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THE EffECT Of DIffERENT TOPICAL BETABLOCKERS ON OCULAR HEmODY- NAmICS AND OPTIC NERVE HEAD BLOOD fLOW IN GLAUCOmA PATIENTS

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国际眼科杂志 2003年第1期3卷 27-27页

作者： A.G.Boehm A.U.Koeller m.f.mueller K.A.mollenhauer L.E.Pillunat Department of Ophthalmology University of Dres-den GermanyDepartment of Ophthalmology University of Dres-den GermanyDepartment of Ophthalmology University of Dres-den GermanyDepartment of Ophthalmology University of Dres-den GermanyDepartment of Ophthalmology University of Dres-den Germany

Purpose: The aim of the study is to evaluate the influence of different betablockers on ocular hemodynamics and optic nerve head blood flow in glaucoma patients. methods: 30 patients (12 male, 18 female) with primary open-angle glaucoma between 39 and 74 years of age were treated for 4 weeks each with betax-olol (BX), metipranolol 0.3% (mL) and timolol 0.5% (TL) in a randomized, double masked, crossover design. At baseline in-

关键词：青光眼患者 β阻滞剂眼内血流动力学视神经乳头血流影响

采用16通道mR线圈对乳腺癌行PET/mR同步成像

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国际医学放射学杂志 2015年第3期 304-304页

作者： I.Dregely T.Lanz S.metz m.f.mueller m.Kuschan m.Nimbalkar 施益洁 Nuklearmedizinische Klinik Klinikum rechts der Isar der Technischen Universitat Munchen

目的使用专用接收阵列线圈对乳腺癌行PET/mR同步成像并予评价。方法采用16通道接收线圈针对PET/mR同步成像进行了优化设计。通过对模型、志愿者和病人成

关键词： PET/mR CT 乳腺癌乳腺肿瘤 mR

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew f.Gary Ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

The evolution of aposematism is accompanied by increased diversification

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Integrative Zoology 2008年第3期3卷 149-156页

作者： Kara PRZECZEK Carla mueller Steven m.VAmOSI Department of Biological Sciences University of CalgaryCalgaryCanada

Although the use of distinct colors to indicate unprofitability to predators(***)is commonly thought of as an adaptation,our knowledge of its macroevolutionary effects is *** aposematism is expected to decrease attacks by predators,we hypothesized that aposematic lineages should be larger on average than their non-aposematic sister groups because of the decreased probability of extinction and/or increased probability of speciation(*** diversification).The results of our sister-group analysis are consistent with the hypothesis that the evolution of aposematism is accompanied by increased diversification of lineages,with the aposematic focal group having more species in 11 of 14 pairs of sister *** the apparent advantages of reduced predation risk on diversification rates,the evolution of aposematism is relatively rare and reversions to a cryptic state are not *** addition to the difficulties in evolving a trait that initially decreases the survivorship of prey among naïve predators,we discuss other factors that may limit the apparent prevalence and success of *** is hoped that the results of our analysis will encourage further analyses of the phylogenetic relationships among aposematic groups and their relatives,and of the evolutionary time scales over which the benefits of aposematism are the greatest to lineages with this condition.

关键词： aposematism diversification predation sister-group comparisons speciation.

Concentrations of organophosphate flame retardants in dust from cars, homes, and offices: An international comparison

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Emerging Contaminants 2016年第2期2卷 66-72页

作者： Stuart Harrad Sandra Brommer Jochen f.mueller School of Geography Earth&Environmental SciencesUniversity of BirminghamBirminghamB152TTUnited Kingdom National Centre for Environmental Toxicology The University of QueenslandKessels RoadBrisbaneQueenslandAustralia

Concentrations of a number of organophosphate flame retardants(PfRs)were measured in floor dust collected from living rooms in Australia(n=42),Canada(n=14),Germany(n=22),and Kazakhstan(n=9);cars from Australia(n=39)and Germany(n=19);and offices from Germany(n=25)and Kazahkstan(n=8).PfR concentrations in these samples were compared with each other and with previously reported data for PfRs in dust from similar microenvironments in the *** data reveal significant between-country differences in both absolute concentrations and the relative abundance of specific PfRs in each of the microenvironments *** notably,concentrations of TCIPP in UK living room dust(median=21 μg g^-1)exceeded significantly(pmber of car dust samples contained elevated concentrations of TDCIPP,and German samples generally contained lower levels of PfRs in all microenvironments *** addition,PfRs were determined in dust samples collected from living room couches in both Australia(n=41)and the UK(n=10).The elevated concentrations of TCIPP in UK living room dust are likely attributable to the favoured use of this PfR in UK couch *** is indicated by concentrations of TCIPP in UK couch dust(median=610 μg g^-1)exceeding significantly those in Australian couch dust(median=2.9 μg g^-1).moreover,concentrations of TCIPP in UK couch dust originating from couches 15 years old or less,display a marked relationship with the age of the couch,with concentrations in such samples increasing significantly(p<0.01)with couch age.

关键词： PfRs Indoor dust Australia Germany Canada Kazakhstan

fast,accurate,and transferable many-body interatomic potentials by symbolic regression

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npj Computational materials 2019年第1期5卷 161-171页

作者： Alberto Hernandez Adarsh Balasubramanian fenglin Yuan Simon A.m.mason Tim mueller Department of materials Science and Engineering Johns Hopkins UniversityBaltimoreMDUSA

The length and time scales of atomistic simulations are limited by the computational cost of the methods used to predict material *** recent years there has been great progress in the use of machine-learning algorithms to develop fast and accurate interatomic potential models,but it remains a challenge to develop models that generalize well and are fast enough to be used at extreme time and length *** address this challenge,we have developed a machine-learning algorithm based on symbolic regression in the form of genetic programming that is capable of discovering accurate,computationally efficient many-body potential *** key to our approach is to explore a hypothesis space of models based on fundamental physical principles and select models within this hypothesis space based on their accuracy,speed,and *** focus on simplicity reduces the risk of overfitting the training data and increases the chances of discovering a model that generalizes *** algorithm was validated by rediscovering an exact Lennard-Jones potential and a Sutton-Chen embedded-atom method potential from training data generated using these *** using training data generated from density functional theory calculations,we found potential models for elemental copper that are simple,as fast as embedded-atom models,and capable of accurately predicting properties outside of their training *** approach requires relatively small sets of training data,making it possible to generate training data using highly accurate methods at a reasonable computational *** present our approach,the forms of the discovered models,and assessments of their transferability,accuracy and speed.

关键词： symbolic simplicity transfer

EffECT Of GAmmA RAYS IN THE PREPARATION Of POLYmER AND HYDROGEL fROm ACRYLAmIDE mONOmER

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Chinese Journal of Polymer Science 2003年第4期21卷 437-442页

作者： m.m.Alam m.f.mina f.Akhtar NRCD INST AERE GPO Box-3787 Dhaka BangladeshNRCD INST AERE GPO Box-3787 Dhaka BangladeshNRCD INST AERE GPO Box-3787 Dhaka Bangladesh

The formation of polymer and hydrogel from aqueous solutions having 20, 30 and 40% concentrations ofacrylamide monomer by γ-ray irradiation processing in the dose range 0.06-30 kGy using a Co-60 source and theircharacterization have been observed. Polymer conversion and gel fraction are found to depend on radiation doses. Polymerconversion increases with the increase of dose, depending on the solution concentration, where maximum conversion isachieved at 0.18, 0.16 and 0.10 kGy for 20%, 30% and 40% concentrations, respectively. On the other hand, gel fractionincreases with dose from the gel point (0.12 kGy) for all concentrations, where 100% conversion of gel occurs at doses≥5 kGy. Tensile strength, viscosity and molecular weight (m_w) of polymer samples increase with both the dose and theconcentration, showing a high value of m_w up to≈10~8. Swelling of hydrogels under water with respect to time varies due tothe variation of cross-linking density formed in the gels and the maximum swelling mainly occurs within 24 h. A remarkable change of surface morphology reveals characteristic features of monomer, polymer and hydrogel films.

关键词： Polymer Hydrogel γ-Radiation Cross-linking Swelling

SWELLING BEHAVIOR Of ACRYLAmIDE HYDROGEL IN DIffERENT SOLVENTS AND pHs

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Chinese Journal of Polymer Science 2005年第3期23卷 269-274页

作者： m.f.mina m.m.Alam Institute of Nuclear Science and Technology Atomic Energy Research EstablishmentGPO Box-3787Dhaka-1000BangladeshInstitute of Nuclear Science and TechnologyAtomic Energy Research EstablishmentGPO Box-3787Dhaka-1000Bangladesh

Swelling property of acrylamide hydrogels,prepared from aqueous solutions of acrylamide monomer havingconcentrations in the range of 10-60 wt% by ray irradiation method using a Co-60 gamma radiation source at dosesranging 1-30.0 kGy,has been investigated under various swelling *** swelling media were basically solvents(solutions),produced by dissolving methanol,ethanol,glucose,sucrose,sodium chloride and sodium persulfate individuallywith distilled water,and solutions prepared with pHs=3,7 and *** investigation was performed in order to observe theeffect of these solvents and pHs as well as the influence of monomer concentrations,radiation doses and times on swellingbehavior of *** values were found higher for hydrogels prepared with lower monomer concentrations(ca.20 wt%)and radiation doses(ca.5 kGy)and showed a leveling off tendency within 24 *** glucose solvent and the buffersolution of pH=10 revealed significant increase of swelling of hydrogels as compared to other *** areexplained based on crosslinking density in hydrogel,polymer-solvent/polymer-polymer interactions in solutions,permeability of molecules in solutions and ionization capacity of hydrogel in pH.

关键词： Acrylamide Hydrogel Co-60 gamma radiation source Swelling.

Challenges and Requirements for the Application of Industry 4.0:A Special Insight with the Usage of Cyber-Physical System

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Chinese Journal of mechanical Engineering 2017年第5期30卷 1050-1057页

作者： Egon mueller Xiao-Li Chen Ralph Riedel Department of factory Planning and factory management Technische Universitt Chemnitz

Considered as a top priority of industrial devel- opment, Industry 4.0 （or Industrie 4.0 as the German ver- sion） has being highlighted as the pursuit of both academy and practice in companies. In this paper, based on the review of state of art and also the state of practice in dif- ferent countries, shortcomings have been revealed as the lacking of applicable framework for the implementation of Industrie 4.0. Therefore, in order to shed some light on the knowledge of the details, a reference architecture is developed, where four perspectives namely manufacturing process, devices, software and engineering have been highlighted. moreover, with a view on the importance of Cyber-Physical systems, the structure of Cyber-Physical System are established for the in-depth analysis. further cases with the usage of Cyber-Physical System are also arranged, which attempts to provide some implications to match the theoretical findings together with the experience of companies. In general, results of this paper could be useful for the extending on the theoretical understanding of Industrie 4.0. Additionally, applied framework and proto- types based on the usage of Cyber-Physical Systems are also potential to help companies to design the layout of sensor nets, to achieve coordination and controlling of smart machines, to realize synchronous production with systematic structure, and to extend the usage of information and communication technologies to the maintenance scheduling.

关键词： Industrie 4.0 - Internet of Things Cyber-Physical System Smart factory Reference architectureIntelligent sensor nets Robot control Synchronousproduction