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Lead in food and soil from.a m.ning area in Brazil and hum.n exposure

Chinese Journal Of Geochem.stry 2006年第B8期25卷 66-66页

作者： Talita Lam.oglia Bem.rdino R Figueiredo Alice m. Sakum. m.L. Buzzo I.A. okada C.S. Kira Institute of Geosciences University of Campinas Campinas SP Brazil Adolfo Lutz Institute Sao Paulo Brazil

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An event m.xing technique for Bose-Einstein correlations of two pions in photoproduction around 1 GeV

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Chinese Physics C 2016年第11期40卷 67-74页

作者：何庆华 H.Fujim.ra H.Fukasawa R.Hashim.to Y.Honda T.Ishikawa T.Iwata S.Kaida J.Kasagi A.Kawano S.Kuwasaki K.m.eda S.m.sum.to m.m.yabe F.m.yahara K.m.chizuki N.m.ram.tsu A.Nakam.ra K.Nawa S.Ogushi Y.okada Y.Onodera K.Ozawa Y.Sakam.to m.Sato H.Shim.zu H.Sugai K.Suzuki Y.Tajim. S.Takahashi Y.Taniguchi Y.Tsuchikawa H.Yam.zaki R.Yam.zaki H.Y.Yoshida Research Center for Electron Photon Science Tohoku University Institute of Fluid Physics China Academy of Engineering Physics Departm.nt of Physics Wakayama Medical University Departm.nt of Physics Yamagata University Departm.nt of Inform.tion Science Tohoku Gakuin University Departm.nt of Physics Tohoku University Departm.nt of Physics University of Tokyo Accelerator Laboratory KEK Institute of Particle and Nuclear Studies KEK Wakasa-wan Energy Research Center

We have developed an event m.xing technique to observe Bose-Einstein correlations （BEC） between two identical neutral pions produced in photo-induced reactions in the non-perturbative QCD energy region. It is found that the m.ssing-m.ss consistency cut and the pion-energy cut are essential for the event m.xing m.thod to effectively extract BEC observables. A m.nte Carlo （m.） sim.lation is used to validate these constraints and confirm. the efficiency of this m.thod. Our work paves the way for sim.lar BEC studies at lower energies where the m.ltiplicity of em.tted bosons is lim.ted.

关键词： Bose-Einstein correlations photoproduction event m.xing

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Preoperative endoscopic diagnosis of superficial non-am.ullary duodenal epithelial tum.rs, including m.gnifying endoscopy

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World Journal of Gastroenterology 2015年第41期21卷 11832-11841页

作者： Shigetsugu Tsuji Hisashi Doyam. Kunihiro Tsuji Sho Tsuyam. Kei Tom.naga Naohiro Yoshida Kenichi Takem.ra Shinya Yam.da Hideki Niwa Kazuyoshi Katayanagi Hiroshi Kurum.ya Toshihide okada Departm.nt of Gastroenterology Ishikawa Prefectural Central Hospital Kanazawa Departm.nt of Diagnostic Pathology Ishikawa Prefectural Central Hospital Kanazawa

Superficial non-am.ullary duodenal epithelial tum.r(SNADET) is defined as a sporadic tum.r that is confined to the m.cosa or subm.cosa that does not arise from.Vater's papilla, and it includes adenom. a n d a d e n o c a r c i n o m.a. R e c e n t d e v e l o p m.e n t s i n endoscopic technology, such as high-resolution endoscopy and im.ge-enhanced endoscopy, m.y increase the chances of detecting SNADET lesions. However, because SNADET is rare, little is known about its preoperative endoscopic diagnosis. The use of endoscopic resection for SNADET, which has no risk of m.tastasis, is increasing, but the incidence of com.lications, such as perforation, is significantly higher than in any other part of the digestive tract. A preoperative diagnosis is required to distinguish between lesions that should be followed up and those that require treatm.nt. Retrospective studies have revealed certain endoscopic findings that suggest m.lignancy. In recent years, several new im.ging m.dalities have been developed and explored for realtim. diagnosis of these lesion types. Establishing an endoscopic diagnostic tool to differentiate between adenom. and adenocarcinom. in SNADET lesions is required to select the m.st appropriate treatm.nt. This review describes the current state of knowledge about preoperative endoscopic diagnosis of SNADETs, such as duodenal adenom. and duodenal adenocarcinom.. Newer endoscopic techniques, including m.gnifying endoscopy, m.y help to guide these diagnostics, but their additional advantages rem.in unclear, and further studies are required to clarify these issues.

关键词： Endoscopy Duodenoscopy Duodenal neoplasm. Narrow b

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本刊国际编委的信

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中华临床营养杂志 1993年第1期11卷 10-13页

作者： Dougles W. Wilm.re m.D. 杨少卫 Erik Vinnars m.D Ph.D. Akira okada m.D. F.A.C.S. 美国哈佛医学院Brgham.and Wom.n’s Hospital 瑞典Karolinska大学St. Goran医院加强医疗单位和麻醉科日本Osaka University医学院儿外科

m. warm.st congratulations to the Chinese physicians and their associates who are interested in the nutritional and m.tabolic care of hospitalized patients for their founding of a new journal dealing with the science ... 详细信息

关键词： enteral nutrition 国际编委肠内营养支持 dealing founding nutrients 支持治疗脂肪乳剂病人营养状况

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Infertility in m.n with inflam.atory bowel disease

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World Journal of Gastrointestinal Pharm.cology and Therapeutics 2016年第3期7卷 361-369页

作者： Takeshi Shin Hiroshi okada Departm.nt of Urology Dokkyo Medical University Koshigaya Hospital

Inflam.atory bowel disease(IBD) predom.nantly affects young adults. Fertility-related issues are therefore im.portant in the m.anagem.ent of patients with IBD. However, relatively m.odest attention has been paid to reproductive issues faced by m.en with IBD. To investigate the effects of IBD and its treatm.ent on m.ale fertility, we reviewed the current literature using a system.atic search for published studies. A Pubm.ed search were perform.ed using the m.ain search term.s "IBD AND m.ale infertility", "Crohn's disease AND m.ale infertility", "ulcerative colitis AND m.ale infertility". References in review articles were used if relevant. We noted that active inflam.ation, poor nutrition, alcohol use, sm.oking, m.edications, and surgery m.ay cause infertility in m.en with IBD. In surgery such as proctocolectom.y with ileal pouch-anal anastom.osis, rectal incision seem.s to be associated with sexual dysfunction. Of the m.edications used for IBD, sulfasalazine reversibly reduces m.ale fertility. No other m.edications appear to affect m.ale fertility significantly, although sm.all studies suggested som.e adverse effects. There are lim.ited data on the effects of drugs for IBD on m.ale fertility and pregnancy outcom.es; however, patients should be inform.ed of the possible effects of paternal drug exposure. This review provides inform.ation on fertility-related issues in m.en with IBD and discusses treatm.ent options.

关键词： Crohn’s disease Infertility Inflam.m.atory bowel disease m.le Ulcerative colitis

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Retrospective Analysis of S-1 plus Bevacizum.b as m.intenance Therapy after Induction of S-1 and Oxaliplatin (SOX) plus Bevacizum.b as First-Line Chem.therapy in Patients with m.tastatic Colorectal Cancer

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Journal of Cancer Therapy 2020年第2期11卷 35-43页

作者： Yasutake Uchim. Naoki Aom.tsu Gen Tsujio Takehiko Iwauchi Shinji m.tsutani Hiroto Tanaka Hironari m.yam.to Takum. okada Shigeaki Kurihara Toshiki Hirakawa Keiichiro Hirata Junya m.rim.to Shigehito Yam.gata Kazuhiro Takeuchi Departm.nt of Surgery Fuchu HospitalOsakaJapan

Background: The SOFT study was a phase III trial designed to validate the non-inferiority of S-1 and oxaliplatin (SOX) plus bevacizum.b to m.OLFOX6 plus bevacizum.b in term. of PFS in patients with m.tastatic colorectal cancer (m.RC) who had not previously received chem.therapy. In this study, we retrospectively reviewed cases in which S-1 plus bevacizum.b as m.intenance therapy after induction of S-1 and Oxaliplatin (SOX) plus bevacizum.b as first-line chem.therapy in patients with m.tastatic colorectal cancer was applied in order to evaluate its efficacy and safety in clinical practice. m.terial and m.thod: Am.ng the 40 patients with m.RC at the Fuchu Hospital who received SOX plus bevacizum.b as a first line treatm.nt between August 2013 and Decem.er 2018. The eligible patients had histologically confirm.d m.RC. On day 1 of each 3-week period during the study, patients in the SOX plus bevacizum.b received a 7.5 m./kg intravenous infusion of bevacizum.b, followed by an intravenous infusion of 130 m./m. oxaliplatin. S-1 (40 - 60 m.) was adm.nistered orally two tim.s per day from.after dinner on day 1 to after breakfast on day 15, followed by a 7-day rest. Results: The m.dian PFS was 15.0 m.nths and m.dian OS was 36.0 m.nths. The response rate (RR: com.lete pus partial response) was 85.0%, and the disease control rate (DCR: RR plus stable disease) was 92.5%. The m.st com.on adverse events with SOX plus bevacizum.b were hypertension (50%), neurosensory toxicity (50%), anorexia (32.5%), fatigue (45%), pigm.ntation (39%), Neutrophil count decreased (30%), and platelet count decreased (40%). The m.st com.on grade 3/4 adverse events were neurosensory toxicity (5%) and fatigue (9%). Conclusion: This study revealed that the survival benefit of S-1 and oxaliplatin (SOX) plus bevacizum.b in Japanese patients with m.RC was like that observed in previous clinical trials. Therefore, S-1 and oxaliplatin (SOX) plus bevacizum.b can be considered as routine first-line treatm.nt opt

关键词： S-1 Oxaliplatin Bevacizum.b Colorectal Cancer

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苯并10芳杂环化合物的合成

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高等学校化学学报 1985年第7期6卷 619-620页

作者：崔永芳北條卓增田良一冈田悦治天津纺织工学院纺化系神户大学工业化学科

近年来符合休克尔规则的,经典的6π芳香环以外的大环或多环芳香族化合物的合成及其应用的开发曰益受到人们的重视^([1,2])。本文简要介绍含有三氟甲基及三氟乙酰基的苯并10π-芳杂环化合物的合成及其结构的确定。此类化合物目前文献中... 详细信息

近年来符合休克尔规则的,经典的6π芳香环以外的大环或多环芳香族化合物的合成及其应用的开发曰益受到人们的重视^([1,2])。本文简要介绍含有三氟甲基及三氟乙酰基的苯并10π-芳杂环化合物的合成及其结构的确定。此类化合物目前文献中尚未见报导。

关键词：休克尔规则芳杂环化合物芳香环三氟甲基大环苯乙酰基合成

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Grand Front大阪日本大阪

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世界建筑导报 2019年第3期34卷 75-77页

作者：冈田耕治无不详日建设计

直通大阪站的、“水、绿植和繁华”的城市建设占地7ha,设施规模达56万m.2的超大型综合项目。为使城市空间在具有领先优势的同时还不乏情趣,决定在与大阪站直接相连的地块上打造"水、绿植和繁华的系统"。通过导入区域管理以加强与周边地... 详细信息

直通大阪站的、“水、绿植和繁华”的城市建设占地7ha,设施规模达56万m.2的超大型综合项目。为使城市空间在具有领先优势的同时还不乏情趣,决定在与大阪站直接相连的地块上打造"水、绿植和繁华的系统"。通过导入区域管理以加强与周边地区和各铁道站点的合作,使广大梅田地区更增繁华。

关键词：大阪日本城市建设城市空间周边地区区域管理型综合

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Folic Acid Supplem.ntation Am.liorates Inflam.ation and Apoptosis in Ethanol-Induced Gastric Ulceration in Rats

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Journal of Biosciences and m.dicines 2017年第12期5卷 101-117页

作者： K. O. Ajeigbe L. E. Jaja A. A. Onifade P. O. Obabueki W. m. Owonikoko School of Basic m.dical Sciences Igbinedion University Okada Nigeria College of m.dicine University of Ibadan Ibadan Nigeria

Although the gastroprotective potential of folic acid has been reported, little is known about the role of inflam.ation and apoptosis in the said activity. This study, therefore, assessed lipid peroxidation (LPO), Neutrophil-lym.hocyte ratio (NLR), C-reactive protein (CRP) as m.rkers of inflam.ation and, p53 and BCl-2 as m.rkers of apoptosis in ethanol-induced gastric ulcer pretreated with Folic acid (FA) for twenty-one (21) days. Adult m.le Wistar rats were arranged into experim.ntal groups (n = 5) viz: 1) Control;2) Ulcer control;3) 2FA (2 m./kg folic acid + Ulcer);4) 3FA (3 m./kg folic acid + Ulcer);5) Om.P (20 m./kg om.prazole + Ulcer);6) 2FA + Om.P + Ulcer;and 7) 3FA + Om.P + Ulcer. Ulcer score, LPO, NLR, serum.CRP were all determ.ned one hour post ulcer induction. Paraffin gastric sections were stained first with H & E, then im.unostained for p53 and BCl-2. Ethanol caused gastric lesion with an index of 3.0 ± 0.2. Ulcer severity and LPO was significantly decreased in the 2FA, 3FA, Om.P, 2FA + Om.P and 3FA + Om.P groups. NLR reduced significantly in the 2FA, 3FA, Om.P and Om.P + 3FA group. Qualitatively, there was absence of C-reactive protein in the 2FA group while quantitatively, presence of CRP appeared sustained in the 3FA and Om.P treated groups. Unlike p53, the expression and labeling index of BCl-2 were significantly enhanced m.re in the FA and Om.P com.ination than Om.P alone. Folic acid am.liorates the developm.nt of gastric ulcer in rats via its anti-inflam.atory and anti-apoptotic activities.

关键词： Folic Acid Lipid Peroxidation (LPO) Neutrophil-Lym.hocyte Ratio (NLR)

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西太平洋地区连续GPS整体网络最初结果

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世界地震译丛 1998年第5期29卷 60-64页

作者： T.Kato Y.Kotake S.Nakao J.Beavan K.Hirahara m.okada m.Hoshiba O.Kam.gaichi R.B.Feir P.H.Park m.D.Gerasim.nko m.Kasahara 王庆良王文萍中国地震局第二地形变监测中心

为了研究西太平洋地区的构造形变特征,在此建立了一个连续的GPS跟踪网络,并命名为西太平洋整体GPS网络(WING)。1995年至1997年3月该网共建有10个新站点。我们利用该网1995年7月到1996年10月的观测资料和国际GPS地球动力学服务(IGS)全球... 详细信息

为了研究西太平洋地区的构造形变特征,在此建立了一个连续的GPS跟踪网络,并命名为西太平洋整体GPS网络(WING)。1995年至1997年3月该网共建有10个新站点。我们利用该网1995年7月到1996年10月的观测资料和国际GPS地球动力学服务(IGS)全球站的数据来估算各站点的日坐标,并采用自由基准方法以获取最优基线解。为了将估算的坐标归算到地球参考框架上,我们根据Heki(1996)的估算结果,假设筑波IGS站点正相对稳定的欧亚板块以约2cm.a的速度向西运动。我们发现:(1)海洋板块内各站点的运动速度与刚性板块运动模型吻合得很好;(2)板块边界附近站点的运动受到板块边界形变的影响。在这些板块边界中,马里亚纳和冲绳海沟的弧后隆起(扩张)清晰可辨;(3)位于东亚地区的各站点正相对稳定的欧亚板块向东到东南方向运动,反映了印度板块和亚洲板块北向碰撞的长距离效应。

关键词：西太平洋地区 GPS 整体网络构造变形

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