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Fatigue crack propagation in a helicopter component subjected to impact damage

Defence Technology（防务技术） 2021年第2期17卷 416-428页

作者： m.fossati m.Pagani m.Giglio A.manes Politecnico di milano Dipartimento di Meccanicavia la Masa 1MilanoItaly

Damage tolerant methodology is increasingly used in aeronautical components,especially due the fact that the Aviation Regulation requires such an assessment in case an accidental damage *** present,there is a strong and actual interest in applying such procedures to helicopter components that are subjected to high frequency cyclic *** this paper,an investigation on a damaged transmission shaft for a tail rotor transmission of an actual helicopter has been carried out focusing on the fatigue crack propagation.A complete sequence of experimental tests was performed in order to create an actual ballistic damage and to subsequently check the damage tolerant *** shaft was damaged by oblique ballistic impact and was subsequently subjected to torsional fatigue *** the fatigue cycles several cracks propagated from the ballistic *** of these steps(impact and fatigue loading)were also simulated by a complex modelling approach based on Finite Element models and fracture mechanics *** comparison between the experimental and numerical results shows a good agreement but it underlines the need for a very refined modelling technique capable to replicate all the features associated with the damage in order to reliably simulate the subsequent propagation phase.

关键词： Ballistic impact Damage Fatigue Crack propagation

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Effect of self-weight consolidation on a hydro-sedimentological model for the Río de la Plata estuary

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International Journal of Sediment Research 2019年第5期34卷 444-454页

作者： Pablo Santoro mónica fossati Pablo Tassi Nicolas Huybrechts Damien Pham Van Bang Ismael Piedra-Cueva Instituto de mecánica de los Fluidos e Ingeniería Ambiental Facultad de Ingeniería Universidad de la República Université Paris-Est Laboratory for Hydraulics Saint-Venant (ENPC-EDF/R& D-CEREMA) Electricity of France R&D Department Sorbonne Universités Université de Technologie de Compiègne FRE UTC-CNRS 3023 Roberval Centre de Recherche Royallieu Cerema Direction Technique Eau Mer et Fleuves Institut National de la Recherche Scientifique Centre-Eau Terre Environnement

The effect of the consolidation process on the morphodynamics and fine sediment dynamics of the Río de la Plata estuary is explored through a circulation-wave-sediment transport model. The consolidation model is calibrated based on settling column experimental data. Different simulations are done in order to initialize the mud layer distribution and to investigate the impact of different erosion parameter assumptions on the modeled sediment dynamics. Finally a two-year simulation is done with and without the consolidation process and realistic hydrodynamic forcings. Considering the consolidation process, the model correctly reproduces measured vertical density profiles in the montevideo Bay access channel. The simulated suspended sediment dynamics behavior in montevideo Bay with the consolidation process provides a more realistic deposition pattern in regard to the dredging activities.

关键词： Cohesive sediment Self-weight consolidation morphodynamics Numerical modeling

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Reliability of enzyme assays in dried blood spots for diagnosis of 4 lysosomal storage disorders

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Advances in Biological Chemistry 2011年第3期1卷 58-64页

作者： Romina Ceci Pablo N. de Francesco Juan m. mucci Lorena N. Cancelarich Carlos A. fossati Paula A. Rozenfeld 不详

Introduction: Lysosomal storage disorders (LSD) are inherited diseases caused, in the majority of them, by the deficiency of lysosomal enzymatic activities. Ob-jectives: We aimed to analyze the usefulness of DBS samples for diagnosis of 4 LSDs, with the availability of a large quantity of patient samples. Design and methods: Blood samples from previously diagnosed patients with Fabry, Gaucher, Hunter, and maro-teaux-Lamy syndromes and normal control individ-uals, were collected and dispen-sed in filter paper, and used for enzymatic activity determination. Results: Diagnosis of hemi/homo-zygous patients with Fabry, Hunter and maroteaux-Lamy diseases using DBS samples showed ideal parameters of 100% sensitivity and specificity. DBS assay for Gaucher disease would need a posterior confirmatory step. Conclusions: Leukocyte measu-rement is the only reliable way to diagnose Gaucher disease. For Hunter, Fabry and maroteaux-Lamy disorders discrimination between patients and controls seems adequate by DBS.

关键词： Lysosomal Storage Disorders Diagnosis Dried Blood Spots Sensitivity Enzymatic Activity Reliability

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应用mRI选择适合行部分乳腺照射的病人:系统评价和meta分析

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国际医学放射学杂志 2016年第1期 75-75页

作者： G.D.Leo R.m.Trimboli A.Benedek B.A.Jereczek-Fossa P.fossati m.C.Leonardi 杨献峰 Radiology Unit IRCCS Policlinico San Donato

摘要目的系统回顾关于mRI评估不适合部分乳腺照射(PBI)病人的文章。材料与方法本研究不需要伦理委员会的批准。通过mEDLINE和EmBASE进行系统性检索。研究结果为标准评估方法[如临床体格检查、乳腺摄片和(或)乳腺超声]定义为适合,而mRI... 详细信息

摘要目的系统回顾关于mRI评估不适合部分乳腺照射(PBI)病人的文章。材料与方法本研究不需要伦理委员会的批准。通过mEDLINE和EmBASE进行系统性检索。研究结果为标准评估方法[如临床体格检查、乳腺摄片和(或)乳腺超声]定义为适合,而mRI定义为不适合PBI的比率。计算优势比(OR)以确定预测值。通过强化流行病学清单中的观测性研究报告以评估研究质量。结果在93篇检索到的文献中,6篇被纳入(共3 136人)。采用国家乳腺癌和肠道外科辅助治疗方案B-39标准评估病人是否适合PBI。标准评价方

关键词：乳腺 PBI 乳房病人 mRI meta

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