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Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBimEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Integration of biocrude production from fast pyrolysis of biomass with solar PV for dispatchable electricity production

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Clean Energy 2018年第2期2卷 85-101页

作者： Greg perkins Ventura Energy Brisbane4001Australia

This article analyses the integration of distributed biocrude production facilities using fast pyrolysis with solar photovoltaic(PV)for dispatchable electricity *** strong growth of intermittent electricity generation from solar PV and wind is leading to a greater need for energy storage at grid scale and dynamic demand *** forms of energy storage,including electrochemical(***),mechanical(***)and gravitational(***-hydro),are being *** work studies the issues of integrating fast pyrolysis of biomass to produce biocrude that can be readily stored in tanks and combusted to produce electricity when required to supplement the electricity generation from a solar PV unit to meet an arbitrary energy demand *** use of biomass pyrolysis in this application has a range of benefits,including the flexibility to augment intermittent renewables,the integration of more bioenergy into the electricity sector and the creation of commercial quantities of biocrudes that can be refined into renewable transport fuels such as jet fuel for which few other alternatives ***,especially partially upgraded,can be stored and used when required in engines and gas turbines,making them a suitable fuel for augmenting the intermittent nature of solar and wind *** development of the distributed 100%renewable power stations using a mix of biomass/biocrude and solar PV and/or wind would also increase the certainty of supply,knowledge of quality and price of raw biocrudes that can also be used to supply a centralized biorefinery,thereby substantially reducing the risk of investing in new biorefinery capacity.

关键词： biomass pyrolysis biocrude intermittent renewables biofuels

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel E.Ocasio Rivera dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge d.miranda department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

A O-dimensional cavity growth submodel for use in reactor models of underground coal gasification

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International Journal of Coal Science & Technology 2019年第3期6卷 334-353页

作者： Greg perkins martin Parry Technology Brisbane QLD 4001 Australia School of Chemical Engineering The University of Queensland Brisbane QLD 4072 Australia

modelling of the underground coal gasification process is dependent upon a range of sub-models. One of the most important is the calculation of the cavity growth rate as a function of various operating conditions and coal properties. While detailed 1-dimensional models of coal block gasification are available, it is not easy to couple them directly with reactor models, which aim to simulate the complete process. In this paper, a O-dimensional cavity growth sub-model is presented. The model is based on the concept of a surface reaction and incorporates physics to account for moisture evaporation, water influx, coal pyrolysis, coal thermo-mechanical fragmentation and the build up of an ash layer on the char. The model is validated using measurements from laboratory experiments on coal cores and coal blocks. A comparison of calculated results from several UCG field trials shows that the model can provide good estimates of cavity growth rate for reasonable input parameters. Finally, simulation results of cavity growth in the combustion and gasification zones as a function of the bulk gas temperature, gas pressure, water influx rate, ash layer thickness and coal fragmentation behaviour are presented.

关键词： Underground coal gasification Cavity growth Chemical reaction

Anodic Cyclizations, Seven-membered Rings, and the Choice of Radical Cation *** Pathways

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Chinese Journal of Chemistry 2019年第7期37卷 672-678页

作者： Robert J.perkins Ruozhu Feng Qingquan Lu Kevin d.moeller department of Chemistry Washington University in St.Louis St.Louis MO 63130 USA

While many steps in an oxidative cyclization reaction can be important,it is the cyclization step itself that plays the central *** this step does not proceed well,then optimization of the rest of the sequence is *** report here that the key to the cyclization is channeling the reaction down the correct *** reactions require the use of a radical pathway and some require the use of a radical cation *** example of each is provided along with a strategy for accessing both pathways using a common intermediate.

关键词： Anodic Cyclizations Seven-membered Rings

Effect of application rate and irrigation on the movement and dissipation of indaziflam

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Journal of Environmental Sciences 2017年第1期29卷 111-119页

作者： Amir m.Gonzalez-delgado manoj K.Shukla Jamshid Ashigh Russ perkins Plant and Environmental Sciences department New Mexico State UniversityLas CrucesNM 88003-8003USA department of Entomology Plant Pathology and Weed ScienceNew Mexico State UniuersityLas CrucesNM 88003-8003USA Bayer CropScience LP Field Development-SouthernIdalouTX 79329USA

Indaziflam is a new preemergence herbicide for the control of annual grass and broadleaf weeds in various cropping systems including pecan *** objectives of this study were to（1） determine the mobility and dissipation of indaziflam and（2） evaluate herbicide efficacy in a flood-irrigated pecan orchard in southern New mexico,*** was applied at 0,35.5,and 73.1 g/ha in areas with（impacted） and without（unimpacted） tree injury *** samples were collected at 0-15,15-30,and 30-46 cm depths 25,63,90,and 125 days after the first herbicide *** soil samples were collected 4,30,and 55 days after the second *** was detected in soil samples collected at each depth,suggesting movement with irrigation *** concentrations decreased with increasing soil depth and *** mass recoveries were greater in the unimpacted area than in the impacted area after the first and second *** half-lives of indaziflam in the soil ranged from 30 to 85 days for total indaziflam recovered from the entire soil profile after the first and second applications in both *** percent weed control was similar in the impacted and unimpacted areas for both rates of indaziflam on 25 and 53 days after application;however,on 90 days after the application,percent weed control was lower in the impacted than unimpacted area.

关键词： Indaziflam Half-life Sorption Soil properties dissipation Persistence