检索结果-南通市图书馆

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

足球头球与脑白质微结构以及认知异常相关

国际医学放射学杂志 2013年第6期 577-577页

作者： m.L.Lipton N.Kim m.e.zimmerman m.Kim W.F.Stewart C.A.Branch 富彦 Albert einstein College of medicine of Yeshiva University 1300 Morris Park Ave Bronx NY 10461

摘要目的探讨足球头球与外伤性脑损伤亚临床表现之间的关系。材料与方法本研究获得伦理审查委员会批准并符合HIPAA。37名业余足球爱好者[平均年龄30.9岁,其

关键词：头球足球球类运动脑震荡颅脑损伤微结构土壤结构脑白质

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

Biological transformation,kinetics and dose-response assessments of bound musk ketone hemoglobin adducts in rainbow trout as biomarkers of environmental exposure

在线全文

学校读者我要写书评

暂无评论

Journal of environmental Sciences 2008年第7期20卷 878-884页

作者： m A mottaleb J H zimmerman T W moy Department of Chemistry and Biochemistry Baylor UniversityP.O.Box 97348WacoTX 76798USA. U.S.environmental Protection Agency National Exposure Research LaboratoryEnvironmental Sciences Division944 East Harmon AveLas VegasNV 89119USA

Low levels (ng/g) of musk ketone (mK),used as a fragrance additive in the formulation of personal care products,are frequently detected in the water and other ***,aquatic organisms can be continuously exposed to *** this study,kinetics and dose-response assessments of 2-amino-mK (AmK) metabolite,bound to cysteine-hemoglobin (Hb) in rainbow trout,formed by enzymatic nitro-reduction of mK have been *** were exposed to a single exposure of 0.010,0.030,0.10,and 0.30 mg mK/g ***...

关键词： biotransformation kinetics hemoglobin adducts dose-response nitro musks biomarker fish

SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Brain-penetrating neurotrophic factor mimetics: HeR-096 as a disease-modifying therapy for Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Search for microglia-specific peptides:advances in the discovery toolbox

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

mAXImIZING ReSTORATION SUCCeSS WHeN THe GOOD GROUND IS GONe

在线全文

学校读者我要写书评

暂无评论

Journal of Green Building 2017年第3期12卷 115-123页

作者： Alex zimmerman the erosion Control Technology Council

INTRODUCTION“The good ground is gone”often refers to the challenging nature of construction sites these *** on steeper slopes and within tighter boundaries while accelerat-ing construction schedules is adding to the challenge of construction *** the revegetation and restoration is unfortunately not planned or timed for successful long-term vegetation *** soil conditions are frequently overlooked and the timing necessary for seed germination,expression,and establishment are rarely factors in determining the schedule of seeding applications for optimum *** too often less than desired results or failure is the accepted *** will increase the future maintenance costs and encourage the repeated“finger pointing”while seeking to blame one cause or ***,this often-repeated process fails to address the fundamental causes and thereby rarely fixes the problems moving *** an effort to break out of this all too often repeated cycle,let’s break down the principle challenges and explore options for successful restoration of challenging ***,long-term revegetation starts with the *** quality soil that takes years to accumulate naturally,revegetation efforts regularly fail or the outcomes are less than *** construction,mining,and general land disturbing activities the soil will be degraded even while practicing the best topsoil harvesting and stock-piling management *** areas where vegetation is desired are essentially mineral without any organic matter or biological *** available,stockpiled topsoil will also degrade;the environment within the pile will create conditions that microbes,essential for plant health,will be negatively *** longer the stripped soils are stockpiled,the more living organisms are *** and even requirements for limiting the depth of the pile to reduce the loss of ben-eficial microbes is rarely possible given the tight bo

关键词： site restoration revegetation vertical task management stabilization methods soil conditions project scheduling erosion control

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied mathematics and mechanics(english edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.eFTeKHARI Department of mechanical engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

关键词： Galerkin methods