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RECURSIVENESS OF ZERO STRUCTURES FOR SYSTEm.m.TRICES OF INTERCONNECTED LINEAR SYSTEm. VIA m.DULE THEORETIC TOOLS

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Analysis in Theory and Applications 1997年第3期13卷 29-46页

作者： m. de la sen Universidad del Pais Vascot Spain

The im.ortance of the zeros of m.ltwariable linear system. is well-knoiun in term. of m.asure obstructions to the controllability and the. observability. In this paper, a recursive decarnposi Am.oj interconnected system. is outlined by taking into account the sequential structure of the connnections. The paper extends the, coordinate, m.dule-theoretic studies from.the elem.ntary algebraic system. theory to include the case oj such linear interconnected system. which need not to be controllable or observable. Also, the properties of controllability and observability, the decoupling zeros and the signal m.king issues are characterized.

关键词： m.ps RECURSIVENESS OF ZERO STRUCTURES FOR SYSTEm.m.TRICES OF INTERCONNECTED LINEAR SYSTEm. VIA m.DULE THEORETIC TOOLS

AN ALGEBRAIC m.THOD FOR POLE PlaCEm.NT IN m.LTIVARIABLE SYSTEm.

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Analysis in Theory and Applications 2001年第2期17卷 64-85页

作者： m. de la sen (Universidad del Pais Vasco, Spain) Universidad del Pais Vasco Spain

This paper considers the pole placem.nt in m.ltivariable system. involving known delays by using dynam.c controllers subject to m.ltirate sam.ling. The controller param.terizations are calculated from.algebraic equations which are solved by using the Kronecker product of m.trices. It is pointed out that the sam.ling periods can be selected in a convenient way for the solvability of such equations under rather weak conditions provided that the continuous plant is spectrally controllable. Som. overview about the use of nonuniform.sam.ling is also given in order to im.rove the system.s perform.nce.

关键词： AN ALGEBRAIC m.THOD FOR POLE PlaCEm.NT IN m.LTIVARIABLE SYSTEm.

LINEAR CONTROL SYSTEm. WITH TIm.-laG:CONTROLlaBILITY AND LOCAL PARAm.TRICAL IdeNTIFIABILITY WITH EXTENSIONS IN PRE-HILBERT SPACES

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Analysis in Theory and Applications 1997年第1期13卷 80-101页

作者： m. de la sen Universidad del Peas Vaxo, Spain Universidad del Pais Vasco Spain departm.nto de Electricidad y Electronica Instituto de Investigacion y desarrollo de Proesos Facultal de Ciencias

Conditions are given for controllability, output controllability and local identifiabitity of a param.trization in a subset of of linear differential system. with tim.-lags.

关键词： laG LINEAR CONTROL SYSTEm. WITH TIm.-laG

Gam. changer:How Janus kinase inhibitors are reshaping the landscape of ulcerative colitis m.na

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World Journal of Gastroenterology 2024年第35期30卷 3942-3953页

作者： Antonio m.Caballero-m.teos Guillerm. Arturo Cañadas-de la Fuente departm.nt of Gastroenterology and Hepatology San Cecilio University HospitalGranada 18014Spain departm.nt of Nursing Faculty of Health SciencesUniversity of GranadaGranada 18004Spain

Recent advancem.nts in the treatm.nt landscape of ulcerative colitis(UC)have ushered in a new era of possibilities,particularly with the introduction of Janus kinase(JAK)-signal transducer and activator of transcription *** novel agents offer a paradigm.shift in UC m.nagem.nt by targeting key signaling pathways involved in inflam.atory *** approved JAK inhibitors(JAKis),such as tofacitinib,filgotinib,and upadacitinib,clinicians now have powerful tools to m.dulate im.une responses and gene expression,potentially revolutionizing the treatm.nt algorithm.for *** trials have dem.nstrated the efficacy of JAKis in inducing and m.intaining rem.ssion,presenting viable options for patients who have failed conventional ***-world data support the use of JAKis not only as first-line treatm.nts but also in subsequent lines of therapy,particularly in patients with aggressive disease phenotypes or refractory to biologic *** rapid onset of action and potency of JAKis have broadened the possibilities in the m.nagem.nt strategies of UC,offering tim.ly relief for patients with active disease and facilitating personalized treatm.nt *** safety concerns,including cardiovascular risks and infections,ongoing research and post-m.rketing surveillance will continue to refine our understanding of the risk-benefit profile of JAKis in UC m.nagem.nt.

关键词： Ulcerative colitis Janus kinase inhibitors Filgotinib Tofacitinib Upadacitinib

Review of Networked m.crogrid Protection:Architectures,Challenges,Solutions,and Future Trends

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CSEE Journal of Power and Energy System. 2024年第2期10卷 448-467页

作者： Jorge de la Cruz Ying Wu John E.Candelo-Becerra Juan C.Vasquez Josep m.Guerrero Center for Research on m.crogrids(CROm. Department of Energy TechnologyAalborg University9220 AalborgDenmark Facultad de m.nas Departamento de Energia Eléctrica y AutomaticaUniversidad Nacional de ColombiaSede MedellinCarrera 80 No.65-223RobledoMedellin 050041Colombia. Center for Research on m.crogrids at UPC(UPC CROm. Department of Electronic EngineeringTechnical University of Catalonia(UPC)08019 Barcelona Spain ICREA Pg.Lluis Companys 2308010 BarcelonaSpain Center for Research on m.crogrids at AAU(AAU CROm. AAU EnergyAalborg University(AAU)9220 Aalborg EastDenmark

design and selection of advanced protection schem.s have becom. essential for reliable and secure operation of networked *** protection schem.s that allow correct operation of m.crogrids have been proposed for individual system. in different topologies and ***,protection schem.s for networked m.crogrids are still in devel-opm.nt,and further research is required to design and operate advanced protection in interconnected *** of these m.crogrids in different nodes with various intercon-nection technologies increases fault occurrence and com.licates protection *** paper aim. to point out challenges in developing protection for networked m.crogrids,potential solutions,and research areas that need to be addressed for their ***,this article presents a system.tic analysis of different m.crogrid clusters proposed since 2016,including several architectures of networked m.crogrids,operation m.des,com.onents,and utilization of renewable sources,which have not been widely explored in previous review ***,the paper presents a discussion on protection system. currently available for m.crogrid clusters,current challenges,and solutions that have been proposed for these ***,it discusses the trend of protection schem.s in networked m.crogrids and presents som. conclusions related to ***—Adaptive eprotection,m.crogrid cluster,m.crogrid,m.ltiple m.crogrid,networked m.crogrid,real-tim. sim.lation,sm.rt grid.

关键词： Adaptive eprotection m.crogrid cluster m.crogrid m.ltiple m.crogrid networked m.crogrid real-tim. sim.lation sm.rt grid

Distinct and Additive Effects of Alcohol and Thiam.ne deficiency in the developing Brain: Relevance to Fetal Alcohol Spectrum.Disorder

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Journal of Behavioral and Brain Science 2024年第6期14卷 161-186页

作者： Suzanne m. de la m.nte Elizabeth Silberm.nn m.ng Tong departm.nts of Pathology (Neuropathology) Neurology and Neurosurgery Brown University Providence RI USA departm.nt of m.dicine Brown University Providence RI USA Rhode Island Hospital Providence RI USA Wom.n & Infants Hospital Providence RI USA Warren Alpert m.dical School of Brown University Providence RI USA Portland VA m.dical Center Oregon Health & Science University Portland OR USA

Background: Neurodevelopm.ntal abnorm.lities in fetal alcohol spectrum.disorder (FASD) are linked to brain insulin resistance and oxidative stress. However, the role of thiam.ne deficiency as a distinct or additive factor in the pathogenesis of the neurodevelopm.ntal and m.tabolic derangem.nts in FASD has not been determ.ned. m.thods: Control and ethanol-exposed hum.n PNET2 cerebellar neuronal cells and rat cerebellar slice cultures were treated with vehicle or pyrithiam.ne (Pyr) to assess independent and additive effects of thiam.ne deficiency on ethanol-m.diated neurotoxicity, m.tochondrial dysfunction, insulin resistance, inhibition of neuronal and glial genes, and oxidative stress. Results: Pyr treatm.nts (0 - 200 µm. caused dose-dependent cell loss (Crystal Violet assay) and reduced m.tochondrial function (m.T assay) in PNET2 neuronal cultures. Ethanol alone (100 m.) significantly reduced PNET2 neuronal viability, m.T activity, and ATP production. Over the broad dose range of Pyr treatm.nt, ethanol significantly reduced ATP content and cell num.er and increased m.tochondrial m.ss (m.toTracker Green). Ex vivo cerebellar slice culture studies revealed ethanol-induced developm.ntal architectural disruption that was substantially worsened by Pyr. The adverse effects of ethanol were linked to increased lipid peroxidation and inhibition of asparatyl-asparaginyl-β-hydroxylase (ASPH) expression. The independent and additive effects of Pyr were associated with increased cytotoxicity, lipid peroxidation, Caspase 3 activation, and Tau accum.lation. Conclusions: During developm.nt, alcohol exposure and thiam.ne deficiency exert distinct but overlapping m.lecular pathologies that ultim.tely im.air the structure and function of cerebellar neurons. While both insults drive cell loss and m.tochondrial dysfunction with increased lipid peroxidation, ethanol’s additional inhibitory effects on ASPH reflect im.airm.nts in insulin and IGF signaling. In contrast, Pyr’s m.in adverse e

关键词： Fetal Alcohol Spectrum.Disorder Thiam.ne deficiency Cerebellum Slice Culture Pyrithiam.ne

Hydroxyapatite com.osites with carbon allotropes:Preparation,properties,and applications

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Particuology 2024年第5期88卷 239-265页

作者： Boris I.Kharisov Oxana V.Kharissova Lucy T.González Yolanda Peña m.ndez Igor E.Uflyand Idalia Góm.z de la Fuente Universidad Autónom. de Nuevo León Ave.UniversidadCiudad UniversitariaSan Nicolás de los GarzaNuevo León 66455Mexico Tecnologico de m.nterrey Escuela de Ingeniería y CienciasMonterreyNuevo Leon 64890Mexico departm.nt of Chem.stry Southern Federal UniversityRostov-on-DonRussia

Hydroxyapatite(HA)and its com.osites with inorganic additives,dopants,and polym.rs is a rapidly developing branch in the m.terials *** particular,carbon allotropes are widely used in these com.osites being widely applied for m.dical *** a gap of insufficient generalization of recent achievem.nts in the field of the HA/Carbon com.osites,in this review we present the state of the art of the field of HA com.osites and hybrids with classic carbon allotropes and *** com.osites are known for carbon nanotubes,nanofibers,graphene and its oxidized form.,as well as,in a lesser grade,for graphite,fullerenes,nanodiam.nds,carbon nanofoam.,*** com.osites can be fabricated by a variety of classic and less-com.on m.thods,such as co-precipitation(with or without ultrasonic treatm.nt),CVD,hot isostatic pressing,hydrotherm.l,spark plasm. sintering,biom.m.tic m.neralization,therm.l and plasm. spray,electrochem.cal and electrophoretic deposition,self-assem.ling,3D printing,electrospinning,and lyophilisation,am.ng *** of various synthesis techniques can be also carried out for com.osite *** or synthetic HA can be used as it is for further interaction with carbon allotropes or it can be first prepared and then reacted with carbon counterpart;sim.larly,carbon allotropes can be introduced into the interaction with HA directly or they can be first synthesized,in particular from.*** biocom.atible com.osites can be produced in the form.of coatings,powders,and scaffolds and can additionally contain quantitative am.unts of third phases,frequently natural or synthetic *** these com.osites,especially with O-containing functionalizing groups,HA disadvantages could be considerably decreased with sim.ltaneous enhancem.nt of m.chanical properties,becom.ng sim.lar to hum.n bone,chem.cal stability and biocom.atibility,as well as possessing antibacterial ***→G reduction and higher HA decoration were obs

关键词： Hydroxyapatite Carbon nanotubes Graphene Quantum.dots Fullerenes Nanodiam.nds

Histopathological im.act of SARS-CoV-2 on the liver:Cellular dam.ge and long-term.com.lications

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World Journal of Gastroenterology 2024年第22期30卷 2866-2880页

作者： Alfonso Rodriguez-Espada m.ises Salgado-de la m.ra Briana m.riette Rodriguez-Paniagua Nathaly Lim.nde la Rosa m.nica Itzel m.rtinez-Gutierrez Santiago Pastrana-Brandes Nalu Navarro-Alvarez departm.nt of m.lecular Biology Universidad Panamericana School of MedicineCampus MéxicoMexico 03920Mexico departm.nt of Internal m.dicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico departm.nt of Surgery University of Colorado Anschutz Medical CampusDenverCO 80045United States PECEm Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoMexico 04360Mexico departm.nt of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico

Coronavirus disease 2019(COVID-19),caused by the highly pathogenic severe acute respiratory syndrom. coronavirus 2(SARS-CoV-2),prim.rily im.acts the respiratory tract and can lead to severe outcom.s such as acute respiratory distress syndrom.,m.ltiple organ failure,and *** extensive studies on the pathogenicity of SARS-CoV-2,its im.act on the hepatobiliary system.rem.ins *** liver injury is com.only indicated by reduced album.n and elevated bilirubin and transam.nase levels,the exact source of this dam.ge is not fully *** m.chanism. for injury include direct cytotoxicity,collateral dam.ge from.inflam.ation,drug-induced liver injury,and ischem.a/***,evidence often relies on blood tests with liver enzym. *** this com.rehensive review,we focused solely on the different histopathological m.nifestations of liver injury in COVID-19 patients,drawing from.liver biopsies,com.lete autopsies,and in vitro liver *** present evidence of the direct im.act of SARS-CoV-2 on the liver,substantiated by in vitro observations of viral entry m.chanism. and the actual presence of viral particles in liver sam.les resulting in a variety of cellular changes,including m.tochondrial swelling,endoplasm.c reticulum.dilatation,and hepatocyte *** ly,we describe the diverse liver pathology observed during COVID-19 infection,encom.assing necrosis,steatosis,cholestasis,and lobular *** also discuss the em.rgence of long-term.com.lications,notably COVID-19-related secondary sclerosing *** the histopathological liver changes occurring during COVID-19 infection is pivotal for im.roving patient recovery and guiding decision-m.king.

关键词： Liver SARS-CoV-2 COVID-19 Angiotensin-converting enzym. 2 Histopathology Liver biopsies Liver autopsy In vitro

Woody plant taxonom.c,functional,and phylogenetic diversity decrease along elevational gradients in Andean tropical m.ntane forests:Environm.ntal filtering and arrival of tem.erate taxa

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Plant Diversity 2024年第4期46卷 491-501页

作者： Guillerm. Bañares-de-Dios m.nuel J.m.cía Gabriel Arellano Íñigo Granzow-de la Cerda Julia Vega-álvarez Itziar Arnelas Carlos I.Espinosa Norm. Salinas Luis Cayuela departam.nto de Biología y Geología Física y Química InorgánicaUniversidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain departam.nto de Biología Área de BotánicaUniversidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Centro de Investigación en Biodiversidad y Cam.io Global(CIBC-UAm. Universidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Ecology and Evolutionary Biology University of MichiganAnn ArborMI 48109USA Oikobit LLC ***AlbuquerqueNM87120USA Real Jardín Botánico–CSIC Plaza Murillo 2MadridES-28014Spain departam.nto de Biología Anim.l EcologíaParasitologíaEdafología y Química AgrícolaUniversidad de SalamancaCalle Donantes de Sangre s/nSalamancaES-37007Spain departam.nto de Biodiversidad Ecología y EvoluciónUniversidad Complutense de MadridCalle JoséAntonio Nováis 12Ciudad UniversitariaES-28040Spain departam.nto de Ciencias Biológicas y Agropecuarias Universidad Técnica Particular de LojaA.P.11-01-608 LojaEcuador Sección Quím.ca Pontificia Universidad Católica del PerúA.P.Lima 32LimaPeru ECI School of Geography and EnvironmentUniversity of OxfordOX13QYOxfordshireUnited Kingdom Instituto de Investigación en Cam.io Global(IICG-URJC) Universidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain

m.untains are param.unt for exploring biodiversity patterns due to the m.saic of topographies and clim.tes encom.assed over short *** research has traditionally focused on taxonom.c diversity when investigating changes along elevational gradients,but other facets should be *** first tim.,we sim.ltaneously assessed elevational trends in taxonom.c,functional,and phylogenetic diversity of woody plants in Andean tropical m.ntane forests and explored their underlying ecological and evolutionary *** investigation covered four transects(traversing ca.2200 m.a.s.l.) encom.assing 114 plots of 0.1 ha across a broad latitudinal range(ca.10°).Using Hill num.ers to quantify abundance-based diversity am.ng 37,869 individuals we observed a consistent decrease in taxonom.c,functional,and phylogenetic diversity as elevation increased,although the decrease was less pronounced for higher Hill *** exception was a slight increase in phylogenetic diversity when dom.nant species were *** decrease in taxonom.c and functional diversity m.ght be attributed to an environm.ntal filtering process towards highlands,where the increasingly harsher conditions exclude species and functional ***,the differences in steepness decrease between Hill orders suggest that rare species disproportionately contribute to functional *** phylogenetic diversity the shifting elevational trend between Hill orders indicates a greater than previously considered influence in central Andean highlands of tropical lowlands originated species with strong niche conservatism.relative to distantly related tem.erate *** could be explained by a decreasing presence and abundance of tem.erate,extratropical taxa towards the central Andes relative to northern or southern Andes,where they are m.re prevalent.

关键词： Altitudinal gradients Andes Environm.ntalﬁltering Out of the Tropical Lowlands Functional rarity Tropical Niche Conservatism