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High-grade pancreatic intraepithelial lesions： prevalence and implications in pancreatic neoplasia

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Hepatobiliary & Pancreatic Diseases International 2017年第2期16卷 202-208页

作者： Jean R Park Feng Li Veeral m Oza Brett C Sklaw Kevin m Cronley michael Wellner Benjamin Swanson Somashekar G krishna Division of Hospital medicine The Ohio State University Wexner Medical Center Columbus Ohio USA Division of Gastroenterology Hepatology and Nutrition The Ohio State University Wexner Medical Center Columbus Ohio USA Department of Pathology The Ohio State University Wexner Medical Center Columbus Ohio USA

BACKGROUND： High-grade pancreatic intraepithelial neoplasia（Pan IN-3）, a precursor of pancreatic ductal adenocarcinoma（PDAC）, is not universally detected in resected pancreatic neoplasms. We sought to determine the prevalence and prognostic relevance of Pan IN-3 lesions in primary surgical resections of PDACs and intraductal papillary mucinous neoplasms（IPmNs）.mETHODS： A retrospective review of a tertiary care center pathology database（1/2000-6/2014） was performed. Demographics, imaging, pathology, disease-recurrence, and survival data were ***： A total of 458 patients who underwent primary pancreatic resection were included. “Pan IN-3” lesions were found in 74（16.2%） patients who either had PDAC（n=67） or main duct（mD）-IPmN（n=7）. Among IPmN-mDs, Pan IN-3 lesions were exclusively found in those with pathological evidence of chronic pancreatitis. For PDACs, the median overall survival（OS） for pancreata with Pan IN-3 lesions was significantly better than those without（OS 1.12 years, interquartile range [IQR] 0.72, 2.05 years vs OS 0.86 years, IQR 0.64,1.60 years respectively; P=0.04）. multivariate Cox regression analysis demonstrated that the presence of Pan IN-3 lesions was associated with a reduced risk of death（HR=0.43; 95% CI： 0.23-0.82; P=0.01）.CONCLUSIONS： Following primary resection of pancreatic adenocarcinoma, the lower survival observed in patients without Pan IN-3 lesions might suggest a state of complete or accelerated transformation. Further investigations are necessary to validate these findings that might impact disease prognosis and management.

关键词： pancreatic intraepithelial neoplasia intraductal papillary mucinous neoplasms pancreatic neoplasia pancreatic ductal adenocarcinoma

The theory of pathological simile:unveiling the essence of homoeopathy

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History & Philosophy of medicine 2024年第1期6卷 1-2页

作者： Sibin Ramabhadran Anandavally Sruthi krishna Gopukumar Sivakumar Thangam Nivedha krishnamoorthy Sajitha Kumari Department of Organon of medicine Sarada Krishna Homoeopathic Medical College(Affiliated to The Tamil Nadu Dr.M.G.R.Medical UniversityChennai)Tamilnadu 629161India Department of Repertory Sarada Krishna Homoeopathic Medical College(Affiliated to The Tamil Nadu Dr.M.G.R.Medical UniversityChennai)Tamilnadu 629161India Research Facilitation Centre Sarada Krishna Homoeopathic Medical College(Affiliated to The Tamil Nadu Dr.M.G.R.Medical UniversityChennai)Tamilnadu 629161India

Background Homoeopathy,a therapeutic method based on the principle of‘Similia Similibus Curentur’(like cures like),has been widely practiced and studied since its discovery by *** Hahnemann in the late 18th *** time,numerous homoeopathic stalwarts have contributed to the development and understanding of this system of *** Hughes,a remarkable figure in the field of homoeopathy,has left an indelible mark on the development and understanding of this extraordinary system of medicine.

关键词： simile has since

Nonlinear Thermal Buoyancy on Ferromagnetic Liquid Stream Over a Radiated Elastic Surface with Non Fourier Heat Flux

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Computer modeling in Engineering & Sciences 2021年第2期126卷 599-616页

作者： T.K.Sreelakshmi Abraham Annamma A.S.Chethan m.krishna murthy C.S.K.Raju Department of mathematics BMS Institute of Technology and ManagementBengaluru560064India Department of mathematics School of Applied SciencesREVA UniversityBengaluru560064India Department of mathematics GITAM School of ScienceGITAM Deemed to be UniversityBengaluru562163India

The current article discusses the heat transfer characteristics of ferromagnetic liquid over an elastic surface with the thermal radiation and non-Fourier heat *** most of the existing studies,the heat flux is considered as constant,but whereas we incorporated the non-Fourier flux to get the exact performance of the ***,we excluded the PWT and PHF cases to control the boundary layer of the *** governing equations related to our contemplate are changed into non-linear ordinary differential equations(ODE’s)by utilizing appropriate similarity changes,which are at the point enlightened by Runge–Kutta based shooting *** equations are broken down concerning boundary conditions and to be explained prescribed wall temperature(PWT)and prescribed heat flux(PHF)*** impacts of diverse non-dimensional physical parameters on velocity and temperature profiles are laid out ***,the assortment of skin friction and local Nusselt number for both PWT and PHF cases for various assessments of non-dimensional parameters have been sorted *** the wrap-up of the examination,we suspect that the friction factor coefficient is higher in the PWT case compared to the PHF *** result helps to conclude that the flux conditions are useful for cooling applications.

关键词： Ferromagnetic liquid nonlinear thermal buoyancy non-Fourier heat flux radiated elastic surface

Influence of material models on theoretical forming limit diagram prediction for Ti-6Al-4V alloy under warm condition

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Transactions of Nonferrous metals Society of China 2016年第3期26卷 736-746页

作者： Nitin KOTKUNDE Sashank SRINIVASAN Geetha krishna Amit Kumar GUPTA Swadesh Kumar SINGH Department of mechanical Engineering Birla Institute of Technology and Science-PilaniHyderabad CampusHyderabad 500078TelanganaIndia Department of mechanical Engineering Gokaraju Rangaraju Institute of Engineering and TechnologyHyderabad 500072TelanganaIndia

Forming limit diagram (FLD) is an important performance index to describe the maximum limit of principal strains that can be sustained by sheet metals till to the onset of localized necking. It offers a convenient and useful tool to predict the forming limit in the sheet metal forming processes. In the present study, FLD has been determined experimentally for Ti?6Al?4V alloy at 400 °C by conducting a Nakazima test with specimens of different widths. Additionally, for theoretical FLD prediction, various anisotropic yield criteria (Barlat 1989, Barlat 1996, Hill 1993) and different hardening models viz., Hollomon power law (HPL), Johnson?Cook (JC), modified Zerilli–Armstrong (m-ZA), modified Arrhenius (m-Arr) models have been developed. Theoretical FLDs have been determined using marciniak and Kuczynski (m?K) theory incorporating the developed yield criteria and constitutive models. It has been observed that the effect of yield model is more pronounced than the effect of constitutive model for theoretical FLDs prediction. However, the value of thickness imperfection factor (f0) is solely dependent on hardening model. Hill (1993) yield criterion is best suited for FLD prediction in the right hand side region. moreover, Barlat (1989) yield criterion is best suited for FLD prediction in left hand side region. Therefore, the proposed hybrid FLD in combination with Barlat (1989) and Hill (1993) yield models with m-Arr hardening model is in the best agreement with experimental FLD.

关键词： Ti-6Al-4V alloy yield criteria hardening model marciniak and Kuczynski theory forming limit diagram

How does the stand structure of treeline-forming species shape the treeline ecotone in different regions of the Nepal Himalayas?

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Journal of mountain Science 2020年第10期17卷 2354-2368页

作者： Parveen K.CHHETRI Raju BISTA krishna B.SHRESTHA Department of Earth Science and Geography California State UniversityDominguez HillsCarsonCalifornia90747USA Department of Biological Sciences University of BergenPO Box 7803N-5020BergenNorway

Stand structure dynamics are considered as major happenings in any forest as a response to environmental ***,this important topic is underrepresented in the treeline studies in the Nepal *** aimed to investigate site-as well as species-specific changes in morphometric features(basal diameter,crown cover,density,and height)along the elevational gradient across treeline ecotones in response to recent environmental *** stand structure characteristics of Abies spectabilis,Pinus wallichiana,and Betula utilis across the treeline ecotone of three study sites in Eastern(Barun),Central(manang),and Western(Dhorpatan)Nepal were analyzed to elucidate structural ***,eight transects(20 m×(60–250 m))across the treeline ecotone were *** of all life forms,trees(>2 m),saplings(0.5–2 m),and seedlings(m),within each transect were enumerated and sampled for the morphometric features and ***-specific and species-specific stand structure dynamics were *** rate of basal area increment was higher in Barun,but the manang treeline,despite profound regeneration in recent years,had a low annual basal area ***,the altitudinal distribution of age and morphometry were not consistent among those ***,intra-specific competition was not *** site-specific stand structure dynamics explain why treelines do not respond uniformly to increasing *** invokes,in further studies,the incorporation of the tree’s morphometric adaptation traits,phenotypic plasticity,and interactions between species genotype and the environment.

关键词： Climate change morphometry Nepal Himalayas Stand structure Treeline Tree-rings

A matched-pair analysis of laparoscopic versus open pancreaticoduodenectomy: oncological outcomes using Leeds Pathology Protocol

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Hepatobiliary & Pancreatic Diseases International 2014年第4期13卷 435-441页

作者： Abdul R Hakeem Caroline S Verbeke Alison Cairns Amer Aldouri Andrew m Smith krishna V menon Department of HPB and Transplant Surgery St James's University Hospital NHS TrustLeeds Teaching Hospitals Beckett street Leeds LS9 7TF United Kingdom Division of Pathology Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden Department of Histopathology St James's University Hospital NHS TrustLeeds Teaching Hospitals Beckett street Leeds LS9 7TF United Kingdom

BACKGROUND： Laparoscopic pancreaticoduodenectomy（LPD）is a safe procedure. Oncological safety of LPD is still a matter for debate. This study aimed to compare the oncological outcomes,in terms of adequacy of resection and recurrence rate following LPD and open pancreaticoduodenectomy（OPD）.mETHODS： Between November 2005 and April 2009, 12LPDs（9 ampullary and 3 distal common bile duct tumors）were performed. A cohort of 12 OPDs were matched for age,gender, body mass index（BmI） and American Society of Anesthesiologists（ASA） score and tumor ***： mean tumor size LPD vs OPD（19.8 vs 19.2 mm,P=0.870）. R0 resection was achieved in 9 LPD vs 8 OPD（P=1.000）. The mean number of metastatic lymph nodes and total number resected for LPD vs OPD were 1.1 vs 2.1（P=0.140）and 20.7 vs 18.5（P=0.534） respectively. Clavien complications grade I/II（5 vs 8）, III/IV（2 vs 6） and pancreatic leak（2 vs 1）were statistically not significant（LPD vs OPD）. The mean high dependency unit（HDU） stay was longer in OPD（3.7 vs 1.4 days,P〈0.001）. There were 2 recurrences each in LPD and OPD（logrank,P=0.983）. Overall mortality for LPD vs OPD was 3 vs 6（log-rank, P=0.283） and recurrence-related mortality was 2 vs *** was one death within 30 days in the OPD group secondary to severe sepsis and none in the LPD ***： Compared to open procedure, LPD achieved a similar rate of R0 resection, lymph node harvest and longterm recurrence for tumors less than 2 cm. Though technically challenging, LPD is safe and does not compromise oncological outcome.

关键词： pancreaticoduodenectomy minimally invasive laparoscopic open oncological outcomes resection margins pathology

Gorkha earthquake (mW7.8) and aftershock sequence: A fractal approach

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Earthquake Science 2022年第3期35卷 193-204页

作者： Ram krishna Tiwari Harihar Paudyal Central Department of Physics Tribhuvan UniversityKirtipurKathmandu 44618Nepal Birendra multiple Campus Tribhuvan UniversityBharatpurChitwan 44200Nepal

On April 25, 2015, Nepal was struck by the mW7.8 Gorkha earthquake followed by an intense aftershock sequence. It was one of the most destructive earthquakes in the Himalayan arc, causing more than 8900 fatalities. In this study, we analyzed the dataset (429 events, magnitude of completeness (mc) ≥ 4.2 local magnitude) of the first 45 days after the Gorkha earthquake to estimate the seismicity parameters b-value, D-value, and p-value. We used the maximum likelihood method to estimate the b-value and Omori-Utsu parameters, whereas the correlation integral method was applied to estimate the fractal dimension (D-value). The analysis was carried out using running and sliding window techniques. The lowest b-value (0.57 ± 0.04) and the highest D-value (1.65 ± 0.02) were computed at the time of the Gorkha earthquake, after which the b-value significantly increased to a maximum of 1.57. It again dropped to 0.93 at the time of the major aftershock on may 12, 2015. The D-value showed an initial quick drop and then decreased in a wavy pattern until the end of the study period, indicating the clustering and scattering of earthquakes in a fault region. The b-value contour map identified the eastern part of the study area as a high stress region (b = ~0.8), implying that the stress shifted to that region. The D-value contour map reveals that the seismogenic structure shifted from linear to planar in the region. The rate of aftershock decay (p = 0.86 ± 0.04) for a short period reflects that the level of stress decreased rapidly. This study helps to understand the level of stress and seismicity pattern of a region, which could be useful for aftershock studies.

关键词： Omori-Utsu law correlation integral fractal dimension b-value central Himalaya

Dual-selective detection of CO and CH_(4) based on hierarchical porous In_(2)O_(3) nanoflowers with Pd modification

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Journal of materiomics 2022年第3期8卷 545-555页

作者： Liuyang Han Saisai Zhang Bo Zhang Bowen Zhang Yan Wang Hari bala Zhanying Zhang School of materials Science and Engineering Cultivating Base for Key Laboratory of Environment-friendly Inorganic Materials in University of Henan ProvinceHenan Polytechnic UniversityJiaozuo454000China State Key Laboratory Cultivation Bases for Gas Geology and Gas Control(Henan Polytechnic University) Jiaozuo454000China

The timely and effective detection of CO and CH_(4) is critical as the explosion and poisoning of them can bring serious potential risks to coal *** this study,combining metal oxide semiconductors with noble metals offers a promising route to achieve this *** porous Pd modified In_(2)O_(3) nanoflowers were prepared via two-step hydrothermal method and exhibited dual detection of CO and CH_(4) at different *** material has been characterized by a number of advanced techniques and the results indicate that Pd modified In_(2)O_(3) are hierarchical porous nanoflowers structure consisting of pores of approximately 1.8 nm in *** sensing properties results show that the Pd modified In_(2)O_(3) based sensor exhibits temperature-dependent dual selectivity detection of CO at 280℃ and CH_(4) at 340℃.In addition,the Pd modified In_(2)O_(3) sensor display higher sensing response of CO(5.824 for 100 ppm)and CH_(4)(1.162 for 1000 ppm),fast response and recovery time,as well as good repeatability,which demonstrating the great potential for practical *** good gas-sensing performance are mainly attributed to the unique flower-like structure,the presence of porosity on the sample surface,and the catalytic effect of Pd.

关键词： Hierarchical porous structure Pd/In_(2)O_(3)nanoflowers Gas sensor Dual selectivity CO and CH_(4)

Geochemical modelling of Fluoride Concentration in Hard Rock Terrain of madhya Pradesh, India

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Acta Geologica Sinica(English Edition) 2013年第5期87卷 1421-1433页

作者： Jay krishna THAKUR Prafull SINGH Sudhir Kumar SINGH Bijendra BHAGHEL Thakur International & Investment (P) Ltd. Amity Institute of Geo-Informatics and Remote Sensing (AIGIRS) Amity University K.Banerjee Centre of Atmospheric and Ocean Studies IIDS University of Allahabad Department of Earth Sciences Barkatullah University

The aim of the present study is to locate and decipher the groundwater quality, types, and hydrogeochemicai reactions, which are responsible for elevated concentration of fluoride in the Chhindwara district in madhya Pradesh, India. Groundwater samples, quality data and other ancillary information were collected for 26 villages in the Chhindwara District, m.P. India during may 2006. The saturation index was computed for the selected samples in the region, which suggest that generally most of the minerals are saturated with respect to water. The concentration of fluoride in the region varies from 0.6 to 4.74 rag/l, which is much higher as per the national and international water quality standards. The study also reveals that the fluoride bearing rock formations are the main source of the higher concentration of fluoride in groundwater along with the conjuncture of land use change. moreover, the area is a hard rock terrain and consists of fractured granites and amygdaloidal and highly jointed compact basalt acting as good aquifer, which is probably enriching the high content of fluoride in groundwater. High concentration of fluoride is found in deeper level of groundwater and it is possible due to rock-water interaction, which requires further detailed investigation. The highly alkaline conditions indicate fluorite dissolution, which works as a major process for higher concentration of fluoride in the study area. The results of this study will ultimately help in the identification of risk areas and taking measures to mitigate negative impacts related to fluoride pollution and toxicity.

关键词： Fluoride rock-water interaction saturation index madhya Pradesh India