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Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

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Genes & Diseases 2024年第1期11卷 189-204页

作者： Ebrahim H.maleki Ahmad Reza Bahrami maryam m.matin Department of Biology Faculty of ScienceFerdowsi University of Mashhad*** MashhadIran Jagiellonian Centre for Experimental Therapeutics(JCET) Jagiellonian University31-007 KrakowPoland Doctoral School of Exact and Natural Sciences Jagiellonian University30-348 KrakowPoland Industrial Biotechnology Research Group Institute of BiotechnologyFerdowsi University of Mashhad*** MashhadIran Novel Diagnostics and Therapeutics Research Group Institute of BiotechnologyFerdowsi University of Mashhad***MashhadIran Stem Cell and Regenerative medicine Research Group Iranian Academic Center for EducationCulture and Research(ACECR)Khorasan Razavi Branch917751376 MashhadIran

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology,as it represents a major obstacle to effective cancer *** tumor cells are highly diverse at genetic,epigenetic,and phenotypic levels,intra-tumor heterogeneity can be assumed as an important contributing factor to the nullification of chemotherapeutic effects,and recurrence of the *** on the role of heterogeneous subpopulations of cancer cells with varying cell-cycle dynamics and behavior during cancer progression and treatment;herein,we aim to establish a comprehensive definition for adaptation of neoplastic cells against *** discuss two parallel and yet distinct subpopulations of tumor cells that play pivotal roles in reducing the effects of chemotherapy:"resistant"and"tolerant"***,this review also highlights the impact of the quiescent phase of the cell cycle as a survival mechanism for cancer *** understanding the mechanisms under-lying the quiescence,it provides an insightful perspective on cancer stem cells(CsCs)and their dual and intertwined functions based on their cell cycle state in response to ***-over,CSCs,epithelial-mesenchymal transformed cells,circulating tumor cells(CTCs),and disseminated tumor cells(DTCs),which are mostly in a quiescent state of the cell cycle are proved to have multiple biological links and can be implicated in our viewpoint of cell cycle heterogeneity in ***,increasing our knowledge of cell cycle heterogeneity is a key to identifying new therapeutic solutions,and this emerging concept may provide us with new opportunities to prevent the dreadful cancer recurrence.

关键词： Cancer stem cells(CSCs) Carcinoma Cell cycle heterogeneity Quiescence Therapy resistance Therapy tolerance Tumor dormancy

Efficient Algorithm for Prolonging Network Lifetime of Wireless Sensor Networks

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Tsinghua Science and Technology 2011年第6期16卷 561-568页

作者： md Nafees Rahman m.a.matin Department of Electrical Engineering and Computer Science North South University

One of the fundamental design challenges in designing a Wireless Sensor Network （WSN） is to maximize the network lifetime, as each sensor node of the network is equipped with a limited power battery. To overcome this challenge, different methods were developed in the last few years using such techniques as network protocols, data fusion algorithms using low power, energy efficient routing, and locating optimal sink position. This paper focuses on finding the optimal sink position. Relay nodes are introduced in conjunction with the sensor nodes to mitigate network geometric deficiencies since in most other approaches the sensor nodes close to the sink become heavily involved in data forwarding and, thus, their batteries are quickly depleted. A Particle Swarm Optimization （PSO） based algorithm is used to locate the optimal sink position with respect to those relay nodes to make the network more energy efficient. The relay nodes communicate with the sink instead of the sensor nodes. Tests show that this approach can save at least 40% of the energy and prolong the network lifetime.

关键词： wireless sensor network lifetime sensor node relay node particle swarm optimization sink

A Coupled Soil-Fluid-Structure Simulation of the Near-Field Earthquake Effects on Gravity Type Quay-Walls

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China Ocean Engineering 2013年第4期27卷 481-494页

作者： m.Zeinoddini H.matin Nikoo F.Ahmadpour Faculty of Civil Engineering K.N.Toosi University of Technology

This study focuses on non-linear seismic response of concrete gravity quay-wall structures subjected to near-fault ground motions, a subject which seems not to have received much attention in the literature. A two-dimensional coupled fluid-structure-soil finite element modelling is employed to obtain the quay-wall response. The seawater medium is represented by acoustic type, potential based fluid elements. The elasto-plastic behavior of the soil medium is idealized using Drucker-Prager yield criterion based on associated flow rule assumption. Four nodded plane strain elements are used to model the concrete wall, foundation, subsoil, backfill and seabed zones. Fluid Structure Interface （FSI） elements are considered between the seawater interfaces with the quay-wall and the seabed. Frictional contact elements are employed between the wall and soil interfaces. The numerical model is validated using field measurements available for permanent drifts in a quay-wall damaged during Kobe earthquake. Reasonable agreements are obtained between the model predictions and the field measurements. Non-linear seismic analyses of the selected quay-wall subjected to both near-fault and far-fault ground motions are performed. An incremental dynamic analysis approach （IDA） is used. In general, at least for models examined in the current study, the gravity quay-walls are found to be more vulnerable to near-field, in comparison with the corresponding far-field, earthquakes.

关键词： coastal structure gravity quay-wall near-fault earthquake Incremental Dynamic Analysis (IDA)

Preparation of La-mo-V mixed-oxide systems and their application in the direct synthesis of acetic acid

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Journal of Natural Gas Chemistry 2008年第3期17卷 213-224页

作者： Hamid Reza Arandiyan matin Parvari Chemical Engineering Department Iran University of Science and Technology

In this study, mixed metal oxides developed with a perovskite-type structure that show great potential for use in catalysis. Perovskite oxide catalysts with the composition LamoxV1-xOn （x = 0.1, 0.3, 0.5, 0.7, and 0.9） have been synthesized by the sol-gel method and then used in the ethane dry reforming reaction for the direct synthesis of acetic acid. The influence of the nature of the metallic source （metal, nitrate, acetylacetonate, and ammonium） on gel formation has been studied by Fourier-transform infrared spectroscopy （FT-IR） and thermogravimetric analysis （TGA-DTA）. After calcination, the obtained perovskites were characterized by X-ray diffraction （XRD） and energy-dispersive X-ray spectrometry （EDS） coupled with scanning electron microscopy （SEm）. The catalysts were then subjected to thermo-programmed reduction （TPR）. The surface area （BET） was found to increase from 2.6 m^2/g （x = 0.1） to 5.1 m2/g （x = 1.0） with increasing molybdenum content following calcinations at 750 °C, and pure LamoxV1-xOn perovskite was obtained with good homogeneity. The catalysts have been characterized by XRD, SEm, EDS, and carbon analysis （CA）. The results indicate that through this synthesis it is possible to obtain highly crystalline, homogeneous and pure solids, with well-defined structures. The direct synthesis of acetic acid from ethane over the perovskite catalysts was studied at temperatures between 450 and 850 °C and elevated pressures between 1 and 8 bar. It was found that the yield of acetic acid and the selectivity of its formation could be increased by incorporating more molybdenum into the perovskite structure. The experimental studies have shown that the calcination temperature and the molybdenum content have a significant influence on the catalytic activity. Amongst the catalysts tested, Lamo0.7V0.3O4.2 exhibited the best activity and stability.

关键词： acetic acid catalyst perovskite activity LamoxV1-xOn

Associations between polymorphisms in leptin and leptin receptor genes and colorectal cancer survival

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Cancer Biology & medicine 2023年第6期20卷 438-451页

作者： meizhi Du Yu Wang Jillian Vallis matin Shariati Patrick S.Parfrey John R.mclaughlin Peizhong Peter Wang Yun Zhu Department of Epidemiology and Biostatistics School of Public HealthTianjin Medical UniversityTianjin 300070China Division of Community Health and Humanities Faculty of MedicineMemorial University of NewfoundlandSt.John's A1B 3V6Canada Clinical Epidemiology Unit Faculty of MedicineMemorial University of NewfoundlandSt.John's A1B 3V6Canada Dalla Lana School of Public Health University of TorontoToronto M5T 3M7Canada Beatrice Hunter Cancer Institute Halifax B3H 4R2Canada Centre for New Immigrant Wellbeing Markham L3R 9V1Canada

Objective:Leptin(LEP)is an obesity-associated adipokine associated with tumor cell *** examined the relevance of genetic variants of LEP and leptin receptor(LEPR)to colorectal cancer(CRC)survival by using data from the Newfoundland Familial Colorectal Cancer ***:A total of 532 patients newly diagnosed with CRC between 1997 and 2003 were followed up until April *** on their demographics and lifestyles were collected via *** of blood samples was performed with the Illumina Human Omni-Quad Bead *** Cox models were used to assess the relationships of 35 tag single-nucleotide polymorphisms(SNPs)in LEP and LEPR with overall survival(OS),disease-free survival(DFS),and CRC-specific ***:At the gene level,LEP was associated with DFS(P=0.017),and LEPR was associated with both DFS(P=0.021)and CRCspecific survival(P=0.013)in patients with *** single-SNP analysis,LEP rs11763517,LEPR rs9436301,and LEPR rs7602 were associated with DFS after adjustment for multiple *** LEPR haplotypes G-C-T(rs7534511-rs9436301-rs1887285)and A-A-G(rs7602-rs970467-rs9436748)were associated with prolonged OS among patients with CRC overall(G-C-T:HR,0.63;95%CI,0.43–0.93;A-A-G:HR,0.59;95%CI,0.38–0.91)and those diagnosed with colon cancer(G-C-T:HR,0.54;95%CI,0.34–0.86;A-A-G:HR,0.49;95%CI,0.29–0.83).Similar results were observed for ***,significant interactions were found among LEPR rs7602(A vs.G),LEPR rs1171278(T vs.C),red meat intake,and BmI status:the associations between these variants and prolonged DFS were limited to patients with below-median red meat consumption and body mass index(BmI)morphic variations in the LEP and LEPR genes were associated with survival of patients after CRC *** LEP/LEPR-CRC survival association was modified by participants’red meat intake and BmI.

关键词： colorectal cancer intake

Anticancer Effects of Valproic Acid on Esophageal Stem-like Carcinoma Cells

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生物化学与生物物理进展 2016年第9期43卷 903-909页

作者： SABOOR-mALEKI Saffiyeh RASSOULI Fatemeh B. matin maryam m. mOUSAVI mahdi Department of Biology Faculty of Science Ferdowsi University of Mashhad Mashhad Iran Cell and molecular Biotechnology Research Group Institute of Biotechnology Ferdowsi University of Mashhad Mashhad Iran

Valproic acid(VPA) is a histone deacetylase inhibitor that has been an object of interest to clinicians for its promising potency in cancer therapy, as it induces apoptosis and differentiation, and enhances of chemotherapy sensitivity. Esophageal squamous cell carcinoma(ESCC) is a malignant disease with growing incidence and low survival rate. Due to limited information on VPA activity in ESCC cells, we aimed to determine effects of VPA on chemotherapy responsiveness and expression of malignant markers in ESCC stem-like cells. Upon coadministration of non-toxic VPA + cisplatin(DDP), paclitaxel and 5-fluorouracil, viability of KYSE30 cells was assessed, and induced apoptosis was evaluated by DAPI staining, DNA laddering and flow cytometry. In addition, real time RT-PCR was performed to study changes in the expression of P21, CD44 and BmI-1 upon treatments. mTT test demonstrated that VPA significantly(P med by DNA laddering, flow cytometry analysis and significant(P moreover, real time RT-PCR results indicated significant(P mI-1 after VPA administration. Present attempt provided evidence, for the first time, that VPA not only improved responsiveness of esophageal stem-like cancer cells to DDP, also negatively regulated cancer stem cells markers in these cells.

关键词：丙戊酸钠肿瘤治疗方法临床分析

New Trends in Olefin Production

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Engineering 2017年第2期3卷 171-178页

作者： Ismael Amghizar Laurien A. Vandewalle Kevin m. Van Geem Guy B. matin Laboratory for Chemical Technology Ghent University Ghent B-9052 Belgium

most olefins （e.g., ethylene and propylene） will continue to be produced through steam cracking （SC） ofhydrocarbons in the coming decade. In an uncertain commodity market, the chemical industry is investingvery little in alternative technologies and feedstocks because of their current lack of economic viability,despite decreasing crude oil reserves and the recognition of global warming. In this perspective, some of themost promising alternatives are compared with the conventional SC process, and the major bottlenecks ofeach of the competing processes are highlighted. These technologies emerge especially from the abundanceof cheap propane, ethane, and methane from shale gas and stranded gas. From an economic point of view,methane is an interesting starting material, if chemicals can be produced from it. The huge availability ofcrude oil and the expected substantial decline in the demand for fuels imply that the future for proventechnologies such as Fischer-Tropsch synthesis （FFS） or methanol to gasoline is not bright. The abundance ofcheap ethane and the large availability of crude oil, on the other hand, have caused the SC industry to shiftto these two extremes, making room for the on-purpose production of light olefins, such as by the catalyticdehydrogenation of orooane.

关键词： Olefin production Steam cracking methane conversionShale gas CO2 emissions

Isolation and molecular identification of cellulolytic bacteria from Dig Rostam hot spring and study of their cellulase activity

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BIOCELL 2020年第1期44卷 63-71页

作者： Sareh HAJIABADI mansour mASHREGHI Ahmad Reza BAHRAmI Kiarash GHAZVINI maryam m.matin Department of Biology Faculty of ScienceFerdowsi University of MashhadMashhadIran Novel Diagnostics and Therapeutics Research Group Institute of BiotechnologyFerdowsi University of MashhadMashhadIran microbiology Research Center&Department of microbiology and Virology Ghaem Medical CenterMashhad University of Medical SciencesMashhadIran

Cellulose is the main structural component of lignocellulosic wastes that can be converted to sugars and biofuels by *** to wide applications of this enzyme in various industries around the world,cellulase is considered as the third industrial *** ability of thermophilic bacteria in the production of heat-stable cellulases has made them valuable tools in *** aim of this study was isolation and molecular identification of cellulolytic thermophile bacteria from Dig Rostam hot spring and investigating their cellulase *** were taken from water and sediments of this hot spring,and cellulolytic bacteria were enriched in media containing cellulose as the only carbon *** bacteria were incubated at 60℃,and single colonies were then isolated on solid *** red assay was used as a quick test for the qualitative screening of cellulase *** to these qualitative results,four colonies named CDB1,CDB2,CDB3,and CDB4 were isolated,and their growth curve and some other characteristics were determined by biochemical ***,endoglucanase,exoglucanase,and FPase activities of the isolates were investigated *** indicated that CDB1 exhibited the highest endoglucanase(0.096 U/mL)and exoglucanase(0.156 U/mL)activities among other isolates.16S rDNA partial sequencing indicated that CDB1 had 99%similarity to the genus Anoxybacillus,and the other isolates showed the highest similarity to the genus *** cellulase gene of CDB1 isolate with the highest cellulase activity was also cloned,and its sequence is reported for the first *** studies on this thermophilic enzyme might be useful for industrial applications.

关键词： Anoxybacillus Cellulase Enzyme activity assay Thermophilic bacteria 16S rDNA

myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer's disease

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Neural Regeneration Research 2016年第12期11卷 1976-1980页

作者： matin Ramezani Niloufar Darbandi Fariba Khodagholi Azam Hashemi Department of Biology Faculty of ScienceArak University Neuroscience Research Center School of MedicineShahid Beheshti University of Medical Sciences

There is currently no treatment for effectively slowing the progression of Alzheimer＇s disease, so early prevention is very important. Numerous studies have shown that flavonoids can improve memory impairment. The present study investigated the effects of myricetin, a member of the flavonoids, on intracerebroventricular streptozotocin induced neuronal loss and memory impairment in rat models of Alzheimer＇s disease. myricetin at 5 or 10 mg/kg was intraperitoneally injected into rats over 21 days. Control rats were treated with 10 m L/kg saline. Behavioral test（the shuttle box test） was performed on day 22 to examine learning and memory in rats. Immediately after that, hematoxylin-eosin staining was performed to observe the morphological change in hippocampal CA3 pyramidal neurons. myricetin greatly increased the number of hippocampal CA3 pyramidal neurons and improved learning and memory impairments in rats with Alzheimer＇s disease. These findings suggest that myricetin is beneficial for treatment of Alzheimer＇s disease.

关键词： nerve regeneration myricetin Alzheimer's disease streptozotocin hippocampus pyramidal neurons CA3 region behavioral test neural regeneration