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Tissue engineering approaches for dental pulp regeneration:The development of novel bioactive materials using pharmacological epigenetic inhibitors

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Bioactive materials 2024年第10期40卷 182-211页

作者： Ross m.Quigley michaela Kearney Oran D.Kennedy Henry F.Duncan Division of Restorative Dentistry&Periodontology Dublin Dental University HospitalTrinity College Dublin(TCD)University of DublinLincoln PlaceDublinIreland Department of Anatomy and Regenerative medicine and Tissue Engineering Research GroupRoyal College of Surgeons in Ireland(RCSI)University of Medicine and Health SciencesDublinIreland The Trinity Centre for Biomedical Engineering(TCBE)and the Advanced materials and Bioengineering Research Centre(AmBER) Royal College of Surgeons in Ireland(RCSI)and Trinity College Dublin(TCD)DublinIreland

The drive for minimally invasive endodontic treatment strategies has shifted focus from technically complex and destructive root canal treatments towards more conservative vital pulp ***,novel approaches to maintaining dental pulp vitality after disease or trauma will require the development of innovative,biologicallydriven regenerative medicine *** example,cell-homing and cell-based therapies have recently been developed in vitro and trialled in preclinical models to study dental pulp *** approaches utilise natural and synthetic scaffolds that can deliver a range of bioactive pharmacological epigenetic modulators(HDACis,DNmTis,and ncRNAs),which are cost-effective and easily applied to stimulate pulp tissue ***,many biological factors hinder the clinical development of regenerative therapies,including a lack of blood supply and poor infection control in the necrotic root canal *** challenges include a need for clinically relevant models and manufacturing challenges such as scalability,cost concerns,and regulatory *** review will describe the current state of bioactive-biomaterial/scaffold-based engineering strategies to stimulate dentine-pulp regeneration,explicitly focusing on epigenetic modulators and therapeutic pharmacological *** will highlight the components of dental pulp regenerative approaches,describe their current limitations,and offer suggestions for the effective translation of novel epigenetic-laden bioactive materials for innovative therapeutics.

关键词： Epigenetics Regenerative medicine Regenerative endodontics Biocompatible materials Tissue engineering

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Spider odors induce stoichiometric changes in fruit fly Drosophila melanogaster

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Current Zoology 2021年第1期67卷 127-129页

作者： Ronalds KRAmS Tatjana KRAmA maris mUNKEVICS Sarah EICHLER David m.BUTLER Linda DOBKEVICA Priit JOERS Jorge CONTRERAS-GARDUNO Janina DAUKSTE Indrikis A.KRAmS Plant Health Estonian University of Life SciencesTartu 51006Estonia Department of Biotechnology Daugavpils UniversityDaugavpils 5401Latvia Institute of Ecology and Earth Sciences University of TartuTartu 51010Estonia Department of Zoology and Animal Ecology Faculty of BiologyUniversity of LatviaRiga 1004Latvia Department of Biological Sciences Kent State UniversityOhioSalem 4460USA Department of Plant Sciences University of TennesseeKnoxville 37996-4561USA Department of Environmental Science Faculty of Geography and Earth SciencesUniversity of LatviaRiga 1004Latvia Department of General and microbial Biochemistry University of TartuTartu 51010Estonia Escuela Nacional de Estudios Superiores Unidad morelia Universidad Nacional Autonoma de MexicoMorelia 58190Mexico Institute of Food Safety Animal Health and Environment BIORRiga 1076Latvia Department of Psychology University of TennesseeKnoxville 37996-4561USA

Animal senses and signals are amazingly diverse,and the major modalities by which animals acquire sensory input from their environments are sound,light,vibration,and chemical *** mainly rely on visual,nociceptive,and olfactory cues to discriminate between rewards and *** has been shown that the visual and olfactory cues of predators substantially affect the adult phenotype in Drosophila melanogaster(Krams et al.2016),a prominent animal model for biological research.

关键词： melanogaster cues Drosophila

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