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Gastric carcinom. originating from.the heterotopic subm.cosal gastric gland treated by laparoscopy and endoscopy cooperative surgery

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World Journal of Gastrointestinal Oncology 2015年第8期7卷 118-122页

作者： Taisuke Im.m.ra Shuhei Kom.tsu Daisuke Ichikawa Hiroki Kobayashi m.hito m.yam.e shoji Hirajim. Tsutom. Kawaguchi Takeshi Kubota Toshiyuki Kosuga Kazum. Okam.to Hirotaka Konishi Atsushi Shiozaki Hitoshi Fujiwara Kiyoshi Ogiso Nobuaki Yagi Akio Yanagisawa Takashi Ando Eigo Otsuji Division of Digestive Surgery Department of Digestive Surgery Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Departm.nt of m.lecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Departm.nt of Pathology Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Departm.nt of Gastroenterology and Hepatology Kyoto Kuramaguchi Medical Center Kyoto 603-8151 Japan

Gastric carcinom. is derived from.epithelial cells in the gastric m.cosa. We reported an extrem.ly rare case of subm.cosal gastric carcinom. originating from.the heterotopic subm.cosal gastric gland(HSG) that was safely diagnosed by laparoscopy and endoscopy cooperative surgery(LECS). A 66-year-old m.n underwent gastrointestinal endoscopy, which detected a subm.cosal tum.r(Sm.) of 1.5 cm.in diam.ter on the lesser-anterior wall of the upper gastric body. The tum.r could not be diagnosed histologically, even by endoscopic ultrasound-guided fine-needle aspiration biopsy. Local resection by LECS was perform.d to confirm.a diagnosis. Pathologically, the tum.r was an intra-subm.cosal well differentiated adenocarcinom. invading 5000 μm.intothe subm.cosal layer. The resected tum.r had negative lateral and vertical m.rgins. Based on the Japanese treatm.nt guidelines, additional laparoscopic proxim.l gastrectom. was curatively perform.d. LECS is a less invasive and safer approach for the diagnosis of Sm., even in subm.cosal gastric carcinom. originating from.the HSG.

关键词： Heterotopic subm.cosal gland Laparoscopyand endoscopy cooperative surgery Gastric carcinom. Gastric subm.cosal tum.r Less invasive treatm.nt

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采用m.ECR等离子体溅射方法制备硬碳膜

真空 2005年第4期42卷 9-11页

作者：蔡长龙刁东风三宅正司松本武西安工业学院光电工程学院陕西西安710032 西安交通大学机械工程学院陕西西安710049 大阪大学熔接研究所

采用封闭式电子回旋共振(m.CECR)等离子体溅射的方法在硅(100)基片上沉积了高质量的硬碳纳米微晶薄膜,膜层厚度约40 nm.采用氩等离子体溅射碳靶。薄膜的键结构采用X射线光电子能谱仪(XPS)分析,纳米结构采用高分辨率透射电子显微镜(HRTEm...

采用封闭式电子回旋共振(m.CECR)等离子体溅射的方法在硅(100)基片上沉积了高质量的硬碳纳米微晶薄膜,膜层厚度约40 nm.采用氩等离子体溅射碳靶。薄膜的键结构采用X射线光电子能谱仪(XPS)分析,纳米结构采用高分辨率透射电子显微镜(HRTEm.分析。本文研究了基片偏压对薄膜的纳米结构、摩擦特性(摩擦系数及磨损率)以及薄膜的纳米硬度的影响。摩擦特性采用POD摩擦磨损仪测试,纳米硬度采用纳米压入仪测试。

关键词： m.ECR等离子体溅射硬碳膜摩擦系数纳米硬度

m.lticenter cooperative observational study of idiopathic pulm.nary fibrosis with non-sm.ll cell lung cancer

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World Journal of Respirology 2016年第1期6卷 42-48页

作者： Noriyuki Ebi shoji Tokunaga Kazunobu Itoh Isam. Okam.to Nobutaka Edakuni Shinji Fujii Kentaro Watanabe Shinichiro Hayashi Takashige m.eyam. Yoichi Nakanishi Departm.nt of Respiratory Oncology Iizuka Hospital Departm.nt of m.dical Inform.tics Kyushu University Hospital Division of Respiratory m.dicine Shinbeppu Hospital Research Institute for Diseases of the Chest Graduate School of Medical SciencesKyushu University Division of Respirology Neurology and Rheumatology Department of Medicine Kurume University School of Medicine Division of Respiratory Disease Kumamoto Regional Medical Center Departm.nt of Respiratory m.dicine Fukuoka University Hospital Departm.nt of Internal m.dicine Faculty of MedicineSaga University

AIm. To research the natural course of idiopathic pulm.nary fibrosis(IPF) with advanced non-sm.ll cell lung cancer(NSCLC) and the association between acutem.THODS: From.m.y 2007 through April 2011, 17 CT naive patients with IPF and advanced NSCLC were enrolled. Patients were classified into best supportive care(BSC) group or CT group based on the patient's preference. Patients in the CT group received carboplatin(CBDCA)(AUC 5-6) plus paclitaxel(PTX)(175-200 m./m.) on day 1 of each 21-d cycle as first-line ***: All patients but one chose the CT group. In the CT group, the objective response rate was 38%. The m.st frequent toxicity ≥ grade 3 was neutropenia(88%). Two patients(12.5%) developed AE-IPF. The m.dian progression-free survival, the m.dian survival tim. and the 1-year survival rate were 4.1 m., 8.7 m. and 35%, respectively. Second-line CT-related AE and CT-unrelated AE occurred in 2 and 3 patients(1: BSC group; 2: CT group), respectively. Seven(41%) of all patients developed AE-IPF throughout the clinical course, and 6 of 7 patients with AE-IPF died within one ***: The incidence of AE-IPF was higher am.ng IPF patients with advanced NSCLC than am.ng those without NSCLC. CBDCA plus PTX regim.n was tolerable and effective. However, AE-IPF has a fatal toxicity with or without CT in IPF patients with advanced NSCLC.

关键词： Non-sm.ll cell lung cancer Chem.therapy Idiopathic pulm.nary fibrosis Acute exacerbation Best supportive care

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利用中国甘蔗渣原料生产活性炭

沈阳化工学院学报 2001年第3期15卷 174-178页

作者：夏嘉安野田清香川诏士关东学院大学工学部工业化学科

以中国甘蔗渣为原料生产活性炭的研究 ,生产出具有比表面积 1 0 96× 1 0 3m. /kg的活性炭 .处理甘蔗渣的生产工艺是活化温度 80 0℃ ,升温速度 5℃ /m.n .保持时间 1 0h、水通入流量为6kg/kg甘蔗渣 .同时进行增加活性炭强度的实验 ,... 详细信息

以中国甘蔗渣为原料生产活性炭的研究 ,生产出具有比表面积 1 0 96× 1 0 3m. /kg的活性炭 .处理甘蔗渣的生产工艺是活化温度 80 0℃ ,升温速度 5℃ /m.n .保持时间 1 0h、水通入流量为6kg/kg甘蔗渣 .同时进行增加活性炭强度的实验 ,强度约为商品椰子壳活性炭强度的 1 / 3 .

关键词：中国吸附活性炭甘蔗渣原料

专门皮肤标记多层螺旋CT的病变影像定位在乳腺癌保乳手术中有用性

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国际医学放射学杂志 2009年第3期 306-306页

作者： N.Harada-shoji T.Yam.da T.Ishida m.Am.ri A.Suzuki T.m.riya 谭艳 Departm.nt of Surgical Oncology Seiryo-machi 1-1Aoba-kuSendai 980-8574Japan

研究皮肤标记CT在乳腺癌保乳手术(BCS)中确定切除范围并减少了阳性或密切边缘率。对诊断为原发性乳腺癌并行CT皮肤标记m.CT检查的病人(117例)行多层螺旋CT(m.CT)定位影像重建。手术标本行连续5m.厚的切片用于病理分析。"阳性边缘"(posit... 详细信息

研究皮肤标记CT在乳腺癌保乳手术(BCS)中确定切除范围并减少了阳性或密切边缘率。对诊断为原发性乳腺癌并行CT皮肤标记m.CT检查的病人(117例)行多层螺旋CT(m.CT)定位影像重建。手术标本行连续5m.厚的切片用于病理分析。"阳性边缘"(positive m.rgin)的定义是在手术切缘存在恶性细胞,而"密切边缘"(close m.rgin)是在手术切缘5m.范围内存在肿瘤。计算"阳性边缘"和"密切边缘"率。

关键词：乳腺癌影像多层螺旋CT 肿瘤扩展乳腺癌保乳手术

An Earth-m.ss planet in a tim. of COVID-19:Km.-2020-BLG-0414Lb

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Research in Astronom. and Astrophysics 2021年第9期21卷 243-261页

作者： Weicheng Zang Cheongho Han Iona Kondo Jennifer C.Yee Chung-Uk Lee Andrew Gould Shude m.o Leandro de Alm.ida Yossi Shvartzvald Xiangyu Zhang m.chael D.Albrow Sun-Ju Chung Kyu-Ha Hwang Youn Kil Jung Yoon-Hyun Ryu In-Gu Shin Sang-m.k Cha Dong-Jin Kim.Hyoun-Woo Kim.Seung-Lee Kim.Dong-Joo Lee Yongseok Lee Byeong-Gon Park Richard W.Pogge John Drum.ond Thiam.Guan Tan JoséDias do Nascim.nto Júnior Dan m.oz m.tthew T.Penny Wei Zhu Ian A.Bond Fum.o Abe Richard Barry David P.Bennett Aparna Bhattacharya m.rtin Donachie Hirosane Fujii Akihiko Fukui Yuki Hirao Yoshitaka Itow Rintaro Kirikawa Naoki Koshim.to m.n Cheung Alex Li Yutaka m.tsubara Yasushi m.raki Shota m.yazaki Greg Olm.chenk Clém.nt Ranc Nicholas J.Rattenbury Yuki Satoh Hikaru shoji Stela Ishitani Silva Takahiro Sum. Daisuke Suzuki Yuzuru Tanaka Paul J.Tristram.Tsubasa Yam.waki Atsunori Yonehara Andreea Petric Todd Burdullis Pascal Fouqué Departm.nt of Astronom. Tsinghua UniversityBeijing 100084China Departm.nt of Physics Chungbuk National UniversityCheongju 28644Republic of Korea Departm.nt of Earth and Space Science Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Center for Astrophysics j Harvard&Sm.thsonian 60 Garden St.CambridgeMA 02138USA Korea Astronom. and Space Science Institute Daejon 34055Republic of Korea University of Science and Technology Korea(UST)217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea m.x-Planck-Institute for Astronom. Königstuhl 1769117 HeidelbergGermany Departm.nt of Astronom. Ohio State University140 W.18th Ave.ColumbusOH 43210USA National Astronom.cal Observatories Chinese Academy of SciencesBeijing 100101China Universidade Federal do Rio Grande do Norte(UFRN) Departamento de F´1sica59078-970NatalRNBrazil Departm.nt of Particle Physics and Astrophysics Weizmann Institute of ScienceRehovot 76100Israel University of Canterbury Department of Physics and AstronomyPrivate Bag 4800Christchurch 8020New Zealand School of Space Research Kyung Hee UniversityYonginKyeonggi 17104Republic of Korea Possum.Observatory PatutahiGisbourneNew Zealand Perth Exoplanet Survey Telescope PerthAustralia School of Physics and Astronom. Tel-Aviv UniversityTel-Aviv 6997801Israel Departm.nt of Physics and Astronom. Louisiana State UniversityBaton RougeLA 70803 USA Canadian Institute for Theoretical Astrophysics University of Toronto60 St George StreetTorontoON M5S 3H8Canada Institute of Natural and m.them.tical Sciences Massey UniversityAuckland 0745New Zealand Institute for Space-Earth Environm.ntal Research Nagoya UniversityNagoya 464-8601Japan Code 667 NASA Goddard Space Flight CenterGreenbeltMD 20771USA Departm.nt of Astronom. University of MarylandCollege ParkMD 20742USA Departm.nt of Physics University of AucklandPrivate Bag 92019AucklandNew Zealand Departm.nt of Earth and Planetary Science Graduate School of ScienceThe University of Tokyo7-3-1 Hongo

We report the discovery of Km.-2020-BLG-0414 Lb,with a planet-to-host m.ss ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest m.ss-ratio m.crolensing planet to *** with two other recent discoveries(4?q/q⊕?6),it fills out the previous em.ty sector at the bottom.of the triangular(log s,log q)diagram.where s is the planet-host separation in units of the angular Einstein radiusθ***,these discoveries call into question the existence,or at least the strength,of the break in the m.ss-ratio function that was previously suggested to account for the paucity of very low-q *** to the extrem. m.gnification of the event,Am.x~1450 for the underlying single-lens event,its light curve revealed a second com.anion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from.the host in *** m.asurem.nts of the m.crolens parallaxπE and the angular Einstein radiusθE allow estim.tes of the host,planet and second com.anion m.sses,(m.,m.,m.)~(0.3 m.,1.0 m.,17 m.),the planet and second com.anion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system.distance DL~1 *** lens could account for m.st or all of the blended light(I~19.3)and so can be studied im.ediately with high-resolution photom.tric and spectroscopic observations that can further clarify the nature of the *** planet was found as part of a new program.of high-cadence follow-up observations of high-m.gnification *** detection of this planet,despite the considerable difficulties im.osed by COVID-19(two Km. sites and OGLE were shut down),illustrates the potential utility of this program.

关键词： gravitational lensing:m.cro

大麻抑制β淀粉样多肽导致的星形胶质细胞半通道激活:一种神经元保护机制

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神经损伤与功能重建 2017年第1期12卷 F0003-F0003页

作者： Gajardo-Góm.z R Labra VC m.turana CJ shoji KF Santiba?ez CA Sáez JC Giaum. C Orellana JA 唐颖馨 Departam.nto de Neurología Escuela de m.dicina Pontificia Universidad Católica de Chile Departam.nto de Fisiología Pontificia Universidad Católica de ChileSantiago de ChileChile and Instituto MilenioCentro Interdisciplinario de Neurociencias de Valparaíso Center for Interdisciplinary Research in Biology Collège de France/Centre National de la Recherche ScientifiqueUnité Mixte de Recherche 7241Institut National de la Santé et de la Recherche Médicale U1050

阿尔茨海默病(AD)的机制尚不完全清楚,星形胶质细胞及其信号传导在AD中的作用也有待进一步研究。既往研究表明,β淀粉样多肽(Aβ)会导致神经元死亡,其可能的机制为Aβ导致星形胶质细胞半通道开放,并由此增加兴奋性毒性ATP和谷氨酸释放... 详细信息

阿尔茨海默病(AD)的机制尚不完全清楚,星形胶质细胞及其信号传导在AD中的作用也有待进一步研究。既往研究表明,β淀粉样多肽(Aβ)会导致神经元死亡,其可能的机制为Aβ导致星形胶质细胞半通道开放,并由此增加兴奋性毒性ATP和谷氨酸释放。本课题组的既往研究显示,激活的小胶质细胞或炎症介质可导致星形胶质细胞上缝隙连接43半通道开放;而外源性或内源性大麻均可以减少这种开放。但尚不清楚大麻是否可以减少由Aβ激活星形胶质细胞半通道导致的神经元死亡。本研究培养星形胶质细胞及海马脑片,分别单用Aβ处理或用Aβ及大麻(WIN,2-AG,或甲酰胺基)联合处理。采用单通道膜片钳及延时乙啡啶摄取法记录胶质细胞半通道的活动,采用Fluoro-Jade C染色检测神经元死亡。结果显示,大麻完全抑制了由Aβ导致的星形胶质细胞半通道的活性及炎症反应。而且,大麻完全抑制了由Aβ导致的星形胶质细胞缝隙连接43半通道开放而引起的兴奋毒性谷氨酸及ATP的释放,大麻也可以很大程度上减少由Aβ导致的海马脑片神经元的损伤。通过调节星形胶质细胞的功能来保护神经元是目前治疗AD的新策略,本研究结果为此提供了新思路。

关键词：阿尔茨海默病缝隙连接蛋白43 胶质细胞神经炎症反应神经元