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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-merz Jorge Hernández-Campano Sergei A.Kirov Jesús m.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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Synergistic effect of nitrocellulose coating on structural and reactivity stabilization of ammonium nitrate oxidizer

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Defence Technology(防务技术) 2025年第1期43卷 35-43页

作者： Amir Abdelaziz Djalal Trache Ahmed Fouzi Tarchoun Hani Boukeciat Yash Pal Sourbh Thakur Weiqiang Pang Thomas m.Klapötke Energetic materials Laboratory(EmLab) Teaching and Research Unit of Energetic ProcessesEcole Militaire PolytechniqueBP 17 Bordj El-BahriAlgiers 16046Algeria School of Aeronautical Science Hindustan Institute of Technology and ScienceChennai 603103India Department of Organic Chemistry Bioorganic Chemistry and BiotechnologySilesian University of TechnologyB.Krzywoustego 4Gliwice 44–100Poland Xi'an modern Chemistry Research Institute 168 Zhangba Rd.EastXi'an 710065China Energetic materials Research Department of ChemistryLudwig-Maximilian UniversityMunich Butenandtstrasse 5-13(D)Munich D-81377Germany

The present work aims to stabilize the room temperature allotropic transition of ammonium nitrate(AN)particles utilizing a microencapsulation technique,which involves solvent/non-solvent in which nitrocellulose(NC)has been employed as a coating *** SEm micrographs revealed distinct features of both pure AN and NC,contrasting with the irregular granular surface topography of the coated AN particles,demonstrating the adherence of NC on the AN *** analysis via infrared spectroscopy(IR)demonstrated a successful association of AN and NC,with slight shifts observed in IR bands indicating interfacial *** X-ray Diffraction(PXRD)analysis further elucidated the structural changes induced by the coating process,revealing that the NC coating altered the crystallization pattern of its pure *** analysis demonstrates distinct profiles for pure and coated AN,for which the coated sample exhibits a temperature increase and an enthalpy decrease of the room temperature allotropic transition by 6℃,and 36%,***,the presence of NC coating alters the intermolecular forces within the composite system,leading to a reduction in melting enthalpy of coated AN by~39%compared to pure *** thermal decomposition analysis shows a two-step thermolysis process for coated AN,with a significant increase in the released heat by about 78%accompanied by an increase in the activation barrier of NC and AN thermolysis,demonstrating a stabilized reactivity of the AN-NC *** findings highlight the synergistic effect of NC coating on AN particles,which contributed to a structural and reactive stabilization of both AN and NC,proving the potential application of NC-coated AN as a strategically advantageous oxidizer in composite solid propellant formulations.

关键词： Ammonium nitrate Nitrocellulose Stabilization Coating Thermolysis kinetics

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Aerosol jet printing of piezoelectric surface acousticwave thermometer

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microsystems & Nanoengineering 2023年第3期9卷 31-42页

作者： Nicholas mcKibben Blake Ryel Jacob manzi Florent muramutsa Joshua Daw Harish Subbaraman David estrada Zhangxian Deng micron School of materials Science and Engineering Boise State University1910 W University DriveBoiseID 83725USA Department of mechanical and Biomedical Engineering Boise State UniversityBoiseID 83725USA School of Electrical Engineering and Computer Science Oregon State University2500 NW Monroe AvenueCorvallisOR 97331USA Idaho National Laboratory Idaho FallsID 83415USA Center for Advanced Energy Studies Idaho FallsID 83401USA

Surface acoustic wave(SAW)devices are a subclass of micro-electromechanical systems(mEmS)that generate an acoustic emission when electrically *** transducers also work as detectors,converting surface strain into readable electrical *** properties of the generated SAW are material dependent and influenced by external factors like *** monitoring temperature-dependent scattering parameters a SAW device can function as a thermometer to elucidate substrate *** fabrication of SAW sensors requires labor-and cost-intensive subtractive processes that produce large volumes of hazardous *** study utilizes an innovative aerosol jet printer to directly write consistent,high-resolution,silver comb electrodes onto a Y-cut LiNbO3 *** printed,two-port,20 mHz SAW sensor exhibited excellent linearity and repeatability while being verified as a thermometer from 25 to 200℃.Sensitivities of the printed SAW thermometer are−96.9×10^(−6)℃^(−1)and−92.0×10^(-6)℃^(−1) when operating in pulse-echo mode and pulse-receiver mode,*** results highlight a repeatable path to the additive fabrication of compact high-frequency SAW thermometers.

关键词： scattering wave surface

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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Overexpression of an ABA biosynthesis gene using a stress-inducible promoter enhances drought resistance in petunia

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Horticulture Research 2015年第1期2卷 255-263页

作者： Alejandro C estrada-melo Chao ma michael S Reid Cai-Zhong Jiang Department of Plant Sciences University of California DavisDavisCAUSA United States Department of Agriculture Crops Pathology and Genetic Research UnitAgricultural Research ServiceDavisCAUSA

The response of plants to drought stress includes reduced transpiration as stomates close in response to increased abscisic acid(ABA)*** overexpression of 9-cis-epoxycarotenoid dioxygenase(NCED),a key enzyme in ABA biosynthesis,increases drought resistance,but causes negative pleiotropic effects on plant growth and *** overexpressed the tomato NCED(LeNCED1)in petunia plants under the control of a stress-inducible promoter,*** water stress,the transgenic plants had increased transcripts of NCED mRNA,elevated leaf ABA concentrations,increased concentrations of proline,and a significant increase in drought *** transgenic plants also displayed the expected decreases in stomatal conductance,transpiration,and *** 14 days without water,the control plants were dead,but the transgenic plants,though wilted,recovered fully when ***-watered transgenic plants grew like non-transformed control plants and there was no effect of the transgene on seed dormancy.

关键词： inducible pet drought

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Hepatorenal syndrome:Paving a pathway from a fatal condition to an opportunity to preserve kidney function

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World Journal of Nephrology 2025年第1期14卷 13-16页

作者： Fernando m Gonzalez Department of Nephrology Faculty of MedicineUniversidad de ChileSantiago 7500922Chile

In the 19^(th)century,von Frerichs F and Flint A identified a type of acute renal impairment associated with advanced liver disease,characterized by oliguria,absence of proteinuria,and normal renal histology,which was later termed hepatorenal syndrome(HRS).HRS primarily affects cirrhotic patients with ascites and often follows severe infections,digestive hemorrhages,or high-volume ***,HRS involves low glomerular filtration rate,hypotension,renin-angiotensin axis activation,water clearance,hyponatremia,and minimal urinary sodium *** conditions mimic those seen in decreased effective circulatory volume(ECV)scenarios such as septic shock or heart *** represents a specific form of prerenal acute kidney injury(AKI)in patients with baseline renal ischemia,where the kidney attempts to correct decreased ECV by retaining sodium and *** renal vasoconstriction,passive hyperemia from ascites,and acute tubular necrosis(ATN)with specific urinary sediment changes are *** oliguria may transition HRS to ATN,although this shift is less straightforward than in other prerenal AKI ***,liver grafts from HRS patients can recover function more rapidly than those from other ischemic *** studies,such as those by Duailibe et al,using omega-3 fatty acids in cirrhotic rat models,have shown promising results in reducing oxidative stress and improving kidney *** findings suggest potential therapeutic strategies and underscore the need for further research to understand the mechanisms of HRS and explore possible *** research should address the impact of omega-3 on survival and secondary outcomes,as well as consider the balance of therapeutic risks and benefits in severe liver disease.

关键词： Hepatorenal syndrome Acute kidney injury Oliguria Ascites Hibernation Cirrhosis

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Effect of Eugenia winzerlingii Extracts on Bemisia tabaci and Evaluation of Its Nursery Propagation

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Phyton-International Journal of Experimental Botany 2019年第2期88卷 161-170页

作者： A.Cruz-estrada E.Ruiz-Sánchez I.L.medina Baizabal E.Balam-Uc m.Gamboa-Angulo Unidad de Biotecnología Centro de Investigación Científica de YucatánCalle 43 No.130Chuburna de HidalgoMérida CP 97205YucatánMéxico Tecnológico Nacional de méxico.Instituto Tecnológico de Conkal.Avenida Tecnológico s/n C.P.97345.ConkalYucatánMéxico

The development of plant-derived products to control Bemisia tabaci Genn.(Hemiptera:Aleyrodidae)is an urgent need for production of horticultural *** extracts and essential oils of several species of the genus Eugenia(myrtaceae)have shown insecticidal *** southern mexico,leaf extracts from Eugenia winzerlingii showed nematicidal effect but its insecticidal properties have not been ***,the objective of this study was to evaluate the insecticidal effect of aqueous and organic extracts from *** leaves on *** egg,nymph and adult stages,and else to explore its nursery ***,extracts of this species were obtained by maceration with different polarity *** were carried out on Capsicum chinense *** assays showed that aqueous and total crude ethanol(TCE)extracts necrosed the eggs(LC50=0.21%w/v and 4.68 mg/mL,respectively),whereas hexane,ethyl acetate(ETA),residual ethanol and TCE extracts affected the nymphs(LC50=0.25-4.85 mg/mL).In adults,oviposition inhibition by free choice assay indicated that TCE and ETA extracts had major activity(EC50=14.62 and 27.86μg/cm2,respectively).On other hand,the sexual and vegetative propagation of *** showed that this species can be easily cultivated by *** conclusion,extracts of *** leaves are highly effective in controlling *** extract,in particular,was toxic to three stages of *** plant could be a potential alternative to develop a novel botanical insecticide to manage this destructive pest.

关键词： Bemisia tabaci bioassays eugenia winzerlingii oviposition inhibition plant propagation

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China's Free Trade Agreements with ASEAN,Japan and Korea:A Comparative Analysis

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China & World Economy 2012年第4期20卷 108-126页

作者： Gemma estrada Donghyun Park Innwon Park Soonchan Park Economics and Research Department Asian Development Bank(ADB) Economics and Research Department ADB Division of International Studies Korea University Department of Economics and International Trade Kongju National University

The role of China in East Asia ＇s recovery from the recent global finaneial and economic crisis highlights China ＇s position as an engine of growth for this region. From the viewpoint of China, there are many potential gains from entering into free trade agreements （FTAs） with its neighbors, who collectively form a large and fast-growing market. In this paper, we qualitatively and quantitatively assess the four main permutations of China＇s FTAs with East Asian major economies： China-ASEAN, China-Japan, China-Korea and ASEAN＋ 3. We compare the effects of these FTAs on China ＂s output and welfare. Our comparative analysis shows that China will gain from all three bilateral FTAs, while gaining the most from the ASEAN＋ 3. Because forming a region-wide FTA, such as the ASEAN＋ 3, is expected to be gradual and difficult, China shoum continue to engage in bilateral FTAs as a mediumterm and alternative strategy. However, in the long term, China should pursue a regionwide FTA.

关键词： ASEAN China computable general equilibrium model East Asia free trade agreement

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Selectivity in feeding preferences and ranging patterns in spider monkeys Ateles geoffroyi yucatanensis of northeastern Yucatan peninsula, mexico

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Current Zoology 2013年第1期59卷 125-134页

作者： Carmen SCHERBAUm Alejandro estrada Department of Animal Ecology and Tropical Biology Biozentrum University of Wiirzburg Germany Estacion de Biologia Tropical Los Tuxtlas Instituto de Biologfa Universidad Nacional Aut6noma de M6xico Apartado Postal94 San Andres Tuxtla Veracruz M6xico C. P. 95700

The spider monkey, a fruit specialist and important seed dispersal agent in the Neotropics, is an endangered primate due to habitat loss, hunting and the pet trade. Spider monkeys have been the subject of a few studies in Central and South Ame- rica, but little is known about the diet and ranging for this primate in southern mexico. Here we report the results of a six-month long study （October 2010 to march 2011） of the feeding preferences and ranging patterns of the Yucatan spider monkey Ateles geoffroyi yucatanensis living in the ＂Ya＇ax＇che＂ reserve by the Caribbean coast in northeast Yucatan peninsula. Focal animal and scan sampling as well as GPS tracking were used to document spider monkey feeding behavior, location of food trees and ranging in the reserve. The spider monkeys used 36 species of plants （94% trees; n = 432） and six non tree morphospecies as a source of food. Six tree species accounted for 〉~80% of total feeding time and for 74% of all trees used. Fruits accounted for 59% of total feeding time, followed by leaves （35%）, palm piths （5%） and other plant parts （1%）. Total range used by the monkeys was esti- mated at 43% of semievergreen rainforest habitat available （ca 40ha）. Range use was not random with segments showing light, moderate and heavy use; the use of different areas of their range varied monthly and was closely linked to the spatial dispersion of the trees used for food [Current Zoology 59 （1）： 125-134, 2013].

关键词： Primates Frugivory Neotropics Conservation Seed dispersal

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