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Strategies to enhance monoclonal antibody uptake and distribution in solid tumors

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Cancer Biology & medicine 2021年第3期18卷 649-664页

作者： brandon m.Bordeau Joseph P.Balthasar Department of Pharmaceutical Science University at BuffaloBuffaloNY 14214USA

Despite the significant resources dedicated to the development of monoclonal antibody(m Ab)therapies for solid tumors,the clinical success,thus far,has been *** efficacy of m Ab in solid tumors likely relates to unique aspects of tumor *** tumors have an aberrant vasculature and a dense extracellular matrix that slow both the convective and diffusive transport of m Abs into and within *** m Abs that are directed against cellular antigens,high antigen expression and rapid antigen turnover can result in perivascular cells binding to and eliminating a significant amount of extravasated m Ab,limiting m Ab distribution to portions of the tumor that are distant from functional *** preclinical investigations have reported strategies to improve m Ab uptake and distribution;however,to our knowledge,none have translated into the ***,we provide an overview of several barriers in solid tumors that limit m Ab uptake and distribution and discuss approaches that have been utilized to overcome these barriers in preclinical studies.

关键词： Solid tumors antibody uptake and distribution monoclonal antibody antibody-drug conjugate

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可持续混凝土的奇特来源

空中英语教室（高级版．彭蒙惠英语） 2024年第1期 14-15,41页

作者： Elissaveta m.brandon 不详

08建筑师对不寻常的建筑材料并不陌生:大麻纤维、龙舌兰酒产业的龙舌兰浆、破碎的马桶、不可回收的塑料,现在更有……用过的尿布?日本北九州市立大学的一群研究人员研发出一种混凝土,可以用碎尿布取代多达40%的沙子。

关键词：建筑材料龙舌兰酒马桶大麻纤维可持续混凝土建筑师

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可爱面面观可爱如何演变并影响消费主义

空中英语教室（高级版．彭蒙惠英语） 2024年第8期 34-35,49,50页

作者： Elissaveta m.brandon 不详

猫咪一直都这么可爱吗?伦敦萨默塞特郡最近的一个展览,尝试通过说明当代文化中可爱的崛起与流行来回答那个问题展览名称就是简单的“可爱”二字,展出数百件毛绒玩具、菲比精灵、护理机器人、宝可梦卡牌、机器狗、拓麻歌子、玩具屋、可... 详细信息

猫咪一直都这么可爱吗?伦敦萨默塞特郡最近的一个展览,尝试通过说明当代文化中可爱的崛起与流行来回答那个问题展览名称就是简单的“可爱”二字,展出数百件毛绒玩具、菲比精灵、护理机器人、宝可梦卡牌、机器狗、拓麻歌子、玩具屋、可爱小雕像——还有,数量极大的猫咪。最后以Hello Kitty装置结尾,庆祝Hello Kitty诞生50周年。

关键词：毛绒玩具机器狗萨默塞特消费主义可爱当代文化

Experimental evidence that soil heterogeneity enhances plant diversity during community assembly

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Journal of Plant Ecology 2014年第5期7卷 461-469页

作者： brandon m.Williams Gregory R.Houseman Department of Biological Sciences Wichita State University1845 FairmountWichitaKS 67260USA

Aims Environmental heterogeneity is a primary mechanism explain-ing species coexistence and extant patterns of *** strong theoretical support and ample observational evidence,few experimental studies in plant communities have been able to demonstrate a causal link between environmental heterogene-ity and plant *** lack of experimental evidence sug-gests that either fine-scale heterogeneity has weak effects on plant diversity or previous experiments have been unable to effectively manipulate ***,we utilize a unique soil manipu-lation to test whether fine-scale soil heterogeneity will increase plant richness through species sorting among experimental patch *** This experiment was conducted in the tallgrass prairie region of south-central Kansas,*** utilized the inherent variation found in the vertical soil profile,which varied in both biotic and abiotic characteristics,and redistributed these strata into either homoge-neous or heterogeneous spatial arrangements in 2.4×2.4 m *** the soil manipulation,34 native prairie species were sown into all *** conducted annual censuses at peak biomass to quantify species composition and plant density by species within the experimental *** Findings After 2 years,species richness was significantly higher in heteroge-neous relative to homogeneous plots and this pattern was independ-ent of total plant *** the heterogeneous plots,13 species had higher establishment in a specific patch type representing one of the three soil ***,no species had greater estab-lishment in the mixed stratum,which comprised the homogene-ous plots,relative to the heterogeneous *** species sorting patterns suggest that fine-scale heterogeneity creates opportunities for plant establishment due to niche differences,which translates into increased plant diversity at the plot *** richness was more strongly related to plant density among patch

关键词： environmental heterogeneity species richness species sorting community assembly niche theory neutral theory

Evaluation of hand infections in the emergency department using point-of-care ultrasound

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World Journal of Emergency medicine 2024年第4期15卷 283-288页

作者： David Ahmad Haidar David mintz brandon m Wubben Omar Rizvi Srikar Adhikari Department of Emergency medicine Michigan MedicineAnn Arbor 48109-1382USA University of Arizona College of medicine Tucson 85724USA Department of Emergency medicine University of IowaIowa City 52242-1009USA Department of Surgery University of Arizona College of MedicineTucson 85724USA Department of Emergency medicine University of Arizona College of MedicineTucson 85724USA

BACKGROUND:we aimed to evaluate the utility of point-of-care ultrasound(POCUS)in the assessment of hand infections that present to the emergency department(ED)and its impact on medical decision making and patient ***:we conducted a retrospective review of patients who presented to two urban academic EDs with clinical presentations concerning for skin and soft tissue infections(SSTI)of the hand between December 2015 and December *** trained POCUS fellowship physicians reviewed an ED POCUS database for POCUS examinations of the *** then reviewed patients’electronic health records(EHR)for demographic characteristics,history,physical examination findings,ED course,additional imaging studies,consultations,impact of POCUS on patient care and final ***:we included a total of 50 cases(28 male,22 female)in the final *** most common presenting symptoms and exam findings were pain(100%),swelling(90%),and erythema(74%).The most common sonographic findings were edema(76%),soft tissue swelling(78%),and fluid surrounding the tendon(57%).POCUS was used in medical decision making 68%of the time(n=34),with the use of POCUS leading to changes in management 38%of the time(n=19).POCUS use led to early antibiotic use(11/19),early consultation(10/19),and led to the performance of a required procedure(8/19).The POCUS diagnosis was consistent with the discharge diagnosis of flexor tenosynovitis 8/12 times,abscess 12/16 times,and cellulitis 14/20 ***:POCUS is beneficial for evaluating of hand infections that present to the ED and can be used as an important part of medical decision making to expedite patient care.

关键词： Ultrasound Point-of-care ultrasound Cellulitis Abscess Flexor tenosynovitis

US-China Relations:Nationalism,the Trade War,and COVID-19

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Fudan Journal of the Humanities and Social Sciences 2021年第1期14卷 23-40页

作者： brandon m.Boylan Jerry mcBeath Bo Wang University of Alaska Fairbanks(UAF) 603 C/D Gruening Building1747 South Chandalar DriveFairbanksAK 99775USA Emeritus of Political Science University of Alaska Fairbanks(UAF)1777 Red Fox DriveFairbanksAK 99709USA School of International Relations China University of International Business and Economics(UIBE)Mail Box 100No.10 Huixin East StreetChangyang DistrictBeijing 100029People’s Republic of China

The trade war between the USA and China has shocked many across the world.A disruption to the interdependence of the two largest economies seemed ***,in an effort to thwart China’s economic practices and boost the US economy,President Trump’s administration levied tariffs on Chinese imports shortly after taking office,moving US foreign economic policy from liberalism,practiced for decades,to *** has retaliated,and the trade war continues *** conceptual insights from the nationalism literature,we explore the nationalist roots of the trade war from both the US and Chinese *** the USA,the Trump administration’s plan to achieve energy autonomy,decrease reliance on foreign resources,and reinvigorate the manufacturing sector has led to protectionist policies,the othering of China,and hence the trade *** reluctant to enter the conflict,China has rebuffed the USA,resisting and counterattacking US actions,owing to a long-felt sense of persecution in the global space and an eagerness to participate fully,and lead in some issue areas,in international *** conflict continues into the COVID-19 era,marked by US scapegoating of China and hits to economic *** both sides are convinced they have achieved their goals,or the USA undergoes an administration change,the conflict will likely continue.

关键词： US-China relations Nationalism International trade Natural resources Energy Political economy COVID-19

重症监护病人脑电数据的自动聚类分析（英文）

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西北大学学报（自然科学版） 2018年第1期48卷 6-9页

作者： Jin Jing Emile D′angremonta Senan Ebrahim mohammad Ghassemi Eric Rosenthal Sahar Zafar m.brandon we.tove. 哈佛医学院/麻省总医院神经内科美国波士顿02114 乌得勒支大学理学院荷兰乌得勒支80125 麻省理工学院理学院美国波士顿02114

癫痫性发作、持续状态及痫样节律性活动是常见的病理性脑部放电状态,通常会在急性脑损伤患者的脑电图(EEG)中表现出来。完成此类病理性波形的有效标记,是进一步诊断与治疗相关疾病的重要前提。为辅助神经内科专家对不同病理波形进行快... 详细信息

癫痫性发作、持续状态及痫样节律性活动是常见的病理性脑部放电状态,通常会在急性脑损伤患者的脑电图(EEG)中表现出来。完成此类病理性波形的有效标记,是进一步诊断与治疗相关疾病的重要前提。为辅助神经内科专家对不同病理波形进行快速标记,文中提出了一种全新的辅助检测标记系统。该系统分别采用特征提取、PCA降维和LE映射可视化等技术,实现EEG中同质模式簇的自动检测。所提方法对哈佛医学院/麻省总医院中10例ICU患者的长时程连续脑电图进行了系统分析。数值实验结果表明,海量脑电数据能够被有效地自动聚类为多种ICU典型标准波形,而且仅通过观测类中心及若干同类成员就能够达到有效标记的目标。同时,LE可视化结果也进一步证实了"发作间期-发作期"连续统假设是成立的。

关键词：聚类重症监护脑电图发作 “发作间期-发作期”连续统假设评分者间统一度

A reproducible and sensitive method for generating high-quality transcriptomes from single whitefly salivary glands and other low-input tissues

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Insect Science 2022年第5期29卷 1318-1328页

作者： marco Gebiola brandon H.Le Kerry Emauck Department of Entomology University of California RiversideRiversideCalifornia Department of Botany and Plant Sciences University of California RiversideRiversideCalifornia Institute of Integrative Genome Biology University of California RiversideRiversideCaliforniaUSA

Transcriptomic studies are an important tool for understanding the molecular pathways underlying host plant use by agricultural pests,including vectors of damaging plant *** far,bulk RNA-Seq has been the main approach for non-model *** method relies on pooling large numbers of whole organisms or hundreds of individually dissected *** latter approach is logistically challenging,may introduce artifacts of handling and storage,and is not compatible with biological ***,we tested an approach to generate transcriptomes of individual salivary glands and other low-input body tissues from whiteflies(Bemisia tabaci mEAm1),which are major vectors of plant *** comparing our outputs to published bulk RNA-Seq datasets for whole whitefly bodies and pools of salivary glands,we demonstrate that this approach recovers similar numbers of transcripts relative to bulk RNA-Seq in a tissue-specific manner,and for some metrics,exceeds performance of bulk tissue *** generated from individual salivary glands also yielded additional novel transcripts not identified in pooled salivary gland datasets,and had hundreds of enriched transcripts when compared with whole head ***,our study demonstrates that it is feasible to produce high quality,replicated transcriptomes of whitefly salivary glands and other low-input *** anticipate that our approach will expand hypothesis-driven research on salivary glands of whiteflies and other Hemiptera,thus enabling novel control strategies to disrupt feeding and virus transmission.

关键词： Aleyrodidae Bemisia tabaci bulk RNA-Seq insect vectors low-input RNA-Seq plant pathogens

High-Content Screening and Analysis of Stem Cell-Derived Neural Interfaces Using a Combinatorial Nanotechnology and machine Learning Approach

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Research 2023年第1期2022卷 153-167页

作者： Letao Yang Brian m.Conley Jinho Yoon Christopher Rathnam Thanapat Pongkulapa brandon Conklin Yannan Hou Ki-Bum Lee Department of Chemistry and Chemical Biology Rutgers UniversityThe State University of New JerseyPiscatawayNJ 08854USA

A systematic investigation of stem cell-derived neural interfaces can facilitate the discovery of the molecular mechanisms behind cell behavior in neurological disorders and accelerate the development of stem cell-based ***,high-throughput investigation of the cell-type-specific biophysical cues associated with stem cell-derived neural interfaces continues to be a significant obstacle to *** this end,we developed a combinatorial nanoarray-based method for high-throughput investigation of neural interface micro-/nanostructures(physical cues comprising geometrical,topographical,and mechanical aspects)and the effects of these complex physical cues on stem cell fate ***,by applying a machine learning(mL)-based analytical approach to a large number of stem cell-derived neural interfaces,we comprehensively mapped stem cell adhesion,differentiation,and proliferation,which allowed for the cell-type-specific design of biomaterials for neural interfacing,including both adult and human-induced pluripotent stem cells(hiPSCs)with varying genetic *** short,we successfully demonstrated how an innovative combinatorial nanoarray and mL-based platform technology can aid with the rational design of stem cell-derived neural interfaces,potentially facilitating precision,and personalized tissue engineering applications.

关键词： overcome neural rational