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DIFFERENTIAL OPERATORS OF INFINITE ORDER IN THE SPACE OF RAPIDLY DECREASING SEQUENCES

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Acta mathematica Scientia 2016年第2期36卷 325-333页

作者： m.mALDONADO J.prada m.J.SENOSIAIN Department of mathematics Salamanca University

We consider the space of rapidly decreasing sequences s and the derivative operator D defined on it. The object of this article is to study the equivalence of a differential operator of infinite order; that is φ（D） =^∞∑k=0φkD^k.φk constant numbers an a power of ***, m.a.ing, is there a isomorphism X （from s onto s） such that Xφ（D） = D^nX？. We prove that if φ（D） is equivalent to Dn, then φ（D） is of finite order, in fact a polynom.a. of degree n. The question of the equivalence of two differential operators of finite order in the space s is addressed too and solved completely when n = 1.

关键词： Ordinary differential operators sequence spaces operators on function spaces

mutational landscape of gastric adenocarcinoma in Latin America: A genetic approach for precision medicine

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Genes & Diseases 2022年第4期9卷 928-940页

作者： Dennis Cerrato-Izaguirre Yolanda I.Chirino Claudia m.García-Cuellar miguel Santibáñez-Andrade Diddier prada Angélica Hernández-Guerrero Octavio Alonso Larraga Javier Camacho Yesennia Sánchez-Pérez Subdirección de Investigación Básica Instituto Nacional de Cancerología(INCan)TlalpanCiudad de MéxicoCP 14080Mexico Departamento de Farmacología Centro de Investigación y de Estudios Avanzados del I.P.N.(CINVESTAV)Ciudad de MéxicoCP 07360Mexico Unidad de Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoLos Reyes IztacalaTlalnepantla de BazEstado de MéxicoCP 54090Mexico Departamento de Informática Biomédica Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoCoyoacánCiudad de MéxicoCP 04510Mexico Department of Environmental Health Science Mailman School of Public HealthColumbia UniversityNew YorkNY 10027USA Servicio de Endoscopía Instituto Nacional de Cancerología(INCan)TlalpanCiudad de MéxicoCP 14080Mexico

Latin-America (LATAm) is the second region in gastric cancer incidence;gastric adenocarcinoma (GA) represents 95% of all cases. We provide a mutational landscape of GA highlighting a) germline pathogenic variants associated with hereditary GA, b) germline risk variants associated with sporadic GA, and c) somatic variants present in sporadic GA in LATAm, and analyze how this landscape can be applied for precision medicine. We found that Brazil, Chile, Colombia, mexico, Peru, and Venezuela are the countries with more published studies from LATAm explicitly related to GA. Our analysis displayed that different germline pathogenic variants for the CDH1 gene have been identified for hereditary GA in Brazilian, Chilean, Colombian, and mexican populations. An increased risk of developing somatic GA is associated with the following germline risk variants: IL-4, IL-8, TNF-α, PTGS2, NFKB1, RAF1, KRAS and mAPK1 in Brazilian;IL-10 in Chilean;IL-10 in Colombian;EGFR and ERRB2 in mexican, TCF7L2 and Chr8q24 in Venezuelan population. The path from mutational landscape to precision medicine requires four development levels: 1) Data compilation, 2) Data analysis and integration, 3) Development and approval of clinical approaches, and 4) Population benefits. Generating local genomic information is the initial padlock to overcome to generate and apply precision medicine.

关键词： Ethnicities Genome Latin America mutati on Precisi on medicine Stomach neoplasms

A 4-year retrospective study of add-on therapy to the fixed combination of dorzolamide/timolol for the treatment of POAG

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 330-334页

作者： Curt Hartleben-matkin Diddier prada Rafael mancilla-Vences Glaucoma Service Instituto de Oftalmología Fundación Conde de Valenciana Unidad de Investigación Biomédica en Cáncer Instituto Nacional de Cancerología de México Departamento de Informática Biomédica Faculty of Medicine Universidad Nacional Autónoma de México(UNAM) Laboratory of Environmental Epigenetics Harvard School of Public Health

AIm:To evaluate the long-term response to the fixed combination of dorzolamide/timolol in patients with primary open angle glaucoma(POAG)and the addition of other intraocular pressure(IOP)lowering medications such as prostaglandin analogs and ***:A retrospective,non-randomized,and descriptive clinical study was performed with 182 eyes diagnosed with *** were divided into three groups:a group with fixed combination of dorzolamide/timolol only,a second group with prostaglandin analogs plus fixed combination of dorzolamide/timolol,and a third group with the addition of brimonidine to the same fixed *** data were gathered retrospectively and the differences between groups were ***:IOP was reduced satisfactorily in all three groups;however,a progressive IOP reduction was noted in the group with the fixed combination plus prostaglandin *** this group,a progressive,significant and more homogeneous response of the reduction was noted in com.a.ison with the other ***:IOP reduction was efficacious in all three *** addition of prostaglandin analogs showed progressive IOP reduction,progressive responseand absence of long-term *** did not show a significant additive effect.

关键词： fixed combination, Cosopt® , dorzolamide/timolol, prostaglandin analogs, brimonidine, glaucoma

Enhancement of output power density in a modified polytetrafluoroethylene surface using a sequential O_(2)/Ar plasma etching for triboelectric nanogenerator applications

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Nano Research 2022年第1期15卷 272-279页

作者： Teerayut prada Viyada Harnchana Anthika Lakhonchai Artit Chingsungnoen Phitsanu Poolcharuansin Narong Chanlek Annop Klamchuen Prasit Thongbai Vittaya Amornkitbamrung Department of Physics Khon Kaen UniversityKhon Kaen 40002Thailand Institute of Nanomaterials Research and Innovation for Energy(IN-RIE) NANOTEC-KKU RNN on Nanomaterials Research and Innovation for EnergyKhon Kaen UniversityKhon Kaen 40002Thailand Technological Plasma Research Unit Department of PhysicsFaculty of ScienceMahasarakham UniversityMaha Sarakham 44150Thailand Synchrotron Light Research Institute(Public Organization) Naklwn Ratchasima 30000Thailand National Nanotechnology Center(NANOTEC) NSTDAPathum Thani 12120Thailand

In this work,the surface modification using a two-steps plasma etching has been developed for enhancing energy conversion performance in polytetrafluoroethylene(PTFE)triboelectric nanogenerator(TENG).Enhancing surface area by a powerful O_(2) and Ar bipolar pulse plasma etching without the use of CF_(4) gas has been demonstrated for the first *** with modified surface PTFE using a sequential two-step O_(2)/Ar plasma has a superior power density of 9.9 W·m^(-2),which is almost thirty times higher than that of a pristine PTFE *** synergistic combination of high surface area and charge trapping sites due to chemical bond defects achieved from the use of a sequential O_(2)/Ar plasma gives rise to the intensified triboelectric charge density and the enhancement of power output of PTFE-based *** effects of plasma species and plasma etching sequence on surface morphologies and surface chemical species were investigated by a field emission scanning electron microscopy(FESEm),atomic force microscopy(AFm),and X-ray photoelectron spectroscopy(XPS).The correlation of surface morphology,chemical structure,and TENG performance was *** addition,the applications of mechanical energy harvesting for lighting,charging capacitors,keyboard sensing and operating a portable calculator were demonstrated.

关键词： two-step plasma etching O_(2)and Ar plasma CF_(4)free triboelectric nanogenerator power output enhancement

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陈列：品牌卖出去的“硬道理”

中国制衣 2006年第3期 64-67页

作者：张玲 prada 北京服装学院

陈列不仅仅在于欣赏,更重要的是直接与销售利润挂钩……终端是让产品实现商品价值的最后一个环节,产品从概念产生直到消费者手中,前期大量工作价值的体现都取决于终端的销售。而陈列作为品牌终端建设的重要一环,成为推动品牌终端销售的... 详细信息

陈列不仅仅在于欣赏,更重要的是直接与销售利润挂钩……终端是让产品实现商品价值的最后一个环节,产品从概念产生直到消费者手中,前期大量工作价值的体现都取决于终端的销售。而陈列作为品牌终端建设的重要一环,成为推动品牌终端销售的强大动力。陈列是品牌设计理念的终端整合美国橱窗设计领域资深专家马丁·m·派格勒说:"如果说设计创造了产品,那么。

关键词：品牌终端陈列购买欲望设计理念陈列师橱窗设计顾客宝姿货品商品消费者购买行为橱窗展示

Fecal immunochemical test accuracy in average-risk colorectal cancer screening

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World Journal of Gastroenterology 2014年第4期20卷 1038-1047页

作者： Vicent Hernandez Joaquin Cubiella m Carmen Gonzalez-mao Felipe Iglesias Concepción Rivera m Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro macenlle Alfonso martínez-Turnes David martínez-Ares Pamela Estevez Estela Cid m Carmen Vidal Angeles López-martínez Elisabeth Hijona marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-prada the COLONPREV study investigators Department of Gastroenterology Complexo Hospitalario Universitario de Vigo Department of Gastroenterology Complexo Hospitalario Universitario de Ourense Department of Clinical Analysis Complexo Hospitalario Universitario de Vigo Department of Pathology Complexo Hospitalario Universitario de Vigo Department of Gastroenterology Donostia Hospital Biodonostia Institute University of the Basque Country UPV/EHU

AIm: To assess the fecal immunochemical test (FIT) accuracy for colorectal cancer (CRC) and advanced neoplasia (AN) detection in CRC screening.

关键词： Colorectal neoplasms Early detection of cancer Sensitivity and specificity Adenoma Occult blood Cost-benefit analysis

Left Ventricle Postinfarction Pseudoaneurysm: Anatomical Forms and Surgical management

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Surgical Science 2014年第4期5卷 138-145页

作者： J. m. Garrido A. Ferreiro J. F. Rodríguez-Vázquez P. prada S. Verdugo J. Silva S. López-Checa I. Sánchez-montesinos Departamento de Anatom.a.y Embriología Humana II Facultad de Medicina Universidad Complutense de Madrid Madrid Spain Departamento de Anatom.a.y Embriología Humana Facultad de Medicina Universidad de Granada Granada Spain Servicio de Cirugía Cardiovascular HU Ramón y Cajal Departamento de Ciencias Morfológicas Universidad Europea de Madrid Madrid Spain Servicio de Cirugía Cardiovascular HU Ramón y Cajal Madrid Spain Servicio de Cirugía Cardiovascular HU Virgen de las Nieves Granada Spain

Introduction: Left Ventricle Postinfarction Pseudoaneurysm (LVPS)—false aneurysm occurs after a free-wall rupture contained by the adjacent pericardium. LVPS lacks the normal structure of the ventricular wall and disrupts the normal chamber anatomy. However, the natural history, clinical presentation and surgical outcome are still unclear. For that reason, it is necessary to describe the most relevant anatomical characteristics of LVPS and the appropriate surgical strategies currently applied. methods: We reviewed the anatomical characteristics of several patients diagnosed of LVPS and the surgical technique performed. In this work two different anatomical types of LVPS are described in detail, with the surgical and structural implications for left ventricle reconstruction. Results: There are two different anatomical forms of LVPS: 1) Typical pseudoaneurysm, with a small gateway neck between the Left Ventricle and the false aneurysm chamber (Figure 1(A));2) Atypical pseudoaneurysm, in which the anatomical defect is bigger, without well-defined edges, extends over a large segment of infarcted and thinned myocardial tissue. In both cases, the therapeutics targets and the surgical techniques used were directed to restore the normal geometry of Left Ventricle, keeping the optimal mitral valve function. Conclusions: The surgical key-step is to preserve or to remodel the ventricular chamber anatomy. This fact restores the ventricular geometry, not only removing the wall discontinuity that generated the pseudoaneurysm. Nevertheless, final prognosis depends on the underlying ischemic cardiomyopathy and mechanical complications, such us mitral regurgitation or ventricular septal defect.

关键词： Ventricular Anatomy Left Ventricle Pseudoaneurysm Surgical Treatment Ventricular Remodelling Restore of Left Ventricle morphology and Function of Left Ventricle Ischemic Cardiomyopathy

LIGHT STRUCTURES FOR INDUSTRIAL ARCHITECTURE

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LIGHT STRUCTURES FOR INDUSTRIAL ARCHITECTURE

交通相关的空气污染与血压和线粒体丰度的关系

International Symposium on New Olympics New Shell and Spatial Structures

作者： Ferrer Ferrer C.m Ferrán Gozálvez J.J Torregrosa Soler J.B Ferrer Gisbert C.m Sánchez Romero F.J Redón Santafé m Vallés prada J.J. Construction Teaching Unit. Departamento de Ingeniería Rural y Agroalimentaria.Universidad Politécnica de Valencia. 46022 Valencia. Spain. Construction Professor. Construction Teaching Unit.Departamento de Ingeniería Rural y Agroalimentaria. Universidad Politécnica de Valencia.46022 Valencia. Spain Assistant Construction Professor. Construction Teaching Unit.Departamento de Ingeniería Rural y Agroalimentaria.Universidad Politécnica de Valencia.46022 Valencia.Spain Assistant Construction Professor. Construction Teaching Unit.Departamento de Ingeniería Rural y Agroalimentaria.Universidad Politécnica de Valencia.46022 Valencia.Spain Assistant Construction Professor. Construction Teaching Unit.Departamento de Ingeniería Rural y Agroalimentaria.Umversidad Politécnica de Valencia. 46022 Valencia.Spain Collabotator Construction Professor. Construction Teaching Unit.Departamento de Ingeniería Rural y Agroalimentaria. Universidad Politécnica de Valencia. 46022 Valencia. Spain Collaborator Construction Professor. Construction Teaching Unit. Departamento de Ingeniería Rural y Agroalimentaria.Universidad Politecnica de Valencia. 46022 Valencia. Spain Construction Professor.

＜正＞In the Educational Construction Unit of the Rural and Agricultural Engineering Department of the Polytechnic University of Valencia, we have been developing a series of space structural typologies, for industria...

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中华高血压杂志 2015年第11期23卷 1099-1099页

作者： Zhong J Cayir A Trevisi L Sanchez-Guerra m Lin X Peng C Bind mA prada D Laue H Brennan KJ Dereix A Sparrow D Vokonas P Schwartz J Baccarelli AA 刘莉叶鹏

该文研究线粒体丰度（一种代偿细胞氧化还原失衡的自适应机制）在黑色碳（车辆交通污染的示踪剂）和血压关系中的作用。方法：纳入标准老龄化研究中的675名老年男性进行一次或多次随访，评估定点监视器中的每日环境黑色碳与血压水平。

关键词：血压水平交通污染线粒体空气污染丰度适应机制氧化还原老年男性