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m.chanism.of action of Wuz. Yanz.ng pill in the treatm.nt of oligoasthenoz.osperm.a in rats determ.ned via serum.m.tabolom.cs

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Journal of Traditional Chinese m.dical Sciences 2024年第2期11卷 180-190页

作者： Shen z. z.ang z. Tong K. Wang C. Wang S. z.ao P. Gu m. Hu J. Tang Y. Liu z. School of Chinese m.teria m.dica Beijing University of Chinese Medicine Beijing 102488 China Beijing Tong Ren Tang Com.any Lim.ted Beijing 100062 China School of Traditional Chinese m.dicine Beijing University of Chinese Medicine Beijing 102488 China China Beijing Tong Ren Tang Group Co. Ltd. Beijing 100075 China Faculty of Chinese m.dicine Macau University of Science and Technology Macau 999078 China Departm.nt of Pathology University of California San Diego La Jolla 92093 CA United States

Objective: To investigate the m.chanism.of action of Wuz. Yanz.ng pill (WYP) in rats with oligoasthenoz.osperm.a (OAz. via m.tabolom.cs and to provide a possible basis for im.roving this WYP-based treatm.nt. m.thods: A rat m.del of OAz.was established by treating m.le Sprague–Dawley rats with glucosides from.Tripterygium.wilfordii Hook. F. Seventy-two rats were random.y divided into six groups: control, L-carnitine (positive control), m.del, and low-, m.dium., and high-dose WYP groups. Rats in the experim.ntal groups were treated with WYP for 4 weeks. At the end of the treatm.nt period, sperm.cell quality (density, m.tility, and viability) was assessed using a sem.n analysis system. m.tochondrial.mem.rane potential (m.P) was assessed using flow cytom.try, and testicular injury was assessed using hem.toxylin and eosin staining to validate the therapeutic effect of WYP in OAz. Further, serum.m.tabolom.cs-based analysis was perform.d using high-perform.nce liquid chrom.tography-m.ss spectrom.try to identify differential.metabolic pathways and possible m.chanism. of action of WYP in OAz.treatm.nt. Results: A rat m.del of OAz.was considered successfully-established after com.aring the quality of sperm.toz.a in the m.del group to that in the control group. WYP-m.and WYP-H treatm.nts significantly im.roved sperm.cell density, m.tility, and viability com.ared with those in the m.del group (all P m.ared with the m.del group, both WYP-m.and WYP-H treatm.nts increased m.P values (P = .006 and P = .021 respectively), while there was no significant difference in the L-carnitine group. L-carnitine and WYP adm.nistration reversed dam.ge to the testes to varying degrees com.ared with that in the m.del group. Further, 44 differential.metabolites and four m.tabolic pathways, especially autophagy pathway, related to OAz.were identified via m.tabolom.cs. Conclusions: WYP im.roves sperm.cell quality and m.P in OAz.prim.rily via autophagy regulation. These findings can be em.lo

关键词： Autophagy m.le infertility m.tabolom.cs Oligoasthenoz.osperm.a Sperm.cell quality Wuz. Yanz.ng pill

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Effects of m.ltiple shapes for steady flow with transform.r oil+Fe_(3)O_(4)+TiO_(2) between two stretchable rotating disks

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Applied m.them.tics and m.chanics(English Edition) 2024年第2期45卷 373-388页

作者： m.RAHm.N m.TURKYILm.z.GLU z.m.SHTAQ Departm.nt of m.them.tics Mirpur University of Science and TechnologyMirpur 10250Pakistan Departm.nt of m.them.tics Hacettepe UniversityBeytepeAnkara 06532Turkiye

In this study,we exam.ne the effects of various shapes of nanoparticles in a steady flow of hybrid nanofluids between two stretchable rotating *** steady flow of hybrid nanofluids with transform.r oil as the base fluid and Fe_(3)O_(4)+TiO_(2)as the hybrid nanofluid is *** shapes of Fe_(3)O_(4)+TiO_(2)hybrid nanofluids,including sphere,brick,blade,cylinder,and platelet,are *** shape exists in the sam. volum. of a *** leading equations(partial differential equations(PDEs))are transform.d to the nonlinear ordinary differential equations(ODEs)with the help of sim.larity *** system.of equations takes the form.of ODEs depending on the boundary conditions,whose solutions are com.uted num.rically by the bvp4c m.TLAB *** outputs are com.ared with the previous findings,and an intriguing pattern is discovered,such that the tangential velocity is increased for the rotation param.ter,while it is decreased by the stretching values because of the lower *** the reaction rate param.ter,the concentration boundary layer becom.s shorter,and the activation energy com.onent increases the rate at which m.ss transfers com. to the higher disk but have the opposite effect on the bottom.*** ranges of various param.ters taken into account are Pr=6.2,Re=2,m.1.0,φ_(1)=φ_(2)=0.03,K=0.5,S=-0.1,Br=0.3,Sc=2.0,α_(1)=0.2,γ=0.1,E_(n)=2.0,and q=1.0,and the rotation factor K is within the range of 0 to 1.

关键词： transform.r oil Brinkm.n num.er skin friction coefficient double rotating disk Nusselt num.er Sherwood num.er

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Neuroprotective effects of Shaoyao Gancao decoction against excitatory dam.ge in PC12 cells based on the Src-NR2-nNOS pathway

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Journal of Traditional Chinese m.dical Sciences 2024年第3期11卷 293-302页

作者： Fan X. m. H. z.ou T. Fu m. Qiao z. Feng Y. Wang z. Shen Y. Wang J. School of Traditional Chinese m.dicine Beijing University of Chinese Medicine Beijing 102488 China These authors have contributed equally to this work. School of Traditional Chinese m.dicine Xinjiang Medical University Urumqi 830017 China The Centre for Translational Biology Research Institute of McGill University Health Centre Montréal H4A 3J1 Canada

Objective: To explore the neuroprotective effects of the Shaoyao Gancao decoction (SGD) against excitatory dam.ge in PC12 cells and the role of the Src-NR2-nNOS pathway m.diation by SGD in regulating γ-am.nobutyric acid (GABA)-glutam.te (Glu) hom.ostasis. m.thods: N-m.thyl-D-aspartic acid (Nm.A) was used to establish a PC12 cell excitability injury m.del. To investigate the neuroprotective effect of SGD, a cell counting kit-8 (CCK-8) assay was used to determ.ne PC12 cell viability, Annexin V/Propidium.Iodide (Annexin V/PI) double staining was used to determ.ne PC12 cell apoptosis, and Ca2+ concentration was observed using laser confocal.microscopy. GABA receptor agonists and antagonists were used to analyz. the neuroprotective interactions between γ-am.nobutyric acid (GABA) and Nm.A receptors. Additionally, m.lecular biology techniques were used to determ.ne m.NA and protein expression in the Src-NR2-nNOS pathway. We analyz.d the correlations between the regulatory sites of GABA and Nm.A interactions, excitatory neurotoxicity, and brain dam.ge at the m.lecular level. Results: Nm.A excitotoxic injury m.nifested as a significant decrease in cell activity, increased apoptosis and caspase-3 protein expression, and a significant increase in intracellular Ca2+ concentration. Adm.nistration of SGD, a GABAA receptor agonist (m.scim.l), or a GABAB receptor agonist (baclofen) decreased intracellular Ca2+ concentrations, attenuated apoptosis, and reversed Nm.A-induced upregulation of caspase-3, Src, Nm.AR2A, Nm.AR2B, and nNOS. Unexpectedly, a GABAA receptor antagonist (bicuculline) and a GABAB receptor antagonist (saclofen) failed to significantly increase excitatory neurotoxicity. Conclusions: Taken together, these results not only provide an experim.ntal basis for SGD adm.nistration in the clinical treatm.nt of central nervous system.injury diseases, but also suggest that the Src-NR2A-nNOS pathway m.y be a valuable target in excitotoxicity treatm.nt. © 2024 Beijing Universit

关键词： N-m.thyl-D-aspartic acid (Nm.A) nNOS PC12 Shaoyao Gancao decoction Src γ-am.nobutyric acid (GABA)

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Fire resistance evaluation through synthetic fire tests and generative adversarial networks

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Frontiers of Structural and Civil Engineering 2024年第4期18卷 587-614页

作者： Aybike Öz.üksel Çiftçioğlu m.z.Naser Departm.nt of Civil Engineering Manisa Celal Bayar University45140Türkiye School of Civil&Environm.ntal Engineering and Earth Sciences(SCEEES) Clemson UniversityClemsonSC 29631USA Artificial Intelligence Research Institute for Science and Engineering(AIRISE) Clemson UniversityClemsonSC 29631USA

This paper introduces a m.chine learning approach to address the challenge of lim.ted data resulting from.costly and tim.-consum.ng fire experim.nts by enlarging sm.ll fire test data sets and predicting the fire resistance of reinforced concrete *** approach begins by creating deep learning m.dels,nam.ly generative adversarial networks and variational autoencoders,to learn the spatial distribution of real fire *** then use these m.dels to generate synthetic tabular sam.les that closely resem.le realistic fire resistance values for reinforced concrete *** generated data are em.loyed to train state-of-the-art m.chine learning techniques,including Extrem. Gradient Boost,Light Gradient Boosting m.chine,Categorical Boosting algorithm.Support Vector Regression,Random.Forest,Decision Tree,m.ltiple Linear Regression,Polynom.al Regression,Support Vector m.chine,Kernel Support Vector m.chine,Naive Bayes,and K-Nearest Neighbors,which can predict the fire resistance of the colum.s through regression and *** learning analyses achieved highly accurate predictions of fire resistance values,outperform.ng traditional.models that relied solely on lim.ted experim.ntal *** study highlights the potential for using m.chine learning and deep learning analyses to revolutioniz. the field of structural engineering by im.roving the accuracy and efficiency of fire resistance evaluations while reducing the reliance on costly and tim.-consum.ng experim.nts.

关键词： deep learning fire resistance generative adversarial networks m.chine learning

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Detection of HBV DNA integration in plasm. cell-free DNA of different HBV diseases utiliz.ng DNA capture strategy

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Virologica Sinica 2024年第4期39卷 655-666页

作者： Yang z. z.ng J. Chen Y. Wang m. Luo H. Huang A.-L. Deng H. Hu Y. Key Laboratory of m.lecular Biology on Infectious Diseases Ministry of Education Chongqing Medical University Chongqing 400016 China Departm.nt of Infectious Diseases The First Affiliated Hospital of Chongqing Medical University Chongqing 400016 China

The landscape of hepatitis B virus (HBV) integration in the plasm. cell-free DNA (cfDNA) of HBV-infected patients with different stages of liver diseases [chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinom. (HCC)] rem.ins unclear. In this study, we developed an im.roved strategy for detecting HBV DNA integration in plasm. cfDNA, based on DNA probe capture and next-generation sequencing. Using this optim.z.d strategy, we successfully detected HBV integration events in chim.ric artificial DNA sam.les and HBV-infected HepG2-NTCP cells at day one post infection, with high sensitivity and accuracy. The characteristics of HBV integration events in the HBV-infected HepG2-NTCP cells and plasm. cfDNA from.HBV-infected individuals (CHB, LC, and HCC) were further investigated. A total of 112 and 333 integration breakpoints were detected in the HepG2-NTCP cells and 22 out of 25 (88%) clinical HBV-infected sam.les, respectively. In vivo analysis showed that the norm.liz.d num.er of support unique sequences (nnsus) in HCC was significantly higher than in CHB or LC patients (P values all integration breakpoints are random.y distributed on hum.n chrom.som.s and are enriched in the HBV genom. around nt 1800. The m.jority of integration breakpoints (61.86%) are located in the gene-coding region. Both non-hom.logous end-joining (NHEJ) and m.crohom.logy-m.diated end-joining (m.EJ) interactions occurred during HBV integration across the three different stages of liver diseases. Our study provides evidence that HBV DNA integration can be detected in the plasm. cfDNA of HBV-infected patients, including those with CHB, LC, or HCC, using this optim.z.d strategy. © 2024 The Authors

关键词： Cell-free DNA (cfDNA) DNA capture DNA integration Hepatitis B virus (HBV)

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Dysregulation of RNA m.dification system. in clinical populations with neurocognitive disorders

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Neural Regeneration Research 2024年第6期19卷 1256-1261页

作者： Helen m.Knight m.rve Dem.rbugen ?z.Adriana Perez.rovas-Saltijeral Division of Cells Organisms and Molecular Genetics School of Life Sciences University of Notingham Departm.nt of Pharm.ceutical Toxicology Faculty of Pharmacy Ankara University

The study of m.dified RNA known as epitranscriptom.cs has becom. increasingly relevant in our understanding of disease-m.difying m.chanism.. m.thylation of N6 adenosine(m.A) and C5 cytosine(m.C) bases occur on m.NAs, tRNA, m.-tRNA, and rRNA species as well as non-coding RNAs. With em.rging knowledge of RNA binding proteins that act as writer, reader, and eraser effector proteins, com.s a new understanding of physiological processes controlled by these system.. Such processes when spatiotem.orally disrupted within cellular nanodom.ins in highly specializ.d tissues such as the brain, give rise to different form. of disease. In this review, we discuss accum.lating evidence that changes in the m.A and m.C m.thylation system. contribute to neurocognitive disorders. Early studies first identified m.tations within Fm.1 to cause intellectual disability Fragile X syndrom.s several years before Fm.1 was identified as an m.A RNA reader protein. Subsequently, fam.lial.mutations within the m.A writer gene m.TTL5, m.C writer genes NSUN2, NSUN3, NSUN5, and NSUN6, as well as THOC2 and THOC6 that form.a protein com.lex with the m.C reader protein alYREF, were recogniz.d to cause intellectual developm.nt disorders. Sim.larly, differences in expression of the m.C writer and reader effector proteins, NSUN6, NSUN7, and alYREF in brain tissue are indicated in individuals with alz.eim.r’s disease, individuals with a high neuropathological load or have suffered traum.tic brain injury. Likewise, an abundance of m.A reader and anti-reader proteins are reported to change across brain regions in Lewy bodies diseases, alz.eim.r’s disease, and individuals with high cognitive reserve. m.A-m.dified RNAs are also reported significantly m.re abundant in dem.ntia with Lewy bodies brain tissue but significantly reduced in Parkinson’s disease tissue, whilst m.dified RNAs are m.splaced within diseased cells, particularly where synapses are located. In parahippocam.al brain tissue, m.A m.dification is en

关键词： 5-m.thylcytosine m.thylation alz.eim.r's disease cognitive diseases epitranscriptom.cs intellectual disability Lewy body diseases N6 adenosine RNA m.dification

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Detailed analysis of the relativistic configuration of Bardeen anisotropic spheres in m.dified f(G)gravity

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Com.unications in Theoretical Physics 2024年第6期76卷 45-56页

作者： Adnan m.lik Ayesha alm.s Tayyaba Naz.Rubab m.nz.or m.z.Bhatti School of m.them.tical Sciences Zhejiang Normal UniversityJinhuaZhejiangChina Departm.nt of m.them.tics University of Management and TechnologySialkot CampusLahorePakistan National University of Com.uter and Em.rging Sciences Lahore CampusPakistan Departm.nt of m.them.tics University of Management and TechnologyJohar Town CampusLahore 54782Pakistan Departm.nt of m.them.tics University of the PunjabQuaid-i-Azam CampusLahore-54590Pakistan

The aim.of this work is to investigate anisotropic com.act objects within the fram.work of f(G)m.dified theory of *** our present work,we utiliz. Krori-Barua m.trics,i.e.,λ(r)=Xr^(2)+Y andβ(r)=z.^(2).We use som. m.tching conditions of spherically sym.etric spacetim. with Bardeen's m.del as an exterior ***,we establish som. expressions of energy density and pressure com.onents to analyz. the stellar configuration of Bardeen com.act stars by assum.ng viable f(G)*** exam.ne the energy conditions for different stellar structures to verify the viability of our considered ***,we also investigate som. other physical features,such as equilibrium.condition,equation of state param.ters,adiabatic index,stability analysis,m.ss function,surface redshift,and com.actness factor,*** is worthwhile to m.ntion here for the current study that our stellar structure in the background of Bardeen's m.del is m.re viable and stable.

关键词： Bardeen com.act stars f(G)m.dified gravity Krori-Barua potential

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Integrated Approaches of m.chanical Barrier, Insecticide and Botanicals against m.ngo m.alybug (Drosicha m.ngiferae)

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Advances in Entom.logy 2024年第3期12卷 195-202页

作者： N. Akhter m. z. al.m m. A. Raham.n m. R. U. m.ah I. H. m.an m. A. Latif Departm.nt of Entom.logy Faculty of Agriculture Sher-e-Bangla Agricultural University Dhaka Bangladesh Departm.nt of Entom.logy Faculty of Agriculture Bangabandhu Sheikh Mujibur Rahman Agricultural University Gazipur Bangladesh Departm.nt of Plant Pathology Faculty of Agriculture Sher-e-Bangla Agricultural University Dhaka Bangladesh Departm.nt of Plant Pathology Bangabandhu Sheikh Mujibur Rahman Agricultural University Gazipur Bangladesh

An experim.nt was conducted to test the efficacy of a m.chanical barrier around the tree trunk with one spray of Cyperm.thrin @ 1 m./l and turm.ric powder extract @ 15 g/500m. of water applied in integrated approaches against m.ngo m.alybug on m.ngo tree. There were 7 treatm.nts including a control. The treatm.nts were m.chanical barrier, Cyperm.thrin spray @ 1 m./l, Turm.ric powder spray @ 15 g/500m. of water, Cyperm.thrin spray + Turm.ric spray, Cyperm.thrin spray + m.chanical barrier, Turm.ric + m.chanical barrier and untreated control. Three-year-old m.ngo plants grafted from.a 5-year-old m.ngo tree (Variety Am.opali) and planted in pots were used in the experim.nt. The treatm.nt, Cyperm.thrin spray + m.chanical barrier gave the highest reduction of m.ngo m.alybug population 87.06% to 93.90% followed by Turm.ric spray + m.chanical barrier and showed 81.13% to 86.04% and m.chanical barrier alone showed 81.13% to 84.59% population reduction. Turm.ric powder extract showed only (8.42% to 23.77%) population reduction of m.ngo m.alybug which was lowest com.ared to other treatm.nts.

关键词： m.ngo m.alybug Integrated m.nagem.nt

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Selection criteria of m.OB-Angola germ.lasm.collection for yield im.rovem.nt of the oil palm

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Oil Crop Science 2024年第1期9卷 20-28页

作者： A.Norz.ha z.z.m.i Y.z.lkifli A.m.Fadila m.m.rhalil m.laysian Palm.Oil Board 6Persiaran InstitusiBandar BaruBangi43000KajangSelangorMalaysia Institute of System.Biology Universiti Kebangsaan Malaysia43600BangiSelangorMalaysia

Oil palm.germ.lasm.collected from.Angola,Africa in 1991 were subjected to genetic variability potential *** collection was planted in the form.of open-pollinated fam.lies as trials at the m.laysian Palm.Oil Board(m.OB)Kluang Research Station,Johor,m.laysia,in *** palm. from.52 fam.lies and tenera palm. from.44 fam.lies of m.OB-Angola were evaluated for their bunch yield and bunch quality *** objectives of this study were to determ.ne the genetic variability am.ng the fam.lies and perform.nce of m.OB-Angola germ.lasm.for yield *** analysis of variance(ANOVA)revealed highly significant differences between the dura and tenera fam.lies for m.st of the traits,suggesting the presence of high genetic variability,which is essential for breeding *** the duras,fam.ly AGO 02.02 displayed the best yield perform.nce,with a high fresh fruit bunch,oil yield and total econom.c product at 240.40,29.46 and 37.93 kg palm.(-1)year^(-1),*** for the teneras,fam.ly AGO 03.04 recorded the highest FFB yield and oil yield at 249.25 and 45.22 kg palm.(-1)year^(-1),*** that,several fam.lies with big fruit siz.s or producing a m.an fruit weight of 14-17 g were also *** dura and tenera from.AGO 01.01 recorded the highest oil to bunch(O/B)of 17.76%and 28.65%,*** findings will facilitate the selection of palm. from.the m.OB-Angola germ.lasm.for future breeding program.es.

关键词： Oil palm Germ.lasm Genetic variability Heritability Yield im.rovem.nt

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Greatly enhanced corrosion/wear resistances of epoxy coating for m. alloy through a synergistic effect between functionaliz.d graphene and insulated blocking layer

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Journal of m.gnesium.and alloys 2024年第1期12卷 332-344页

作者： z.Y.Xue X.J.Li J.H.Chu m.m.Li D.N.z.u L.B.Tong School of m.tallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China State Key Laboratory of Advanced Design and m.nufacturing for Vehicle Body Hunan UniversityChangsha 410082China

The poor corrosion and wear resistances of m. alloys seriously lim.t their potential applications in various *** conventional epoxy coating easily form. m.ny intrinsic defects during the solidification process,which cannot provide sufficient *** the current study,we design a double-layer epoxy com.osite coating on m. alloy with enhanced anti-corrosion/wear properties,via the spin-assisted assem.ly *** outer layer is functionaliz.d graphene(FG)in waterborne epoxy resin(WEP)and the inner layer is Ce-based conversion(Ce)*** FG sheets can be hom.geneously dispersed within the epoxy m.trix to fill the intrinsic defects and im.rove the barrier *** Ce film.connects the outer layer with the substrate,showing the transition *** corrosion rate of Ce/WEP/FG com.osite coating is 2131 tim.s lower than that of bare m. alloy,and the wear rate is decreased by~90%.The im.roved corrosion resistance is attributed to the labyrinth effect(hindering the penetration of corrosive m.dium.and the obstruction of galvanic coupling *** synergistic effect derived from.the FG sheet and blocking layer exhibits great potential in realiz.ng the im.rovem.nt of m.lti-functional integration,which will open up a new avenue for the developm.nt of novel com.osite protection coatings of m. alloys.

关键词： m. alloy Functionaliz.d graphene Epoxy coating Corrosion/wear resistance Blocking layer

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