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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel e.Ocasio Rivera dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge d.miranda department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain eAAT-1/GLAST eAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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TRANSSCLeRAL dIOde LASeR CONTACT CYCLOPHOTOCOAGULATION IN THe TReATmeNT OF HIGH RISK

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国际眼科杂志 2003年第1期3卷 122-123页

作者： Berumen-Alatorre m.e.gilbert-luc.d. N.d.C.Ruiz-Quintero F.Berumen-Ala-torre Berumen Clinic Sanatorio Oftalmologico Merida (SOM) and Asociacion Para Evitar La Ceguera En Mexico MexicoBerumen Clinic Sanatorio Oftalmologico Merida (SOM) and Asociacion Para Evitar La Ceguera En Mexico MexicoBerumen Clinic Sanatorio Oftalmologico Merida (SOM) and Asociacion Para Evitar La Ceguera En Mexico MexicoBerumen Clinic Sanatorio Oftalmologico Merida (SOM) and Asociacion Para Evitar La Ceguera En Mexico Mexico

Purpose: To evaluate the clinical outcome of transscleral cy-clophotocoagulation (TSCPC) with diode laser in high risk glaucomas as a primary treatment methods: A prospectively study was done of 15 patients (17 eyes) with different glaucomas. Average age 55years. Follow-up ranged from 6 to 36 months. most of the patients had neovascular glaucoma (13eyes), chronic

关键词：高风险青光眼经巩膜睫状体光凝固激光疗法二极管激光器治疗

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The 3d Inverse Problem of the Wave equation for a General multi-connected Vibrating membrane with a Finite Number of Piecewise Smooth Boundary Conditions

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Acta mathematica Sinica,english Series 2005年第4期21卷 733-752页

作者： e.m.e.ZAYed mathematics department Faculty of ScienceZagazig UniversityZagazig.Egypt

The trace of the wave kernel μ（t） =∑ω=1^∞ exp（-iteω^1/2）, where {eω}ω^∞=1 are the eigenvalues of the negative Laplacian -△↓2 = -∑k^3=1 （δ/δxk）^2 in the （x^1, x^2, x^3）-space, is studied for a variety of bounded domains, where -∞ 〈 t 〈 ∞ and i= √-1. The dependence of μ （t） on the connectivity of bounded domains and the dirichlet, Neumann and Robin boundary conditions are analyzed. Particular attention is given for a multi-connected vibrating membrane Ω in Ra surrounded by simply connected bounded domains Ω j with smooth bounding surfaces S j （j = 1,……, n）, where a finite number of piecewise smooth dirichlet, Neumann and Robin boundary conditions on the piecewise smooth components Si^＊（i = 1 ＋ kj-1,……, kj） of the bounding surfaces S j are considered, such that S j = Ui-1＋kj-1^kj Si^＊, where k0=0. The basic problem is to extract information on the geometry Ω by using the wave equation approach from a complete knowledge of its eigenvalues. Some geometrical quantities of Ω （e.g. the volume, the surface area, the mean curvuture and the Gaussian curvature） are determined from the asymptotic expansion ofexpansion of μ（t） for small │t│.

关键词： Inverse problem Wave kernal eigenvalues Greens function multi-connected vibrating membrane Negative Laplacian Heat kernel

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Influence of the Choice of NN Potential model on γd→τ~0d Observables near η-Threshold

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Chinese Physics Letters 2016年第4期33卷 14-18页

作者： e.m.darwish Physics department Faculty of ScienceTaibah University Physics department Faculty of ScienceSohag University

Influence of the choice of the NN potential model governing the deuteron wave function on the observables for coherent π0-photoproduction on the deuteron near η-threshom is investigated by using a three-body model for the intermediate ηN N system with separable two-body interactions. Results for unpolarized differential cross section and polarization observables are predicted. It is revealed that the choice of the NN potential model has a visible effect on the differential cross section and most of the polarization observables, especially in the photon energy range of 600-800 meV and extreme backward pion angles. We find that the deviation among results obtained by using different deuteron wave functions is quite large. The use of the Cd-Bonn NN potential for deuteron wave function doubles the differential cross section in this kinematic region. Compared with the experimental data from CLAS collaboration for differential cross section, sizeable discrepancies are found.

关键词： of in Observables near Threshold NN that for on CLAS

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Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

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Community knowledge,attitudes and practices related to schistosomiasis and associated healthcare-seeking behaviours in northern Côte d’Ivoire and southern mauritania

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Infectious diseases of Poverty 2018年第1期7卷 691-703页

作者： Amoin Jeanne d’Arc Koffi mohamed doumbia gilbert Fokou moussa Keita Brama Kone N’doumy Noel Abe department of Research and development Centre Suisse de Recherches Scientifiques en Cote d’IvoireAbidjanCote d’Ivoire environment and Communication Training Unit University Alassane OuattaraBouakeCote d’Ivoire ethno-Sociology Institute University Felix Houphouet-BoignyAbidjanCote d’Ivoire Faculty of Letters and Social Sciences University of NouakchottNouakchottMauritania University Peleforo-Gbon-Coulibaly KorhogoCote d’Ivoire

Background:Among parasitic infections,schistosomiasis ranks second after malaria in terms of worldwide *** efforts to contain transmission,more than 230 million people are infected,of which 85%live in Sub-Saharan *** the epidemiologic characteristics of schistosomiasis have been extensively studied across endemic settings,social factors have been paid less *** current study assesses community knowledge of schistosomiasis causes,transmission,signs,symptoms and prevention,as well as healthcare-seeking behaviours in two West African settings,with the aim of strengthening schistosomiasis control ***:From August 2014 to June 2015,we conducted two cross-sectional surveys in Korhogo,Cote d’Ivoire and Kaedi,*** applied a questionnaire to collect quantitative data at the household level in Korhogo(n=1456)and Kaedi(n=1453).Focus group discussions(Korhogo:n=32,Kaedi:n=32)and participatory photography(photovoice)(Korhogo:n=16,Kaedi:n=16)were conducted within the communities to gather qualitative *** addition,semi-structured interviews were used to discuss with key informants from control programmes,nongovernmental organizations and health districts(Korhogo:n=8,Kaedi:n=7).Results:The study demonstrated that schistosomiasis is not well known by the communities;64.1%claimed to know the causes of the disease,but the reality is *** knowledge is more from cultural than biomedical *** was observed that social construction of the disease is different from the biomedical *** Korhogo,schistosomiasis was often associated with several other diseases,notably stomach ulcer and *** populations believe that schistosomiasis is caused by exposure to goat or dog urine in the *** Kaedi,schistosomiasis is considered as a disease transmitted by environmenal elements such as sunshine and dirty *** both settings,the care-seeking pathways were found to be strongly influenced by local c

关键词： Community knowledge Healthcare-seeking behaviour Schistosomiasis Korhogo Kaedi Côte d’Ivoire mauritania

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ASYmPTOTIC LImITS ANd STABILIZATION FOR THe 1d NONLINeAR mINdLIN-TImOSHeNKO SYSTem

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Journal of Systems Science & Complexity 2010年第3期23卷 414-430页

作者： F.d.ARARUNA P.BRAZ e SILVA e.ZUAZUA departamento de matemática Universidade Federal da Paraíba departamento Ikerbasque Research Professor Basque Center for Applied Mathematics(BCAM)

This paper shows how the so called von Karman model can be obtained as a singular limit of a modified mindlin-Timoshenko system when the modulus of elasticity in shear κ tends to infinity, provided a regularizing term through a fourth order dispersive operator is added. Introducing damping mechanisms, the authors also show that the energy of solutions for this modified mindlin-Timoshenko system decays exponentially, uniformly with respect to the parameter k. As κ→∞, the authors obtain the damped von Karman model with associated energy exponentially decaying to zero as well.

关键词： mindlin-Timoshenko system singular limit uniform stabilization vibrating beams von Karman system.

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBimed-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

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Preliminary performance analysis and optimization based on 1d neutronics model for Indian demO HCCB blanket

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Plasma Science and Technology 2020年第8期22卷 184-191页

作者： d AGGARWAL C dANANI m Z YOUSSeF Institute for Plasma Research GandhinagarGujarat 382428India Homi Bhabha National Institute(HBNI) AnushaktinagarMumbai 400094India University of California-Los Angeles Los AngelesCA 90095United States of America

India,under its breeding blanket R&d program for demO,is focusing on the development of two tritium breeding blanket concepts;namely the lead-lithium-cooled ceramic breeder and the helium-cooled ceramic breeder(HCCB).The study presented in this paper focuses on the neutronic design analysis and optimization from the tritium breeding perspective of the HCCB *** Indian concept has an edge-on configuration and is one of the variants of the helium-cooled solid breeder blanket concepts proposed by several partner countries in *** Indian HCCB blanket having lithium titanate(Li2TiO3)as the tritium breeder and beryllium(Be)as the neutron multiplier with reduced-activation ferritic/martensitic steel structure aims at utilizing the low-energy neutrons at the rear part of the *** aim of the optimization study is to minimize the radial blanket thickness while ensuring tritium self-sufficiency and provide data for further neutronic design and thermal-hydraulic layout of the HCCB *** is found that inboard and outboard blanket thicknesses of 40 cm and 60 cm,respectively,can give a tritium breeding ratio(TBR)>1.3,with 60%6Li enrichment,which is assumed to be sufficient to cover potential tritium losses and associated *** results also demonstrated that the Be packing fraction(PF)has a more profound impact on the TBR as compared to 6Li enrichment and the PF of Li2TiO3.

关键词： demO helium-cooled ceramic breeder blanket neutronic optimization study tritium breeding ratio

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