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Applied mathematics and mechanics(English Edition) 2012年第10期33卷 1265-1274页

作者： A.H.mOSAFFA F.TALATI m.a.rosen H.BASIRAT-TABRIZI Faculty of mechanical Engineering University of Tabriz Faculty of Engineering and Applied Science University of Ontario Institute of TechnologyL1H 7K4 OshawaOntarioCanada Department of mechanical Engineering Amirkabir University of Technology

The Green＇s function method is applied for the transient temperature of an annular fin when a phase change material （PCm） solidifies on it. The solidification of the PCms takes place in a cylindrical shell storage. The thickness of the solid PCm on the fin varies with time and is obtained by the megerlin method. The models are found with the Bessel equation to form an analytical solution. Three different kinds of boundary conditions are investigated. The comparison between analytical and numerical solutions is given. The results demonstrate that the significant accuracy is obtained for the temperature distribution for the fin in all cases.

关键词： annular fin analytical solution Green's function phase change material(PCm) solidification thermal energy storage

mRI扩散加权成像预测乳腺癌新辅助治疗的病理反应:ACRIN 6698多中心实验

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国际医学放射学杂志 2019年第1期 109-110页

作者： S.C.Partridge Z.Zhang D.C.Newitt J.E.Gibbs T.L.Chenevert m.a.rosen 王静 Department of Radiology University of Washington

摘要目的探讨扩散加权(DW)mRI肿瘤表观扩散系数(ADC)的变化能否预测乳腺癌新辅助化疗的病理完全缓解(pCR)。材料与方法本前瞻性多中心研究连续纳入2012年

关键词：乳腺癌 ADC CR ACRIN 6698 新辅助化疗 AUC mRI

在动态对比增强mR影像上利用计算机影像分析识别三阴性乳腺癌并与其他分子亚型的乳腺癌进行鉴别的可行性研究

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国际医学放射学杂志 2014年第5期 472-473页

作者： S.C.Agner m.a.rosen S.Englander J.E.Tomaszewski m.D.Feldman P.Zhang 方晓堃 Department of Biomedical Engineering Rutgers University

摘要目的验证应用计算机辅助诊断(CAD)系统在动态增强mR影像上区分三阴性乳腺癌、雌激素受体(ER)阳性的乳腺癌、人类表皮生长因子受体2型(HER2)阳性的乳腺

关键词：三阴性乳腺癌动态增强 CAD 乳腺纤维腺瘤 mR

乳腺癌新辅助化疗:mR功能性肿瘤体积成像预测无瘤生存率——来自ACRIN 6657/CALGB 150007 I-SPY 1的临床研究结果

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国际医学放射学杂志 2016年第3期 309-309页

作者： N.m.Hylton C.A.Gatsonis m.a.rosen C.D.Lehman D.C.Newitt S.C.Partridge 孔祥 Department of Radiology University of California

摘要目的评估容积mR成像预测乳腺癌新辅助化疗方案(NACT)的无瘤生存率(RFS)和其对病理完全缓解(PCR)的预测价值。方法本研究为一项符合HIPAA要求的前瞻性多中心研究,该研究通过伦理委员会审查,且受试者均签署知情同意书。本研究纳入对... 详细信息

摘要目的评估容积mR成像预测乳腺癌新辅助化疗方案(NACT)的无瘤生存率(RFS)和其对病理完全缓解(PCR)的预测价值。方法本研究为一项符合HIPAA要求的前瞻性多中心研究,该研究通过伦理委员会审查,且受试者均签署知情同意书。本研究纳入对象是计划进行新辅助化疗方案且肿块≥3 cm的女性乳腺癌病人,在治疗前(试验1)、化疗1个疗程后(试验2)、化疗中期(试验3)和手术治疗前(试验4)均进行动态对比增强mR成像。采用mR成像强化

关键词：乳腺癌 FTV RFS 乳腺肿瘤新辅助化疗 ACRIN 6657/CALGB 150007 I-SPY 1 mR

乳腺mR增强诊断的良性病变最终确诊为恶性的比例:来自美国影像网络放射学会6667例诊断结果

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国际医学放射学杂志 2010年第4期 381-381页

作者： S.P.Weinstein L.G.Hanna C.Gatsonis m.D.Schnall m.a.rosen C.D.Lehman 郭丽君 Department of Radiology University of Pennsylvania Medical Center3400 Spruce St1 Silverstein BuildingPhiladelphiaPA 19104USA

目的美国影像网络放射学会(ACRIN)登记的6667例诊断结果中,已知乳腺癌病人对侧乳腺mR筛查,检出良性病变中最终确诊为恶性的比例。材料与方法由ACRIN指导多个机构,对近期确诊

关键词：良性病变 mR 乳腺乳房诊断结果放射学会美国美利坚合众国北美洲

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

The role of undifferentiated adipose-derived stem cells in peripheral nerve repair

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Neural Regeneration Research 2018年第5期13卷 757-763页

作者： Rui Zhang Joseph m.rosen Dartmouth Geisel School of medicine Dartmouth-Hitchcock Medical Center

Peripheral nerve injuries impose significant health and economic consequences, yet no surgical repair can deliver a complete recovery of sensory or motor function. Traditional methods of repair are less than ideal： direct coaptation can only be performed when tension-free repair is possible, and transplantation of nerve autograft can cause donor-site morbidity and neuroma formation. Cell-based therapy delivered via nerve conduits has thus been explored as an alternative method of nerve repair in recent years. Stem cells are promising sources of the regenerative core material in a nerve conduit because stem cells are multipotent in function, abundant in supply, and more accessible than the myelinating Schwann cells. Among different types of stem cells, undifferentiated adipose-derived stem cell（uASC）, which can be processed from adipose tissue in less than two hours, is a promising yet underexplored cell type. Studies of uASC have emerged in the past decade and have shown that autologous uASCs are non-immunogenic, easy to access, abundant in supply, and efficacious at promoting nerve regeneration. Two theories have been proposed as the primary regenerative mechanisms of uASC： in situ trans-differentiation towards Schwann cells, and secretion of trophic and anti-inflammatory factors. Future studies need to fully elucidate the mechanisms, side effects, and efficacy of uASC-based nerve regeneration so that uASCs can be utilized in clinical settings.

关键词： peripheral nerve injury adipose-derived stem cells Schwann cells cell therapy nerve conduits axonal regeneration stem cell differentiation neurotrophic factors anti-apoptosis immunosuppression

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

mathematical modelling of translational motion of rail-guided cart with suspended payload

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第9期8卷 1395-1400页

作者： mITREV rosen Department of Engineering Logistics Material handling and Construction MachinesTechnical University of SofiaSofia 1000Bulgaria

In this paper modelling of the translational motion of transportation rail-guided cart with rope suspended payload is considered. The linearly moving cart,driven by a travel mechanism,is modelled as a discrete six degrees of freedom (DOF) dynamic system. The hoisting mechanism for lowering and lifting the payload is considered and is included in the dynamic model as one DOF system. Differential equations of motion of the cart elements are derived using Lagrangian dynamics and are solved for a set of real-life constant parameters of the cart. A two-sided interaction was observed between the swinging payload and the travel mechanism. Results for kinematical and force parameters of the system are obtained. A verification of the proposed model was conducted.

关键词： Transportation rail-guided cart Travel mechanism Swinging payload Discrete dynamical model mathematical model