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Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity

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molecular Plant 2022年第3期15卷 520-536页

作者： genevieve Hoopes Xiaoxi meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas guesdes marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis max J.Feldman Kyle m.gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard g.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum m.Isabel Vales Kelly Vining Richard g.F.visser Jack Vossen g.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura m.Shannon martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers Department of Plant Biology Michigan State UniversityEast LansingMI 48824USA Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Department of Plant Science McGill UniversitySainte-Anne-de-BellevueQC H9X 3V9Canada Plant Breeding Wageningen University&ResearchPlant Breeding6708 PB Wageningenthe Netherlands IBg-4 Bioinformatics Forschungszentrum JülichWilhelm Johnen Str52428 JülichGermany Department of Plant Soiland Microbial SciencesMichigan State UniversityEast LansingMI 48824USA Bayer Crop Science WoodlandCA 95695USA Averis Seeds B.V. 9640 AA Veendamthe Netherlands International Potato Center 1895 Avenida La MolinaLimaPeru USDA-ARS ProsserWA 99350USA Agriculture and Agri-Food Canada Fredericton Research and Development Centre FrederictonNB E3B 4Z7Canada School of Integrative Plant Science Cornell UniversityIthacaNY 14853-1901USA Department of Plant Sciences University of IdahoMoscowID 83844USA USDA-ARS Small Grains and Potato Germplasm ResearchAberdeenID 83210USA HZPC Research B.V. Edisonweg 58501 XG Jourethe Netherlands Department of Crop and Soil Science Oregon State UniversityHermistonOR 97838USA School of Biology and Ecology University of Maine5735 Hitchner Hall OronoME 04469USA Department of Horticultural Sciences Texas A&M UniversityCollege StationTX 77843-2133USA Department of Horticulture Oregon State UniversityCorvallisOR 97331USA Department of Horticultural Science North Carolina State UniversityRaleighNC 27695-7609USA Department of Horticulture University of Wisconsin-MadisonMadisonWI 53706USA Department of Horticulture Michigan State UniversityEast LansingMI 48824USA Institute for Biological Data Science Heinrich Heine UniversityDusseldorf40225 DusseldorfGermany Plant Resilience Institute Michigan State UniversityEast LansingMI 48824USA Present address:genNovation B.V. Wageningenthe Netherlands

Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous *** assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous *** species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding *** a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid *** a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic *** StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent *** of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids.

关键词： potato allele diversity phased assembly polyploid pan-genome wild introgressions

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25－羟维生素D和甲状旁腺激素与高血压的相关性

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中华高血压杂志 2014年第6期22卷 587-588页

作者： van Ballegooijen AJ Kestenbaum B Sachs mC de Boer IH Siscovick DS Hoofnagle AN Ix JH visser m Brouwer IA 练桂丽叶鹏机构不详

有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高... 详细信息

有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高血压的进展。目前还没有前瞻性研究同时评估维生素D和PTH水平与高血压发病的关系。该研究分析多民族动脉粥样硬化研究的前瞻性数据,发现低水平25羟维生素D[25(OH)D]和高水平PTH与高血压发病相关,特别是在肥胖人群中。但在校正混杂因素后,25(OH)D水平与高血压发病的相关性无统计学意义,而PTH水平与高血压发病仍然相关。鉴于维生素D缺乏和PTH过量在人群中是普遍现象,该研究对于更好地了解高血压发病机制,在人群中开展高血压预防工作有重要意义。

关键词： 25-羟维生素D 甲状旁腺激素高血压相关性维生素D缺乏肾素血管紧张素系统血管炎性反应 25(OH)D

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Thin-shell wormholes and modified Chaplygin gas with relativistic corrections

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Communications in Theoretical Physics 2023年第12期75卷 84-96页

作者： m Z Bhatti Z Yousaf m Yousaf Department of mathematics University of the PunjabQuaid-i-Azam CampusLahore-54590Pakistan

In this paper,we analyze thin-shell wormholes from two identical copies of charged static cylindrically symmetric spacetimes using visser’s‘cut and paste’approach under the influence of f(R,T)gravity Harko,Lobo,Nojiri,and Odintsov(2011,***.D 84,024020).In this scenario,the modified Chaplygin gas supports the exotic matter in the shell which allows,one to examine the dynamics of constructed *** utilize the junction condition to connect the interior and exterior geometries across the hypersurface and calculate different components of the Lanczos equation recently computed by Roza in Rosa(2021,***.D 103,104069).We analyze the stability of the thin-shell wormhole models under linear perturbations while keeping the cylindrical symmetry and also examine the influence of charge on their *** positive quantity of the second derivative of potential at the throat radius might be interpreted as the stability *** find both unstable and stable wormhole solutions for different parameters included in the equation of state and specific forms of considered gravity and illustrate them theoretically as well as *** examine the impact of electric charge on the stability region of a constructed wormhole,which suggests that a wormhole model with a charge may exhibit more stable behavior compared to an uncharged system.

关键词： wormholes gravitation mathematical and relativistic aspects of cosmology

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Duodenal adenocarcinoma: Advances in diagnosis and surgical management

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World Journal of gastrointestinal Surgery 2016年第3期8卷 212-221页

作者： Jordan m Cloyd Elizabeth george Brendan C visser Department of Surgical Oncology University of Texas MD Anderson Cancer Center Department of Surgery Stanford University

Duodenal adenocarcinoma is a rare but aggressive malignancy. given its rarity, previous studies have traditionally combined duodenal adenocarcinoma(DA) with either other periampullary cancers or small bowel adenocarcinomas, limiting the available data to guide treatment decisions. Nevertheless, management primarily involves complete surgical resection when technically feasible. Surgery may require pancreaticoduodenectomy or segmental duodenal resection; either are acceptable options as long as negative margins are achievable and an adequate lymphadenectomy can be performed. Adjuvant chemotherapy and radiation are important components of multi-modality treatment for patients at high risk of recurrence. Further research would benefit from multiinstitutional trials that do not combine DA with other periampullary or small bowel malignancies. The purpose of this article is to perform a comprehensive review of DA with special focus on the surgical management and principles.

关键词： Duodenal cancer Duodenal adenocarcinoma Periampullary Whipple Pancreaticoduodenectomy Segmental resection Small bowel

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压裂诱发地震的控制因素以及活动性预测：以加拿部盆地为例

压裂诱发地震的控制因素以及活动性预测：以加拿部盆地为例

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2023年中国地球科学联合学术年会

作者：王备 Honn Kao 俞红玉李戈 Ramin m.H.Dokht Ryan visser 浙江工业大学 geological Survey of Canada 浙江大学

为了有效降低与水力压裂相关的地震风险,最具挑战性的工作之一为是否能够预测由单个水力压裂平台产生的诱发地震的活动水平。当然,一个可靠的预测在很大程度上取决于是否能够全面解读诱发地震与可能相关的控制因素之间的关系(包括地质... 详细信息

为了有效降低与水力压裂相关的地震风险,最具挑战性的工作之一为是否能够预测由单个水力压裂平台产生的诱发地震的活动水平。当然,一个可靠的预测在很大程度上取决于是否能够全面解读诱发地震与可能相关的控制因素之间的关系(包括地质因素和水力压裂参数因素)。为了解决这个难题,我们以加拿大西部的Southern montney Play盆地为例进行了系统的分析。

关键词：地震活动性地震成因模式

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运用7.0TmR磁化预备的3D-FLAIR和3D-DIR序列对多发性硬化病灶的检测

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国际医学放射学杂志 2012年第2期 194-195页

作者： W.L.de graaf J.J.Zwanenburg F.visser m.P.Wattjes P.J.W.Pouwels J.J.g.geurts 卞读军 Department of Radiology VU University Medical Center AmsterdamDe Boelelaan 1117NL-1081 HVAmsterdamthe Netherlands

目的为了探讨7.0TmR三维T2加权液体衰减反转恢复(FLAIR)和双反转恢复(DIR)mR成像序列对多发性硬化(mS)病灶检测的可行性和价值。方法选10例mS病人和5名健康志愿者,7.0TmR扫描设备,将磁化预备

关键词： mRI,方法成像三维多发性硬化/诊断学多发性硬化,病理学大脑皮质,病理学

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利扎曲普坦5mg用于青少年偏头痛的急性治疗:一项双盲单次给药的研究与两项开放性多次给药研究

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 40-41页

作者： visser W.H. Winner P. Strohmaier K. 李锐 BL 1-12 Merck Research Laboratories West Point PA 19486 United States Dr.

Objective. To examine the short and long term efficacy and tolerabilty of rizatriptan 5 mg in adolescents with migraine. methods. Two studies were condu cted in patients aged 12 to 17 years. The first study was a randomized, double blind, placebo controlled, single attack study followed by a randomized, 1 ye ar, open label extension. The second study was a randomized, 1 year, open lab el study. In the single attack study, patients treated a moderate or severe mig raine headache and up to two recurrences with rizatriptan 5-mg tablets (n = 234 ) or placebo (n = 242). Patients were instructed to use the study medication onl y on nonschool days. Headache severity, associated symptoms, and functional disa bility were assessed by the patient at 0.5,1, 1.5, 2, 3, and 4 hours after the i nitial dose. In the 1 year studies, patients treated up to 6 migraine attacks p er month with rizatriptan 5-mg tablets (n = 273), rizatriptan 5-mg wafers (n = 281), or standard care therapy (n = 132). Headache severity was assessed by the patient at 2 hours after the initial dose. In all studies, the primary efficacy measure was pain relief at 2 hours post dose. Results. In the single attack study, the proportion of patients with pain relief at 2 hours was not significan tly different between rizatriptan 5 mg (68.2%) and placebo (68.8%). Fewer pat ients than expected (about 30%) treated their migraine attacks on the weekend. Among these patients, the proportion with pain relief at 2 hours was significant ly higher in the rizatriptan group than in the placebo group (74%vs. 58%, P = 0.022). In the multiple attack studies, pain relief at 2 hours was achieved in significantly more attacks treated with rizatriptan 5-mg tablet (77%) or with rizatriptan 5-mg wafer (77%) than with standard care (64%). Rizatriptan 5 mg was well tolerated in both the studies, with an adverse event profile not signif icantly different from that of placebo or standard care. Conclusions. Rizatrip tan 5 mg was not more e

关键词：单次给药性治疗安慰剂对照随机研究缓解程度药物不良反应

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运用《国际功能、残疾和健康分类》比较脑卒中康复功能性结局测量的内容

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中国康复理论与实践 2008年第12期14卷 1116-1119页

作者： V. P. m. SCHEPERS m. KETELAAR I. g. L. VAN DE PORT J. m. A. visser-mEIL Y ＆ E. LINDEmAN 王朴(译) 李沁燚(译) 邱卓英(审校) 吴弦光(审校) Center of Excellence for Rehabilitation medicine Utrecht Rehabilitation Center De Hoogstraat and Rudolf Magnus Institu te of Neuroscience University Medical Center Utrecht Utrecht The Netherlands 天津医科大学运动康复与健康学系天津市300070 不详

目的确定常用于脑卒中康复结局测量内容,主要是关于活动和参与的,并与《国际功能、残疾和健康分类》(ICF)对照。方法将以下量表的结构与ICF建立联系:Barthel指数(BI)、Berg平衡功能量表(BBS)、Chedoke mc master脑卒中评定量表(CmSA)、E... 详细信息

目的确定常用于脑卒中康复结局测量内容,主要是关于活动和参与的,并与《国际功能、残疾和健康分类》(ICF)对照。方法将以下量表的结构与ICF建立联系:Barthel指数(BI)、Berg平衡功能量表(BBS)、Chedoke mc master脑卒中评定量表(CmSA)、Euroqol-5D欧洲生活质量量表(EQ5D)、FI m功能独立性测量、Frenchay活动指数、Nottingham健康测验(NHP)、Rankin量表(RS)、Rivermead动作测量(RmA)、Rivermead移动指数(RmI)、中风影响测验-30(SASIP30)、医学结局研究简表(SF36),卒中影响量表(SIS)、脑卒中特定生存质量量表(SSQOL)和站立行走测验(TUg)。结果功能性结局测量中的绝大多数结构可与ICF分类建立联系。这些测量工具可以归入活动和参与的成份,活动是测量工具中最常见的类目内容。虽然测量工具的选择是基于它们主要关注的"活动"与"参与"内容,但有27%的结构属于身体功能类目,也有大约10%的结构与ICF不相关。结论在脑卒中的康复中,ICF是一种有效的工具来检测和比较脑卒中各测量工具的内容。这些内容上的比较使得临床医生和研究者们选择最符合他们兴趣和要求的测量。

关键词：康复结果结局测量结局评估腩卒中

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围生期急诊子宫切除:荷兰的一项前瞻性研究

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世界核心医学期刊文摘（妇产科学分册） 2006年第5期2卷 16-16页

作者： Kwee A Bots m.L visser g.H.A Bruinse H.W 朱磊 University medical Centre Utrecht Location WKZ Department of Obstetrics and Gynaecology Lundlaan 6 3584 EA Utrecht Netherlands

To determine the incidence, indication, association with caesarean section (CS) and outcome of emergency peripartum hysterectomy (EPH) in The Netherlands. Study design: All 100 Dutch obstetric departments were asked to participate in a prospective nationwide registration of EPH between 1 April 2002 and 1 April 2003. For every case, a form with questions about obstetrical history, current pregnancy and delivery,maternal and neonatal outcome was completed. Results: Eighty-nine (89% ) hospitals participated and registered in total 48 EPH. The estimated incidence of EPH is 0.33/1000 births. The main indication for EPH was placenta accreta (50% ), followed by uterine atony (27% ). There were two maternal deaths (4% ). Severe maternal morbidity included: urinary tract injury 15% , relaparotomy 25% , transfusion > 10 units red blood cells 67% , intensive care admission 77% . Both previous CS and CS in the index pregnancy were associated with a significant increased risk of EPH. The number of previous CS was related to an increased risk of placenta accreta, from 0.19% for one previous CS to 9.1% for four or more previous CS. Conclusion: Emergency peripartum hysterectomy is associated with a high incidence of maternal morbidity and a case fatality rate of 4% . It is significantly related to CS in index or previous pregnancy. Placenta accreta is the most common indication to perform a peripartum hysterectomy.

关键词：子宫切除围生期剖腹术胎盘植入手术指征尿路损伤子宫收缩乏力分娩情况并发症发病率重症监

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不同起搏部位再同步治疗的血流动力学比较:起搏导线定位需个体化

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世界核心医学期刊文摘(心脏病学分册) 2007年第5期 36-36页

作者： Van Campen C.m.C. visser F.C. De Cock C.C. F.C. visser 罗亮 Department of Cardiology VU University Medical Center De Boelelaan 1117 1081 HV Amsterdam Netherlands

背景:双心室起搏是一种新的心力衰竭治疗方法,但许多患者对这种治疗没有反应。假设:个体化的最佳起搏点将会改善血流动力学反应,并能增加治疗有效患者的数量。方法:研究由两个右心室和两个左心室起搏

关键词：血流动力患者心室起搏心脏指数个体化

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