, 14, 19, 27 and 28 have promising activity against Hela cell line with IC50 values of 2.41,3.06, 6.46, 2.22 and 6.25 mmol/L, respectively, in comparison to doxorubicin as a reference antitumor agent（IC50 2.05 mmol/L）. In addition, compound 3 displayed excellent activity against COS-7 cell line with IC50 value of 4.31 mmol/L in comparison to doxorubicin（IC50 3.04 mmol/L）. In the present work,structure based pharmacophore mapping, molecular docking, protein-ligand interaction, fingerprints and binding energy calculations were employed in a virtual screening strategy to identify the interaction between the compounds and the active site of the putative target, EGFR tyrosine kinase. molecular properties, toxicity, drug-likeness, and drug score profiles of compounds 3, 14, 19, 27, 28 and 29 were also assessed.

关键词： Benzothiazole Schiff bases Antitumor activity molecular modeling In silico studies