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Inhibiting tau-induced elevated nSmase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model

The Fifth International Conference on Information and management Sciences

作者： Sara Arasteh Chih-Cheng Hung Tommy coleman School of Computing and Software Engineering Southern Polytechnic State University Marietta GA 30060 School of Computing and Software Engineering Southern Polytechnic State University Marietta GA 30060 HSCaRSAlabama A＆M University Normal AL 35762 HSCaRSAlabama A＆m University NormalAL 35762

＜正＞Auroral images are the set of images that are taken by Ultraviolet Imager （UVI） on Polar satellite. These images can help, through image analysis technique, find out how solar wind affects the earth magnetic field. In order to have better segmentation results of aurora images it is appropriate to have some types of image quality measures. In this paper we compared two different image quality measures for a set of auroral images. We showed that Absolute Central moment （ACm） is a good measure for image contrast degradation and out of focus aberration. However, ACm is not robust to image noise. Center-Symmetric Auto Correlation （SAC） measure was also applied to the same image set. It is demonstrated that the SAC histogram can be used to discriminate between noisy and noiseless images. However, SAC is not as sensitive as ACm to image contrast.

关键词： Image quality Quality measure Auroral

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Translational Neurodegeneration 2023年第1期12卷 70-89页

作者： Carolyn Tallon Benjamin J.Bell medhinee m.malvankar Pragney Deme Carlos Nogueras-Ortiz Erden Eren Ajit G.Thomas Kristen R.Hollinger Arindom Pal maja mustapic meixiang Huang Kaleem.coleman Tawnjerae R.Joe Rana Rais Norman J.Haughey Dimitrios Kapogiannis Barbara S.Slusher Johns Hopkins Drug Discovery Johns Hopkins University School of MedicineBaltimoreMD 21205USA Neurology Johns Hopkins University School of MedicineBaltimoreMD 21205USA Cell Biology Johns Hopkins University School of MedicineBaltimoreMD 21205USA Oncology Johns Hopkins University School of MedicineBaltimoreMD 21205USA medicine Johns Hopkins University School of MedicineBaltimoreMD 21205USA Pharmacology and molecular Sciences Johns Hopkins University School of MedicineBaltimoreMD 21205USA Psychiatry and Behavioral Science Johns Hopkins University School of Medicine855 N.Wolfe StreetRangos 278BaltimoreMD 21205USA Intramural Research Program Laboratory of Clinical InvestigationNational Institute on AgingNational Institutes of Health251 Bayview BlvdSte 8C228BaltimoreMD 21224USA Johns Hopkins University School of medicine 600 N.Wolfe StreetPathology 517BaltimoreMD 21287USA

Background Cognitive decline in Alzheimer’s disease(AD)is associated with hyperphosphorylated tau(pTau)propagation between neurons along synaptically connected networks,in part via extracellular vesicles(EVs).EV biogenesis is triggered by ceramide enrichment at the plasma membrane from neutral sphingomyelinase2(nSmase2)-mediated cleavage of *** report,for the first time,that human tau expression elevates brain ceramides and nSmase2 *** To determine the therapeutic benefit of inhibiting this elevation,we evaluated PDDC,the first potent,selective,orally bioavailable,and brain-penetrable nSmase2 inhibitor in the transgenic PS19 AD mouse ***,we directly evaluated the effect of PDDC on tau propagation in a mouse model where an adeno-associated virus(AAV)encoding P301L/S320F double mutant human tau was stereotaxically-injected unilaterally into the *** contralateral transfer of the double mutant human tau to the dentate gyrus was *** examined ceramide levels,histopathological changes,and pTau content within EVs isolated from the mouse *** Similar to human AD,the PS19 mice exhibited increased brain ceramide levels and nSmase2 activity;both were completely normalized by PDDC *** PS19 mice also exhibited elevated tau immunostaining,thinning of hippocampal neuronal cell layers,increased mossy fiber synaptophysin immunostaining,and glial activation,all of which were pathologic features of human *** treatment reduced these *** plasma of PDDC-treated PS19 mice had reduced levels of neuronal-and microglial-derived EVs,the former carrying lower pTau levels,compared to untreated *** the tau propagation model,PDDC normalized the tau-induced increase in brain ceramides and significantly reduced the amount of tau propagation to the contralateral *** PDDC is a first-in-class therapeutic candidate that normalizes elevated brain ceramides and nSmase2 activity,leading to the slo

关键词： Alzheimer’s disease Extracellular vesicles Neutral sphingomyelinase 2 Tau Ceramide

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用锌还原水作氢的同位素分析

地球与环境 1983年第3期 55-57页

作者： m.L.coleman ,何禄卿中南矿冶学院中心实验室

本文制定了一种使用金属锌从毫克量水制备氢气的新方法。对小量样品而言,该方法具有比常用的方法更精确和制备时间更短的优点。本设计方案起源下***的设想,并且最初是为了作天然和人工合成晶体中流体包裹体中极小量水的同位素分析而设... 详细信息

本文制定了一种使用金属锌从毫克量水制备氢气的新方法。对小量样品而言,该方法具有比常用的方法更精确和制备时间更短的优点。本设计方案起源下***的设想,并且最初是为了作天然和人工合成晶体中流体包裹体中极小量水的同位素分析而设计的。通常采用的方法(1,2)需要将水样引入到高真

关键词：同位素分析氢气水样工业气体反应管矿物包体流体包裹体样品管真空系统质谱计锌粒

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巴塘事变：康区及其在近代汉藏史上的重要性

西南民族大学学报（人文社会科学版） 2014年第3期35卷 1-9页

作者：何溯源(William m. coleman, IV)[美] 汤芸彭文斌美国驻沈阳总领事馆美国哥伦比亚大学历史系西南民族大学民族研究院四川成都610041 加拿大不列颠哥伦比亚大学亚洲研究所重庆大学人文社科高等研究院人类学中心重庆400030

文章从历史文献学的角度对清末川边巴塘事变进行讨论,运用杜赞奇的"权力文化网络"(the cultural nexus of power)概念来剖析巴塘事变前后该地的文化政治生态。20世纪前巴塘的"权力文化网络"由四个方面维系(土司、寺院、清廷在当地的代... 详细信息

文章从历史文献学的角度对清末川边巴塘事变进行讨论,运用杜赞奇的"权力文化网络"(the cultural nexus of power)概念来剖析巴塘事变前后该地的文化政治生态。20世纪前巴塘的"权力文化网络"由四个方面维系(土司、寺院、清廷在当地的代表和商人)。巴塘事变以后,随着改土归流政策的推行,巴塘的地方权力架构失去平衡,这一汉藏交界地区的重镇,在清廷激进的边疆政策的影响下,越来越被纳入中原地区的国家/民族与现代化进程。

关键词：权力的文化网络巴塘地方政治近代社会变迁

Use of the medifast meal Replacement Program for Weight Loss in Overweight and Obese Clients: A Retrospective Chart Review of Three medifast Weight Control Centers (mWCC)

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Food and Nutrition Sciences 2012年第10期3卷 1433-1444页

作者： Christopher coleman Jessica Kiel Andrea Hanlon-mitola Carmine Sonzone Nicholas Fuller Lisa Davis medifast Inc Owings Mills MD 21117 mitola Clifton Park NY 12065.

Objective: A chart review was performed to evaluate the effectiveness of the medifast (mD) meal replacement (mR) plan in a medifast Weight Control Center (mWCC) on body weight, body composition, and other health measures at 4, 12, 24 weeks, and final weight loss visit. methods: Charts included adults aged 18 - 70 (n = 446) with a BmI ≥ 25 kg/m2 who attended one of three mWCCs and were following the mD mR program. Data were collected electronically and included weight, systolic and diastolic blood pressure, pulse, lean muscle mass (Lmm), body fat mass, % body fat, and abdominal circumference. Compliance measures included attendance at weekly visits, intake of mRs and supplements, food journals, and ketone testing. Results: Significant weight loss and % weight loss were achieved at all time points with clinically significant weight loss (>5%) occurring in just 4 weeks. Additionally, significant improvements in body composition were seen at all time points coupled with increases in % total body weight as Lmm (% Lmm improved by 3.5%, 9.8%, 16.0%, and 13.9%, respectively). Blood pressure and pulse were significantly improved, demonstrating the clinical benefit for clients. multivariate regression revealed a strong inverse relationship between weight change, % compliance with attendance, and the number of weeks that mRs were taken as recommended as well as a positive association with number of ketone tests. Conclusion: The mD mR plan, combined with the support and accountability available in the mWCC, is an efficacious program that promotes significant weight loss and improvements in body composition. These results reveal significant associations between components of compliance and weight loss, but particularly highlight the importance of attendance, a focus of the mWCC model compared to nonclinic models.

关键词： meal Replacements Weight Loss Compliance Body Composition Obesity

低噪声金属—半导体—金属(mSm)微波振荡器

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微纳电子技术 1974年第Z1期 42-45页

作者： D.J.coleman S.m.Sze 实践

一、前言低噪声微波连续波振荡器已经用一个10微米的硅薄片两边做两个PtSi肖特基势垒接触的金属—半导体—金属(mSm)的结构获得,在5千兆赫,输出了50毫瓦以上的连续波功率并具有1.8％的效率。距离载波1兆赫的调频噪声是22.8分贝,它比硅... 详细信息

一、前言低噪声微波连续波振荡器已经用一个10微米的硅薄片两边做两个PtSi肖特基势垒接触的金属—半导体—金属(mSm)的结构获得,在5千兆赫,输出了50毫瓦以上的连续波功率并具有1.8％的效率。距离载波1兆赫的调频噪声是22.8分贝,它比硅雪崩振荡器的噪声低得多。微波振荡的机理是两个原因:(1)由于在前向偏置的接触点的少数载流子的注入使该处载流子数目指数地增加;(2)注入载流子通过耗尽区的渡越时间

关键词：低噪声器件微波功率 mSm 微波振荡临界电压起晕电压偏置电流载流子金属金属材料

应用在数据中心10G及更高带宽的Om3光纤技术

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智能建筑与城市信息 2009年第2期 100-103页

作者： Doug coleman 姚鹏美国康宁公司

10G光网络以激光优化50μm多模光纤（Om3）作为首选的传输介质，在数据中心和局域网骨干网络得以悄然应用。Om3光网络优化光纤通信路由与空间利用率，简化安装施工与系统测试，在降低能耗和制冷方面表现不俗，并且支持系统设备与配线面... 详细信息

10G光网络以激光优化50μm多模光纤（Om3）作为首选的传输介质，在数据中心和局域网骨干网络得以悄然应用。Om3光网络优化光纤通信路由与空间利用率，简化安装施工与系统测试，在降低能耗和制冷方面表现不俗，并且支持系统设备与配线面板的高密度部署。事实上，2芯光纤的串行传输已经成为用于以太网和光纤通道技术达到10G速率的传输方式。

关键词：光纤技术数据中心应用高带宽光纤通道技术网络优化支持系统空间利用率

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如何延展你的数据中心多模光纤网络

智能建筑与智慧城市 2016年第5期 53-57页

作者： Doug coleman 房毅康宁光通信

1.前言多模光纤依然是数据中心中首选的较为经济的布线介质,这是由于数据中心中那些相对较短链路都在利用低成本收发器所带来的优势。当多模光纤成为经济性的首选时,对于那些可能存在的较长的链路（如大于300m）和需要多个连接（增加插... 详细信息

1.前言多模光纤依然是数据中心中首选的较为经济的布线介质,这是由于数据中心中那些相对较短链路都在利用低成本收发器所带来的优势。当多模光纤成为经济性的首选时,对于那些可能存在的较长的链路（如大于300m）和需要多个连接（增加插入损耗）的情形,它可能被认为有局限性。在本文中,我们将主要对那些超出通道长度和损耗的标准规定的可能性进行一些讨论。

关键词：多模光纤数据中心插入损耗收发器降阶光纤通道光纤带宽光脉冲光纤损耗评估表

基于遗传算法的多光谱影像非监督训练分类系统(英文)

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遥感学报 2007年第5期11卷 702-709页

作者： HUNG Chih-Cheng XIANG mei minh Pham KUO Bor-Chen Tommy L. coleman 南方技术州立大学计算与软件学院乔治亚州30067美国阿拉巴马农工大学农业与环境科学学院阿拉巴马州35762美国国立台中大学教育管理与统计研究所台中中国台湾

本文将遗传算法(GA)应用于非监督训练,提高了遥感数据的分类精度。遗传竞争学习算法(GA-CL)综合了遗传算法和简单的竞争学习算法,可用于改进非监督训练的结果。遗传算法在典型样本聚类的过程中可以避免得到局部最优值。Jeffries-matusit... 详细信息

本文将遗传算法(GA)应用于非监督训练,提高了遥感数据的分类精度。遗传竞争学习算法(GA-CL)综合了遗传算法和简单的竞争学习算法,可用于改进非监督训练的结果。遗传算法在典型样本聚类的过程中可以避免得到局部最优值。Jeffries-matusita(J-m)距离法是通过统计测量两个训练类别之间的分离度,可用于评价这种算法。将此算法应用于Tm数据的结果显示,遗传算法改进了简单的竞争学习算法,与其他非监督训练算法相比,其提供了K-均值,GA-K-均值和简单的竞争学习算法。

关键词：非监督训练聚类算法人工神经网络竞争学习算法遗传算法