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The effect of adsorbent textural and functional properties on model naphthenic acid adsorption

Journal of Environmental Sciences 2025年第2期148卷 27-37页

作者： Tyler m.Roy Elmira Nazari Oliver K.L.Strong Paul R.Pede Andrew J.Vreugdenhil material Science Department of ChemistryTrent University1600 West BankPeterboroughOntario K9L 0G2Canada Carbonix 690 Mountain RdSuite 200Fort William First NationOntario P7J 1G8Canada

Naphthenic acids,NAs,are a major contaminant of concern and a focus of much research around remediation of oil sand process affected waters,*** activated carbon adsorbents are an attractive option given their low cost of fabrication and implementation.A deeper evaluation of the effect NA structural differences have on uptake affinity is *** we provide an in-depth exploration of NA adsorption including many more model NA species than have been assessed previously with evaluation of adsorption kinetics and isotherms at the relevant alkaline pH of OSPW using several different carbon adsorbents with pH buffering to simulate the behaviour of real *** for the NA varied considerably regardless of the activated carbon used,ranging from 350 mg/g to near zero highlighting recalcitrant *** equilibrium data was explored to identify structural features of these species and key physiochemical properties that influence *** found that certainNAwill be resistant to adsorptionwhen hydrophobic adsorbents are *** isotherm modelling helped explore interactions occurring at the interface between NA and adsorbent *** identified the importance of NA hydrophobicity for activated carbon *** is also presented that indicates favorable hydrogen bonding between certain NA and surface site hydroxyl groups,demonstrating the importance of adsorbent surface functionality for NA *** research highlights the challenges associated with removing NAs from OSPW through adsorption and also identifies howadsorbent surface chemistry modification can be used to increase the removal efficiency of recalcitrant NA species.

关键词： Adsorption Activated carbon model naphthenic acids Isotherm modelling

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The formation,development and classification of rail corrugation:a survey on Chinese metro

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Railway Engineering Science 2025年第1期33卷 43-61页

作者： Yang Wang Hong Xiao Zhihai Zhang Xuhao Cui Yihao Chi mahantesh m.Nadakatti School of Civil Engineering Beijing Jiaotong UniversityBeijing 100044China Beijing Key Laboratory of Track Engineering Beijing Jiaotong UniversityBeijing 100044China Faculty of Architecture Civil and Transportation EngineeringBeijing University of TechnologyBeijing 100124China Department of mechanical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

Investigations into rail corrugation within metro systems have traditionally focused on specific mechanisms,thereby limiting the generalizability of proposed *** the commonalities in rail corrugation across diverse metro lines remains pivotal for elucidating its underlying *** present study conducted extensive field surveys and tracking tests across 14 Chinese metro *** employing t-distributed stochastic neighbor embedding(t-SNE)for dimensional reduction and employing the unsupervised clustering algorithm DBSCAN,the research redefines the classification of metro rail corrugation based on characteristic *** analysis encompassed spatial distribution and temporal evolution of this *** revealed that floating slab tracks exhibited the highest proportion of rail corrugation at 47%.Notably,ordinary monolithic bed tracks employing damping fasteners were more prone to inducing rail *** primarily manifested in curve sections with radii between 300 and 500 m,featuring ordinary monolithic bed track and steel-spring floating slab track structures,with wavelengths typically between 30 and 120 ***–slip vibrations of the wheel–rail system maybe led to short-wavelength corrugations(40–60 mm),while longer wavelengths(200–300 mm)exhibited distinct fatigue damage characteristics,mainly observed in steel-spring floating slab tracks and small-radius curve sections of ordinary monolithic bed tracks and ladder sleeper tracks.A classification system comprising 57 correlated features categorized metro rail corrugation into four distinct *** research outcomes serve as critical benchmarks for validating various theories pertaining to rail corrugation formation.

关键词： metro Rail corrugation Formation mechanism Development law Field test

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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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Efficacy of antimicrobials in preventing resistance in solid organ transplant recipients:A systematic review of clinical trials

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World Journal of Transplantation 2025年第1期15卷 156-164页

作者： Carlos m Ardila Pradeep K Yadalam Jaime Ramírez-Arbelaez Department of Basic Sciences Faculty of Dentistry Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia Department of Postdoctoral Program CIFE University CenterCuernavaca 62330MorelosMexico Department of Periodontics Saveetha Dental CollegeSaveetha Institute of Medical and HealthSIMATSSaveetha UniversityChennai 600077Tamil NaduIndia Department of Transplantation Hospital San Vicente FundaciónRionegro 054047Colombia

BACKGROUND In the absence of effective antimicrobials,transplant surgery is not viable,and antirejection immunosuppressants cannot be administered,as resistant infections compromise the life-saving goal of organ *** To evaluate the efficacy of antimicrobials in preventing resistance in solid organ transplant *** A systematic review was conducted using a search methodology consistent with the preferred reporting items for systematic reviews and *** review included randomized clinical trials that evaluated the efficacy of antimicrobial agents(prophylactic or therapeutic)aimed at preventing antimicrobial *** search strategy involved analyzing multiple databases,including Pubmed/mEDLINE,Web of Science,Embase,Scopus,and SciELO,as well as examining gray literature sources on Google Scholar.A comprehensive electronic database search was conducted from the databases’inception until may 2024,with no language *** After the final phase of the eligibility assessment,this systematic review ultimate-ly included 7 articles.A total of 2318 patients were *** most studied microorganisms were cytomegalovirus,although vancomycinresistant enterococci,Clostridioides difficile,and multidrug-resistant Enterobacterales were also *** antimicrobials used in the interventions were mainly maribavir,valganciclovir,gancic-lovir,and *** concern,all clinical trials showed significant proportions of resistant microorga-nisms after the interventions,with no statistically significant differences between the groups(mean resistance 13.47%vs 14.39%),except for two studies that demonstrated greater efficacy of maribavir and valganciclovir(mean resistance 22.2%vs 41.1%in the control group;Pmicrobial-resistant microor

关键词： Antimicrobial resistance Antimicrobials Antivirals Solid organ transplant recipients Infections microorganisms Cytomegalovirus

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A comprehensive review of phytochemical approaches in treatment of acute myeloid leukemia:Associated pathways and molecular mechanisms

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Chinese Herbal medicines 2025年第1期17卷 41-55页

作者： mouvanal Sajana T.S.Gopenath Basalingappa m.Kanthesh Division of molecular Biology School of Life SciencesJSS AHER Department of Biotechnology and Bioinformatics School of Life SciencesJSS AHER

Acute myeloid leukemia(AmL) is a type of cancer that affects the blood and bone *** review conducts a thorough analysis of AmL, addressing its genetic *** examination extends to the current therapeutic approaches employed for AmL,shedding light on their efficacy and the notable side effects experienced by patients undergoing these treatments,leading to a low overall survival ***,exploring alternative treatments,such as phytochemicals,is ***,the review explores the complex landscape of phytochemicals,categorizing them based on their diverse properties,which include alkaloids,phenols,terpenoids,organo-sulfur compounds,and other compounds,including quinones,and elucidating their mechanisms of *** emphasis is placed on their involvement in critical signaling pathways,with a particular focus on how these phytochemicals impact AmL when evaluated across a spectrum of cell *** in-depth exploration aims to uncover potential targets within the molecular landscape of AmL where phytochemicals can exert their therapeutic *** review investigates the potential role of plant-derived phytochemicals as adjunctive therapies for *** exploration encompasses the identification of specific phytochemicals that exhibit promising anti-leukemic properties and evaluates their potential in clinical *** conventional treatments,the review explores the integration of complementary and alternative medicine as a holistic approach to managing *** examination encompasses the synergy between conventional therapies and alternative interventions,exploring how these combined strategies may enhance overall therapeutic outcomes and mitigate side *** a forward-looking perspective,the overarching goal is to contribute to the evolving landscape of AmL treatment by considering innovative approaches that harness the therapeutic potential of phytochemicals,both independently and in conjunction with establishe

关键词： cell death complementary and alternative medicine leukemia phytochemicals signaling pathways therapeutic targets

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Longitudinal assessment of measured and estimated glomerular filtration-rate in autosomal dominant polycystic kidney disease:Real practice experience

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World Journal of Nephrology 2025年第1期14卷 99-109页

作者： Juan m Fernandez JoséC Rodriguez-Pérez m mercedes Lorenzo-medina Fancisco Rodriguez-Esparragon Juan C Quevedo-Reina Carmen R Hernandez-Socorro medical manager Southern Europe Baxter Healthcare Ltd.Madrid 28830Spain Escuela de Doctorado Universidad De Las Palmas De Gran CanariaLas Palmas 35001Canary IslandsSpain Department of Research Universidad Fernando Pessoa CanariasLas Palmas 35450Canary IslandsSpain Department of Clinical Chemistry Hospital Universitario De Gran Canaria Doctor NegrínLas Palmas 35010Canary IslandsSpain Department of Research Hospital Universitario De Gran Canaria Doctor NegrínLas Palmas 35010Canary IslandsSpain Department of Nephrology Hospital Universitario De Gran Canaria Doctor NegrínLas Palmas 35010Canary IslandsSpain Department of Radiology Hospital Universitario De Gran Canaria Doctor NegrínLas Palmas 35010Canary IslandsSpain

BACKGROUND Equations for estimation glomerular filtration rate(eGFR)have been associated with poor clinical performance and their clinical accuracy and reliability have been called into *** To assess the longitudinal changes in measured glomerular filtration rate(mGFR)in patients with autosomal dominant polycystic kidney disease(ADPKD).mETHODS Analysis of an ambispective data base conducted on consecutive patients diagnosed with *** mGFR was assessed by iohexol clearance;while eGFR was calculated by three different formulas:(1)The chronic kidney disease epidemiology collaboration(CKD-EPI);(2)modification of diet in renal disease(mDRD);and(3)The 24-hour urine creatinine clearance(CrCl).The primary end-points were the mean change in mGFR between the baseline and final visit,as well as the comparison of the mean change in mGFR with the change estimated by the different *** Thirty-seven patients were included in the *** compared to baseline,month-6 mGFR was significantly decrease by-4.4 mL/minute±10.3 mL/minute(P=0.0132).However,the CKD-EPI,mDRD,and CrCl formulas underestimated this change by 48.3%,89.0%,and 45.8%respectively,though none of these differences reached statistical significance(P=0.3647;P=0.0505;and P=0.736,respectively).The discrepancies between measured and estimated glomerular filtration rate values,as evaluated by CKD-EPI(r=0.29,P=0.086);mDRD(r=0.19,P=0.272);and CrCl(r=0.09,P=0.683),were not correlated with baseline mGFR *** This study indicated that eGFR inaccurately reflects the decline in mGFR and cannot reliably track changes over *** poses significant challenges for clinical decision-making,particularly in treatment strategies.

关键词： Autosomal dominant polycystic kidney disease Glomerular filtration rate End-stage kidney disease Iohexol Chronic kidney disease epidemiology collaboration modification of diet in renal disease

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Hunting for a viral proxy in bioaerosols of swine buildings using molecular detection and metagenomics

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Journal of Environmental Sciences 2025年第2期148卷 69-78页

作者： Valérie Létourneau marie-Josée Gagné Jonathan m.Vyskocil Vincent Brochu Kim Robitaille martin Gauthier Julie Brassard Caroline Duchaine Quebec Heart and Lung Institute Research Centre-UniversitéLaval 2725 Chemin Sainte-FoyQuebecG1V 4G5Canada Saint-Hyacinthe Research and Development Centre Agriculture and Agri-Food Canada3600 Casavant Boulevard WestSaint-HyacintheJ2S 8E3Canada Department of Biochemistry Microbiologyand Bio-informaticsFaculty of Science and EngineeringUniversitéLaval1045 Avenue de la MédecineQuebecG1V 0A6Canada The Swine and Poultry Infectious Diseases Research Centre Faculty of Veterinary Medicine of Universitéde Montréal3200 Rue SicotteSaint-HyacintheJ2S 2M2Canada

There are limited biosecurity measures directed at preventing airborne transmission of viruses in *** effectiveness of dust mitigation strategies such as oil sprinkling,to decrease risk of airborne virus transmission are *** and qPCR for common fecal viruses were used to hunt for a ubiquitous virus to serve as a proxy when evaluating the efficiency of mitigation strategies against airborne viral infectious *** particles were collected from swine buildings using high-volume air *** DNA and RNA were used to perform specific RT-qPCR and qPCR and analyzed by highthroughput *** astroviruses group 2 were common(from 102 to 105 genomic copies per cubic meter of air or gc/m^(3),93%positivity)while no norovirus genogroup II was recovered from air *** torque teno sus virus were detected by qPCR in low concentrations(from 101 to 102 gc/m^(3),47%positivity).Among the identified viral families by metagenomics analysis,Herelleviridae,microviridae,myoviridae,Podoviridae,and Siphoviridae were *** phage vB_Avim_AVP of Aerococcus was present in all air samples and a newly designed qPCR revealed between 101 and 105 gc/m^(3) among the samples taken for the present study(97%positivity)and banked samples from5-and 15-year old studies(89%positivity).According to the present study,both the porcine astrovirus group 2 and the phage vB_Avim_AVP of Aerococcus could be proxy for airborne viruses of swine buildings.

关键词： Bioaerosols Viral metagenomics Astrovirus Aerococcus phage Swine buildings

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Hybrid and enhanced electrokinetic system for soil remediation from heavy metals and organic matter

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Journal of Environmental Sciences 2025年第1期147卷 424-450页

作者： Faris m.Hamdi Namuun Ganbat Ali Altaee Akshaya K.Samal Ibrar Ibrar John L.Zhou Adel O.Sharif Centre for Green Technology School of Civil and Environmental EngineeringThe University of Technology Sydney15 BroadwayNSW 2007Australia Department of Civil Engineering Jazan UniversityJazan 82822Saudi Arabia Centre for Nano and material Sciences Jain UniversityRamanagaraBangaloreKarnataka 562112India School of mechanical Sciences Faculty of Engineering and Physical SciencesUniversity of SurreyAustralia

The electrokinetic(EK)process has been proposed for soil decontamination from heavy metals and organic *** advantages of the EK process include the low operating energy,suitability for fine-grained soil decontamination,and no need for *** the last three decades,enhanced and hybrid EK systems were developed and tested for improving the efficiency of contaminants removal from *** enhanced-EK processes exhibited excellent efficiency in removing contaminants by controlling the soil pH or the chemical reaction of *** hybrid systems were tested to overcome environmental hurdles or technical drawbacks of decontamination *** of the EK process with phytoremediation,bioremediation,or reactive filtermedia(RFm)improved the remediation process performance by capturing contaminants or facilitating biological agents’movement in the ***,EK process coupling with solar energy was proposed to treat off-grid contaminated soils or reduce the EK energy *** study reviews recent advancements in the enhancement and hybrid EK systems for soil remediation and the type of contaminants targeted by the *** study also covered the impact of operating parameters,imperfect pollution separation,and differences in the physicochemical characteristics and microstructure of soil/sediment on the EK ***,a comparison between various remediation processes was presented to highlight the pros and cons of these technologies.

关键词： Electrokinetic Soil remediation Reactive filter media Enhanced electrokinetic Contaminants

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Advancing healthcare through laboratory on a chip technology:Transforming microorganism identification and diagnostics

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World Journal of Clinical Cases 2025年第3期13卷 9-19页

作者： Carlos m Ardila Department of Basic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a recent case report in the World Journal of Clinical Cases,emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment ***-on-a-chip(LOC)technology has emerged as a transformative tool in health care,offering rapid,sensitive,and specific identification of *** editorial provides a comprehensive overview of LOC technology,highlighting its principles,advantages,applications,challenges,and future *** studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics,epidemiology,and food *** studies have underscored the superiority of LOC technology over traditional methods,showcasing improvements in speed,accuracy,and *** future integration of LOC with biosensors,artificial intelligence,and data analytics promises further innovation and *** call to action emphasizes the importance of continued research,investment,and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.

关键词： Laboratory-on-a-chip microorganism identification Diagnostics Point-ofcare testing Biosensors

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LOBO Optimization-Tuned Deep-Convolutional Neural Network for Brain Tumor Classification Approach

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Journal of Shanghai Jiaotong university(Science) 2025年第1期30卷 107-114页

作者： A.Sahaya Anselin Nisha NARmADHA R. AmIRTHALAKSHmIT.m. BALAmURUGAN V. VEDANARAYANAN V. School of Electrical and Electronics Sathyabama Institute of Science and TechnologyChennaiTamil Nadu600119India Department of Electronics and Communication Engineering SRM Institute of Science and TechnologyRamapuram CampusChennaiTamil Nadu600089India

The categorization of brain tumors is a significant issue for healthcare *** and timely identification of brain tumors is important for employing an effective treatment of this *** tumors possess high changes in terms of size,shape,and amount,and hence the classification process acts as a more difficult research *** paper suggests a deep learning model using the magnetic resonance imaging technique that overcomes the limitations associated with the existing classification *** effectiveness of the suggested method depends on the coyote optimization algorithm,also known as the LOBO algorithm,which optimizes the weights of the deep-convolutional neural network *** accuracy,sensitivity,and specificity indices,which are obtained to be 92.40%,94.15%,and 91.92%,respectively,are used to validate the effectiveness of the suggested *** result suggests that the suggested strategy is superior for effectively classifying brain tumors.

关键词： brain tumor magnetic resonance imaging deep learning deep-convolutional neural network classifier LOBO optimization

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