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Creation and research of the SAW transducer with a single-phase grid and a piezoelectric zinc oxide film

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Journal of Advanced Dielectrics 2022年第5期12卷 48-52页

作者： G.Ya.Karapetyan m.e.kutepov e.m.Kaidashev A.L.Nikolaev Laboratory of Nanomaterials Southern Federal University 200/1 Stachki Avenue344090 Rostov-on-DonRussia

A method for obtaining a new type of surface acoustic wave(SAW)transducer operating at double frequency with a single-phase closed-loop lattice and a piezoelectric zinc oxide film is developed and experimentally investigated.A method for calculating such a transducer has been developed,its equivalent circuit has been compiled,taking into account propagation losses,losses in the metal film and the inductance of the connecting *** the frequency is doubled,the SAW attenuation per unit length increases.

关键词： Surface acoustic wave(SAW) interdigital transducer(IDT) zinc oxide(ZnO)film.

Optimizing VO_(2)film properties for use in SAW devices

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Journal of Advanced Dielectrics 2021年第5期11卷 44-47页

作者： m.e.kutepov G.Ya.Karapetyan I.V.Lisnevskaya K.G.Abdulvakhidov A.A.Kozmin e.m.Kaidashev Laboratory of Nanomaterials Southern Federal University Stachki200/1344090 Rostov-on-DonRussia Department of Chemistry Southern Federal University Zorge7344090Rostov-on-DonRussia Smart materials Research Institute Southern Federal University Sladkova178/24344090Rostov-on-DonRussia

The aim of this study is to optimize the conditions for producing thin VO_(2)films for their use in SAW *** used the pulsed laser deposition(PLD)method to produce VO_(2)*** used a metallic vanadium *** dependence of the oxygen pressure during PLD on the resistive metal-insulator transition(mIT)on substrates of c-sapphire and LiNbO_(3)YX/128°was *** resulting films had sharp metal-insulator temperature transitions on c-Al_(2)O_(3).The most high-quality films showed resistance change by four orders of *** the lower point of the hysteresis,the resistance of these samples was in the range of 50-100Ω.The synthesized VO_(2)films had a sharp temperature transition and a relatively small width of thermal *** SAW damping during its passage through a VO_(2)/ZnO/LiNbO_(3)YX/128°film at the metal-insulator phase transition temperature was *** SAW decreases with increasing temperature from 52 dB/cm to 0 dB/cm.

关键词： Surface acoustic wave VO_(2)film laser pulsed deposition parameter S21 metal-insulator transition

embedding epitaxial VO_(2)film with quality metal-insulator transition to SAW devices

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Journal of Advanced Dielectrics 2022年第5期12卷 53-59页

作者： m.e.kutepov §,G.Ya.Karapetyan T.A.minasyan V.e.Kaydashev I.V.Lisnevskaya K.G.Abdulvakhidov A.A.Kozmin e.m.Kaidashev Laboratory of Nanomaterials Southern Federal University200/1 Stachki Ave.344090 Rostov-on-DonRussia Department of Chemistry Southern Federal University7 Zorge St.344090 Rostov-on-DonRussia Smart materials Research Institute Southern Federal University178/24 Sladkova St.344090 Rostov-on-DonRussia

epitaxial VO_(2)films grown by pulsed laser deposition(PLD)method with superior phase transition related switching characteristics are successfully embedded to SAW devices using concept of the“impedance loaded SAW sensor”.A resistance of VO2 sensor abruptly drops from 0.7 mΩto 90Ωwhen it is heated above~65℃and shows a narrow hysteresis loops when *** designs of SAW devices are examined in which RF signal is reflected back from interdigital transducer(IDT)or a surface acoustic waves(SAW)is transferred through a coupler and the RF response is altered 2 and 3 times correspondingly upon the phase transition in *** the proposed devices with external load,a SAW does not propagate via VO2 film and therefore is not attenuated which is beneficiary for wireless ***,a SAW phase shift as great as 50°is induced to the SAW transferred through the coupler due to the phase transition in *** proposed approach may boost the development of remotely controlled autonomous sensors,including those based on VO2 metamaterials and hybrid plasmonic structures for near IR/middle IR and sub-THz/THz applications.

关键词： Surface acoustic wave SAW pulsed laser deposition PLD VO_(2) epitaxial film.

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Brain-penetrating neurotrophic factor mimetics: HeR-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

SBL-JP-0004: A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology research 2025年第1期33卷 235-243页

作者： Hassan m Otifi Department of Pathology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Background:Gastric cancer (GC) remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, making them attractive targets for therapeutic interventions.methods:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and SNU-5 GC cells were used for evaluation.Results:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases, as evidenced by molecular docking scores and molecular dynamics simulations. Binding interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target proteins. SBL-JP-0004 displayed an half-maximal inhibitory concentration (IC) value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD enzymes. SBL-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells, with half-maximal growth inhibitory concentration (GI) values of 250.8 and 516.3 nm, respectively. A significant elevation in the early phase apoptosis (28.53% in KATOIII cells and 26.85% in SNU-5 cells) and late phase apoptosis (17.37% in KATOIII cells and 10.05% in SNU-5 cells) were observed with SBL-JP-0004 treatment compared to 2.1% and 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Dual inhibition Gastric cancer (GC) JAK2 molecular docking molecular dynamics simulation PI3KCD SBL-JP-0004

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(english edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.eFTeKHARI Department of mechanical engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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