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数字化乳腺体层融合引导的真空辅助活检:初步经验及与俯卧位立体定向真空辅助活检对比

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国际医学放射学杂志 2015年第3期 266-266页

作者： S.Schrading m.distelmaier T.Dirrichs S.Detering L.Brolund K.Strobel 施益洁 Department of Diagnostic and Interventional Radiology University of Aachen RWTHPauwelsstr 30 52074 Aachen Germany

目的对全视野数字化乳腺摄影筛查发现的靶病灶行数字化乳腺体层融合(DBT)引导下的真空辅助活检(VAB)取样,并与俯卧位立体定向(PS)VAB的临床应用进行

关键词：真空辅助活检乳腺乳房靶病灶俯卧位立体定向体层

细胞毒性皮肤归巢CD8^+淋巴细胞在皮肤细胞毒性T细胞淋巴瘤和苔藓样糠疹中的作用

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 9-10页

作者： Wenzel J. Gü tgemann I. distelmaier m. 刘芯 Dr. Department of Dermatology University of Bonn Sigmund- Freud- Strasse 2553105 BonnGermany

Background: Pityriasis lichenoides (PL) is a rare cutaneous lymphoproliferative disorder of unknown origin. malignant transitions of PL have been described, but are very rare. We recently observed the fatal course of a 26- year- old patient who presented with a clinical picture resembling PL but had cytotoxic CD8+ T- cell lymphoma of the skin (CxCTL). This case prompted us to reinvestigate the role of cytotoxic T lymphocytes in PL and its relationship to antiviral immunity. methods: Skin biopsy specimens of 11 patients with PL and two biopsy specimens of CxCTL were included. In all, 5 biopsy specimens taken from healthy skin and 5 samples of varicella- zoster virus (VZV) skin lesions were analyzed for control purposes. The inflammatory infiltrate was characterized by immunohistochemistry using monoclonal antibodies against CD3, CD4, CD8, CD20, cutaneous lymphocyte- associated antigen (CLA), CCR4, CXCR3, GranzymeB, Tia- 1, andmxA. Flowcytometry was used to analyze the expression of chemokine receptors on peripheral blood mononuclear cells in CxCTL. Results: The CxCTL skin lesions were dominated by a dense infiltration of CD8+ cytotoxic lymphocytes with a skin- homing CLA+ CCR4+ phenotype. PL and VZV skin lesions were also characterized by a predominantly CD8+ T cellular infiltrate with strong expression of the cytotoxic molecules Granzyme B and Tia- 1 and the skin- homing molecules CLA and CCR4. Coexpression analyses confirmed that skin CLA+ CD8 + cytotoxic T cells are present in CxCTL, VZV, and PL skin lesions. Strong lesional production of the antiviral protein mxA, which is specifically induced by type I interferons, could be found in all investigated disorders. The study was based on histologic, immunohistologic, and flow cytometric analyses in a limited number of patients, because of the rareness of the investigated diseases. Conclusion: Our results revealed a striking similarity between the immunohistologic picture of malignant CxCTL, benign PL, and VZV skin le

关键词： T细胞淋巴瘤细胞毒性 CD8 糠疹苔藓样归巢粒酶抗病毒免疫组织学特征活检标本

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The antioxidant Trolox restores mitochondrial membrane potential and Ca2+-stimulated ATP production in human complex Ⅰ deficiency

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世界最新医学信息文摘 2017年第30期 281-281页

作者： Felix distelmaier Henk-Jan Visch Jan A.m.Smeitink Ertan mayatepek Werner J.H.Koopman Peter H.G.m.Willems

malfunction of mitochondrial complex I caused by nuclear gene mutations causes early-onset neurodegenerative *** work using cultured fibroblasts of complex-I-deficient patients revealed elevated levels of reactive oxygen species（ROS） and reductions in both total Ca2+content of the endoplasmic reticulum(ERCa) and bradykinin（Bk）-induced increases in cytosolic and mitochondrial free Ca2+([Ca2+]C;[Ca2+]m) and ATP（[ATP]C;[ATP]m） ***,we determined the mitochondrial membrane potential（Aw） in patient skin fibroblasts and show significant correlations with cellular ROS levels and ERCa,i.e.,the less negative Aw,the higher these levels and the lower *** with 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid（Trolox） normalized △Ψ and Bk-induced increases in[Ca2+]mand[ATP]*** effects were accompanied by an increase in ERCaand Bkinduced increase in[Ca2+]***,these results provide evidence for an integral role of increased ROS levels in complex I deficiency and point to the potential therapeutic value of antioxidant treatment.

关键词： Reactive oxygen species Oxidative stress mitochondrial membrane potential Endoplasmic reticulum Ca2+ content mitochondrial disease Antioxidant Human skin fibroblasts

The antioxidant Trolox restores mitochondrial membrane potential and Ca2+-stimulated ATP production in human complex I deficiency

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世界最新医学信息文摘 2016年第11期 8-8页

作者： Felix distelmaier Henk-Jan Visch Jan A.m.Smeitink Ertan mayatepek Werner J.H.Koopman Peter H.G.m.Willems

malfunction of mitochondrial complex I caused by nuclear gene mutations causes early-onset neurodegenerative diseases. Previous work using cultured fibroblasts of complex-I-deficient patients revealed elevated levels of reactive oxygen species（ros） and reductions in both total Ca2+content of the endoplasmic reticulum(ERCa) and bradykinin（Bk）-induced increases in cytosolic and mitochondrial free Ca2+([Ca2+]c; [Ca2+]m) and ATP（[ATP]C; [ATP]m） concentration. Here, we determined the mitochondrial membrane potential（Δψ） in patient skin fibroblasts and show significant correlations with cellular ros levels and ERCa, i.e., the less negative Δψ, the higher these levels and the lower ERCa. Treatment with 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid（Trolox） normalized Δψ and Bk-induced increases in [Ca2+]mand [ATP]m. these effects were accompanied by an increase in ERCaand Bkinduced increase in [Ca2+]c. together, these results provide evidence for an integral role of increased ROS levels in complex I deficiency and point to the potential therapeutic value of antioxidant treatment.

关键词： Reactive oxygen species Oxidative stress mitochondrial membrane potential Endoplasmic reticulum Ca2+ content mitochondrial disease Antioxidant Human skin fibroblasts