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Isoimperatorin alleviates acetic acid-induced colitis in rats

Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 147-153页

作者： saied Goodarzi Amir Hossein Abdolghaffari Behnaz Najafi mostafa Pirali Hamedani Saeed Tavakoli mahshad marvi maryam Baeeri Narguess Yassa Abbas Hadjiakhoondi mohammad Abdollahi Zahra Tofighi medicinal Plants Research Center Faculty of PharmacyTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehranIran Department of Pharmacognosy Faculty of PharmacyTehran University of Medical SciencesTehranIran medicinal Plants Research Center Institute of Medicinal PlantsACECRKarajIran International Campus School of Pharmacy Tehran University of Medical SciencesTehranIran Toxicology and Diseases group The Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehranIran

Objective:To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis ***:Colitis was induced by intracolonic administration of acetic acid solution(4%v/v)in *** were divided into six groups including the sham group,the negative control group,the dexamethasone-treated group,and the groups treated with isoimperatorin(0.1,1,and 10 mg/kg/d by gavage).The treatments were administered for three days and then colonic status was assessed by macroscopic,histopathological,and biochemical ***:Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced *** also significantly reduced myeloperoxidase,TNF-α,IL-1β,and malodialdehyde ***:Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis.

关键词： Isoimperatorin Inflammatory bowel disease Acetic acid Colitis TNF-α IL-1β

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Japanese Sign Language Recognition by Combining Joint Skeleton-Based Handcrafted and Pixel-Based Deep Learning Features with machine Learning Classification

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Computer modeling in Engineering & Sciences 2024年第6期139卷 2605-2625页

作者： Jungpil Shin md.Al mehedi Hasan abu Saleh musa miah Kota Suzuki Koki Hirooka School of Computer Science and Engineering The University of AizuAizuwakamatsu965-8580Japan Department of Computer Science&Engineering Rajshahi University of Engineering&TechnologyRajshahi6204Bangladesh

Sign language recognition is vital for enhancing communication accessibility among the Deaf and hard-of-hearing *** Japan,approximately 360,000 individualswith hearing and speech disabilities rely on Japanese Sign Language(JSL)for ***,existing JSL recognition systems have faced significant performance limitations due to inherent *** response to these challenges,we present a novel JSL recognition system that employs a strategic fusion approach,combining joint skeleton-based handcrafted features and pixel-based deep learning *** system incorporates two distinct streams:the first stream extracts crucial handcrafted features,emphasizing the capture of hand and body movements within JSL ***,a deep learning-based transfer learning stream captures hierarchical representations of JSL gestures in the second ***,we concatenated the critical information of the first stream and the hierarchy of the second stream features to produce the multiple levels of the fusion features,aiming to create a comprehensive representation of the JSL *** reducing the dimensionality of the feature,a feature selection approach and a kernel-based support vector machine(SVm)were used for the *** assess the effectiveness of our approach,we conducted extensive experiments on our Lab JSL dataset and a publicly available Arabic sign language(ArSL)*** results unequivocally demonstrate that our fusion approach significantly enhances JSL recognition accuracy and robustness compared to individual feature sets or traditional recognition methods.

关键词： Japanese Sign Language(JSL) hand gesture recognition geometric feature distance feature angle feature GoogleNet

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maximizing Resource Efficiency in Cloud Data Centers through Knowledge-Based Flower Pollination Algorithm (KB-FPA)

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Computers, materials & Continua 2024年第6期79卷 3757-3782页

作者： Nidhika Chauhan Navneet Kaur Kamaljit Singh Saini Sahil Verma Kavita Ruba abu Khurma Pedro A.Castillo University Institute of Computing Department Chandigarh UniversityPunjab140413India Department of Computer Science and Engineering Chandigarh UniversityPunjab140413India Universidade Federal do Piauí TeresinaPiauí64049-550Brazil mEU Research Unit Faculty of Information TechnologyMiddle East UniversityAmman11831Jordan Applied Science Research Center Applied Science Private UniversityAmman11931Jordan Department of Computer Engineering Automatics and RoboticsUniversity of GranadaGranada18071Spain

Cloud computing is a dynamic and rapidly evolving field,where the demand for resources fluctuates *** paper delves into the imperative need for adaptability in the allocation of resources to applications and services within cloud computing *** motivation stems from the pressing issue of accommodating fluctuating levels of user demand *** adhering to the proposed resource allocation method,we aim to achieve a substantial reduction in energy *** reduction hinges on the precise and efficient allocation of resources to the tasks that require those most,aligning with the broader goal of sustainable and eco-friendly cloud computing *** enhance the resource allocation process,we introduce a novel knowledge-based optimization *** this study,we rigorously evaluate its efficacy by comparing it to existing algorithms,including the Flower Pollination Algorithm(FPA),Spark Lion Whale Optimization(SLWO),and Firefly *** findings reveal that our proposed algorithm,Knowledge Based Flower Pollination Algorithm(KB-FPA),consistently outperforms these conventional methods in both resource allocation efficiency and energy consumption *** paper underscores the profound significance of resource allocation in the realm of cloud *** addressing the critical issue of adaptability and energy efficiency,it lays the groundwork for a more sustainable future in cloud computing *** contribution to the field lies in the introduction of a new resource allocation strategy,offering the potential for significantly improved efficiency and sustainability within cloud computing infrastructures.

关键词： Cloud computing resource allocation energy consumption optimization algorithm flower pollination algorithm

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Tribological behavior of shape-specific microplate-enriched synovial fluids on a linear two-axis tribometer

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Friction 2024年第3期12卷 539-553页

作者： Agnese FRAGASSI Antonietta GRECO martina DI FRANCESCO Luca CESERACCIU Aiman abu AmmAR Israel DVIR Thomas Lee mOORE Haytam KASEm Paolo DECUZZI Laboratory of Nanotechnology for Precision medicine Fondazione Istituto Italiano di TecnologiaGenova 16163Italy Department of Chemistry and Industrial Chemistry University of GenovaGenoa 16146Italy materials Characterization Facility Istituto Italiano di TecnologiaGenova 16163Italy Department of Pharmaceutical Engineering Azrieli College of Engineering JerusalemJerusalem 9103501Israel Department of mechanical Engineering Azrieli College of Engineering JerusalemJerusalem 9103501Israel

Nano-and micro-particles are being increasingly used to tune interfacial frictional properties in diverse applications,from friction modifiers in industrial lubrication to enhanced biological fluids in human osteoarthritic ***,we assessed the tribological properties of a simulated synovial fluid enriched with non-spherical,poly lactic-co-glycolic acid(PLGA)microparticles(μPL)that have been previously demonstrated for the pharmacological management of osteoarthritis(OA).Three different μPL configurations were fabricated presenting a 20μm×20μm square base and a thickness of 5μm(thin,5H μPL),10μm(10H μPL),and 20μm(cubical,20H μPL).After extensive morphological and physicochemical characterizations,the apparent Young’s modulus of the μPL was quantified under compressive loading returning an average value of~6 kPa,independently of the particle ***,using a linear two-axis tribometer,the static(μ_(s))and dynamic(μ_(d))friction coefficients of the μPL-enriched simulated synovial fluid were determined in terms of particle configuration and concentration,varying from 0(fluid only)to 6×10^(5) μPL/*** particle morphology had a modest influence on friction,possibly because the μPL were fully squeezed between two mating surfaces by a 5.8 N normal load realizing boundary-like lubrication ***,friction was observed to depend on the dimensionless parameterW,defined as the ratio between the total volume of the μPL enriching the simulated synovial fluid and the volume of the fluid *** coefficients of friction were documented to grow withWreaching a plateau of μ_(s)~0.4 and μ_(d)~0.15,already at Ω~2×10^(-3).Future investigations will have to systematically analyze the effect of sliding velocity,normal load,and rigidity of the mating surfaces to elucidate in full the tribological behavior of μPL in the context of osteoarthritis.

关键词： osteoarthritis microparticles tribology synovial fluid pin on plate

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Tilt Angle Optimality Criteria for Stand Alone PV Systems

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Journal of Power and Energy Engineering 2024年第3期12卷 1-18页

作者： mohammad abu-Naser Faculty of Engineering and Technology Philadelphia University Amman Jordan

The conventional approach to optimizing tilt angles for fixed solar panels aims to maximize energy generation over the entire year. However, in the context of a supply controlled electric grid, where solar energy availability varies, this criterion may not be optimal. This study explores two alternative optimization criteria focused on maximizing baseload supply potential and minimizing required storage capacity to address seasonality in energy generation. The optimal tilt angles determined for these criteria differed significantly from the standard approach. This research highlights additional factors crucial for designing solar power systems beyond gross energy generation, essential for the global transition towards a fully renewable energy-based electric grid in the future.

关键词： Electric Grid Fixed Solar Panels Optimal PV Tilt Angle Seasonal Solar Variability Renewable Energy Supply-Demand Balance

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Quality of life and psychological distress in end-stage renal disease patients undergoing hemodialysis and transplantation

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World Journal of Nephrology 2024年第3期13卷 34-40页

作者： Emad A Shdaifat Firas T abu-Sneineh Abdallah m Ibrahim Community Nursing Department Imam Abdulrahman Bin Faisal UniversityDammam 1982Saudi Arabia Department of Fundamental Nursing Imam Abdulrahman Bin Faisal UniversityDammam 1982Saudi Arabia

BACKGROUND Among diverse profound impacts on patients’quality of life(QoL),end-stage renal disease(ESRD)frequently results in increased levels of depression,anxiety,and *** replacement therapies such as hemodialysis(HD)and transplantation(TX)are intended to enhance QoL,although their ability to alleviate psychological distress remains *** research posits the existence of a significant correlation between negative emotional states and QoL among ESRD patients,with varying effects observed in HD and TX *** To examine the relationship between QoL and negative emotional states(depression,anxiety,and stress)and predicted QoL in various end-stage renal replacement therapy patients with *** This cross-sectional study included HD or TX patients in the Eastern Region of Saudi *** 36-item Short Form Survey and Depression Anxiety Stress Scale(DASS)was used for data collection,and correlation and regression analyses were *** The HD and TX transplantation groups showed statistically significant inverse relationships between QoL and DASS *** patients with high anxiety levels and less education scored low on the physical component summary(PCS).In addition,the results of the mental component summary(mCS)were associated with reduced *** with older transplant patients,TX patients’PCS scores were lower,and depression,stress,and negative working conditions were highly correlated with mCS *** The findings of this study revealed notable connections between well-being and mental turmoil experienced by individuals undergoing HD and *** PCS of HD patients is affected by heightened levels of anxiety and lower educational attainment,while the mCS of transplant patients is influenced by advancing age and elevated stress *** insights will contribute to a more comprehensive understanding of patient support.

关键词： Anxiety Depression End-stage renal disease Hemodialysis Patient Reported Outcome measures Psychological distress Quality of life Renal replacement therapy outcomes Saudi Arabia Stress

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Regeneration mechanisms and therapeutic strategies for neuromuscular junctions in aging and diseases

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Neural Regeneration Research 2025年第1期20卷 193-194页

作者： masashi Fujitani abu md mamun Tarif Yoshinori Otani Department of Anatomy and Neuroscience Faculty of MedicineShimane UniversityShimaneJapan

The neuromuscular junction(NmJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NmJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NmJs have a smaller,fragmented structure throughout *** NmJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).

关键词： aging structure Figure

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Robotic Process Automation with New Future Trends

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Journal of Computer and Communications 2024年第6期12卷 12-24页

作者： abu Tayab Yanwen Li School of mechanical Engineering Yanshan University Qinhuangdao China

The invention concept of Robotic Process Automation (RPA) has emerged as a transformative technology that has revolved the local business processes by programming repetitive task and efficiency adjusting the operations. This research had focused on developing the RPA environment and its future features in order to elaborate on the projected policies based on its comprehensive experiences. The current and previous situations of industry are looking for IT solutions to fully scale their company Improve business flexibility, improve customer satisfaction, improve productivity, accuracy and reduce costs, quick scalability in RPA has currently appeared as an advance technology with exceptional performance. It emphasizes future trends and foresees the evolution of RPA by integrating artificial intelligence, learning of machine and cognitive automation into RPA frameworks. moreover, it has analyzed the technical constraints, including the scalability, security issues and interoperability, while investigating regulatory and ethical considerations that are so important to the ethical utilization of RPA. By providing a comprehensive analysis of RPA with new future trends in this study, researcher’s ambitions to provide valuable insights the benefits of it on industrial performances from the gap observed so as to guide the strategic decision and future implementation of the RPA.

关键词： Robotic Process Automation Artificial Intelligence machine Learning Cognitive Computing Interoperability Data Security

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Traffic Control Based on Integrated Kalman Filtering and Adaptive Quantized Q-Learning Framework for Internet of Vehicles

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Computer modeling in Engineering & Sciences 2024年第3期138卷 2103-2127页

作者： Othman S.Al-Heety Zahriladha Zakaria Ahmed abu-Khadrah mahamod Ismail Sarmad Nozad mahmood mohammed mudhafar Shakir Hussein Alsariera Faculty of Electronic and Computer Engineering Universiti Teknikal Malaysia Melaka(UTeM)Durian TunggalMalaysia College of Computing&Informatics Saudi Electronic UniversityRiyadhSaudi Arabia Department of Electrical Electronic and System EngineeringUniversiti Kebangsaan MalaysiaUKM BangiSelangorMalaysia Computer Technology Engineering College of Engineering TechnologyAl-Kitab UniversityKirkukIraq Faculty of Engineering and Electronic Engineering Universiti Tun Hussein Onn Malaysia(UTHM)Batu PahatMalaysia 6Research Center DepartmentThe University of MashreqBaghdadIraq

Intelligent traffic control requires accurate estimation of the road states and incorporation of adaptive or dynamically adjusted intelligent algorithms for making the *** this article,these issues are handled by proposing a novel framework for traffic control using vehicular communications and Internet of Things *** framework integrates Kalman filtering and *** smoothing Kalman filtering,our data fusion Kalman filter incorporates a process-aware model which makes it superior in terms of the prediction *** traditional Q-learning,our Q-learning algorithm enables adaptive state quantization by changing the threshold of separating low traffic from high traffic on the road according to the maximum number of vehicles in the junction *** evaluation,the model has been simulated on a single intersection consisting of four roads:east,west,north,and south.A comparison of the developed adaptive quantized Q-learning(AQQL)framework with state-of-the-art and greedy approaches shows the superiority of AQQL with an improvement percentage in terms of the released number of vehicles of AQQL is 5%over the greedy approach and 340%over the state-of-the-art ***,AQQL provides an effective traffic control that can be applied in today’s intelligent traffic system.

关键词： Q-learning intelligent transportation system(ITS) traffic control vehicular communication kalman filtering smart city Internet of Things

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An Innovative Approach Using TKN-Cryptology for Identifying the Replay Assault

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Computers, materials & Continua 2024年第1期78卷 589-616页

作者： Syeda Wajiha Zahra muhammad Nadeem Ali Arshad Saman Riaz muhammad abu Bakr Ashit Kumar Dutta Zaid Alzaid Badr Almutairi Sultan Almotairi Department of Computer Science Alhamd Islamic UniversityIslamabad44000Pakistan Department of Computer Science and Technology University of Science and Technology BeijingBeijing100083China Department of Computer Science National University of TechnologyIslamabad44000Pakistan Department of Electrical Engineering National University of TechnologyIslamabad44000Pakistan Department of Computer Science and Information Systems College of Applied SciencesAlMaarefa UniversityRiyadh13713Saudi Arabia Department of Computer Science Faculty of Computer and Information SystemsIslamic University of MadinahMedinah42351Saudi Arabia Department of Information Technology College of Computer Sciences and Information Technology CollegeMajmaah UniversityAl-Majmaah11952Saudi Arabia Department of Natural and Applied Sciences Faculty of Community CollegeMajmaah UniversityMajmaah11952Saudi Arabia

Various organizations store data online rather than on physical *** the number of user’s data stored in cloud servers increases,the attack rate to access data from cloud servers also *** researchers worked on different algorithms to protect cloud data from replay *** of the papers used a technique that simultaneously detects a full-message and partial-message replay *** study presents the development of a TKN(Text,Key and Name)cryptographic algorithm aimed at protecting data from replay *** program employs distinct ways to encrypt plain text[P],a user-defined Key[K],and a Secret Code[N].The novelty of the TKN cryptographic algorithm is that the bit value of each text is linked to another value with the help of the proposed algorithm,and the length of the cipher text obtained is twice the length of the original *** the scenario that an attacker executes a replay attack on the cloud server,engages in cryptanalysis,or manipulates any data,it will result in automated modification of all associated values inside the *** mechanism has the benefit of enhancing the detectability of replay ***,the attacker cannot access data not included in any of the papers,regardless of how effective the attack strategy *** the end of paper,the proposed algorithm’s novelty will be compared with different algorithms,and it will be discussed how far the proposed algorithm is better than all other algorithms.

关键词： Replay attack malware message attack file encryption cryptology data security

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