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Insights from an academic endeavor into central nervous system drug discovery

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Neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： Lieve van Veggel An m.Voets Tim Vanmierlo Rudy Schreiber BIOmED Biomedical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium Department of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharmacology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University mS Center(UmSC) Hasselt-PeltBelgium

Historically,"big pharma"did most central nervous system drug discovery R&D ***,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(mazzucato,2013).

关键词： academic approval consequences

Neurocircuit regeneration by extracellular matrix reprogramming

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Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su Ian N.Levasseur Kimberly m.Alonge Department of medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECm),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECm regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(miyata et al.,2012),cation buffering(moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECm indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 177-192页

作者： m.NAVEED m.ImRAN T.ASGHAR Z.ABBAS Department of mathematics Division of Science and TechnologyUniversity of Education Department of mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAm).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词： hybrid nanofluid oscillating curved stretchable sheet gyrotactic microorganism Cattaneo-Christov heat and mass flux chemical reaction analytical solution O368

Quantitative measures for assessment of the hydraulic excavator digging efficiency

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第12期13卷 926-942页

作者： Dragoslav JANOSEVIC rosen mITREV Boban ANDJELKOVIC Plamen PETROV Faculty of mechanical Engineering University of Nis Faculty of mechanical Engineering Technical University of Sofia

In this paper,quantitative measures for the assessment of the hydraulic excavator digging efficiency are proposed and *** following factors are considered:(a) boundary digging forces allowed for by the stability of an excavator,(b) boundary digging forces enabled by the driving mechanisms of the excavator,(c) factors taking into consideration the digging position in the working range of an excavator,and(d) sign and direction of potential digging resistive force.A corrected digging force is defined and a mathematical model of kinematic chain and drive mechanisms of a five-member excavator configuration was developed comprising:an undercarriage,a rotational platform and an attachment with boom,stick,and *** the basis of the mathematical model of the excavator,software was developed for computation and detailed analysis of the digging forces in the entire workspace of the *** using the developed software,the analysis of boundary digging forces is conducted and the corrected digging force is determined for two models of hydraulic excavators of the same mass(around 17 000 kg) with identical kinematic chain parameters but with different parameters of manipulator driving *** results of the analysis show that the proposed set of quantitative measures can be used for assessment of the digging efficiency of existing excavator models and to serve as an optimization criterion in the synthesis of manipulator driving mechanisms of new excavator models.

关键词： Hydraulic excavators Digging efficiency Quantitative measures

Fault diagnosis model based on multi-manifold learning and PSO-SVm for machinery

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仪器仪表学报 2014年第S2期35卷 210-214页

作者： Wang Hongjun Xu Xiaoli rosen B G Key Laboratory of modern measurement & Control Technology Beijing Information Science & Technology University School of mechanic and Electric Engineering Beijing Information Science&Technology University Halmstad University

Fault diagnosis technology plays an important role in the industries due to the emergency fault of a machine could bring the heavy lost for the people and the company. A fault diagnosis model based on multi-manifold learning and particle swarm optimization support vector machine(PSO-SVm) is studied. This fault diagnosis model is used for a rolling bearing experimental of three kinds faults. The results are verified that this model based on multi-manifold learning and PSO-SVm is good at the fault sensitive features acquisition with effective accuracy.

关键词： fault diagnosis multi-manifold learning particle swarm optimization support vector machine

Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 193-208页

作者： K.mUHAmmAD m.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(mHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in mATHEmATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

关键词： convective boundary condition Darcy-Forchheimer medium hybrid nanofluid Joule heating magnetohydrodynamic (mHD) numerical solution squeezing flow regression analysis O361 O175.2

The European registry of quality outcomes for cataract and refractive surgery(EUREQUO):a database study of trends in volumes,surgical techniques and outcomes of refractive surgery

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Eye and Vision 2015年第1期2卷 76-84页

作者： mats Lundström Sonia manning Peter Barry Ulf Stenevi Ype Henry Paul rosen Department of Clinical Sciences OphthalmologyFaculty of MedicineLund UniversityLundSweden Department of Ophthalmology Mater Misericordiae University HospitalDublinIreland Department of Ophthalmology St.Vincent’s University HospitalDublinIreland Department of Ophthalmology Sahlgren’s University HospitalMolndalSweden Department of Ophthalmology VumcAmsterdamThe Netherlands Oxford Eye Hospital OxfordUK.

Background:A European web-based registry for refractive surgery was established in 2008;The European Registry of Quality Outcomes for Cataract and Refractive Surgery(EUREQUO).The aim of the registry was to improve treatment and standards of care for refractive *** aims were to offer a tool for benchmarking by establishing a reference database and for surgeons to enter and analyze their own *** purpose of this study was to characterize the registry and analyze the data collected during its first ***:The characteristics of the web-based registry are *** collected from February 4^(th) 2004 until June 30th 2014 are included in the *** database is analyzed in terms of surgical technique,indications for surgery,complications,and refractive and visual ***:Data have been reported from 47 centers in 14 countries until *** 4,000 procedures were reported *** most frequent procedure was laser-assisted in-situ keratomileusis(LASIK)with 11697 reported *** time in the database,LASIK declined(pmy(PRK)and refractive lens exchange(RLE)increased(pms of preoperative refraction and age,were stable over time,for all types of *** complications were reported infrequently and with a well-known relationship to the type of surgical *** reported refractive outcomes were *** visual outcomes indicate a significant increase of visual acuity after high myopia treatment by phakic intraocular lens in the anterior(phakic IOL AC)and the posterior(phakic IOL PC)chamber and a poorer visual outcome,after both myopia and hyperopia treatment,by epithelial LASIK(Epi-LASIK).Conclusions:We describe the establishment of a European registry for refractive *** database increases at a rate of approximately 4000 refractive procedures per *** most frequent procedure is LASIK,but

关键词： Refractive surgery Registry European database Outcomes

Thick Electrodes of a Self-Assembled mXene Hydrogel Composite for High-Rate Energy Storage

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Energy & Environmental materials 2024年第4期7卷 255-261页

作者： Leiqiang Qin Jianxia Jiang Lintao Hou Fengling Zhang Johanna rosen Department of Physics Chemistry and Biology(IFM)LinkEoping UniversityLinkEoping SE-58183Sweden Flexible Electronics Innovation Institute(FEII) Jiangxi Key Laboratory of Flexible ElectronicsJiangxi Science and Technology Normal UniversityNanchang 330013China Guangzhou Key Laboratory of Vacuum Coating Technologies and New Energy materials Physics DepartmentJinan UniversityGuangzhou 510632China

Supercapacitors based on two-dimensional mXene(Ti_(3)C_(2)T_(z))have shown extraordinary performance in ultrathin electrodes with low mass loading,but usually there is a significant reduction in high-rate performance as the thickness increases,caused by increasing ion diffusion *** limitations include restacking of the nanosheets,which makes it challenging to realize the full potential of these electrode ***,we demonstrate the design of a vertically aligned mXene hydrogel composite,achieved by thermal-assisted self-assembled gelation,for high-rate energy *** highly interconnected mXene network in the hydrogel architecture provides very good electron transport properties,and its vertical ion channel structure facilitates rapid ion *** resulting hydrogel electrode show excellent performance in both aqueous and organic electrolytes with respect to high capacitance,stability,and high-rate capability for up to 300μm thick electrodes,which represents a significant step toward practical applications.

关键词： energy storage high-rate hydrogel mXene self-assemble

Predicting maximum Lifespan Limits at mean menopausal Age

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Journal of mathematical Research with Applications 2025年第1期 133-142页

作者： m.SUmATHI S.ANTONY CARLA Department of mathematics N.M.S.S.Vellaichamy Nadar College Research Scholar (Part-time) Madurai Kamaraj University

The age at which a woman enters natural menopause has also been associated to death from any cause. menopause is a natural component of aging that happens between the ages of 45 and 55, with the average menopausal age being 51. Previous research has revealed the age at which women reach menopause, but there is no evidence to support the link between menopause and longevity. We made a study in assessing the limits of maximum lifespan at menopausal age in our previous article. In this paper, we aim to predict the maximum lifespan of women at mean menopausal age.

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