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SELF-LUBRICATINg BEHAVIOR OF Fe-Re BINARY ALLOYS

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中国有色金属学会会刊：英文版 1995年第2期5卷 93-97,105页

作者： Xiong, Dangsheng Li, Shizhuo Jiang, Xiaoxia peterson, m B (Powder metallurgy Research Institute,Central South University of Technology, Changsha 410083 Institute of metal Research, Chinese Academy of Science, Shenyang 110015 Wear Sciences, 925 mallard C Central South Univ of Technology Changsha China

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关键词： lubrication Re oxide film glaze

Using a Collateral Damage model to Explain Survival Data in West Nile Virus Infections

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Advances in microbiology 2016年第4期6卷 251-262页

作者： James K. peterson Alison m. Kesson Nicholas J. C. King Department of mathematical and Biological Sciences Clemson University Clemson SC USA Department of Infectious Diseases and microbiology The Children’s Hospital Sydney Australia Discipline of Pediatrics and Child Health The Marie Bashir Institute for Emerging Infectious Diseases and Biosecurity University of Sydney Sydney Australia Discipline of Pathology University of Sydney Sydney Australia

Simulation code for a model of the adaptive immune response seen in flavivirus infections is used to explain the immunopathological consequences seen in West Nile Virus virus (WNV) infections. We use a model that specifically handles the differences in how the virus infects resting cells, the g0 state, versus dividing cells, the g1 state, which includes vastly increased mHC-I upregulation for resting cells over dividing cells. The simulation suggests how the infection progresses in a one host model and the results shed insight into the unusual survival curve data obtained for this infection: there is an increase in health even though viral load has increased.

关键词： Auto Immune Responses West Nile Virus Host Survival models mHC-I Upregulation IFN-γ Upregulation Free Antigen Levels

A Simulation for Flavivirus Infection Decoy Responses

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Advances in microbiology 2015年第2期5卷 123-142页

作者： James K. peterson Alison m. Kesson Nicholas J. C. King Department of mathematical and Biological Sciences Clemson University Clemson USA Discipline of Paediatrics and Child Health Sydney Institute for Emerging Infectious Diseases and Biosecurity Sydney Medical School The Children’s Hospital at Westmead Westmead Australia Discipline of Pathology University of Sydney Sydney Australia

In this work, we discuss the development of simulation code for a model of the cross-reactive adaptive immune response seen in flavivirus infections. The model specifically addresses flavivirus pathogen virulence in g0?vs g1?cell states. The mHC-I upregulation of resting cells (g0 state) allows the T-cells generated for flavivirus peptide antigens to attack healthy cells also. The cells in g1?state are not upregulated as much and so virus hides in them and hence is propagated upon rupture. Hence, this type of model is referred to as a decoy model because the immune system is decoyed into preferentially recognizing the upregulated cells while the virus actively propagates in another small, but important, cell population. We show that the generic assumption of upregulation via a model which includes the?g0/g1?differential upregulation leads to immunopathological consequences. We outline the details behind the simulation code decisions and provide some theoretical justification for our model of collateral damage and upregulation.

关键词： West Nile Virus Decoy model mHC-I Upregulation g0 vs g1 Cell State Upregulation Differences

Impact of Non-Clinical Years on Surgery Residents’ Technical Skills: Evaluation of a Technical Skills Refresher Curriculum

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Surgical Science 2013年第2期4卷 131-134页

作者： Ross E. Willis Kent R. Van Sickle Richard m. peterson Department of Surgery University of Texas Health Science Center San Antonio USA Ross E. Willis

We ascertained the opinions of residents and faculty regarding technical skills decay during non-clinical training years and evaluated the effectiveness of a technical skills refresher curriculum (TSRC) offered to residents in the month prior to rejoining clinical training years. 32 faculty and 14 residents completed surveys which gleaned opinions regarding technical skills decay during non-clinical years. Six residents completed a TSRC during the month prior to rejoining clinical training. We compared clinical evaluations of the residents who completed the TSRC to residents who rejoined clinical training prior to the implementation of the curriculum. Surveys indicated that residents and faculty believe that non-clinical years have a slightly negative impact on technical skills and residents who completed dedicated research years would require up to 4 months for technical skills to return to the level of their non-research peers. Residents who completed the TSRC reported having significantly higher comfort levels with their technical skills after the curriculum

关键词： Technical Skills Decay Research Years Non-Clinical Years Surgical Education

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牛金属硫蛋白基因序列测定及结构分析

科学通报 1992年第12期37卷 1124-1127页

作者：杨靖沈孝宙杨卫民 m. g. peterson J. F. B. mercer Savio L. C. Woo 中国科学院发育生物学研究所北京100080 中国科学院动物研究所生殖生物学开放研究实验室北京100080 澳大利亚皇家儿童医院美国贝勒医学院细胞生物系

金属硫蛋白(metallothionein,简称mT)是一类能特异性地结合重金属,并富含半胱氨酸的低分子量蛋白质,它们广泛地存在于从酵母到人类的真核细胞生物体中。mT基因是动物细胞基因表达调控中一直受人重视的实验模型。为了在转基因家畜的研究... 详细信息

金属硫蛋白(metallothionein,简称mT)是一类能特异性地结合重金属,并富含半胱氨酸的低分子量蛋白质,它们广泛地存在于从酵母到人类的真核细胞生物体中。mT基因是动物细胞基因表达调控中一直受人重视的实验模型。为了在转基因家畜的研究中提供可诱导的调控元件,我们克隆了牛金属硫蛋白基因(bmT),并发现牛的mT基因家族至少含有4个成员。本文对其中一个具有功能的基因(bmTc)进行了序列测定,在此基础上对该基因的结构特性作了分析。

关键词：牛金属硫蛋白基因 DNA序列测定

Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3836-3846页

作者： melissa m.Clemens Stefanie Kennon-mcgill Joel H.Vazquez Owen W.Stephens Erich A.peterson Donald J.Johann Felicia D.Allard Eric U.Yee Sandra SmcCullough Laura P.James Brian N.Finck mitchell R.mcgill Department of Pharmacology and Toxicology College of MedicineUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Interdisciplinary graduate Program in Biomedical Sciences Graduate SchoolUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Environmental and Occupational Health Fay W.Boozman College of Public HealthUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Winthrop P.Rockefeller Cancer Institute University of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA Department of Pediatrics College of MedicineUniversity of Arkansas for Medical SciencesLittle RockAR2205USA Division of geriatrics and Nutritional Sciences Department of Internal MedicineWashington University School of MedicineSt.LouisMO 63110USA Center for Dietary Supplement Research University of Arkansas for Medical SciencesLittle RockAR 72205USA

We previously demonstrated that endogenous phosphatidic acid(PA)promotes liver regeneration after acetaminophen(APAP)***,we hypothesized that exogenous PA is also *** test that,we treated mice with a toxic APAP dose at 0 h,followed by PA or vehicle(Veh)*** then collected blood and liver at 6,24,and 52 ***-treatment with PA 2 h after APAP protected against liver injury at 6 h,and the combination of PA and N-acetyl-L-cysteine(NAC)reduced injury more than NAC ***,PA did not affect canonical mechanisms of APAP ***,transcriptomics revealed that PA activated interleukin-6(IL-6)signaling in the *** with that,serum IL-6 and hepatic signal transducer and activator of transcription 3(Stat3)phosphorylation increased in PA-treated ***,PA failed to protect against APAP in IL-6-deficient ***,IL-6 expression increased 18-fold in adipose tissue after PA,indicating that adipose is a source of PA-induced circulating ***,however,exogenous PA did not alter regeneration,despite the importance of endogenous PA in liver repair,possibly due to its short *** data demonstrate that exogenous PA is also beneficial in APAP toxicity and reinforce the protective effects of IL-6 in this model.

关键词： Acute liver injury Acute liver failure Adipokine Cytokine Dietary supplement Drug-induced liver injury Hepatotoxicity Lipid

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由三叶形纽结得到的三维流形的不变量

科学通报 1996年第21期41卷 1924-1930页

作者：李邦河李起升 Chariya peterson 中国科学院系统科学研究所河南大学数学系 Department.of mathematics Northwestern UniversityEvanstonIL 60206 USA

关于Witten不变量,已有不少研究,可参见文献[1～9].Freed和gompf及Neil曾对若干三维流形Witten不变量τ_r(m)用计算机进行了近似的数值计算.本文给出所有由三叶结作整系数换球术得出的三维流形的不变量(?)_p(m,A)的计算公式(定理1),并... 详细信息

关于Witten不变量,已有不少研究,可参见文献[1～9].Freed和gompf及Neil曾对若干三维流形Witten不变量τ_r(m)用计算机进行了近似的数值计算.本文给出所有由三叶结作整系数换球术得出的三维流形的不变量(?)_p(m,A)的计算公式(定理1),并通过计算机对p≤13进行符号计算,得到了几个有意思的结论.文中的记号是标准的,可参见文献[3,6,9],不另说明.若记L_n和R_n分别是由左手和右手标架为n的三叶结作换球术得到的三维流形,则L_(-n)和R_n是反向同胚的,于是(?)p(R_n,A)(?)(?)p(L_(-n),A),因此只需计算(?)p(Ln,A).记是m分支的标架全为零的链环,则有引理1〈e_(i_1),…,e_(i_m)〉k_m=e_(i_1)(λ_(i_2))…e_(i_(m-1))(λ_(i_m))〈e_(i_m)〉其中λ_j=-A^(2j+2)-A^(-2j-2).

关键词：纽结三维流形不变量流形三叶形纽结

脂质体-阿霉素诱导完全缓解的严重日晒患者出现3级皮肤毒性反应

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 38-39页

作者： markman m. Kulp B. peterson g. 马向东 Dept.ofObstetrics and gynecolog y M.D.Anderson Can-cer Center1515Holcombe Blvd.#4377030-4009HoustonTXUnited States

***-plantar erythrodysestehsia(PPE)is a potentially serious toxicity of a nu mber of cytotoxic chemotherapeutic agents,includin g liposomal *** that may increase the ris k of this toxicity should be *** report.A patient wi th platinum-resistant ovarian cancer,responded to,and to lerated(including no skin rash)an initial cycle of liposomal doxoru bicin(40mg /m 2 ).Unfortunately,several days before her next scheduled cycle,she developed sign ificant sunburn(intense erythemawithout blisterin g).Despite an additional1-week delay(total of 5weeks from the prior liposo maldoxorubicin),and complete visual recovery from t he effects of the sunburn,the patient developed severe(grade 3)PPE involving both hands(pain,pronounced erythema,blistering,without ulceration),and a slightly less exten-sive reaction of both feet,followin g subsequent treatmen-twith a 25%reduced dose of the agent (30mg /m 2 ).*** is advised when considering the ad-ministration of liposomal doxorubi cin following a major sunburn,despite total resolution o f the visible effects on the skin.A delay of several weeks may be appropriate to avoid exacerbation by the chemotherapeutic agent of per-sistent subclinical damage to norma l epithelial cells.

关键词：皮肤毒性毒性反应晒伤化疗药物亚临床损害感觉障碍局部反应细胞毒性上皮细胞持续性

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夏日的狂暴

疯狂英语(新策略) 2009年第3期 16-18页

作者： Nancy m.peterson

第一阵雨意来势汹汹。它们碎裂于尘埃之上,在玻璃窗上印满了点点斑痕。雨点把通风管敲得叮咚作响,将露台顶打得噼噼啪啪。树叶被砸得瑟瑟发抖,难以抬头;而人行道则披上了一层熠熠闪光的外衣。

关键词：丁香花暴风雨