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Control of disability glare by means of electrochromic filtering glasses:A pilot study

Journal of Innovative Optical Health Sciences 2017年第1期10卷 11-20页

作者： Rosa maria coco-martín Ruben Cuadrado-Asensio Ceesar Vega-Colado Ricardo Vergaz Jose m.Sanchez-Pena Ana Viñuales Sergi Peris Pau Artús m.begona coco-martín IOBA Universidad de ValladolidValladolidSpain GDAF-UC3m Grupo de Displays y Aplicaciones Fotonicas Department de Tecnologia Electronica Universidad Carlos III de MadridSpain IK4-CIDETEC Parque Tecnologico de San Sebastian GuipuzcoaSpain Indo Optical Group Departamento I+D SantCugat del Valles BarcelonaSpain GIDFYS European University Miguel de Cervantes(UEMC)Department of HealthSciencesSpain

Purpose:To evaluate the potential clinical usability of a new prototype of ophthalmic blue light filters developed by using electrochromic technology in pseudophakic patients complaining of ***:A prototype of electrochromic device was developed,with a specific frame that enclosed an electronic driver that allowed personalizing its function for each patient.A pro-spective,observational case series study was performed to test *** patients who had un-dergone cataract surgery with clear intraocular lenses and complaining of glare were included in the *** outcome measures were the results obtained in the satisfaction questionnaire that was delivered to ***,visual acuity,contrast sensitivity,and reading ability data were evaluated with and without the prototype under diferent lighting conditions and different modes of the prototype after a complete month of *** transmittance was also ***:Visual acuity,contrast sensitivity and reading function did not change significantly with prototype *** main activity for which the prototype was used was *** one patient found that the dimming level was *** patients reported variable discomfort when passing tunnels,not sufficiently clear indoors,or put on and remove *** lenses slightly decreased their transmittance at the end of the ***:Glasses based on elect rochromic technology may be acceptable for outdoor/indoor use and for distance-near *** studies with larger samples must be conducted to confirm the clinical usability of these glasses.

关键词： Optical filters electro-optical devices technical visual aids electronic control.

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Intravitreal stem cell paracrine properties as a potential neuroprotective therapy for retinal photoreceptor neurodegenerative diseases

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neural Regeneration Research 2020年第9期15卷 1631-1638页

作者： Kevin Puertas-neyra Ricardo Usategui-martín Rosa mcoco Ivan Fernandez-Bueno Instituto Universitario de Oftalmobiologia Aplicada Universidad de ValladolidValladolidSpain Centro en Red de medicina Regenerativa y Terapia Celular de Castilla y Leon ValladolidSpain Red Tematica de Investigacion Cooperativa en Salud OftaredInstituto de Salud CarlosⅢValladolidSpain

Retinal degenerations are the leading causes of irreversible visual loss worldwide. many pathologies included under this umbrella involve progressive degeneration and ultimate loss of the photoreceptor cells, with age-related macular degeneration and inherited and ischemic retinal diseases the most relevant. These diseases greatly impact patients' daily lives, with accompanying marked social and economic consequences. However, the currently available treatments only delay the onset or slow progression of visual impairment, and there are no cures for these photoreceptor diseases. Therefore, new therapeutic strategies are being investigated, such as gene therapy, optogenetics, cell replacement, or cell-based neuroprotection. Specifically, stem cells can secrete neurotrophic, immunomodulatory, and anti-angiogenic factors that potentially protect and preserve retinal cells from neurodegeneration. Further, neuroprotection can be used in different types of retinal degenerative diseases and at different disease stages, unlike other potential therapies. This review summarizes stem cell-based paracrine neuroprotective strategies for photoreceptor degeneration, which are under study in clinical trials, and the latest preclinical studies. Effective retinal neuroprotection could be the next frontier in photoreceptor diseases, and the development of novel neuroprotective strategies will address the unmet therapeutic needs.

关键词： clinical trials growth factors intraocular injection intravitreal injection neuroprotection paracrine properties photoreceptors preclinical models retinal diseases stem cells

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Potential of video games for the promotion of neuroadaptation to multifocal intraocular lenses: a narrative review

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International Journal of Ophthalmology(English edition) 2019年第11期12卷 1782-1787页

作者： maria begona coco-martin Pedro LValenzuela miguel Jmaldonado-López Alejandro Santos-Lozano Ainhoa molina-martin David P Pinero Research Unit Hospital Clínico Universitario de Valladolid.ICSCYLValladolid 47003Spain Grupo de Cirugía Refractivay Rehabilitación Visual.Instituto Universitario de Oftalmobiología Aplicada(IOBA) Universidad de ValladolidValladolid 47011Spain Physiology Unit Systems Biology DepartmentUniversity of AlcaláMadrid 28801Spain Grupo de Investigación i+Health Departamento de Ciencias de la SaludUniversidad Europea Miguel de CervantesValladolid 47012Spain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicante 03690Spain Department of Ophthalmology(ImQO-Oftalmar) Vithas Medimar International HospitalAlicante 03016Spain

multifocal intraocular lenses(IOLs) are currently usually implanted for the treatment of cataracts because they have been proved to be superior to monofocal IOLs with respect to spectacle independence. In turn, they are associated with a higher prevalence of dysphotopsia symptoms that is one of the most common causes of patient dissatisfaction. neuroadaptation seems to play a major role in the optimal adaptation to multifocal IOLs. In this context, the development of strategies that facilitate the neuroadaptation process to multifocality might be an effective strategy to reduce patients' dissatisfaction. Video games have been proved to be effective for the improvement of visual acuity and for the promotion of neuroplasticity in elderly subjects and other populations with cortical-related visual impairment. This narrative review highlights the physiological potential of video games as a perceptual strategy to improve visual acuity and promote neuroplasticity in patients using multifocalIOLs, although research is still needed to confirm these benefits in this specific population, with only one comparative study to this date providing evidence of them.

关键词： multifocal intraocular lens dysphotopsia photic phenomena halos video games neuroadaptation neuroplasticity

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Interferon-free treatments in patients with hepatitis C genotype 1-4 infections in a real-world setting

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第2期8卷 137-146页

作者： Huascar Ramos Pedro Linares Ester Badia Isabel martín Judith Gómez Carolina Almohalla Francisco Jorquera Sara Calvo Isidro García Pilar Conde begona álvarez Guillermo Karpman Sara Lorenzo Visitación Gozalo mónica Vásquez Diana Joao marina de Benito Lourdes Ruiz Felipe Jiménez Federico Sáez-Royuela 无 Department of Gastroenterology and Hepatology Hospital Universitario de Burgos Department of Gastroenterology and Hepatology Complejo Asistencial Universitario de León Department of Gastroenterology and Hepatology Hospital Universitario de Salamanca Department of Hepatology Hospital Universitario Rio Hortega CIBERehd IBIOmED Fundación Burgos por la Investigación de la Salud Hospital Universitario de Burgos Department of Gastroenterology and Hepatology Complejo Asistencial de Palencia Department of Gastroenterology and Hepatology Complejo Asistencial de Zamora Department of Gastroenterology and Hepatology Hospital El Bierzo Department of Gastroenterology and Hepatology Hospital Clínico Universitario de Valladolid Department of Gastroenterology and Hepatology Hospital Santos Reyes Asociación Castellano y Leonesa de Hepatología(ACyLHE)

AIm To investigated the real-world effectiveness and safety of various regimens of interferon-free treatments in patients infected with hepatitis C virus(HCV).mETHODS We performed an observational study to analyze different antiviral treatments administered to 462 HCV-infected patients, of which 56.7% had liver cirrhosis. HCV RnA after 4 wk of treatment and at 12 wk after treatment sustained virologic response(SVR) as well as serious adverse events(SAEs) was analyzed first for the whole cohort and then separately in patients who met or did not meet the inclusion criteria of a clinical trial(CT-met and CT-unmet, respectively).RESULTS The most frequently prescribed treatment was simeprevir/sofosbuvir(36.4%), followed by sofosbuvir/ledipasvir(24.9%) and ombitasvir/paritaprevir/ritonavir(r)/dasabuvir(19.9%). Ribavirin(RBV) was administered in 198 patients(42.9%). SVRs occurred in 437/462 patients(94.6%). The SVRs ranged between 93.3% and 100% for genotypes 1-4. SVRs were achieved in 96.2% patients in the CTmet group vs 91.9% patients in the CT-unmet group(P = 0.049). Undetectable HCV RnA at week 4 occurred in 72.9% of the patients. In the univariate analysis, the factors associated with SVRs were lower liver stiffness, absence of cirrhosis, higher platelet count, higher albumin levels, no RBV dose reduction, undetectable HCV RnA at week 4 and CT-met group. In the multivariate analysis, only albumin was an independent predictor of treatment failure(P = 0.04). Eleven patients(2.4%) developed SAEs; 5.2% and 0.7% of the patients in the CT-unmet and CT-met groups, respectively(P = 0.003).COnCLUSIOn A high proportion of patients with HCV infection achieved SVRs. For patients who did not meet the CT criteria, treatment regimens must be optimized.

关键词： Hepatitis C virus infection Genotype 1-4 Real world treatment Direct-acting antiviral agents

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