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预防医院耐药菌感染--2014年美国

上海预防医学 2017年第2期29卷 163-167页

作者： Lindsey m.Weiner,mPH Scott K.Fridkin,mD Zuleika Aponte-Torres,mPH Lacey Avery,mA Nicole Coffin,mA margaret A.Dudeck,mPH Jonathan R.Edwards,mStat John A.Jernigan,mD Rebecca Konnor,mPH minn m.Soe,mBBS,mPH Kelly peterson L.Clifford mcDonald,mD 刘洪霞(综述) 金克峙(审校) Division of Healthcare Quality Promotion National Center for Emerging and Zoonotic Infectious Diseases CDC. 不详

耐药菌是一种世界性的公共卫生威胁。2013年疾病预防控制中心（CDC）的一项报告概述了美国前18位危急和严重级别的耐药相关的威胁。

关键词：疾病预防控制中心耐药菌感染美国医院公共卫生

Nature：大规模研究揭示生命所必需的基因

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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, mary E. Flenniken, Ann m. Ji, Xiao Teboul, Lydia Wong, michael D. White, Jacqueline K. meehan, Terrence F. Weninger, Wolfgang J. Westerberg, Henrik Adissu, Hibret Baker, Candice N. Bower, Lynette Brown, James m. Caddle, L. Brianna Chiani, Francesco Clary, Dave Cleak, James Daly, mark J. Denegre, James m. Doe, Brendan Dolan, mary E. Edie, Sarah m. Fuchs, Helmut gailus-Durner, Valerie galli, Antonella gambadoro, Alessia gallegos, Juan guo, Shiying Horner, Neil R. Hsu, Chih-Wei Johnson, Sara J. Kalaga, Sowmya Keith, Lance C. Lanoue, Louise Lawson, Thomas N. Lek, monkol mark, manuel Arschall, Susan m. mason, Jeremy mcElwee, melissa L. Newbigging, Susan Nutter, Lauryl m. J. peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas J. Ryder, Edward Samocha, Kaitlin E. Seavitt, John R. Selloum, mohammed Szoke-Kovacs, Zsombor Tamura, masaru Trainor, Amanda g. Tudose, Ilinca Wakana, Shigeharu Warren, Jonathan Wendling, Olivia West, David B. Wong, Leeyean Yoshiki, Atsushi macArthur, Daniel g. Tocchini-Valentini, glauco P. gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William C. Justice, monica J. Parkinson, Helen E. moore, mark Wells, Sara Braun, Robert E. Svenson, Karen L. de Angelis, martin Hrabe Herault, Yann mohun, Tim mallon, Ann-marie Henkelman, R. mark Brown, Steve D. m. Adams, David J. Lloyd, K. C. Kent mcKerlie, Colin Beaudet, Arthur L. Bucan, maja murray, Stephen A. Dept mol Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phenogen Toronto ON M5T 3H7 Canada mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA med Res Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England mary Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Children 555 Univ Ave Toronto ON M5G 1X8 Canada Jackson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy massachusetts gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst mIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA german Res Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany german mouse Clin D-85764 Neuherberg Germany Baylor Coll med Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Hosp Oakland Res Inst Oakland CA 94609 USA ImPC San Anselmo CA 94960 USA Tech Univ munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany german Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developmental phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

复发性头痛青少年疼痛、抑郁症状及功能性残疾之间的年龄相关性关系

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世界核心医学期刊文摘(神经病学分册) 2006年第8期 24-24页

作者： Lewandowski A.S. Palermo T.m. peterson C.C. 王孝文 Department of Psychology Case Western Reserve University Mather Memorial Building

Objective. - To assess age differences associated with depressive symptoms and functional disability in children and adolescents with recurrent headache. Background. - Research has indicated that psychological factors, especially depression, are related to the extent and nature of functional disability experienced from headaches. There is a lack of research examining how age impacts the relationship between pain, psychological factors, and activity restriction in children and adolescents with recurrent headache. methods. - Seventy- seven participants from a pediatric neurology clinic completed self- report measures of pain intensity, depressive symptoms, and functional disability. Results. - Findings demonstrated a significant positive correlation between pain and functional disability, and depressive symptoms and functional disability for children. Correlations for adolescents failed to reach significance. Functional disability emerged as a mediator between headache pain and depressive symptoms for children but not for adolescents. Conclusions. - Results indicate potentially important age differences when examining the impact of functional disability on depressive symptoms in this sample. Findings suggest that functional disability may contribute to depressive symptoms differently for children versus adolescents with recurrent headache. Age- specific interventions that differentially focus on the specific roles that pain, depressive symptoms, and disability have for children and adolescents with recurrent headache may be warranted.

关键词：抑郁症状头痛头疼复发性功能性疼痛

The Use of Eucalyptus Activated Biocarbon for Water Treatment-Adsorption Processes

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American Journal of Analytical Chemistry 2017年第8期8卷 515-522页

作者： Roberta m. Nunes Damaris Costa Nilce Ortiz Center for Environmental Chemistry Institute for Nuclear and Energy Research-IPEN S&atilde o Paulo Brazil

A biocarbon after activation process showed the removal percentage of 92% of methylene blue in solution, the equilibrium parameter—RL value was in the interval from 0 to 1, with 46% of surface coverage degree. The Freundlich constant (n) was higher than 1 as an indication of the physical adsorption process. The Radlich-peterson calculations obtained the higher R2 value which g constant near 1, a high similarity with Langmuir model. Temkin constant B1 was a positive indication of endothermic process. All calculations provided favorable results for the use of activated biocarbon for dye removing and possible for other organic substances.

关键词： Biocarbon Radlich-peterson Eucalyptus Temkin

molecular phylogeny, morphology, pigment chemistry and ecology in Hygrophoraceae (Agaricales)

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Fungal Diversity 2014年第1期64卷 1-99页

作者： D.Jean Lodge mahajabeen Padamsee P.Brandon matheny m.Catherine Aime Sharon A.Cantrell David Boertmann Alexander Kovalenko Alfredo Vizzini Bryn T.m.Dentinger Paul m.Kirk A.martyn Ainsworth Jean-marc moncalvo Rytas Vilgalys Ellen Larsson Robert Lücking gareth W.griffith matthew E.Smith Lorelei L.Norvell Dennis E.Desjardin Scott A.Redhead Clark L.Ovrebo Edgar B.Lickey Enrico Ercole Karen W.Hughes Régis Courtecuisse Anthony Young manfred Binder Andrew m.minnis Daniel L.Lindner Beatriz Ortiz-Santana John Haight Thomas Læssøe Timothy J.Baroni József geml Tsutomu Hattori Center for Forest mycology Research Northern Research StationUSDA-Forest ServiceLuquilloPR 00773-1377USA Systematics Team Landcare Research231 Morrin RoadAuckland 1072New Zealand Ecology&Evolutionary Biology University of TennesseeKnoxvilleTN 37996-1610USA Department of Botany&Plant Pathology Purdue UniversityWest LafayetteIN 47907USA Science and Technology Universidad del TuraboGuraboPR 00778-3030USA Department of Bioscience Aarhus UniversityFrederiksborgvej 399DK-4000 RoskildeDenmark Komarov Botanical Institute of the Russian Academy of Sciences 2 Prof.Popov Str.St.Petersburg 197376Russia Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale P.A.Mattioli 2510125 TorinoItaly mycology Royal Botanic GardensKewRichmondSurrey TW93DSUK Royal Ontario museum 100 Queen’s ParkTorontoONCanada Biology Department Duke UniversityDurhamNC 27708-0338USA Biological&Environmental Sciences University of GothenburgGöteborgSweden Science&Eduaction Integrative Research&Collections(Botany)The Field Museum of Natural History1400 Lake Shore Dr.ChicagoIL 60605-2496USA University of Wales AberystwythCeredigion SY233DDUK Department of Plant Pathology University of FloridaGainesvilleFL 32611-0680USA Pacific Northwest mycology Service 6720 NW Skyline BvdPortlandOR 97229-1309USA Department of Biology San Francisco State University1600 Holloway Ave.San FranciscoCA 94132USA National mycological Herbarium(DAOm) Science and Technology BranchAgriculture&Agri-FoodsCanada960 Carling AvenueOttawaOntarioCanada ONT K1A 0C6 Department of Biology University of Central OklahomaEdmondOK 73034USA Department of Biology Bridgewater College402 E.College St.BridgewaterVA 22812USA Department of Botany Faculty of Pharmaceutical&Biological SciencesLilleFrance 100 Langton Road BlackbuttQld 4306Australia CBS Fungal Biodiversity Centre Evolutionary PhytopathologyInst.of the Royal Netherlands Academy of Arts&Sciences(KNAW)Uppsalalaan 83584 CT UtrechtThe Netherlands

molecular phylogenies using 1–4 gene regions and information on ecology,morphology and pigment chemistry were used in a partial revision of the agaric family *** phylogenetically supported genera we recognize here in the Hygrophoraceae based on these and previous analyses are:Acantholichen,Ampulloclitocybe,Arrhenia,Cantharellula,Cantharocybe,Chromosera,Chrysomphalina,Cora,Corella,Cuphophyllus,Cyphellostereum,Dictyonema,Eonema,gliophorus,Haasiella,Humidicutis,Hygroaster,Hygrocybe,Hygrophorus,Lichenomphalia,Neohygrocybe,Porpolomopsis and Pseudoarmillariella.A new genus that is sister to Chromosera is described as *** were made at the ranks of subfamily,tribe,genus,subgenus,section and *** present three new subfamilies,eight tribes(five new),eight subgenera(one new,one new combination and one ***.),26 sections(five new and three new combinations and two ***.)and 14 subsections(two new,two ***.).Species of Chromosera,gliophorus,Humidicutis,and Neohygrocybe are often treated within the genus Hygrocybe;we therefore provide valid names in both classification *** used a minimalist approach in transferring genera and creating new names and ***,we retain in the Hygrophoraceae the basal cuphophylloid grade comprising the genera Cuphophyllus,Ampulloclitocybe andCantharocybe,despite weak phylogenetic *** include Aeruginospora and Semiomphalina in Hygrophoraceae based on morphology though molecular data are *** lower hygrophoroid clade is basal to Hygrophoraceae s.s.,comprising the genera Aphroditeola,macrotyphula,Phyllotopsis,Pleurocybella,Sarcomyxa,Tricholomopsis and Typhula.

关键词： Hygrophoraceae Fungi Revisionary systematics Nomenclatural revision Phylogenetics Pigment chemistry Lamellar trama construction Hymenial morphology Ecology

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加快大型数据中心服务的可重构结构

中国集成电路 2015年第1期24卷 55-68,89页

作者： Andrew Putnam Adrian m.Caulfield Eric S.Chung Derek Chiou Kypros Constantinide John Demme Hadi Esmaeilzadeh Jeremy Fowers gopi Prashanth gopal Jan gray michael Haselman Scott Hauck Stephen Heil Amir Hormati Joo-Young Kim Sitaram Lanka James Larus Eric peterson Simon Pope Aaron Smith Jason Thong Phillip Yi Xiao Doug Burger 微软公司

数据中心的工作负载要求高计算能力、灵活性、能效和低成本。同时改善所有这些因素非常具有挑战性。为了推进数据中心超出商用服务器设计可以提供的能力,我们设计并构建了一个可组合、可重构的结构,来加速部分大型软件服务。结构的每个... 详细信息

数据中心的工作负载要求高计算能力、灵活性、能效和低成本。同时改善所有这些因素非常具有挑战性。为了推进数据中心超出商用服务器设计可以提供的能力,我们设计并构建了一个可组合、可重构的结构,来加速部分大型软件服务。结构的每个实例都由嵌入48台机器的半机架6×8二维环面高端Stratix V FPgA组成。每台服务器中都放置了一个FPgA,可以通过PCIe来访问,并用成对的10 gb SAS电缆直接连接到其他FPgA。在本文中,我们描述了这种结构在1,632台服务器组(bed)的中等规模的部署,并测量了其在加快Bing搜索引擎方面的功效。我们描述了系统的要求和架构,详细介绍了关键技术挑战,以及使系统在出现故障情况下保持鲁棒性所需的解决方案,还有根据排名候选文档测量的系统性能、功率和弹性。在高负载时,一定范围内的可重构结构提高了每台服务器固定延迟分布的吞吐量排名95%——或在保持等效吞吐量时,减少29%的尾延迟。

关键词：可重构结构服务器组数据中心 Stratix FPgA 计算能力工作负载软件服务

氯吡格雷的使用与药物洗脱支架植入后远期临床结果

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美国医学会杂志（中文版） 2007年第3期26卷 131-139页

作者： Eric L Eisenstein, DBA Kevin J. Anstrom, PhD David F. Kong, mD Linda K. Shaw, mS Robert H. Tuttle, mSPH Daniel B. mark, mD, mPH Judith m. Kramer, mD, mS Robert A. Harrington, mD David B. matchar, mD David E. Kandzari, mD 1 Eric D. peterson, mD, mPH Kevin A. Schulman, mD Robert m. Califf, mD 李呈亿（译） David E. Kandzari, mD Department of medicine Duke Clinical Research Institute Biostatistics and Bioinformatics Duke Clinical Research Institute Duke University medical Center Duke Clinical Research Institute Duke Translational medicine Institute Durham NC the Duke Center for Clinical Health Policy Research Durham NC 不详

背景：近来的冠状动脉内药物洗脱支架研究提示，现行的抗血小板治疗方案可能并不足以预防后期支架内血栓形成。目的：于接受药物洗脱支架（drug-eluting stents，DESs）和裸金属支架（bare-metal stents，BmSs）治疗的冠状动脉病患者中... 详细信息

背景：近来的冠状动脉内药物洗脱支架研究提示，现行的抗血小板治疗方案可能并不足以预防后期支架内血栓形成。目的：于接受药物洗脱支架（drug-eluting stents，DESs）和裸金属支架（bare-metal stents，BmSs）治疗的冠状动脉病患者中评估氯吡格雷使用与患者远期结果的关系。设计、地点及患者：于连续患者中进行观察性研究。患者于2000年1月1日至2005年7月31日在杜克心脏治疗中心（一家位于北卡罗来纳州达累姆市的三级治疗中心）接受冠状动脉内支架治疗。于6、12、24个月时进行随访，直至2006年9月7日。研究人群包括4666例最初接受BmS（n=3165）或DES（n=1501）经皮冠状动脉介入治疗的患者。对随访6和12个月没有事件（没有死亡、心肌梗死或血管重建手术）的患者进行界标分析（landmark analysis）。在这些时间点上根据支架类型以及自我报告之氯吡格雷的使用情况将患者分为4组：DES使用氯吡格雷组、DES不用氯吡格雷组、BmS使用氯吡格雷组以及BmS不用氯吡格雷组。主要观测指标：随访24个月时死亡、非致命性心肌梗死以及死亡或心肌梗死之复合终点。结果：在6个月时没有事件发生的DES组患者（637例使用、579例未使用氯吡格雷）中，氯吡格雷的使用是随访24个月校正死亡率较低（使用2．0％比未使用5．3％；差异，-3．3％；95％CI，-6．3％至-0．3％；P=0．03）以及死亡或心肌梗死发生率较低（3．1％比7．2％；差异，-4．1％；95％CI，-7．6％至-0．6％；P=0．02）的显著预测指标。然而，在BmS组患者中（417例使用、1976例未用氯吡格雷），死亡（3．7％比4．5％；差异，-0．7％；95％CI，-2．9％至1．4％；P=0．50）以及死亡或心肌梗死发生率（5．5％比6．0％；差异，-0．5％；95％CI，-3．2％至2．2％；P：0．70）没有差异。在12个月随访没有事件发生的DES组患者（252例使用、276例未用氯吡格雷）中，氯吡格雷的使用依然可以预测24个月死亡（0％比3．5％；差异，-3．5％；95％CI，-5．9％至-1．1％；P=0．004）以及死亡或心肌梗死发生率（0％比4．5％；差异，-4．5％；95％CI，-7．1％至-1．9％；P〈0．001）较低。然而，在BmS组患者中（346例使用、1644例未用氯吡格雷），在死亡（3．3％比2．7％；差异，0．6％；95％CI，1．5％至2．8％；P=0．57）以及死亡或心肌梗死（4．7％比3．6％；差异，1．0％；95％CI，-1．6％至3．6％；P=0．44）发生方面，依然没有差异。结论：在接受DES治疗的患者中，延长氯吡格雷的使用可以使死亡以及死亡或心肌梗死的发生率下降。然而，使用氯吡格雷的适宜期限只能通过大型临床随机试验确定。

关键词：药物洗脱支架氯吡格雷临床结果经皮冠状动脉介入治疗植入后冠状动脉内心肌梗死支架内血栓形成

在中国西藏边远地区和印度Haryana地区进行心血管高危人群简化规范管理:一项集群随机对照研究

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中华高血压杂志 2015年第7期23卷 607-607页

作者：李金凤叶鹏 Tian m Ajay V Dunzhu D Hameed S Li X Liu Z Li C Chen H Cho K Li R Zhao X Jindal D Rawal I Ali mK peterson ED Ji J Amarchand R Krishnan A Tandon N Xu LQ Wu Y Prab-hakaran D Yan L

在中国和印度边远地区，治疗心血管病的经济负担十分沉重，但是这些地区经济落后，医疗保健资源有限。该研究旨在设计和评估由社区医护人员（community health workers，CHW）实施，

关键词：边远地区心血管病随机对照研究高危人群印度中国集群管理

Bioadsorption of Cd (II) from Contaminated Water on Treated Sawdust: Adsorption mechanism and Optimization

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Journal of Water Resource and Protection 2013年第1期5卷 82-90页

作者： Ali Hashem E. Adam H. A. Hussein m. A. Sanousy A. Ayoub Department of Basic Sciences Faculty of Engineering in Benha Benha University Benha Egypt Department of Chemistry Faculty of Science Sebha University Sebha Libya Faculty of Science and Arts at Shaqra Shaqra University Shaqra KSA

Sawdust (SD) a very low cost material has been utilized as adsorbent material for the removal of Cd (II) from aqueous solutions after treatment with mono methylol urea (mmU) in the presence of zinc chloride as a catalyst to form mmU-SD. The reaction of mmU-SD was carried out under different conditions including mmU/SD molar ratio, catalyst concentration, and reaction time and temperature. Adsorption studies have been carried out to determine the effect of agitation time, pH, adsorbent and adsorbate concentrations on the adsorption capacity of Cd (II) ions onto mmU-SD. Langmuir, Freundlich and Redlich-peterson isotherm models were applied in the adsorption studies. The experimental data were analyzed using various sorption kinetic models. The removal processes of Cd (II) onto mmU-SD particles could be well described by the pseudo-second order model. The maximum adsorption capacity of Cd(II) onto mmU-SD was 909 mg/g. Similarly, the Freundlich constant 1/n value was 0.45.

关键词： Sawdust methylolation Adsorption Isotherm Cd (II) Ion Removal