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国际医学放射学杂志 2016年第6期 681-682页

作者： m.Koini m.filippi m.A.Rocca T.Yousry O.Ciccarelli G.Tedeschi 徐佳圆 Department of Neurology Medical University of Graz

摘要目的研究多发性硬化病人脑结构和功能mRI之间的关系,从而解释病人信息处理速度和执行功能的改变。方法本次前瞻性的多中心研究经所有中心的伦理委员会批

关键词：执行功能信息处理计算机应用多发性硬化病丘脑区 mR

联合钆和超顺磁性氧化铁对比剂mR增强成像评估多发性硬化的活动性

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国际医学放射学杂志 2012年第5期 478-479页

作者： T.Tourdias S.Roggerone m.filippi m.Kanagaki m.Rovaris D.H.miller 刘永康 Department of Neuroradiology and INSERm U1049 CHU de BordeauxUniversité Bordeaux SegalenBordeauxFrance

摘要目的应用钆和超微超顺磁性氧化铁(USPIO)颗粒作为对比剂,比较多发性硬化病变随时间变化的mR成像特征。方法该研究获得当地伦理委员会批准,所有受试者签署知情同意书。对24例多发性硬化病人(10例复发型、14例进展型)给予钆和USPIO增... 详细信息

摘要目的应用钆和超微超顺磁性氧化铁(USPIO)颗粒作为对比剂,比较多发性硬化病变随时间变化的mR成像特征。方法该研究获得当地伦理委员会批准,所有受试者签署知情同意书。对24例多发性硬化病人(10例复发型、14例进展型)给予钆和USPIO增强mRI检查并随访6个月。采用Pearsonχ2或Fisher确切检验比较单独使用钆增强强化的病变、USPIO增强强化的病变及两者都强化的病变数量,用U检验比较病变大小。

关键词：对比剂病灶进展型 USPIO 活动性 mR

视神经脊髓炎谱系疾病的脊髓萎缩在空间上与脊髓病变和残疾有关联

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国际医学放射学杂志 2020年第6期 741-741页

作者：董力宁 L.Cacciaguerra P.Valsasina S.mesaros V.martinelli J.Drulovic m.filippi Neuroimaging Research Unit Institute of Experimental Neurology Division of Neuroscience IRCCS San Raffaele Scientific Institute

摘要视神经脊髓炎谱系疾病(NmOSD)病人的脊髓常被累及,但炎症和萎缩之间的关系仍不清楚。目的研究NmOSD病人mRI上脊髓内T1低信号病变的空间分布特征

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偏头痛患者T2可见损伤的脑灰质改变:一项3T mRI研究

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 41-41页

作者： Rocca m.A. Ceccarelli A. Falini A. m.filippi 郭俊 Dr.Department of Neurology Scientific InstituteUniversity Ospedale San RaffaeleVia Olgettina6020132 MilanItaly

BACKGROUND AND PURPOSE-In migraine patients,functional imaging studies have shown changes in several brain gray matter(Gm)***,1.5-T mRI has failed to detect any structural abnormality of these *** used a 3-T mRI scanner and voxel-based morphometry(VBm)to assess whether Gm density abnormalities can be seen in patients with migraine with T2-visible abnormalities and to grade their ***-In 16 migraine patients with T2 visible abnormalities and 15 matched controls,we acquired a T2-weighted and a high-resolution T1-weighted *** loads were measured on T2-weighted *** optimized version of VBm analysis was used to assess regional differences in Gm densities on T1-weighted scans of patients versus *** parametric maps were thresholded at P multiple ***-Compared with controls,migraine patients had areas of reduced Gm density,mainly located in the frontal and temporal ***,patients showed increased periacqueduc-tal Gm(PAG)*** with patients without aura,migraine patients with aura had increased density of the PAG and of the dorsolateral *** migraine patients,reduced Gm density was strongly related to age,disease duration,and T2-visible lesion load(r ranging from-0.84 to-0.73).CONCLUSIONS-Structural Gm abnormalities can be detected in migraine patients with brain T2-visible lesions using VBm and a high-field mRI *** Gm changes comprise areas with reduced and increased density and are likely related to the pathological substrates associated with this disease.

关键词：偏头痛密度脑病 T2 患者脑灰质

弥散张量mRI对视神经脊髓炎和多发性硬化症的颈髓损害进行分级

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 21-21页

作者： Benedetti B. Valsasina P. Judica E. m.filippi 郭俊 Dr.Department of Neurology Scientific InstituteUniversity Ospedale San RaffaeleVia Olgettina6020132 MilanItaly

The authors assessed the ability of diffusion tensor mRI to grade cervical cord damage in 10 patients with neuromyelitis optica,10 patients with multiple sclerosis,and 10 healthy *** three groups differed in terms of average mean diffusivity(p = 0.008)and average fractional anisotropy(p = 0.04).There was a correlation between the Expanded Standard Disability Status Scale score and cord average mean diffusivity(r = 0.52,p = 0.02).

关键词：多发性硬化症视神经脊髓炎 mRI 弥散张量颈髓

区域性而不是全脑性脑损伤导致多发性硬化的疲劳

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国际医学放射学杂志 2015年第1期 68-68页

作者： m.A.Rocca L.Parisi E.Pagani m.Copetti m.Rodegher m.filippi Neuroimaging Research Unit CERMACSan Raffaele Scientific InstituteVita-Salute San Raffaele University

目的使用mR成像和先进的分析评估正常白质(NAWm)和灰质(Gm)损伤、全脑与区域性损伤、萎缩与微结构异常病变在多发性硬化(mS)疲劳发病机制中的作用。材

关键词：多发性硬化灰质全脑异常病变发病机制扩散张量白质髓质脑损伤区域性

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多发硬化病人的丘脑损伤和长期残障进展

国际医学放射学杂志 2011年第1期34卷 75-页

作者： m.A.Rocca S.mesaros E.Pagani m.P.Sormani G.Comi m.filippi 李睿 Neuroimaging Research Unit Institute of Experimental NeurologyDivision of NeuroscienceScientific Institute and University Hospital San Raffaele

目的评估磁化转移(mT)mR成像所显示初期丘脑萎缩和异常及其后12个月的变化,以预测一组相对大样本的间断发作型多发硬化(mS)

关键词：多发硬化 mS 丘脑萎缩病人残障

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原发性进行性多发性硬化:颈髓触觉相关性功能mR成像

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国际医学放射学杂志 2009年第6期 588-588页

作者： F.Agosta P.Valsasina m.Absinta S.Sala D.Caputo m.filippi 邓怀福 Neuroimaging Research Unit Institute of Experimental NeurologyScientific Institute and University Hospital San Raffaelevia Olgettina 6020132 MilanItaly

目的利用mRI显示原发性进行性(PP)多发性硬化(mS)病人的触觉相关性颈髓活动范围,探讨颈髓的功能活动与颈髓和脑结构性损伤程度的相关性。材料与方法本研究经过伦理委员会批准并获得受试者知情同意。23例PPmS病人和18例健康志愿者,对受试

关键词：颈髓 mR 多发性硬化进行性原发性相关性触觉

Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： matheus Truccolo michalczuk Larisse Longo melina Belén Keingeski Bruno de Souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEduardo Vargas Cláudia P Oliveira Carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski Eduardo filippi-Chiela mário ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Department of Gastroenterology(LIm07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Department of morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUND Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(mASLD).AIm To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEN)in drinking water and Veh gavage],and RIF[HFCD,DEN and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRNAs were *** All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(mmp2),and metalloproteinases-9(mmp9)were significantly higher in the *** opposite occurred with Becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(map1 Lc3b),and p62/sequestosome-1(p62/SQSTm1)-*** with controls,map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(Pm1 was lower in HCC compared to RIF(Pmmp9 was higher in HCC in relation to the control;the opposite was observed for p62/Sqstm1(Pm1 protein was lower in the RIF-group compared to the control(P=0.024).There was no difference among groups for Tuba-1c,Aldolase-B,alpha-fetoprotein,and mmp2(P>0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(PmiR-26b was lower in HCC compared to RIF,and the inverse was observed for miR-224(Pmong groups regarding miR-33a,miR-143,miR-155,miR-375 and miR-21(P>0.05).CONCLUSION RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma metabolic dysfunction-associated steatotic liver disease Rifaximin

多发性硬化:认知康复效应在结构功能mRI上的测量的探索性研究

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国际医学放射学杂志 2012年第3期 274-274页

作者： m.filippi G.Riccitelli F.mattioli R.Capra C.Stampatori E.Pagani 李金芳 Neuroimaging Research Unit Institute of Experimental NeurologyDepartment of NeurologyDivision of Neuroscienceand Scientific Institute and Vita-Salute UniversityHospital San RaffaeleVia Olgettina 6020132 MilanItaly

目的应用神经心理学评估方法和结构及功能mRI技术评价临床稳定的复发缓解(relapsing-remitting,RR)型多发性硬化(multiple sclerosis,mS)病人认知康复后的脑变化。材料与方法本研究通过机构审查委员会的许可。每例病人签署知情同意书。... 详细信息

目的应用神经心理学评估方法和结构及功能mRI技术评价临床稳定的复发缓解(relapsing-remitting,RR)型多发性硬化(multiple sclerosis,mS)病人认知康复后的脑变化。材料与方法本研究通过机构审查委员会的许可。每例病人签署知情同意书。将20例具有认知缺陷的RRmS病人随

关键词：认知康复病人 mS RR 神经心理学 mRI