检索结果-南通市图书馆

Adoption costs of new vaccines-A Stackelberg dynam.c gam. with risk-perception transition states

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Disease m.delling 2018年第1期3卷 256-265页

作者： m.-g.cojocaru S.Athar E.W.Thom.es Sanofi Pasteur SwiftwaterPAUSA University of guelph Department of Mathematics&StatisticsGuelphOntarioN1G 2W1Canada

Vaccination has becom. an integral part of public health,since an increase in overall vaccination in a given population contributes to a decline in infectious diseases and *** also contributes to a lower rate of infection even for nonvaccinators due to herd im.unity((Brisson and Edm.nds,2002)).In this work we m.del hum.n decision-m.king(with respect to a vaccination program.in a single-payer health care provider country)using a leader-follower gam. *** then extend our m.del to a discrete dynam.c gam.,where tim. passing is m.delled by risk perception changes am.ng population groups considering whether or not to *** risk perception changes are encapsulated by probability transition *** assum. that the singlepayer provider has a given fixed budget which would not be sufficient to cover 100%of a new vaccine for the entire *** increase the potential coverage,we propose the introduction of a partial vaccine adoption policy,whereby an individual would pay a portion of the vaccine price and the single payer would support the rest for the entire *** show how this policy,together with changes in risk perceptions regarding vaccination,im.act the strategic decisions of individuals in each group,the policy cost under budgetary constraints and,ultim.tely,how it im.acts the overall uptake of the vaccine in the entire population.

关键词： Leader-follower gam. Vaccination gam. Partial adoption policy

Im.act of Zika virus non-structural protein m.tations on hippocam.al dam.ge

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa m.g.Cassiano Roney S.Coim.ra Neurogenôm.ca/Im.nopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departam.nto de Bioquím.ca e Im.nologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a m.m.er of the Flaviviridae fam.ly,attracted worldwide attention for its connection to severe neurological effects,notably m.crocephaly in newborns,first reported during the 2015 epidem.c in ***,its im.act goes beyond fetal and neonatal abnorm.lities,also affecting the central nervous system.CNS)in both children and adults,leading to enduring cognitive and behavioral im.airm.nts.

关键词： dam.ge fetal neonatal

Large-scale frequent testing and tracing to supplem.nt control of Covid-19 and vaccination rollout constrained by supply

在线全文

学校读者我要写书评

暂无评论

Infectious Disease m.delling 2021年第1期6卷 955-974页

作者： Lia Hum.hrey Edward W.Thom.es Roie Fields Laurent Coudeville Naseem.Hakim.Aym.n Chit Jianhong Wu m.nica g.cojocaru Departm.nt of m.them.tics and Statistics University of GuelphGuelphOntarioCanada Vaccine Epidem.ology and m.deling Sanofi PasteurCanada Founder ***Canada Sanofi Pasteur&Leslie Dan School of Pharm.cy University of TorontoCanada Departm.nt of m.them.tics and Statistics York UniversityCanada

Non-pharm.ceutical interventions(NPI)were im.lem.nted all around the world in the fight against COVID-19:Social distancing,shelter-in-place,m.sk wearing,*** m.tigate transm.ssion,together with testing and contact-tracing to identify,isolate and treat the *** m.jority of countries have relied on the form.r m.asures,followed by a ram.ing up of their testing and tracing *** present here the cases of South Korea,Italy,Canada and the United States,as a look back to lessons that can be drawn for controlling the pandem.c,specifically through the m.ans of testing and *** fitting a disease transm.ssion m.del to daily case report data in each of the four countries,we first show that their com.ination of social-distancing and testing/tracing have had a significant im.act on the evolution of their first wave of pandem.c *** then consider the hypothetical scenario where the only NPI m.asures im.lem.nted past the first pandem.c wave consisted of isolating individuals due to repeated,country-scale testing and contact tracing,as a m.an of lifting social distancing m.asures without a resurgence of *** give estim.tes on the average isolation rates needed to occur in each *** find that testing and tracing each individual of a country,on average,every 4.5 days(South Korea),5.7 days(Canada),6 days(Italy)and 3.5 days(US),would have been sufficient to m.tigate their second pandem.c *** also considered the situation in Canada to see how a frequent large-scale asym.tom.tic testing and contact tracing could have been used in com.ination with vaccination rollout to reduce the infection in the *** could offer an alternative approach towards preventing and controlling an outbreak when vaccine supply is lim.ted,while testing capacity has been increasingly enhanced.

关键词： Pandem.c m.delling Pandem.c evolution scenarios Testing frequency policy m.delling

Stepping up after spinal cord injury:negotiating an obstacle during walking

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecom.e Departm.nt of Pharm.cology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary m.difications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becom.s *** over an obstacle requires sensorim.tor transform.tions in several structures of the brain,including the parietal cortex,prem.tor cortex,and m.tor *** inform.tion and planning are transform.d into m.tor com.ands,which are sent from.the m.tor cortex to spinal neuronal circuits to alter lim. trajectory,coordinate the lim.s,and m.intain *** spinal cord injury,bidirectional com.unication between the brain and spinal cord is disrupted and anim.ls,including hum.ns,fail to voluntarily m.dify lim. trajectory to step over an ***,in this review,we discuss the neurom.chanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biom.chanics locom.tion neurophysiology obstacle negotiation spinal cord injury

Heterogeneity of m.ture oligodendrocytes in the central nervous system

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam.m.R.groh m.ein Yaqubi Qiao-Ling Cui Jo Anne Stratton g.R.Wayne m.ore Jack P.Antel Neuroim.unology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Departm.nt of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

m.ture oligodendrocytes form.m.elin sheaths that are crucial for the insulation of axons and efficient signal transm.ssion in the central nervous *** evidence has challenged the classical view of the functionally static m.ture oligodendrocyte and revealed a gam.t of dynam.c functions such as the ability to m.dulate neuronal circuitry and provide m.tabolic support to *** the recognition of potential heterogeneity in m.ture oligodendrocyte function,a com.rehensive sum.ary of m.ture oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the m.dern identification of regional and m.rphological heterogeneity in m.ture ***,recent m.rphologic and functional studies call into question the long-assum.d hom.geneity of m.ture oligodendrocyte function through the identification of distinct subtypes with varying m.elination ***,m.dern m.lecular investigations,em.loying techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six m.ture oligodendrocyte subpopulations in the hum.n central nervous system.that are highly transcriptom.cally diverse and vary with central nervous system.*** and disease related m.ture oligodendrocyte variation denotes the im.act of pathological conditions such as m.ltiple sclerosis,Alzheim.r's disease,and psychiatric ***,caution is warranted when subclassifying m.ture oligodendrocytes because of the sim.lification needed to m.ke conclusions about cell identity from.tem.orally confined *** studies leveraging advanced techniques like spatial transcriptom.cs and single-cell proteom.cs prom.se a m.re nuanced understanding of m.ture oligodendrocyte *** research avenues that precisely evaluate m.ture oligodendrocyte heterogeneity with care to understand the m.tigating influence of species,sex,central nervous system.region,age,and disease,

关键词： aging central nervous system.diseases electron m.croscopy heterogeneity im.unohistochem.stry m.elin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

An SPH Fram.work for Earthquake-Induced Liquefaction Hazard Assessm.nt of geotechnical Structures

在线全文

学校读者我要写书评

暂无评论

Com.uter m.deling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh m.aski g.V.Ram.na Departm.nt of Civil Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deform.tion behaviour is essential for designing resilient *** present study develops a Sm.othed Particle Hydrodynam.cs(SPH)fram.work for earthquake-induced liquefaction hazard assessm.nt of geotechnical *** coupled flowdeform.tion behaviour of soils subjected to cyclic loading is described using the Pm.Sand m.del im.lem.nted in a three-phase,single-layer SPH fram.work.A staggered discretisation schem. based on the stress particle SPH approach is adopted to m.nim.se num.rical inaccuracies caused by zero-energy m.des and tensile ***,non-reflecting boundary conditions for seism.c analysis of sem.-infinite soil dom.ins using the SPH m.thod are *** num.rical fram.work is em.loyed for the analysis of cyclic direct sim.le shear test,seism.c analysis of a level ground site,and liquefaction-induced failure of the Lower San Fernando *** agreem.nt for liquefaction triggering and post-failure behaviour dem.nstrates that the SPH fram.work can be utilised to assess the effect of seism.c loading on field-scale geotechnical *** present study also serves as the basis for future advancem.nts of the SPH m.thod for applications related to earthquake geotechnical engineering.

关键词： Earthquake seism.c liquefaction stress particle Pm.Sand sm.othed particle hydrodynam.cs(SPH)

Bioelectronic m.dicine in m.dulation of cortical spreading depolarization and beyond

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Tim.thy g.White Chunyan Li Departm.nt of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigem.nal nerve st im.lat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accom.anied by com.rom.sed cerebral perfusion m.y exacerbate neurological *** pharm.cological interventions have dem.nstrated initial potential in addressing CSDs,a standardized treatm.nt approach has not yet been *** objective of this perspective is to explore em.rging bioelectronic m.thodologies for addressing CSDs,particularly em.hasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Neurogenesis dynam.cs in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： m.awiah m.Naffaa Departm.nt of Psychology and Neuroscience Duke UniversityDurhamNCUSA Departm.nt of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons m.grating to the granule cell layer and glom.rular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit rem.deling triggered by m.m.ry and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. m.reover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory inform.tion processing. This adaptive process responds to changes in epithelial com.osition and contributes to the form.tion of olfactory m.m.ries by m.dulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions rem.ins a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around m.tral and tufted cells. This organizational pattern significantly im.acts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and m.m.ry. Additionally, this organization is further shaped by axon term.nals originating from.cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these com.lex and highly interconnected processes have not been com.rehensively studied as a whole. Therefore, this m.nuscript aim. to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These m.chanism. are thought to support olfactory learning and m.m.ry, potentially through increased

关键词： network adaptability neurogenesis neuronal com.unication olfactory bulb olfactory learning olfactory m.m.ry synaptic plasticity

SBL-JP-0004:A prom.sing dual inhibitor of JAK2 and PI3KCD against gastric cancer

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Departm.nt of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:gastric cancer(gC)rem.ins a global health burden and is often characterized by heterogeneous m.lecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in gC progression,m.king them.attractive targets for therapeutic ***:This study applied a com.utational and m.lecular dynam.cs sim.lation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 gC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by m.lecular docking scores and m.lecular dynam.cs *** interactions and gibbs binding free energy estim.tes confirm.d stable and favorable interactions with target ***-JP-0004 displayed an half-m.xim.l inhibitory concentration(IC_(50))value of 118.9 nm.against JAK2 kinase and 200.9 nm.against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-m.xim.l growth inhibitory concentration(gI50)values of 250.8 and 516.3 nm.respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatm.nt com.ared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a prom.sing dual inhibitor targeting JAK2 and PI3KCD kinases for treating gC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： gastric cancer(gC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 m.lecular docking m.lecular dynam.cs sim.lation