检索结果-南通市图书馆

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Bentonite,Hydrogel and Biochar Amendments on Soil Hydraulic Properties from Saturation to Oven Dryness

引用

Pedosphere 2019年第5期29卷 598-607页

作者： Osama m0HAWESH Wolfgang DURNER Department of Plant Production Faculty of AgricultureMutah UniversityKarak 61710 (Jordan) Division of Environmental Science and Technology Graduate School of AgricultureKyoto UniversityKyoto 6110011 (Japan) Institute of Geoecology Technical University of BraunschweigLanger Kamp 19cBraunschweig 38106 (Germany)

Effects of hydrogel, bentonite, and biochar as soil amendments on soil hydraulic properties and improving water availability from saturation to oven dryness were investigated. Soils were mixed with hydrogel (0.10%, 0.25%, and 0.50%), bentonite (0.5%, 1.0%, and 2.5%), and biochar (1.0%, 2.5%, and 5.0%) as soil amendments (weight:weight). Three methods (extended multistep outflow (XmSO), evaporation (EVA), and WP4 dewpoint potentiometer) were used to measure soil hydraulic properties from saturation to oven dryness. The cumulative XmSO results were more uniform across all the applied pressure steps for the amended soils. The EVA exhibited a shorter linear decrease during the first evaporation stage and a lower evaporation rate during the second evaporation stage. The WP4 results also exhibited that soil amendments increased the soil water content of the amended soils at low matric potentials. The results of soil water retention curves revealed that the unamended soil retained less water at any matric potential compared to the amended soils. Soil hydraulic conductivity decreased with increasing amount of soil amendments. The saturated hydraulic conductivity was higher for the unamended soil than the soils amended w计h 2.5% bentonite, 0.50% hydrogel, and 5.0% biochar by 11, 3, and 18 times, respectively. These results suggested that soil amendments improved soil water retentivity, which confirmed the appropriateness of these soil amendments for potential use in sandy soil improvements. However, field experiments and economical perception studies should be considered for further investigation.

关键词： evaporation extended multistep outflow soil amendment soil matric potential soil moisture soil water retentivity water availability WP4 dewpoint potentiometer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

引用

Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

引用

Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Implementing Symmetries of a Free Bose field via White Noise Operators

引用

Acta mathematica Sinica,English Series 2003年第1期19卷 147-158页

作者： ShunLongLU0 InstituteofAppliedmathematics AcademyofMathematicsandSystemSciencesChineseAcademyofSciencesBeijing1

Linear symmetries of a free Bose field are exploited in the framework of Hida's white noise functionals triple. General symplectic automorphisms on the single particle space are implemented by generalized operators. The intertwining operators are constructed in a physically intuitive way, characterized analytically in terms of symbols, and factorized into three fundamental parts according to Wick ordering procedure. In particular, the classical Shale's theorem is rederived.

关键词： free Bose field Symplectic automorphisms symbols gaussian Kernel operators Signs and symbols bose white noise

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Search for microglia-specific peptides:advances in the discovery toolbox

引用

Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SBL-JP-0004: A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

引用

Oncology research 2025年第1期33卷 235-243页

作者： Hassan m Otifi Department of Pathology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Background:Gastric cancer (GC) remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, making them attractive targets for therapeutic interventions.methods:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and SNU-5 GC cells were used for evaluation.Results:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases, as evidenced by molecular docking scores and molecular dynamics simulations. Binding interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target proteins. SBL-JP-0004 displayed an half-maximal inhibitory concentration (IC) value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD enzymes. SBL-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells, with half-maximal growth inhibitory concentration (GI) values of 250.8 and 516.3 nm, respectively. A significant elevation in the early phase apoptosis (28.53% in KATOIII cells and 26.85% in SNU-5 cells) and late phase apoptosis (17.37% in KATOIII cells and 10.05% in SNU-5 cells) were observed with SBL-JP-0004 treatment compared to 2.1% and 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Dual inhibition Gastric cancer (GC) JAK2 molecular docking molecular dynamics simulation PI3KCD SBL-JP-0004

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A New Approach to Nonlinear Partial Differential Equations

引用

Communications in Nonlinear Science and Numerical Simulation 1997年第4期2卷 230-235页

作者： Jihuan HE (Shanghai University,Shanghai Institute of Applied mathematics and mechanics,Shanghai 2 0 0 0 72 ,China) Shanghai University Shanghai Institute of Applied Mathematics and Mechanics Shanghai 200072 China

In this paper,a novel method called variational iteration method is proposed to solve nonlinear partial differential equations without linearization or small *** this method,a correction functional is constructed by a general Lagrange multiplier,which can be identified via variational *** analytical solution can be obtained from its trial- function with possible unknown constants,which can be identified by imposing the boundary conditions,by successively iteration.

关键词： Nonlinear Problems Partial Differential Equations Variational Iteration method Variational Theory

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Valued Gabriel quiver of a wedge product and semiprime coalgebras

引用

Frontiers of mathematics in China 2013年第5期8卷 1157-1183页

作者： Gabriel NAVARR0 Department of Computer Sciences and AI University of Granada E1 Greco s/n E-51002Ceuta Spain

We describe the valued Gabriel quiver of a wedge product of coalgebras and study the category of comodules of a semiprime coalgebra. In particular, we prove that any monomial semiprime k-tame fc-tame coalgebra is string. We also prove a version of Eisenbud-Griffith theorem for coalgebras, namely, any hereditary semiprime strictly quasi-finite coalgebra is serial.

关键词： Wedge product semiprime coalgebras representation theory,valued Gabriel quiver

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

引用

Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：