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国际医学放射学杂志 2024年第3期 372-372页

作者： m.Nachit m.dioguardi burgio A.Abyzov P.Garteiser V.Paradis V.Vilgrain 余翔玲

摘要目的评估非酒精性脂肪肝（NAFLD）病人骨骼肌脂肪浸润（肌肉脂肪变性）与肝细胞肝癌（HCC）之间的关系。方法纳入72例经组织学证实的NAFLD病人并进行横断面

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modelling the interaction of the Astro Bio Cube Sat with the Van Allen's Belt radiative field using monte Carlo transport codes

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Radiation Detection Technology and methods 2022年第2期6卷 262-279页

作者： N.burgio L.Cretara m.Corcione m.Frullini L.lannascoli A.Nascetti A.Santagata G.Palmerini A.Quintino J.R.Brucato A.meneghin D.Paglialunga ENEA FSN-FISS-RNRC.R.CasacciaRomeItaly DIAEE Sapienza UniversitàDi RomaVia Eudossiana 1800184 RomeItaly School of Aerospace Engineering Sapienza University of RomeVia Salaria 85100138 RomeItaly INAF-Astrophysical Observatory of Arcetri L.go E.Fermi 550125 FlorenceItaly

Purpose The AstroBio Cube Satellite(ABCS)will deploy within the inner Van Allen belt on the Vega C maiden Flight launch opportunity of the European Space *** this altitude,ABCS will experience radiation doses orders of magnitude greater than in low earth orbit,where CubeSats usually *** paper aims to estimate the irradiation effect on the ABCS payload in the orbital condition,their possible mitigation designing shielding solutions and performs a preliminary representativity simulation study on the ABCS irradiation with fission neutron at the TAPIRO(TAratura Pila Rapida Potenza 0)nuclear research reactor facility at *** We quantify the contributions of geomagnetically trapped particles(electron and proton),Galactic Cosmic Rays(GCR ions),Solar energetic particle within the ABCS orbit using the ESA's SPace ENVironment information ***(Fluktuierende Kaskade-Fluctuating Cascade)code models the ABCS interaction with the orbital *** We found a shielding solution of the weight of 300 g constituted by subsequent layers of tungsten,resins,and aluminium that decreases on average the 20%overall dose rate relative to the shielding offered by the only satellite's ***,simulations of neutron irradiation of the whole ABCS structure within the TAPIRO's thermal column cavity show that a relatively short irradiation time is requested to reach the same level of 1 meV neutron Silicon equivalent damage of the orbital *** The finding deserves the planning of a future experimental approach to confirm the TAPIRO's performance and establish an irradiation protocol for testing aerospatial electronic components.

关键词： Galactic cosmic rays and solar energetic particles Spacecraft shielding Dosimetry monte Carlo methods mCNP and FLUKA

Three-dimensional imaging reconstruction of the kidney’s anatomy for a tailored minimally invasive partial nephrectomy:A pilot study

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Asian Journal of Urology 2022年第3期9卷 263-271页

作者： Daniele Amparore Angela Pecoraro Federico Piramide Paolo Verri Enrico Checcucci Sabrina De Cillis Alberto Piana mariano burgio michele Di Dio matteo manfredi Cristian Fiori Francesco Porpiglia Department of Urology San Luigi Gonzaga HospitalUniversity of TurinOrbassanoTurinItaly European Association of Urology(EAU)Young Academic Urologists(YAU)Renal Cancer Working Group ArnhemNetherlands European Association of Urology(EAU)Young Academic Urologists(YAU)Uro-technology and Some Working Group ArnhemNetherlands Division of Urology Department of SurgerySS Annunziata HospitalCosenzaItaly

Objective:The aim of the study was to evaluate three-dimensional virtual models(3DVms)usefulness in the intraoperative assistance of minimally-invasive partial nephrectomy in highly complex renal ***:At our institution cT1-2N0m0 all renal masses with Preoperative Aspects and Dimensions Used for an Anatomical classification score≥10 treated with minimally-invasive partial nephrectomy were considered for the present *** inclusion a baseline contrast-enhanced computed tomography in order to obtain 3DVms,the baseline and postoperative serum creatinine as well as estimated glomerular filtration rate values were *** patients,in which 3DVms were used to assist the surgeon in the planning and intraoperative guidance,were then compared with a control group of patients who underwent minimally-invasive partial nephrectomy with the same renal function assessments,but without *** logistic regression models were used to predict the margin,ischemia,and complication score ***:Overall,79 patients met the inclusion criteria and were compared with 143 complex renal masses without 3DVm *** 3DVm group showed better postoperative outcomes in terms of baseline-weighted differential estimated glomerular filtration rate(-17.7%vs.-22.2%,p=0.03),postoperative complications(16.5%vs.23.1%,p=0.03),and major complications(Clavien Dindo>III,2.5%vs.5.6%,p=0.03).At multivariable logistic regression 3DVm assistance independently predicted higher rates of successful partial nephrectomy(odds ratio:1.42,p=0.03).Conclusion:3DVms represent a useful tool to plan a tailored surgical approach in case of surgically complex *** can be used in different ways,matching the surgeon's needs from the planning phase to the demolitive and reconstructive phase,leading towards maximum safety and efficacy outcomes.

关键词： Three-dimensional Kidney cancer Renal cell carcinoma Robotic Laparoscopic Nephron-sparing surgery Complex renal mass

Hyperon-hyperon interaction in relativistic mean field model

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Chinese Physics B 2007年第7期16卷 1934-1940页

作者：李昂左维米爱军 burgio G Institute of modern Physics Chinese Academy of Sciences Lanzhou 730000 China School of Physical Science and Technology Lanzhou University Lanzhou 730000 China INFN Sezione di Catania Via Santa Sofia 64 1-95123 Catania Italy 060853

By using the new experimental data of AA potential, this paper has performed a full calculation for strange hadronic matter with different strangeness contents as well as its consequences on the global properties of neutron star matter in relativistic mean field model. It finds that the new weak hyperon-hyperon interaction makes the equations of state much stiffer than the result of the previous strong hyperon hyperon interaction, and even stiffer than the result without consideration of hyperon-hyperon interaction. This new hyperon-hyperon interaction results in a maximum mass of 1.75m⊙ （where m⊙ stands for the mass of the Sun）, about 0.2-0.5m⊙ larger than the previous prediction with the presence of hyperons. After examining carefully the onset densities of kaon condensation it finds that this new weak version of hyperon-hyperon interaction favours the occurrence of kaons in comparison with the strong one.

关键词： hyperon-hyperon interaction equations of state neutron star kaon condensation

Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease

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Journal of Geriatric Cardiology 2016年第8期13卷 701-711页

作者： Giovanni Corsetti Evasio Pasini Tiziano m Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S dioguardi Department of Clinical & Experimental Sciences Division of Human Anatomy & Physiopathology University of Brescia Brescia Italy 'S.maugeri Foundation ' IRCCS Cardiology Division Medical Centre of Lumezzane Brescia Italy Zena and michael A Wiener Cardiovascular Institute Mount Sinai Medical Center New York USA Center for Heart and Vessel Preclinical Studies St. John Hospital & Medical Center Wayne State University School of Medicine Detroit USA VA Ann Arbor Health Care System University of Michigan Ann Arbor USA Department of Cardiovascular Surgery 'San Rocco' Hospital Ome Brescia Italy Department of Biotechnological and Applied Clinical Sciences University of L 'Aquila L 'Aquila Italy Division of Sport-Internal medicine Department of Clinical & Experimental Sciences University of Brescia Brescia Italy Department of Clinical Sciences and Community Health University of Milan Milan Italy

BackgroundKlotho 蛋白质(α； - 并且 β；) 是基于膜的传播调整细胞新陈代谢的蛋白质，以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险，建议 ... 详细信息

BackgroundKlotho 蛋白质(α； - 并且 β；) 是基于膜的传播调整细胞新陈代谢的蛋白质，以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险，建议 Klotho 有在心血管的疾病的一个保护的角色。然而，尽管到目前为止它在各种各样的机关被识别了，它是未知的是否，并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF ， FGF 和另外的 *** 与心血管的疾病和 10 匹配年龄的控制使遭到，估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视，我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示，并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示，氧化应力，发炎并且 *** ，有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示，但是 FGF 的更高的表情。而且，更高心血管的风险与增加的表示被联系氧化并且网状的应力，发炎和 *** 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示， Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的，当压力相关的分子的表示显著地被增加时。

关键词：动脉粥样硬化患者疾病 Cardiomyocytes 心血管的风险人的心 Klotho

magnetic resonance imaging of the cirrhotic liver in the eraof gadoxetic acid

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World Journal of Gastroenterology 2016年第1期22卷 103-111页

作者： Francesco Agnello marco dioguardi burgio Dario Picone Federica Vernuccio Giuseppe Cabibbo Lydia Giannitrapani Adele Taibbi Antonino Agrusa Tommaso Vincenzo Bartolotta massimo Galia Roberto Lagalla massimo midiri Giuseppe Brancatelli Section of Radiological Sciences DIBIMEDUniversity of Palermo90127 PalermoItaly Section of Gastroenterology DIBIMISUniversity of Palermo90127 PalermoItaly Section of Internal medicine DIBIMISUniversity of Palermo90127 PalermoItaly Department of General Surgery Urgencyand Organ TransplantationUniversity of Palermo90127 PalermoItaly

Gadoxetic acid improves detection and characterization of focal liver lesions in cirrhotic patients and can estimate liver function in patients undergoing liver *** purpose of this article is to describe the optimal gadoxetic acid study protocol for the liver,the unique characteristics of gadoxetic acid,the differences between gadoxetic acid and extra-cellular gadolium chelates,and the differences in phases of enhancement between cirrhotic and normal liver using gadoxetic *** also discuss how to obtain and recognize an adequate hepatobiliary phase.

关键词： Hepatobiliary contrast materials Gadoxeticacid Cirrhosis magnetic resonance imaging Liver

Sampling variability of computer-aided fractal-corrected measures of liver fibrosis in needle biopsy specimens

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World Journal of Gastroenterology 2006年第47期12卷 7660-7665页

作者： Fabio Grizzi Carlo Russo Barbara Franceschini mariagrazia Di Rocco Valter Torri Emanuela morenghi Luigi Rainiero Fassati Nicola dioguardi Laboralori di medicina Quanlitativa Islituto Clinico Humanitas IRCCS Rozzano Milan Italy Department of Pathology Istituto ClinicoHumanitas IRCCS Rozzano Milan Italy Laboratory of Clinical Research in Oncology Mario Negri Institute of Pharmacological Research Milan Italy Clinical Research Office Istituto ClinicoHumanitas IRCCS Rozzano Milan Italy Department of General Surgery and Transplantation Ospedale Maggiore IRCCS Milan Italy

瞄准：估计采样可变性电脑辅助，在肝活体检视的纤维变性的 fractal-correctedmeasures。方法：样品从与经历 orthotopic 肝移植的临床上并且组织学地证明的肝硬化从 12 个病人移开的肝的六～八不同部分被导出。有 2 妈妈的厚度的天狼... 详细信息

瞄准：估计采样可变性电脑辅助，在肝活体检视的纤维变性的 fractal-correctedmeasures。方法：样品从与经历 orthotopic 肝移植的临床上并且组织学地证明的肝硬化从 12 个病人移开的肝的六～八不同部分被导出。有 2 妈妈的厚度的天狼星染色红的节用自动地测量纤维变性，以及它的轮廓的表面的一个电脑辅助的图象分析系统被数字化周界，分数维的表面和轮廓尺寸，起皱的海角，和林中小丘系数。结果：我们在表面的大小发现了内部样品的可变性的高度[变化(CV ) 的系数 =43%+/-13%] 并且起皱的海角(CV =28%+/-9%) 纤维变性，而是林中小丘的内部样品的可变性“ s 代表是低的(CV =14%+/-2%) 。结论：这研究建议那林中小丘“ s 代表可能在整个机关在临床的实践被用作纤维变性的最好的组织学的估计，并且证实事实活体检视节，为长期的肝炎的质的诊断基本，在肝织物在建筑上的变化的量的估计起一个关键作用。

关键词：活组织检查肝病纤维化变异性肝硬化