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Unraveling the potential of acute intermittent hypoxia as a strategy for inducing robust repair in multiple sclerosis

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Neural Regeneration Research 2024年第11期19卷 2339-2340页

作者： Valerie m.K.Verge Nataliya Tokarska Justin m.Naniong Department of Anatomy Physiology and PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Cameco mS Neuroscience Research Center University of SaskatchewanSaskatoonSKCanada

multiple sclerosis(mS)is a debilitating inflammatory disease of the central nervous system characterized by immune-mediated segmental demyelination and variable degrees of axonal and neuronal degeneration that contribute to *** efficient and effective repair programs following demyelination is a major goal and challenge in *** mS therapies focus largely on modulating the immune aspects of the disease contributing to *** this alleviates some symptoms and mitigates damage,it does not tackle the fundamental challenge of effective remyelination,which few mS patients experience,especially in the progressive phase of the disease.

关键词： sclerosis degeneration damage

Imaging mass spectrometry:a molecular microscope for studying the role of lipids in Parkinson's disease

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Neural Regeneration Research 2024年第6期19卷 1179-1180页

作者： Vinata Vedam-mai Jacob m.Samuel Boone m.Prentice Department of Neurology University of FloridaGainesvilleFLUSA Department of Chemistry University of FloridaGainesvilleFLUSA

Parkinson's disease–A lipidopathy?The histopathological hallmark of Parkinson's disease(PD)and dementia with Lewy bodies are inclusions enriched inα-synuclein(α-syn),known as Lewy bodies,which are not only composed of proteins,but also a core of lipid *** has been thus far principally thought of as a“proteinopathy”caused by the misfolding of α-syn.

关键词： lipids species folding

Revealing high-dimensional dynamical symmetry in alignment magnetic resonance

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Science China(Physics,mechanics & Astronomy) 2024年第10期67卷 162-163页

作者： m.Suhail Zubairy Institute for Quantum Science and Engineering(IQSE)and Department of Physics and Astronomy Texas A&M UniversityCollege StationTexas 77843-4242USA

Symmetry permeates throughout science,underlying people's understanding on intriguing physical *** include conserved quantities,critical phenomena and selection *** symmetry,the counterpart of geometrical symmetry or static symmetry referring to the geometrical shape or structure of a physical system,is present in the motion behavior.

关键词： properties symmetry alignment

Genesis of nanocrystalline Ho_2O_3 via thermal decomposition of holmium acetate: Structure evolution and electrical conductivity properties

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Journal of Rare Earths 2019年第2期37卷 185-192页

作者： Bahaa m.abu-Zied Abdullah m.Asiri Center of Excellence for Advanced materials Research (CEAmR) King Abdulaziz University Chemistry Department Faculty of Science King Abdulaziz University Chemistry Department Faculty of Science Assiut University

This study focuses on the preparation of nanostructured holmium oxide via the decomposition of holmium acetate precursor utilizing the non-isothermal strategy. Thermogravimetric analysis(TGA) was used to follow up the various thermal events involved in the decomposition process. Dehydration completes approximately at 150℃, which is followed by the decomposition of the anhydrous acetate leading to the formation of holmium oxide. Based on the TGA results the acetate precursor was heated non-isothermally at the temperature range of 150 e700℃. The obtained solids were characterized using powder X-ray diffraction(XRD), X-ray photoelectron spectroscopy(XPS), Fourier transform infrared spectroscopy(FT-IR), field-emission scanning electron microscopy(FE-SEm) and transmission electron microscopy(TEm). It is found that nanocrystalline Ho_2 O_3 starts to form at 500℃ and presents the only phase detected at the 500 e700℃ range. The electrical conductivity of the solids that form at the temperature range of 300 e700℃ was investigated. The obtained values were correlated with the observed structural modifications accompanying the heat treatment. The electrical conductivity of the Ho_2 O_3 samples prepared at 500, 600 and 700℃ reaches the values of 1.92 × 10^(-7), 1.61 × 10^(-7) and 8.33 × 10^(-8) Ω^(-1)cm^(-1) at a measuring temperature of 500℃, respectively. These values are potentially advantageous for high-resistivity devices.

关键词： Nanocrystalline Ho2O3 Thermal decomposition Ho2O3 Holmium oxide Rare earth oxides Nanomaterials

Synthesis of Dy_2O_3 nanoparticles via hydroxide precipitation: effect of calcination temperature

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Journal of Rare Earths 2014年第3期32卷 259-264页

作者： Bahaa m.abu-Zied Abdullah m.Asiri Chemistry Department Faculty of Science King Abdulaziz University Center of Excellence for Advanced materials Research (CEAmR) King Abdulaziz University Chemistry Department Faculty of Science Assiut University

This work described the preparation of dysprosium oxide, Dy203, nanoparticles using the homogeneous precipitation method. Dy3＋ ions were precipitated using NaOH solution. The obtained product was filtered, dried, and then calcined for 1 h at the temperature range of 300-700 ℃ in static air. The calcination temperature of the Dy-precttrsor was chosen based on its decomposi- tion as indicated by the TGA analysis. The crystalline structure and surface morphology of the calcined solids were studied by X-ray diffraction （XRD）, field emission scanning electron microscopy （FE-SEm）, transmission electron microscopy （TEm） and X-ray pho- toelectron spectroscopy （XPS）. The obtained results revealed that Dy203 with crystallites size of 11-21 nm was formed at 500 ℃. Such value increased to 25-37 nm for the sample calcined at 700 ℃.

关键词： nanocrystalline dysprosium oxide Dy203 precipitation method Dy203 nanoparticles rare earths

Direct microwave leaching conditions of rare earth elements in fluorescent wastes

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Journal of Rare Earths 2024年第6期42卷 1165-1174,I0007页

作者： A.Bilen B.Birol m.N.Saridede S.S.Kaplan m.S.Sonmez Department of metallurgical and materials Engineering Yildiz Technical UniversityIstanbulTurkey Department of Chemical Engineering and materials Science Stevens Institute of TechnologyNew JereyUSA Department of metallurgical and materials Engineering Istanbul Technical UniversityIstanbulTurkey

The luminescent phosphor powder in the fluorescent lamp constitutes 2%of the lamp’s *** can be mentioned that fluorescent wastes are a crucial raw material to produce rare earth *** the present study,microwave leaching process was conducted to dissolve rare earth elements yttrium(Y),europium(Eu),and remaining rare earth elements(REEs)present in the phosphor powder of the fluorescent *** the yields were *** the microwave leaching process,the effects of the temperature(80-160℃),acid type(hydrochloric acid(HCl),nitric acid(HNO_(3)),sulphuric acid(H_(2)SO_(4))),acid concentration(0.5-6 mol/L),solid to liquid ratio(0.1:10-0.5:10)and reaction time(5-90 min)parameters on leaching efficiencies of varying rare earth elements and calcium were *** highest yield was obtained in the direct microwave leaching of fluorescent waste with the experimental conditions of 6 mol/L HCl,160℃,0.1:10 solid-to-liquid ratio(S:L),and 90 *** energy calculations were made,and kinetic models of the reactions were obtained,and it is observed that Y and Eu dissolution is diffusion-controlled,on the other hand,lanthanum(La),cerium(Ce),and terbium(Tb)were examined to be chemical reaction ***,calcium(Ca)and gadolinium(Gd)seem coherent with the mixed ***,mathematical models of all experimental studies are created with the response surface Box-Behnken method and the correlation coefficients of all the models are over 90%.

关键词： Rare earth elements(REEs) Direct microwave leaching Fluorescent waste Kinetic models Response surface method

Functional Outcomes of Adult Tibia Shaft Fractures Treated with Solid Intramedullary Nails versus Hollow Nails: A Systematic Review

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Open Journal of Orthopedics 2024年第3期14卷 149-172页

作者： Kwadwo Aning abu Bernard Hammond mohammed Issah Suglo Bukari Kizito Kakra Vormawor Ronald Awoonor-Williams David Anyitey-Kokor Paa Kwesi Baidoo Dominic Konadu-Yeboah Department of Orthopaedics St. John of God Hospital Duayaw Nkwanta Ghana Directorate of Trauma and Orthopaedics Komfo Anokye Teaching Hospital Kumasi Ghana Department of Surgery Tamale Teaching Hospital Tamale Ghana Department of Orthopadics and Trauma Seventh Day Adventist Hospital Asamang Ghana

Introduction: The management of fractures of the tibia shaft is an important aspect of orthopaedic care, and the selection of the surgical method for fixation can substantially impact patient outcomes. The current review aims to compare the outcomes of adult tibia fractures treated with solid nails to those treated with hollow nails. methods: A search on Scopus, Pubmed, and Cochrane Library, using three keywords (Outcome, Tibia shaft fractures, Nail) was conducted in April 2023. Results were compiled and two independent reviewers screened and selected eligible articles After removing duplicates, titles and abstracts were read to exclude ineligible studies. Full-text articles of the remaining papers were read to select eligible studies which were further critically appraised to ascertain their methodological quality. The data extracted from the selected papers were synthesized using a combination of pooling of results, tests of statistical difference (t-test and chi-square) and narrative synthesis methods. Results: A total of 2295 articles were obtained from the databases and citation searching. A total of 9 papers were identified as eligible and included in the review. Findings revealed that there is no statistical difference in the outcomes of tibia fractures treated with either solid or hollow nail groups such as duration of surgery (p = 0.541), rate of delayed and non-union (p = 0.342), and rate of surgical site infections (p = 0.395). Conclusion: Intramedullary nailing of tibia shaft fractures with either solid or hollow nails have similar functional outcomes.

关键词： Tibia Shaft Fractures Functional Outcome SIGN Nail Hollow Nail

The role of N-glycosylation in cancer

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1098-1110页

作者： Yu Lin David m.Lubman Department of Surgery University of Michigan Medical CenterAnn ArborMI 48109USA

Despite advances in understanding the development and progression of cancer in recent years,there remains a lack of comprehensive characterization of the cancer *** play an important role in medicine and are involved in various human disease conditions including ***-moieties participate in fundamental cancer processes like cell signaling,invasion,angiogenesis,and *** N-glycosylation significantly impacts cancer processes and targeted therapies in ***,understanding N-glycosylation in a tumor is essential for comprehending disease progression and discovering anti-cancer targets and biomarkers for therapy monitoring and *** review presents the fundamental process of protein N-glycosylation and summarizes glycosylation changes in tumor cells,including increased terminal sialylation,N-glycan branching,and ***,the role of N-glycosylation in tumor signaling pathways,migration,and metabolism are *** and glycopeptides as potential biomarkers for early detection of cancer based on site specificity have been ***,understanding and exploring the cancer glycoproteome,along with its role in medicine,implication in cancer and other human diseases,highlights the significance of N-glycosylation in tumor processes,necessitating further research for potential anticancer targets and biomarkers.

关键词： N-Glycosylated proteins Cancer signaling Cancer angiogenesis Cancer metabolism Cancer biomarkers

A FLEXIBLE OBJECTIVE-CONSTRAINT APPROACH AND A NEW ALGORITHm FOR CONSTRUCTING THE PARETO FRONT OF mULTIOBJECTIVE OPTImIZATION PROBLEmS

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Acta mathematica Scientia 2024年第2期44卷 702-720页

作者： N.HOSEINPOOR m.GHAZNAVI Faculty of mathematical Sciences Shahrood University of TechnologyShahroodIran

In this article, a novel scalarization technique, called the improved objective-constraint approach, is introduced to find efficient solutions of a given multiobjective programming problem. The presented scalarized problem extends the objective-constraint problem. It is demonstrated that how adding variables to the scalarized problem, can lead to find conditions for (weakly, properly) Pareto optimal solutions. Applying the obtained necessary and sufficient conditions, two algorithms for generating the Pareto front approximation of bi-objective and three-objective programming problems are designed. These algorithms are easy to implement and can achieve an even approximation of (weakly, properly) Pareto optimal solutions. These algorithms can be generalized for optimization problems with more than three criterion functions, too. The effectiveness and capability of the algorithms are demonstrated in test problems.

关键词： multiobjective optimization Pareto front scalarization objective-constraint approach proper efficient solution