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Immunotherapy and immunoescape in colorectal cancer

World Journal of gastroenterology 2007年第44期13卷 5822-5831页

作者： guillermo mazzolini Oihana murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta carmen Berasain José L Perez-gracia Alvaro g.nzalez Ignacio melero Liver Unit Facultad de Ciencias Biomédicas Universidad Austral Presidente Perón 1500 (1635) Derqui-Pilar Buenos Aires Argentina Centro de Investigación médica Aplicada and Clínica Universitaria Universidad de Navarra Pamplona Spain

Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.

关键词： Colorectal carcinoma Immunotherapy gene therapy interleukin-12 Dendritic cells CD137 indoleamine 2, 3 dioxygenase

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Chronic pain, posttraumatic stress disorder, and opioid intake: A systematic review

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World Journal of Clinical Cases 2019年第24期7卷 4254-4269页

作者： Alicia E López-martínez ángela Reyes-Pérez Elena Rocío Serrano-Ibá?ez Rosa Esteve carmen Ramírez-maestre Facultad de Psicología Instituto de Investigaciones Biomédicas (IBIMA)Universidad de Málaga

BACKgROUND The literature suggests that there is a high degree of co-occurrence between chronic pain and posttraumatic stress disorder(PTSD). An association has been found between PTSD and substance abuse. PTSD is a severe disorder that should be taken into account when opioids are prescribed. It has been found that the prevalence of opioid use disorder(OUD) in chronic pain patients is higher among those with PTSD than those without this *** To perform a systematic review on the association between PTSD, chronic noncancer pain(CNCP), and opioid intake(i.e., prescription, misuse, and abuse).mETHODS We conducted a systematic review following the Preferred Reporting Items for Systematic Reviews and meta-Analyses guidelines. The Patient, Intervention,Comparator, and Outcomes(PICOS) criteria were formulated a priori in the protocol of the systematic review. A search was conducted of the PROSPERO database. In march 2019, searches were also conducted of 5 other databases:Pub med, mEDLINE, Psyc INFO, Web of Science, and PILOTS. The Scottish Intercollegiate guidelines Network checklist for cohort studies was used to assess the selected studies for their methodological quality and risk of bias. Each study was evaluated according to its internal validity, participant sampling,confounding variables, and the statistical *** A total of 151 potentially eligible studies were identified of which 17 were retained for analysis. Only 10 met the selection criteria. All the studies were published between 2008 and 2018 and were conducted in the United States. The eligible studies included a total of 1622785 unique participants. Of these, 196516 had comorbid CNCP and PTSD and were consuming opiates. The participants had a cross-study mean age of 35.2 years. The majority of participants were men(81.6%). The most common chronic pain condition was musculoskeletal pain:back pain(47.14% across studies;range: 16%-60.6%), arthritis and joint pain(31.1%;range: 18%-67.5%), and

关键词： Posttraumatic stress disorder Chronic pain Opioid prescription Opioid misuse Opioid abuse

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《语言的功能取向》述介

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当代语言学 2016年第3期18卷 452-456页

作者： Shannon T. Bischoff carmen Jany 丁健不详中国社会科学院语言研究所 100732

当代语言学中的功能主义兴起于20世纪60年代末，其根本出发点是从语言结构之外寻找解释语言形成和结构规律的因素，并强调基于语言运用的研究模式。在过去的半个世纪中，功能主义学说为一大批学者所青睐，不仅在语言学理论上有所建树，... 详细信息

当代语言学中的功能主义兴起于20世纪60年代末，其根本出发点是从语言结构之外寻找解释语言形成和结构规律的因素，并强调基于语言运用的研究模式。在过去的半个世纪中，功能主义学说为一大批学者所青睐，不仅在语言学理论上有所建树，而且还对社会语言学、语言教学、语言习得、

关键词：当代语言学功能主义语言学理论社会语言学 60年代 20世纪结构规律语言形成

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Culture mixed-Sex and monosex of Tilapia in Ponds in mexico City

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Agricultural Sciences 2015年第2期6卷 187-194页

作者： Jose Luis gomez-márquez Bertha Pena-mendoza maria del carmen Alejo-Plata Jose Luis guzmán-Santiago Laboratorio de Limnología Facultad de Estudios Superiores ZaragozaUniversidad Nacional Autónoma de MéxicoMéxicoD.F.México Campus Puerto Angel Universidad del MarCiudad UniversitariaPuertoángelMéxico

In this study, the growth of Oreochromis niloticus both mixed sex and males sexually reversed were analyzed in concrete ponds in the FES Zaragoza, UNAm, under the environmental conditions of the mexico City. The experiment was carried from may to November 2013, in two concrete ponds of 50 m2. Similar feeding regime and stocking density of fish were maintained for the culture systems. Different growth parameters like body weight, length, daily weight gain (DWg), specific growth rate (SgR), feed conversion rate (FCR), Fulton’s condition index (K) and survival were analyzed during six months culture period. It was found that culture with monosex males tilapias yielded the highest weight, length, DWg and SgR compared to mixed sex populations tilapias. Water quality was monitored along the experiment. Based on the results, there were statistically significant differences in size (W = 20942.5, p 5 mg/L), warm water (>20°C), productive (3) and slightly basic (pH > 8). Acceptable growth of fish and a yield of 3 ton/ha/6 months were obtained in both two ponds;therefore, the culture of tilapia under conditions of mexico City was recommended.

关键词： Tilapia Culture growth Survival mexico City

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Analysis of the Sensory and Hedonic Impacts of Sweet and Bitter Tastes in Perinatally Underfed Rats

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Journal of Behavioral and Brain Science 2014年第9期4卷 423-431页

作者： Lorena Rubio-Navarro carmen Torrero mirelta Regalado manuel Salas Departamento de Neurobiología del Desarrollo y Neurofisiología Instituto de Neurobiología Universidad Nacional Autónoma de México Campus UNAM Juriquilla Querétaro México

Newborn rats discriminate tastes and generate gustofacial response (gFR) because the neuronal substrate is already operating. The oral application of sucrose or quinine hydrochloride produces a specific gFR. We analyzed the effects of perinatal undernutrition on the gFR development of rats at two cue concentrations. In the undernourished group, pregnant dams received different percentages of a balance diet. After birth, prenatally underfed pups continue the undernourishment by remaining for 12 h with a foster dam, and for 12 h with a nipple-ligated mother. Cues were presented as a single droplet of sucrose, sodium chloride, or quinine at low or high concentrations onto the lips at postnatal days (PDs) 1 and 3, and mouth-opening (mOF) and lip-licking frequencies (LLF) were noted. On PD 1 the undernourished group showed smaller mOF increases in response to low salt and quinine stimuli than the controls but no differences at high concentrations. On PD 3, both low and high concentrations of the sucrose and quinine cues significantly increased the mOF in the underfed compared to the control group. Low but not high salt decreased LLF on PD1 in the underfed compared to the control group. On PD 3 the undernourished pups showed significant increases of LLF with low quinine compared with the control rats, but the reverse was observed with high quinine. These data suggest that perinatal undernutrition affects the development of the sensory and hedonic aspects of taste causing changes in gFR expression.

关键词： Undernutrition gustofacial Responses gustatory System Development Rats

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用分光光度法测定酒醋中的总副花青素

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国外分析仪器技术与应用 1999年第4期 53-56页

作者： carmen,m 许子小曲

采用广泛使用的测定酒中副花青素的方法分光光度来测定酒醋样品。确定了试浓度，而且也试验了该可能有的基体效应。儿茶酸的回收率接近９８％，方法检测限为０．４８ｍｇ１＾－１。估计了日内与日间的精确性，根据双尾Ｆ－检验，精确... 详细信息

采用广泛使用的测定酒中副花青素的方法分光光度来测定酒醋样品。确定了试浓度，而且也试验了该可能有的基体效应。儿茶酸的回收率接近９８％，方法检测限为０．４８ｍｇ１＾－１。估计了日内与日间的精确性，根据双尾Ｆ－检验，精确度统计等效。对于用传统和快速醋化法分析酒醋获得的数据表明两组间的浓度有所不同。

关键词：测定酒醋分光光度法副花青素

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Sweet and Bitter Tastes Evoked Different Neuronal Activation in the Rostral Portion of the Nucleus of the Solitary Tract of Developing Rats

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Journal of Behavioral and Brain Science 2012年第3期2卷 291-298页

The impact of the gustatory stimuli on the rostral portion of the nucleus of the solitary tract (rNST) was investigated in developing rats, by using c-fos immunohistochemical staining. Wistar male rats of 5, 15, and 25 days of age were isolated from the mother for 12 h, then stimulated via the intraoral route with quinine, sucrose, or NaCl, and sacrificed 90 min later. The water-stimulated group showed minimal c-fos-like immunoreactivity (FLI) compared with taste-stimulated groups that exhibited different FLI in the rNST at the different ages. At all ages the quinine-stimulated group induced FLI in the medial subfield, while sucrose induced FLI in the lateral subfield of the rNST. The intensity of FLI was highest at P15, and it declined at P25. These findings provide detailed insight into the anatomical basis of rNST activation that is involved in early food intake and the learning capacity of the newborn.

关键词： c-fos Rostral Portion of the Nucleus of the Solitary Tract gustatory Development Rats

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Structural Bioinformatics of Protein &DNA, as Early Stimulation in Basic Education of Rural and Indigenous Communities of Oaxaca

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Engineering（科研） 2013年第10期5卷 255-258页

作者： Susana Lozano-muniz maria del carmen Urzua-Hernandez Biotechnology Institute Universidad del Papaloapan Tuxtepec Mexico International Foundation for Biotechnology Research & Early Stimulation in the Culture of Health Nutrition Sport Art Science Technology & Society A.C. San Juan Bautista Tuxtepec Mexico International Foundation for Biotechnology Research & Early Stimulation in the Culture of Health Nutrition Sport Art Science Technology & Society A.C. San Juan Bautista Tuxtepec Mexico Facultad de Quimica Universidad Nacional Autonoma de Mexico Ciudad de México Mexico

As stated in the Declaration of the Rights of the Child, children have the right to go to school for free, to play, and to have the same opportunity to develop and to learn to be responsible and useful[1]. Young children are curious by nature and they have passion for learning [2]. An environment that encourages scientific thinking is what gives young children the time, space and materials to exercise their curiosity [3]. The aim of this paper is to present a methodology for the development of educational environments based on digital technology, internet and free programs available on the web, for the use and application of structural bioinformatics protein and DNA, for early stimulation in basic education at rural and indigenous communities in state of Oaxaca, conducted in On Line Learning & Training “OLL & T”. The course is divided into 4 sections: 1)Introduction to the topic of protein and DNA structure;2)Search in protein data bank;3)Download RasTop program and use it as bioinformatics tool;4)Emulation of building a viral molecule. Workshops were given to children in elementary, middle and high school at the Universidad Del Papaloapan during the National Week of Science and Technology, every year in Oaxaca since 2007 to 2012 and in monterrey 2010 at the Universidad Autonoma de Nuevo León. Conclusions: positive impact was achieved in basic education in the area of natural sciences by analyzing the molecular basis of protein and deoxyribonucleic acid, theoretically and practically, as a support for teachers.

关键词： TICs Childhood Improvement Achievement

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Enhanced depth OCT imaging of the lamina cribrosa for 24 hours

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 306-309页

作者： Pedro Naranjo Bonilla Rafael giménez gómez David Ríos Jiménez maría Luísa Varas Fabra maría del carmen munoz Villanueva Rocío garcía Catalán Pilar Font Ugalde maría Soledad Poblador Fernández JoséLuís Lancho Alonso Josémaría gallardo galera Department of Ophthalmology Reina Sofia University HospitalCordoba 14004Spain methodological Support to Research Maimonides Institute for Biomedical ResearchReina Sofia University HospitalCordoba 14004Spain Department of medicine UCO Maimonides Institute for Biomedical ResearchReina Sofia University HospitalCordoba 14004Spain Department of morphological Sciences Faculty of MedicineCordoba 14004Spain

The lamina cribrosa thickness（LCT） could be affected by dynamic changes in its *** spectral-domainoptical coherence tomography（SD-OCT）,we have studied the behaviour of the laminar region in 14 young subjects over 24 *** changes in LCT were observed,depending on the time at which the measurement was taken,with the maximum thickness being observed at 7.30 p.m.,and the minimum at 7.30 *** finding could suggests a circadian pattern in the LCT thickness in healthy subjects,which could have implications for the classification,diagnosis and prognosis of both normal and glaucomatous subjects.

关键词： lamina cribrosa laminar region glaucoma optical coherence tomography twenty-four-hours

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Is there a role for systemic targeted therapy after surgical treatment for metastases of renal cell carcinoma?

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World Journal of Nephrology 2015年第2期4卷 254-262页

作者： Adrian Husillos Alonso manuel Carbonero garcía carmen gonzález Enguita Servicio de Urología Hospital Universitario Infanta Elena (HUIE)

metastatic renal cell carcinoma(m RCC) is a challenging disease. Despite the new targeted therapies, complete remissions occur only in 1%-3% of the cases, and the most effective first-line treatment drugs have reached a ceiling in overall survival(ranging from 9 to 49 mo). metastasectomy remains to be the only curative option in most patients with m RCC. Prognostic nomograms have been recently published, so we have tools to classify patients in risk groups, allowing us to detect the cases with the higher risk of recurrence after metastasectomy. Although sparse, there is some evidence of effectiveness of neoadjuvant targeted therapy before metastasectomy; but with an increase in surgical complications due to the effects of these new drugs in tissue healing. We have aimed to answer the question: Is there a role for systemic targeted therapy after surgical treatment for metastases of renal cell carcinoma? We have made a search in Pubmed database. As far as we know, evidence is low and it's based in case reports and small series of patients treated with adjuvant drugs after neoadjuvant therapy plus metastasectomy in cases of partial response to initial systemic treatment. Despite the limitations and high risk of bias, promising results and cases with longterm survival with this approach have been described. Two ongoing clinical trials may answer the question that concerns us.

关键词： metastatic renal cell carcinoma Targeted therapy metastasectomy Surgery Adjuvant treatment

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