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Single low-dose lipopolysaccharide preconditioning:neuroprotective against axonal injury and modulates glial cells

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Neuroimmunology and Neuroinflammation 2017年第1期4卷 6-15页

作者： Ryan C.Turner Zachary J.Naser brandon P.Lucke-Wold Aric F.Logsdon Reyna L.Vangilder Rae R.matsumoto Jason D.Huber Charles L.Rosen Department of Neurosurgery West Virginia UniversitySchool of MedicineMorgantownWV26506USA Center for Neuroscience West Virginia UniversitySchool of MedicineMorgantownWV 26506USA Department of Basic Pharmaceutical Sciences West Virginia UniversitySchool of PharmacyMorgantownWV 26506USA Center for Health Restoration West Virginia UniversitySchool of NursingMorgantownWV 26506USA

Aim:Over 7 million traumatic brain injuries (TBI) are reported each year in the United ***,treatments and neuroprotection following TBI are limited because secondary injury cascades are poorly *** (LPS) administration before controlled cortical impact can contribute to ***,the underlying mechanisms and whether LPS preconditioning confers neuroprotection against closed-head injuries remains ***:The authors hypothesized that preconditioning with a low dose of LPS (0.2 mg/kg) would regulate glial reactivity and protect against diffuse axonal injury induced by weight *** was administered 7 days prior to *** administration reduced locomotion,which recovered completely by time of ***:LPS preconditioning significantly reduced the post-injury gliosis response near the corpus callosum,possibly by downregulating the oncostatin m *** novel findings demonstrate a protective role of LPS preconditioning against diffuse axonal *** preconditioning successfully prevented neurodegeneration near the corpus callosum,as measured by fluorojade ***:Further work is required to elucidate whether LPS preconditioning confers long-term protection against behavioral deficits and to elucidate the biochemical mechanisms responsible for LPS-induced neuroprotective effects.

关键词： Lipopolysaccharide preconditioning oncostatin m receptor diffuse axonal injury gliosis neuroprotection

Incidenee and time-varying predictors of HIV and sexually transmitted infections among male sex workers in mexico City

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Infectious Diseases of Poverty 2021年第1期10卷 36-45页

作者： Karla Y.Ganley marta Wilson-Barthes Andrew R.Zullo Sandra G.Sosa-Rubi Carlos J.Conde-Glez Santa Garcia-Cisneros mark N.Lurie brandon D.L.marshall Don Operario Kenneth H.mayer Omar Galarraga Department of Narrative medicine Columbia UniversityNew YorkNYUSA Department of Epidemiology School of Public HealthBrown UniversityProvide neeRlUSA Department of Health Services Policyand PracticeSchool of Public HealthBrown University121 South Main StreetBox G-121S-2ProvidenceRl 02912USA National Institute of Public Health(INSP) CuernavacaMorelosMexico Department of Behavioral and Social Science School of Public HealthBrown UniversityProvidenceRlUSA Fenway Health and Harvard University BostonMAUSA.

Background:male sex workers are at high-risk for acquisition of sexually transmitted infections(STIs),including human immunodeficiency virus(HIV).we quantified incidence rates of STIs and identified their time-varying predictors among male sex workers in mexico ***:From January 2012 to may 2014,male sex workers recruited from the largest HIV clinic and community sites in mexico City were tested for chlamydia,gonorrhea,syphilis,hepatitis,and HIV at baseline,6-months,and *** nee rates with 95%bootstrapped confide nee limits were *** examined potential timevarying predictors using generalized estimating equations for a population averaged ***:Among 227 male sex workers,median age was 24 and baseline HIV prevalence was 32%.Incidence rates(per 100 person-years)were as follows:HIV[5.23;95%confidence interval(CI):2.15-10.31],chlamydia(5.15;95%CI:2.58-9.34),gonorrhea(3.93;95%CI:1.88-7.83),syphilis(13.04;95%CI:8.24-19.94),hepatitis B(2.11;95%CI:0.53-4.89),hepatitis C(0.95;95%CI:0.00-3.16),any STI except HIV(30.99;95%CI:21.73-40.26),and any STI including HIV(50.08;95%CI:37.6062.55).In the multivariable-adjusted model,incident STI(excluding HIV)were lower among those who reported consistently using condoms during anal and vaginal intercourse(odds ratio=0.03,95%CI:0.00-0.68)compared to those who reported inconsistently using condoms during anal and vaginal ***:Incidence of STIs is high among male sex workers in mexico *** condom use is an important protective factor for STIs,and should be an important comp on ent of interventions to prevent incide nt infect i ons.

关键词： male sex worker men who have sex with men HIV Sexually transmitted infection Transmission Risk factor mexico

Treatment-Plan Comparison of Three Advanced Radiation Treatment modalities for Fractionated Stereotactic Radiotherapy to the Head and Neck

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International Journal of medical Physics, Clinical Engineering and Radiation Oncology 2019年第2期8卷 106-120页

作者： He Wang James N. Yang Xiaodong Zhang Jing Li Steven J. Frank Zhongxiang Zhao Dershan Luo Xiaorong Zhu Congjun Wang Samuel Tung Adam S. Garden David I. Rosenthal Clifton David Fuller Gary brandon Gunn Amol J. Ghia Jay P. Reddy Shaan m. Raza Franco De monte mark S. Chambers Paul D. Brown Shirley Su Jack Phan Department of Radiation Physics The University of Texas MD Anderson Cancer Center Houston TX USA Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Neurosurgery The University of Texas MD Anderson Cancer Center Houston TX USA Department of Oncologic Dentistry Prosthodontics Thoracic/Head &Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX USA Department of Radiation Oncology The Mayo Clinic Rochester MN USA

Purpose: Fractionated stereotactic radiosurgery (FSRS) can be given with at least three modalities: Gamma Knife, with the noninvasive frameless extend system (GKE);linear accelerator-based volumetric modulated arc therapy (VmAT);and intensity-modulated proton therapy (ImPT). we extracted treatment plans for patients who had received FSRS with GKE for recurrent skull base or intracranial tumors, created corresponding plans for VmAT and ImPT, and compared the quality of the three sets of plans. methods and materials: Plans were extracted for 9 patients with recurrent malignant skull-base tumors (n = 6) or large intracranial tumors (n = 3) who had received FSRS with GKE (median dose 24 Gy in 3 fractions) in 2013 through 2015. Plans for VmAT were generated with a TrueBeam STx LINAC machine using 6-mV photons, and plans for ImPT were generated with multi-field optimization. The optimized VmAT and ImPT plans were normalized to achieve the best possible target coverage while meeting the same dose-volume constraints on organs at risk (OARs) as the GKE plans. Plans were evaluated on the basis of target coverage, conformity index, homogeneity index, gradient index, and treatment efficiency. Results: The median target volume was 10.2 cm3 (range 1.9 - 33.8 cm3). The VmAT and ImPT plans met all OAR constraints, and target coverage and conformity were comparable among all plans. VmAT and ImPT plans showed significantly better target uniformity and treatment delivery efficiency (P P Conclusion: FSRS for skull base and large intracranial lesions delivered by VmAT and ImPT can achieve comparable target coverage, conformity, and sparing of critical structure as the GKE while providing superior target uniformity and treatment delivery efficiency. The GKE had superior high-dose gradients outside the target and thus better protected surrounding normal structures.

关键词： Gamma Knife Extend System Stereotactic Radiosurgery Volumetric modulated Arc Therapy Intensity-modulated Proton Therapy Spot Scanning Proton Therapy

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长江中下游长江江豚种群数量研究

长江中下游长江江豚种群数量研究

野生动物生态与资源保护第四届全国学术研讨会

作者：赵修江王丁 Barlow,J. Pitman,R.L. Taylor,B.L. 王克雄魏卓张先锋李松海 Barrett.L.A. Akamatsu,T. Turvey,S.T. Reeves,R.R. Stewart,B.S. Richlen,m. brandon,J.R. 中国科学院水生生物研究所中国科学院研究生院 NOAA Fisheries Southwest Fisheries Science CenterLa Jolla CA 92037USA

长江江豚是唯一的江豚淡水亚种,仅分布于长江中下游及其主要附属湖泊中。为评价其种群现状,2006年11月至12月,我们在长江中下游干流江段进行了截线抽样法考察。考察采用两条大型考察船,航程约3400千米。根据动物密度,考察区域被划分为...

长江江豚是唯一的江豚淡水亚种,仅分布于长江中下游及其主要附属湖泊中。为评价其种群现状,2006年11月至12月,我们在长江中下游干流江段进行了截线抽样法考察。考察采用两条大型考察船,航程约3400千米。根据动物密度,考察区域被划分为三个江段进

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声波激励的超小型纳机电系统磁电天线

通信对抗 2017年第4期36卷 51-58页

作者： Tianxiang Nan Hwaider Lin Yuan Gao Alexei matyushov Guoliang Yu Huaihao Chen Neville Sun Shengjun wei Zhiguang Wang menghui Li Xinjun Wang Amine Belkessam Rongdi Guo Brian Chen James Zhou Zhenyun Qian Yu Hui matteo Rinaldi michael E.mcConney brandon m.Howe Zhongqiang Hu John G.Jones Gail J.Brown Nian Xiang Sun 张建强(翻译) 陈鼎鼎(审校) W.m.Keck Laboratory for Integrated Ferroics and Department of Electrical and Computer EngineeringNortheastern UniversityBostonMA 02115USA westford Academy WestfordMA 01886USA Andover High School AndoverMA 01810USA materials and manufacturing Directorate Air Force Research LaboratoryWright-Patterson Air Force BaseDaytonOH 45433USA 不详

当前的小型天线依赖于电磁波的谐振,因此天线的尺寸与电磁波波长相关。典型的天线尺寸大于波长的1/10,而进一步缩小天线尺寸在近十年来都是一个公开的挑战。介绍一种通过悬浮铁氧/压电薄膜异质结构的声波激励纳机械磁电天线。这种磁电... 详细信息

当前的小型天线依赖于电磁波的谐振,因此天线的尺寸与电磁波波长相关。典型的天线尺寸大于波长的1/10,而进一步缩小天线尺寸在近十年来都是一个公开的挑战。介绍一种通过悬浮铁氧/压电薄膜异质结构的声波激励纳机械磁电天线。这种磁电天线通过其在声波谐振频率处的磁电效应接收和发射电磁波。磁电天线中的体声波激发铁磁薄膜的磁化振荡,产生电磁波的辐射;反之,天线感应电磁波的磁场,得到压电电压输出。这种磁电天线(尺寸仅为波长的千分之一)比现有小型天线的尺寸小1到2个数量级,但性能却没有降低,在便携式无线通信系统中具有很大的应用潜力。

关键词：纳米板薄膜体声波谐振器纳机电系统

Short-term influence of anaerobically-digested and conventional swine manure, and N fertilizer on organic C and N, and available nutrients in two contrasting soils

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Agricultural Sciences 2012年第5期3卷 678-696页

作者： Sukhdev S. malhi R. L. Lemke m. Stumborg F. Selles Agriculture and Agri-Food Canada Brandon Manitoba Canada Agriculture and Agri-Food Canada Melfort Saskatchewan Canada Agriculture and Agri-Food Canada Saskatoon Saskatchewan Canada Agriculture and Agri-Food Canada Swift Current Saskatchewan Canada

A three-year (2006-2008) field experiment was conducted at Swift Current and Star City in Saskatchewan to determine the short-term in-fluence of land-applied anaerobically digested swine manure (ADSm), conventionally treated swine manure (CTSm) and N fertilizer on total organic C (TOC), total organic N (TON), light fraction organic C (LFOC), light fraction organic N (LFON) and pH in the 0 - 7.5 and 7.5 - 15 cm soil layers, and ammonium-N, nitrate-N, extractable P, exchangeable K and sulphate-S in the 0 - 15, 15 - 30, 30 - 60, 60 - 90 and 90 - 120 cm soil layers. Treatments included spring and autumn applications of CTSm and ADSm at a 1x rate (10,000 and 7150 L·ha-1, respectively) applied each year, a 3x rate (30,000 and 21,450 L·ha-1, respectively) applied once at the beginning of the experiment, plus a treatment receiving commercial fertilizer (UAN at 60 kg·N·ha-1·yr-1) and a zero-N control. There was no effect of swine manure rate, type and application time on soil pH. mass of TOC and TON in the 15 cm soil layer increased significantly with swine manure application compared to the control, mainly at the Swift Current site, with greater increases from 3x rate than 1x rate (by 2.21 mg·C·ha-1 and 0.167 mg·N·ha-1). Compared to the control, mass of LFOC and LFON in the 15 cm soil layer increased with swine manure application at sites, with greater increases from 3x rate than 1x rate (by 287 kg·C·ha-1 and 26 kg·N·ha-1 at Star City, and by 194 kg·C·ha-1 and 19·kg·N ha-1 at Swift Current). mass of TOC and TON in soil layer was tended to be greater with ADSm than CTSm, but mass of LFOC and LFON in soil was greater with CTSm than ADSm. mass of TOC, TON, LFOC and LFON in soil also increased with annual N fertilizer application compared to the control (by 3.2 mg·C·ha-1 for TOC, 0.195 mg·N·ha-1 for TON, 708 kg·C·ha-1 for LFOC and 45 kg·N·ha-1 for LFON). In conclusion, our findings suggest that the quantity and quality of organic C and N in soil can be affected by swine manure

关键词： Anaerobic Digestion Available N P K and S Organic C and N Soil Swine manure

孔隙压力贯人仪记录了路易斯安娜近海和墨西哥湾陆坡多个海底滑坡处近海底的强超压

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海洋地质 2009年第1期25卷 61-61页

作者： Peter Flemings brandon Dugan Julia Schneider Hilary Strong 杨丽娟（译）闫章存（校对）德克萨斯大学奥斯汀分校美国莱斯大学美国不详

在综合大洋钻探计划308航次中，使用孔隙压力贯人仪分别在墨西哥湾的深水区和路易斯安娜近海的U1322和U1324站位海底下200m内进行了测量，测量到的超压达到了流体静有效应力（λ＊=（u-uk）／（α′th））的60％-70％。强超压出现在低... 详细信息

在综合大洋钻探计划308航次中，使用孔隙压力贯人仪分别在墨西哥湾的深水区和路易斯安娜近海的U1322和U1324站位海底下200m内进行了测量，测量到的超压达到了流体静有效应力（λ＊=（u-uk）／（α′th））的60％-70％。强超压出现在低渗透性的泥岩层中，其中有多个非常大的更新世海底滑坡。在U1324站位，海底200m之下的孔隙压力显著下降：在泥岩、粉砂岩和砂岩的交互层中没有海底滑坡。我们认为所观察到的强超压是由来自古密西西比河的低渗透率物质的快速沉积所导致的。

关键词：海底滑坡孔隙压力墨西哥湾超压近海综合大洋钻探计划陆坡密西西比河

近端指间关节掌腱膜挛缩治疗中早期的软组织分离术与筋膜切除术之后的马缰韧带松解术

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中国美容整形外科杂志 2013年第1期24卷 I0018-I0018页

作者： Randall O. Croft Anthony A. Smith brandon Cofalde Wdliam J. Casey Ⅲ manna m. Rebecca Scott F. m. Duncan 吕梦竹(译) 郭澍(译) 孙强(译) 魏峰(译) 高景恒(译) 美国亚利桑那州斯科茨代尔梅约诊所整形再造外科中心外科部及骨科中国医科大学附属第一医院整形外科《中国美容整形外科杂志》编辑部

背景与目的用马缰韧带松解术来治疗近端指间关节掌腱膜挛缩并不能解决手指动脉短缩及皮肤不足的问题，DigitWidget应用软组织分离的方法成功克服了这些问题。本研究将先行筋膜切除术再行马缰韧带松解术，与先行软组织分离术再行有效松... 详细信息

背景与目的用马缰韧带松解术来治疗近端指间关节掌腱膜挛缩并不能解决手指动脉短缩及皮肤不足的问题，DigitWidget应用软组织分离的方法成功克服了这些问题。本研究将先行筋膜切除术再行马缰韧带松解术，与先行软组织分离术再行有效松解，这两种方法在治疗近端指间关节掌腱膜挛缩的效果上进行了对比。方法作者在2001—2008年间比较了应用筋膜切除术联合马缰韧带松解与DigitWidget软组织分离术的治疗效果。

关键词：近端指间关节韧带松解术掌腱膜挛缩治疗效果膜切除术分离术软组织中早期

OSP-03大洋边缘和大洋岛屿沉积物块体运移及其影响：何时？何地？起因？（二）——墨西哥湾陆坡Ursa盆地斜坡失稳的触发因素

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海洋地质 2009年第1期25卷 57-57页

作者： Roger Urgeles Jacques Locat Peter B. Flemings brandon Dugan Nguyen Thi Thanh Binh Derek E. Sawye 杨丽娟（译）闫章存（校对）巴塞罗纳大学西班牙拉瓦尔大学加拿大得克萨斯大学奥斯汀分校美国莱斯大学美国东京大学日本不详

Ursa盆地水深1000m，位于密西西比峡谷的东部隆起上，是研究大型无震滑坡现象的超级天然实验室。近期的研究表明，本地区有记载的地震活动有可能是由浅层重力滑动而不是深层构造作用导致的。在Ursa盆地，块体运移沉积物广泛存在，其时... 详细信息

Ursa盆地水深1000m，位于密西西比峡谷的东部隆起上，是研究大型无震滑坡现象的超级天然实验室。近期的研究表明，本地区有记载的地震活动有可能是由浅层重力滑动而不是深层构造作用导致的。在Ursa盆地，块体运移沉积物广泛存在，其时空关系在多波束以及地震反射资料中都有显示。2005年6月，综合大洋钻探项目（IODP）308航次在靠近全新世大滑坡以及泥火山型流体溢出构造附近钻了三个孔，钻穿了更新世-全新世一系列块体运移沉积物，采集了这几个钻孔的测井、沉积学以及土工资料，

关键词：沉积物大洋边缘运移块体触发因素斜坡失稳盆地墨西哥湾