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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Sam.e. e.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain eAAT-1/GLAST eAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa m.G.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a mem.e. of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

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日本市场何以成为封闭型一项补充研究

世界经济与政治论坛 1990年第5期 8-13页

作者： m.e.克莱宁花俊

近年来,美日之间的贸易摩擦愈演愈烈,部分原因是两国之间贸易的不平衡。虽然近来日本在进口方面取得了较大的突破,但是这种摩擦并没有因此而减弱。因为日本进口的增长大都集中在亚洲的劳动密集型产品而不是诸如复杂的机械之类的产品,在... 详细信息

近年来,美日之间的贸易摩擦愈演愈烈,部分原因是两国之间贸易的不平衡。虽然近来日本在进口方面取得了较大的突破,但是这种摩擦并没有因此而减弱。因为日本进口的增长大都集中在亚洲的劳动密集型产品而不是诸如复杂的机械之类的产品,在这些产品的进口上,美国和日本是直接的竟争对手。

关键词：国际竞争性招标竟争对手劳动密集型产品不平衡澳大利亚人非关税壁垒资本设备购买行为工程项目投标公共建设

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摇滚乐:天才和崇拜者

世界社会科学 1990年第5期 44-45页

作者： m.e.伊利 ,立早

当代摇滚乐是一个非常复杂和矛盾的现象。在摇滚乐中流派和风格众多,乐手们的社会态度和创作或商业性任务亦各不相同。为了对我国40多支摇滚乐队做出评价,我们于1988年5—6月分别向17位专家进行了问卷调查,他们中有记者、科研人员、社... 详细信息

当代摇滚乐是一个非常复杂和矛盾的现象。在摇滚乐中流派和风格众多,乐手们的社会态度和创作或商业性任务亦各不相同。为了对我国40多支摇滚乐队做出评价,我们于1988年5—6月分别向17位专家进行了问卷调查,他们中有记者、科研人员、社会学家、音乐家、音乐厅演出部主任、电视台的青年编辑、六城市(莫斯科、列宁格勒、彼尔姆、古比雪夫、塔林、第聂伯彼得罗夫斯克)摇滚乐俱乐部的代表。这些专家大部分是参加列宁格勒第六次摇滚乐汇演评判委员会的成员。由于专家们的评分幅度相差甚远(7—17分),我们还参照了列宁格勒音乐学院1987年在通俗音乐演唱会上所做

关键词：摇滚乐队专家莫斯科乐队编制俄罗斯古代经典音乐音乐作品古典音乐列宁格勒

用水貂阿留申病毒单克隆抗体对该病毒蛋白抗原性的分析

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病毒学报 1993年第3期9卷 236-240页

作者：吴威聂金珍 Bloom m.e. 中国农业科学院特产研究所吉林市132109 美国NIH落基山研究室

制备的5株抗阿留申病毒(Aleutian disease virus,ADV)G株单克隆抗体(Y9、Y19、Y13、Y21和B4),都具有中和能力,都能和经乙醚处理的ADV-G发生中和反应。通过Y9与ADV-G7个基因克隆表达的抗原反应,确定了一个中和抗原决定簇编码核酸位于2750... 详细信息

制备的5株抗阿留申病毒(Aleutian disease virus,ADV)G株单克隆抗体(Y9、Y19、Y13、Y21和B4),都具有中和能力,都能和经乙醚处理的ADV-G发生中和反应。通过Y9与ADV-G7个基因克隆表达的抗原反应,确定了一个中和抗原决定簇编码核酸位于2750-3439碱基之间,并确定对流免疫电泳(CIeP)抗原结合蛋白位点在32k和25k蛋白上。以上工作为制备亚单位疫苗提供了理论基础。

关键词：水貂阿留申病毒单克隆抗体蛋白

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钢结构脆性破坏的防止

Predatory pollinator deception： Does the orchid mantis resemble a model species？

1966年

作者：（美）m.e.香克凌川译

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Current Zoology 2014年第1期60卷 90-103页

作者： J.C. O'HANLON G. I. HOLWeLL m.e. HeRBeRSTeIN Department of Biological Sciences Macquarie University North Ryde 2109 Australia School of Biological Sciences University of Auckland Auckland 1142 New Zealand

Cases of im.e.fect or non-model mimicry are common in plants and animals and challenge intuitive assumptions about the nature of directional selection on mimics. many non-rewarding flower species do not mimic a particular species, but at- tract pollinators through ＇generalised food deception＇. Some predatory animals also attract pollinators by resembling flowers, perhaps the most well known, yet least well understood, is the orchid mantis Hymenopus coronatus. This praying mantis has been hypothesised to mimic a flower corolla and we have previously shown that it attracts and captures pollinating insects as prey. Predatory pollinator deception is relatively unstudied and whether this occurs through model mimicry or generalised food decep- tion in the orchid mantis is unknown. To test whether the orchid mantis mimics a specific model flower species we investigated similarities between its morphology and that of flowers in its natural habitat in peninsular malaysia. Geometric morphometrics were used to compare the shape of mantis femoral lobes to flower petals. Physiological vision models were used to compare the colour of mantises and flowers from the perspective of bees, flies and birds. We did not find strong evidence for a specific model flower species for the orchid mantis. The mantis＇ colour and shape varied within the range of that exhibited by many flower pet- als rather than resembling one type in particular. We suggest that the orchid mantis resembles an average, or generalised flower-like stimulus. Thus predatory pollinator deception in the orchid mantis is likely to function as a form of generalised food deception, as opposed to model mimicry .

关键词： mimicry Orchid mantis Hymenopus coronatus Generalised food deception Aggressive mimicry

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角动量理论第1版

environmental chemical study on the marsh of Fatimid cemetery at Aswan City, egypt

1963年

作者： m.e.洛斯（m.e.Rose）万乙译

角动量理论

ISBN: (纸本)3119·18

角动量理论

关键词：角动量学科:理论角动量定律

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Journal of environmental Sciences 2002年第4期14卷 464-473页

作者： m.e.Soltan Chemistry Department Faculty of Science

environmental chemical study were carried out on the Fatimid cemetery marsh at Aswan City(24°1'N and 32°9'e), egypt. marsh contents(warter, soil, sediment, metal and nonmetal bearing salts, and emergent weed) were analysed to known the source of marsh water, speciation of the different elements between the marsh contents, and the toleration of emergent weed (Phargmites australies) for different metals and their bioaccumulation coefficients. Thus, metals(Ca, mg, Na, K, Ni, Fe, mn, Cu, Zn, Cd and Pb) and nonmetals(CO 2- 3, HCO - 3, Cl -, SO 2- 4, PO 3- 4, NO - 3, SiO 2, organic matter and pH value) were determined in the samples. According to the chemical analysis, and applying the base exchange equation(water type) and calculate the hydrochemical parameters for marsh water samples, we can indicate that the marsh water is ground water with Na SO 4 type and deep meteoric genesis. Topsoil of marsh dry land characterized by CaCl as dominant salt,while NaCl is a dominant salt in subsoil. The elevated pH values of marsh contents minimized the metal solubilities in different samples. Phragmites australies showed a strong ability to accumulate mn and Fe in the aerial part in opposite to Co, Ni and Cd.

关键词： marsh water soil sediment emergent weed egypt