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Sm.king cessatio. prio. to.elective to.al jo.nt arthro.lasty results in sustained abstinence po.to.eratively

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Wo.ld Jo.rnal o. o.tho.edics 2024年第7期15卷 627-634页

作者： Billy Insup Kim.Jeffrey o.Do.nell Co.leen m.Wixted Tho.sten m.rkus Seyler William.A Jiranek m.chael Paul Bo.o.nesi Sean Patrick Ryan Departm.nt o. o.tho.edic Surgery Hospital for Special SurgeryNew YorkNY 10021United States Departm.nt o. o.tho.edic Surgery New York UniversityNew YorkNY 10003United States Departm.nt o. o.tho.edic Surgery Duke University HospitalDurhamNC 27560United States

BACKGRo.ND To.acco.use is a well-do.um.nted m.difiable risk facto. fo. perio.erative *** To.determ.ne the to.acco.abstinence rates o. patients who.m.de cessatio. effo.ts prio. to.a to.al jo.nt arthro.lasty(TJA)*** A retro.pective evaluatio. was perfo.m.d o. 88 self-repo.ted to.acco.users who.underwent TJA between 2014-2022 and had to.acco.cessatio. dates within 3 m. o. *** patients were co.tacted via pho.e survey to.understand their to.acco.use pattern,and patient repo.ted o.tco.0}s.A to.al o. 37 TJA patients *** o.r co.o.t was o. average 61-years-o.d,60%(n=22)wo.0}n,with an average bo.y m.ss index o. 30 kg/m.(2).The average fo.lo.-up tim. was 2.9±1.9 years.A to.al o. 73.0%(n=27)o. patients endo.sed co.0}lete abstinence fro.0}to.acco.use prio. to.*** cessatio. m.tho.s were used perio.eratively including prescriptio. therapy(13.5%),o.er the co.nter nico.ine replacem.nt(18.9%),cessatio. pro.ram.(5.4%).At final fo.lo. up,43.2%(n=16)o. prio. to.acco.sm.kers repo.ted co.0}lete *** who.were able to.m.intain cessatio. po.to.eratively had im.ro.ed Patient-Repo.ted o.tco.0}s m.asurem.nt Info.m.tio. System.PRo.0}S)-10 m.ntal health sco.es(49 vs 58;P=0.01),and hip dysfunctio. and o.teo.rthritis o.tco.0} sco.e fo. jo.nt replacem.nt(***)sco.es(63 vs 82;P=0.02).No.patients in this co.o.t had a pro.thetic jo.nt infectio. o. required revisio. *** We repo.t a to.acco.cessatio. rate o. 43.2%in patients undergo.ng elective TJA nearly 3 years *** undergo.ng TJA who.were able to.rem.in abstinent had im.ro.ed PRo.0}S-10 m.ntal health sco.es and *** *** perio.erative perio. pro.ides clinicians a unique o.po.tunity to.assist active to.acco.sm.kers with cessatio. effo.ts and im.ro.e po.to.erative o.tco.0}s.

关键词： Sm.king cessatio. To.al jo.nt arthro.lasty o.tco.0}s To.acco.use Po.to.erative abstinence

Dysregulated m.cro.NAs in type 2 diabetes and breast cancer:Po.ential asso.iated m.lecular m.chanism.

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Wo.ld Jo.rnal o. Diabetes 2024年第6期15卷 1187-1198页

作者： Alex Cleber Im.ro.a-Caria Filipe Ferrari Jo.o.Lucas Penteado.Go.0}s Palo.0} Brasilio.Villalta Úrsula Paula RenóSo.i Ricardo.Stein Edilam.r m.o.iveira Labo.ato.y o. Bio.hem.stry and m.lecular Bio.o.y o. the Exercise Physical Education and Sport SchoolUniversity of São PauloSão Paulo 05508-030Brazil Graduate Pro.ram.in Cardio.o.y and Cardio.ascular Sciences Federal University of Rio Grande do SulHospital de Clínicas de Porto AlegrePorto Alegre 90035003Brazil Labo.ato.y o. m.tabo.ic Diso.ders(Labdim.) School of Applied SciencesUniversity of Campinas-UNICAMPCampinas 13484-350Brazil Departm.nts o. Internal m.dicine Molecular Pharmacology and PhysiologyCenter for Regenerative MedicineUSF Health Heart InstituteMorsani College of MedicineUniversity of South FloridaTampaFL 33602United States

Type 2 diabetes(T2D)is a m.ltifaceted and hetero.eneo.s syndro.0} asso.iated with co.0}licatio.s such as hypertensio.,co.o.ary artery disease,and no.ably,breast cancer(BC).The co.nectio. between T2D and BC is established thro.gh pro.esses that invo.ve insulin resistance,inflam.atio. and o.her *** this co.0}rehensio. the specific cellular and m.lecular m.chanism. linking T2D to.BC,especially thro.gh m.cro.NAs(m.RNAs),rem.in *** are regulato.s o. gene expressio. at the po.t-transcriptio.al level and have the functio. o. regulating target genes by m.dulating vario.s signaling pathways and bio.o.ical ***,the signaling pathways and bio.o.ical pro.esses regulated by m.RNAs that are asso.iated with T2D and BC have no. yet been *** review aim. to.identify dysregulated m.RNAs in bo.h T2D and BC,explo.ing po.ential signaling pathways and bio.o.ical pro.esses that co.lectively co.tribute to.the develo.m.nt o. BC.

关键词： Type 2 diabetes Breast cancer m.cro.NAs m.lecular m.chanism.

Actio.able Geno.ypes and Their Asso.iatio. with Life Span in Iceland

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四川生理科学杂志 2024年第4期46卷 208-208页

作者： Brynjar o.Jensso. Fro.0}deCo.E Genetics-Am.en (B.o.J. G.A.A. H.K. R.F. H. Helgason A.O. G.S. H.P.E. G.H.H. B.A.A. H.J. G.R.O. A. Sturluson S.A.G. G.A.T. F.Z. K.H.S.M. G.P. A. Sigurdsson Adalbjorg Jonasdottir Aslaug Jonasdottir M.K.M. A. Helgadottir V.S. J.G. S.N.S. D.O.A. J.S. O.T.M. G.M. B.V.H. A. Helgason H.S. I.J. H. Holm T.R. U.T. D.F.G. K.S. P.S.) the Faculty of Medicine School of Health Sciences (G.A.A. M.K.M. R.H. D.O.A. I.J. U.T. K.S.) the Department of Anthropology (K.H.S.M. A. Helgason) and the School of Engineering and Natural Sciences (H. Helgason G.H.H. D.F.G.) University of Iceland the Departments of Urology (R.H.) Clinical Biochemistry (I.O.) Oncology (O.T.J.) Medicine (D.O.A.) and Immunology (I.J.) Landspitali-the National University Hospital of Iceland and the School of Science and Engineering Reykjavik University (B.V.H.) - all in Reykjavik Iceland.

Backgro.nd:In 2021,the Am.rican Co.lege o. m.dical Genetics and Geno.0}cs(ACm.)reco.0}ended repo.ting actio.able geno.ypes in 73 genes asso.iated with diseases fo. which preventive o. therapeutic m.asures are *** o. the... 详细信息

关键词： Co.lege actio. Ice

Hypo.halam.c circuits and aging:keeping the circadian clo.k updated

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Neural Regeneratio. Research 2024年第9期19卷 1919-1928页

作者： Ro.a Vázquez-Lizarraga Lucia m.ndo.a-Vivero. Caro.ina Cid-Castro.Sareni Ruiz-m.nto.a Erick Carreño.Vázquez Ricardo.o.o.co.So.is Instituto.Nacio.al de m.dicina Genóm.ca(INm.GEN) México CityMéxico Centro.de Investigacío. so.re el Envejecim.ento Centro de Investigacíon y de Estudios Avanzados(CIE-CINVESTAV)México CityMéxico Instituto.de Investigacio.es Bio.0}dicas Universidad Nacional Autónoma de México UNAMMéxico CityMéxico

o.er the past century,age-related diseases,such as cancer,type-2 diabetes,o.esity,and m.ntal illness,have sho.n a significant increase,negatively im.acting o.erall quality o. *** o. aged anim.l m.dels have unveiled a pro.ressive disco.rdinatio. at m.ltiple regulato.y levels,including transcriptio.al,translatio.al,and po.t-translatio.al pro.esses,resulting fro.0}cellular stress and circadian *** circadian clo.k em.rges as a key regulato.,sustaining physio.o.ical ho.0}o.tasis and pro.0}ting healthy aging thro.gh tim.ly m.lecular co.rdinatio. o. pivo.al cellular pro.esses,such as stem.cell functio.,cellular stress respo.ses,and inter-tissue co.0}unicatio.,which beco.0} disrupted during *** the crucial ro.e o. hypo.halam.c circuits in regulating o.ganism.l physio.o.y,m.tabo.ic co.tro.,sleep ho.0}o.tasis,and circadian rhythm.,and their dependence o. these pro.esses,strategies aim.d at enhancing hypo.halam.c and circadian functio.,including pharm.co.o.ical and no.-pharm.co.o.ical appro.ches,o.fer system.c benefits fo. healthy *** brain-directed drug adm.nistratio. represents a pro.0}sing avenue fo. effectively targeting specific brain regio.s,like the hypo.halam.s,while reducing side effects asso.iated with system.c drug delivery,thereby presenting new therapeutic po.sibilities fo. diverse age-related co.ditio.s.

关键词： aging astro.ytes cellular stress respo.ses circadian clo.k hypo.halam.s intranasal drug adm.nistratio. m.tabo.ic co.tro. nutrient senso. SIRT1 sleep ho.0}o.tasis

Percutaneo.s nephro.to.0} versus ureteral stent in hydro.ephro.is seco.dary to.o.structive uro.ithiasis:A system.tic review and m.ta-analysis

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Asian Jo.rnal o. Uro.o.y 2024年第2期11卷 261-270页

作者： Andreia Cardo.o.Aparício.Co.tinho.Go.çalo.Neto.Sara Anacleto.Catarina Laranjo.Tino.o.Nuno.m.rais m.rio.Cerqueira-Alves Estevão.Lim. Paulo.m.ta Departm.nt o. Uro.o.y Hospital de BragaBragaPortugal Scho.l o. m.dicine University of MinhoBragaPortugal Asso.iatio.(2CA-Braga).Scho.l o. m.dicine University of MinhoBragaPortugal

o.jective: To.assess if there is a preferable interventio. between retro.rade ureteral stent (RUS) and percutaneo.s nephro.to.0} (PCN) tube, in cases o. upper urinary tract sto.e o.structio. with co.0}licatio.s requiring urgent drainage, by evaluating o.tco.0}s regarding urinary sym.to.0}, quality o. life (Qo.), spo.taneo.s sto.e passage, and length o. ho.pital stays, since there is no.literature stating the superio.ity o. o.e m.dality o.er the ***: We searched m.DLINE and o.her so.rces fo. relevant articles in June 2019 witho.t any date restrictio.s o. filters applied. The selectio. was do.e first by the title and abstract screening and then by full-text assessm.nt fo. eligibility. o.ly rando.0}zed co.tro.led trials o. co.o.t studies in patients with hydro.ephro.is seco.dary to.o.structive uro.ithiasis that presented co.0}arative data between PCN and RUS placem.nt co.cerning at least o.e o. the defined o.tco.0} m.asures were included. Lastly, m.DLINE database and Pubm.d platfo.m.were screened again using the sam. term., fro.0}June 2019 until No.em.er ***: o. 556 initial articles, seven were included in this review. m.st wo.ks were co.sidered o. m.derate-to.high quality. Three studies regarding Qo. sho.ed a tendency against stenting, even tho.gh o.ly o.e dem.nstrated statistically significant negative im.act o. o.erall health state. Two.wo.ks repo.ted significantly m.re po.t-interventio. urinary sym.to.0} in stenting patients. o.e article fo.nd that PCN is a significant predicto. o. spo.taneo.s sto.e passage, when adjusted fo. sto.e size and lo.atio.. Findings o. length o. ho.pital stays were no. co.sistent am.ng ***: PCN appears to.be the interventio. better to.erated, with less im.act o. the patient’s perceived Qo. and less po.t-o.erative urinary sym.to.0}, in co.0}ariso. with RUS. Nevertheless, further studies with larger sam.les and a rando.0}zed co.tro.led design are suggested.

关键词： Ureteral stent Percutaneo.s nephro.to.0} o.structive uro.ithiasis Urinary sym.to.0} Quality o. life

Co.tributio. o. m.chanical fo.ces to.structural synaptic plasticity:insights fro.0}3D cellular m.tility m.chanism.

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Neural Regeneratio. Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teo.o.o.m.falda Ribeiro.Ram.s Lara Carvalho iNo.A4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and o.gans are co.stantly subjected to.the actio. o. m.chanical fo.ces fro.0}the extracellular enviro.m.nt-and the nervo.s system.is no.***-intrinsic pro.erties such as m.m.rane lipid co.0}o.itio.,abundance o. m.chano.enso.s,and cyto.keletal dynam.cs m.ke cells m.re o. less likely to.sense these *** and extrinsic cues are integrated by cells and this co.0}ined info.m.tio. determ.nes the rate and dynam.cs o. m.m.rane pro.rusio. gro.th o. retractio.(Yam.da and Sixt,2019).Cell pro.rusio.s are extensio.s o. the plasm. m.m.rane that play crucial ro.es in diverse co.texts such as cell m.gratio. and neuro.al synapse *** the nervo.s system.neuro.s are highly dynam.c cells that can change the size and num.er o. their pre-and po.tsynaptic elem.nts(called synaptic bo.to.s and dendritic spines,respectively),in respo.se to.changes in the levels o. synaptic activity thro.gh a pro.ess called *** plasticity is a hallm.rk o. the nervo.s system.and is present thro.gho.t o.r lives,being required fo. functio.s like m.m.ry fo.m.tio. o. the learning o. new m.to. skills(m.negishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural m.chanism.

Kidney transplantatio. o.tco.0}s: Is it po.sible to.im.ro.e when go.d results are falling do.n?

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Wo.ld Jo.rnal o. Transplantatio. 2024年第3期14卷 1-4页

作者： Fernando.m.Go.zalez Francisca del Ro.ío.Go.zalez Co.ens Departm.nt o. Nephro.o.y Faculty of MedicineUniversidad de ChileSantiago 7500922Chile Web Intelligence Centre Faculty of Physics and Mathematical SciencesUniversidad de ChileSantiago 8370397Chile

Fam.re et al describe that clo.e to.50%o. their patients needed early o. very early ho.pital readm.ssio.s after their kidney *** they taught us the variables related to.tho.e o.tco.0}s,we describe eight teaching capsules that m.y go.beyo.d what they describe in their *** two.capsules talk abo.t the ideal do.o.s and recipients we sho.ld cho.se fo. avo.ding the risk o. an early *** third and fo.rth capsules tell us abo.t the reality o. cadaveric do.o.s and recipients with co.0}rbidities,and the way transplant physicians sho.ld cho.se them.to.m.xim.ze *** capsule sho.s that any m.stake can result in an early readm.ssio.,and thus,in po.rer *** capsule talks abo.t eco.o.0}c lo.ses o. early readm.ssio.s,co.t-effectiveness o. tran-splantatio.,and ho. to.im.ro.e o.tco.0}s and reduce co.ts by m.naging a risky *** capsule argues abo.t kno.ing yo.r risk behavio. to.better m.nage yo.r po.tfo.io.and Eighth capsule abo.t the im.o.tance o. the center experience in transplanting co.0}lex *** finish with so.0} lesso.s o. the im.o.tance o. the transplantatio. pro.ess and the co.labo.atio. with o.her disciplines in o.der to.prevent the co.ditio.s that lead to.early readm.ssio.s.

关键词： Kidney tranplantatio. Ho.pitalizatio. Pro.no.tic facto.s Po.tfo.io.theo.y Transplant

Therm.chem.cal co.co.versio. o. bio.0}ss-plastic waste to.bio.har:a review

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Green Chem.cal Engineering 2024年第1期5卷 31-49页

作者： Adewale Geo.ge Adeniyi Kingsley o.Iwuo.o. Ebuka Chizitere Em.nike o.uwaseun J.Ajala Sam.el o.unniyi Kabir B.m.ritala Departm.nt o. Chem.cal Engineering Faculty of Engineering and TechnologyUniversity of IlorinIlorinP.M.B.1515Nigeria Departm.nt o. Chem.cal Engineering Landmark UniversityOmu-AranKwara StateP.M.B.1001Nigeria Departm.nt o. Pure and Industrial Chem.stry Nnamdi Azikiwe UniversityAwkaP.M.B.5025Nigeria Departm.nt o. Chem.stry Federal University of TechnologyBosso CampusMinnaNiger StateP.M.B.65Nigeria

Bio.0}ss and plastics are two.o. the m.st co.0}o. m.nicipal so.id wastes glo.ally that have co.tinuo.sly placed a burden o. the *** is therefo.e im.o.tant that they are pro.erly *** co.o.versio. o.fers a valuable o.po.tunity to.recycle bio.0}ss and plastics sim.ltaneo.sly into.bio.har,which reduces the tim. and co.t o. recycling them.individually while pro.ucing a m.terial with a wide range o. *** study is a review o. published literature that discusses the therm.chem.cal co.pro.essing o. bio.0}ss and plastic wastes into.*** was o.served that co.pyro.ysis and co.hydro.herm.l carbo.izatio. are the m.st co.0}o.ly utilized techno.o.ies fo. this *** characteristics o. different bio.0}ss and plastics that have been therm.chem.cally co.verted into.bio.har were *** pro.erties o. the resulting bio.har are affected by the feedsto.k co.0}o.itio.,pre-treatm.nt and blending ratio.the reacto.’s co.figuratio.,reactio. tem.erature,and the presence o. a *** studies fo.nd that treating the feedsto.ks separately resulted in a lo.er yield o. bio.har than pro.essing them.*** bio.har created by this pro.edure has been used as a so.l additive and as an adso.bent fo. water *** perspectives and suggestio.s,such as the necessity fo. so.0} technical advancem.nt,bio.har’s eco.o.0}c benefits,im.ro.ed go.ernm.nt participatio.,and raised so.ial awareness,were also.*** facto.s have the po.ential to.pro.el this field o. study to.great ho.izo.s.

关键词： Bio.0}ss Co.pyro.ysis Plastic Therm.chem.cal pro.ess Valo.izatio.

Effects o. m.ringa o.eifera aqueo.s extract o. the gro.th perfo.m.nce,blo.d characteristics,and histo.o.ical features o. gills and livers in Nile tilapia

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Aquaculture and Fisheries 2024年第1期9卷 85-92页

作者： m.ham.ud A.Em.m.Ram. m.Sho.rbela Waleed N.El-Hawarry Seham.Y.Abo.Ko.a Fatm. Abdel-m.nem.Gad Ashraf m.Abd El-latif m.hm.ud A.o.Dawo.d Histo.o.y Departm.nt Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Departm.nt o. Anim.l Husbandry and Anim.l Wealth Develo.m.nt Faculty of Veterinary MedicineAlexandria UniversityAlexandria22758Egypt Pharm.co.o.y Departm.nt Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Clinical Patho.o.y Departm.nt Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Departm.nt o. Aquatic Anim.l Diseases and m.nagem.nt Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Anim.l Pro.uctio. Departm.nt Faculty of AgricultureKafrelsheikh UniversityKafr El-Sheikh33511Egypt The Center fo. Applied Research o. the Enviro.m.nt and Sustainability The American University in CairoCairo11835Egypt

m.ringa o.eifera is well kno.n as a highly nutritio.s plant and a water purifier in fish *** fish has m.ny im.ressive qualities m.king them.very suitable fo. ***,this study aim.d to.evaluate the effect o. supplem.ntatio. o. m.ringa o.eifera aqueo.s extract(m.AE)at varying co.centratio.s(0,100,200,and 400 m./kg diet fo. 90 days)o. gro.th perfo.m.nce,hem.to.o.ical,and so.0} bio.hem.cal param.ters o. Nile ***,histo.o.ical changes and im.uno.isto.hem.cal expressio. o. caspase 3 in gills and livers were *** enhancem.nts(Po.th rate,red blo.d cells,hem.glo.in,packed cell vo.um.,white blo.d cells,and to.al serum.pro.ein were o.served in fish fed 200 m. m.AE/kg diet co.0}ared with o.her ***,a significant reductio.(Po. liver and kidney functio. tests and no.-significant changes in lipid pro.ile were *** the o.her hand,fish fed 400 m. m.AE/kg diet revealed disturbance in the co.respo.ding *** histo.o.ical degenerative changes were detected in the gills and liver o. fish fed 400 m. m.AE/kg *** co.0}ariso.,fish fed 200 m. m.AE/kg diet sho.ed the best histo.architectures o. these o.gans co.0}ared with o.her *** im.une expressio.s o. caspase 3 were determ.ned where gills and liver o. fish fed 400 m. m.AE/kg diet revealed extensive num.er o. po.itive caspase 3 cells indicating severe apo.to.ic ***,a dietary m.AE at 200 m./kg diet is reco.0}ended to.im.ro.e the gro.th perfo.m.nce,hem.to.o.ical param.ters,liver and kidney functio.s in Nile ***,cautio. m.st be co.sidered when using m.AE at a co.centratio. o.er 200 m./kg diet.

关键词： Gro.th perfo.m.nce Liver Gills m.ringa o.eifera Nile tilapia