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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： mohamed Aghyad al Kabbani Christoph Köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for molecular medicine Cologne(CmmC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human mAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Nanosecond pulse and dual-wavelength Q-switched 1.5 μm fiber laser using mAX phase Cr2TialC2 saturable absorber

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Optoelectronics Letters 2025年第1期21卷 7-12页

作者： Ahmed Shakir al-HITI Hiba HASSAN Department of Electrical Engineering Faculty of Engineering University of Anbar Department of Laser and Optoelectronics Engineering University of Technology-Iraq

We demonstrated a new type of mAX phase material, chromium titanium aluminum carbide（Cr2TialC2） polymer film, to generate a passively Q-switched erbium-doped fiber laser（EDFL）. The film thickness was measured to be around 45 μm, which was fabricated using the embedding method with polyvinyl alcohol（PVA） polymer as hoster. The saturable absorber（SA） film demonstrates a dual-wavelength passively Q-switched EDFL which operates at 1 531 nm and 1 560.19 nm, respectively. The Q-switching pulse duration could be varied from 2.46 μs to 770 ns, while the repetition rate varied from 92.76 kHz to 106.6 kHz with an increasing input pumping range from 154 mW to 300 mW. The maximum output power and pulse energy of 15.05 mW and 141.18 nJ were obtained at the maximum input power of 300 mW, respectively.

关键词： Saturable absorbers

Comparative chemical sensor for detection of chromium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura H.al-REKABI A.A.alWAHIB Electrical Technique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing heavy and toxic metals such as chromium（Cr） has been investigated. One of the extremely harmful pollutants in rivers and seawater is the heavy metal ions due to their direct impacts on human, animals and plants are hexavalent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） technique has attracted huge research interest in detecting heavy metals specifically. In this study, three types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect the presence of Cr（Ⅵ） ions in water. The base Au layer with thickness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, the Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on these results, the Au/PANI nanofibers are the most sensitive to Cr（Ⅵ） among the tested sensing materials.

关键词： Titanium dioxide

multi-segmented nanowires for vortex magnetic domain wall racetrack memory

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Chinese Physics B 2023年第12期32卷 582-588页

作者： m al Bahri m al Hinaai T al Harthy Department of Basic Sciences A'Sharqiyah UniversityPost Box 42PC 400IbraOman

A vortex domain wall's(VW) magnetic racetrack memory's high performance depends on VW structural stability,high speed, low power consumption and high storage density. In this study, these critical parameters were investigated in magnetic multi-segmented nanowires using micromagnetic simulation. Thus, an offset magnetic nanowire with a junction at the center was proposed for this purpose. This junction was implemented by shifting one portion of the magnetic nanowire horizontally in the x-direction(l) and vertically(d) in the y-direction. The VW structure became stable by manipulating magnetic properties, such as magnetic saturation(m_(4)) and magnetic anisotropy energy(K_(u)). In this case, increasing the values of m_(4) ≥ 800 kA/m keeps the VW structure stable during its dynamics and pinning and depinning in offset nanowires,which contributes to maintenance of the storage memory's lifetime for a longer period. It was also found that the VW moved with a speed of 500 m/s, which is desirable for VW racetrack memory devices. moreover, it was revealed that the VW velocity could be controlled by adjusting the offset area dimensions(l and d), which helps to drive the VW by using low current densities and reducing the thermal-magnetic spin fluctuations. Further, the depinning current density of the VW(J_(d)) over the offset area increases as d increases and l decreases. In addition, magnetic properties, such as the m_(4) and K_(u),can affect the depinning process of the VW through the offset area. For high storage density, magnetic nanowires(multisegmented) with four junctions were designed. In total, six states were found with high VW stability, which means three bits per cell. Herein, we observed that the depinning current density(J_(d)) for moving the VW from one state to another was highly influenced by the offset area geometry(l and d) and the material's magnetic properties, such as the m_(4) and K_(u).

关键词： micromagnetic simulation vortex domain wall racetrack memory multi-segmented magnetic nanowire spin transfer torque

Unveiling the impact:COVID-19's influence on bacterial resistance in the Kingdom of Bahrain

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World Journal of Virology 2025年第1期14卷 83-98页

作者： Nermin K Saeed Safiya K almusawi Noor A albalooshi mohammed al-Beltagi medical microbiology Section Department of PathologySalmaniya Medical ComplexGovernmental HospitalsManama 12Bahrain medical microbiology Section Department of PathologyRoyal College of Surgeons in Ireland-Medical University of BahrainBusaiteen 15503MuharraqBahrain Department of Paediatrics Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671AlgharbiaBahrain

BACKGROUND Antibiotic resistance is a growing global health threat,and understanding local trends in bacterial isolates and their susceptibility patterns is crucial for effective infection control and antimicrobial *** coronavirus disease 2019(COVID-19)pandemic has introduced additional complexities,potentially influencing these *** To analyze trends in bacterial isolates and their antibiotic susceptibility patterns at Salmaniya medical Complex from 2018 to 2023,with a specific focus on the impact of the COVID-19 pandemic on these *** A retrospective analysis of microbiological data was conducted,covering the period from 2018 to *** study included key bacterial pathogens such as Escherichia coli(***),Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa,and Staphylococcus aureus,among *** antibiotic susceptibility profiles of these isolates were assessed using standard laboratory *** contextualize the findings,the findings were compared with similar studies from other regions,including China,India,Romania,Saudi Arabia,the United Arab Emirates,malaysia,and United *** The study revealed fluctuating trends in the prevalence of bacterial isolates,with notable changes during the COVID-19 *** example,a significant increase in the prevalence of Staphylococcus aureus was observed during the pandemic years,while the prevalence of *** showed a more variable *** resistance rates varied among the different pathogens,with a concerning rise in resistance to commonly used antibiotics,particularly among Klebsiella pneumoniae and ***,the study identified an alarming increase in the prevalence of multidrug-resistant(mDR)strains,especially within Klebsiella pneumoniae and *** *** impact of the COVID-19 pandemic on these trends was evident,with shifts in the frequency,resistance patterns,and the emergence of mDR bacteria among several key ***

关键词： multidrug-resistant organisms Antibiotic susceptibility COVID-19 pandemic Antimicrobial stewardship Bacterial isolates Salmaniya medical Complex Bahrain

machine learning in solid organ transplantation:Charting the evolving landscape

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World Journal of Transplantation 2025年第1期15卷 165-177页

作者： Badi Rawashdeh Haneen al-abdallat Emre Arpali Beje Thomas Ty B Dunn matthew Cooper Division of Transplant Surgery Medical College of WisconsinMilwaukeeWI 53202United States Department of medicine Jordan University HospitalAmman 11263Jordan Department of Nephrology Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND machine learning(mL),a major branch of artificial intelligence,has not only demonstrated the potential to significantly improve numerous sectors of healthcare but has also made significant contributions to the field of solid organ *** provides revolutionary opportunities in areas such as donorrecipient matching,post-transplant monitoring,and patient care by automatically analyzing large amounts of data,identifying patterns,and forecasting *** To conduct a comprehensive bibliometric analysis of publications on the use of mL in transplantation to understand current research trends and their *** On July 18,a thorough search strategy was used with the Web of Science *** and transplantation-related keywords were *** the aid of the VOS viewer application,the identified articles were subjected to bibliometric variable analysis in order to determine publication counts,citation counts,contributing countries,and institutions,among other *** Of the 529 articles that were first identified,427 were deemed relevant for bibliometric analysis.A surge in publications was observed over the last four years,especially after 2018,signifying growing interest in this *** 209 publications,the United States emerged as the top ***,the"Journal of Heart and Lung Transplantation"and the"American Journal of Transplantation"emerged as the leading journals,publishing the highest number of relevant *** keyword searches revealed that patient survival,mortality,outcomes,allocation,and risk assessment were significant themes of *** The growing body of pertinent publications highlights mL's growing presence in the field of solid organ *** bibliometric analysis highlights the growing importance of mL in transplant research and highlights its exciting potential to change medical practices and enhance patient *** collaboration between signific

关键词： machine learning Artificial Intelligence Solid organ transplantation Bibliometric analysis

Charged Particles Capture Cross-section by a Weakly Charged Schwarzschild Black Hole

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Research in Astronomy and Astrophysics 2024年第8期24卷 141-146页

作者： A.m.al Zahrani A.al-Jama Physics Department King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia

We study the capture cross-section of charged particles by a weakly charged Schwarzschild black *** dependence of the maximum impact parameter for capture on the particle’s energy is investigated numerically for different values of the electromagnetic coupling strength between the particle and the black *** capture cross-section is then *** show that the capture cross-section is independent of the electromagnetic coupling for ultra-relativistic *** astrophysical implications of our results are discussed.

关键词： stars black holes-accretion-accretion disks-black hole physics

Assessment of water resources in Yarmouk River Basin using geospatial technique during the period 1980–2020

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Journal of Arid Land 2022年第2期14卷 154-166页

作者： Noor m al-KHARABSHEH Department of Water Resources and Environmental management Al-Balqa Applied UniversityAl-Salt 19117Jordan

It is common knowledge that Yarmouk River Basin(YRB)is shared between Jordan and *** of YRB trans-boundary water resources is attracting increasing interest because it is a strategic water resource for the riparian ***,lack of sharing information regarding hydrological flows and basin’s water management between partners’countries makes it difficult to distinguish between natural and man-made factors affecting the water ***,this study seeks to address and assess the main on-site changes that exert on *** technique and arithmetic equations were combined to carry out an assessment of the changes on water resources in ***,information and field measurements of the basin were aggregated,compiled and presented to determine the extent of changes during the period *** findings showed that precipitation amount in the basin significantly declined during the period 1980-2020 in particularly after the year *** rate of groundwater was 550 x 103 m3/a,exceeding the basin’s safe *** down of static groundwater level over time approached the value of-3.2 m/a due to the over abstraction in the aquifer ***,the evaporation rate reached more than 99%in some regions in the ***,the number of private wells has increased from 98 wells in 1980 to 126 wells in 2020,showing the excessive extraction of *** findings indicate that the study area is subjected to a considerable groundwater depletion in the near future due to extensive abstraction,continuous drilling of illegal wells and decreased annual precipitation under the shadow of the rapid population growth and continuous influx of ***,decision makers-informed scenarios are suggested in the development of water resource portfolios,which involves the combination of management and infrastructural actions that enhance the water productivity of the *** studies are recommended to evaluate the on-sit

关键词： assessment geospatial technique on-site changes water resources Yarmouk River Basin

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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