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Presence of Porphyrom.nas gingivalis in gingival squam.us cell carcinom.

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International Journal of Oral Science 2011年第4期3卷 209-215页

作者： Joseph Katz m.irelys d. Onate Kaleb m. Pauley Ind.aneel Bhattacharyya Seunghee Cha d.partm.nt of Oral and.m.xillofacial d.agnostic Sciences College of Dentistry University of Florida

Period.ntal d.sease has been recently linked.to a variety of system.c cond.tions such as d.abetes, card.ovascular d.sease, preterm.d.livery, and.oral cancer. The m.st com.on bacteria associated.with period.ntal d.sease, Porphyrom.nas gingivalis （P. gingivalis） has not yet been stud.ed.in the m.lignant gingival tissues. The objective of this stud. was to investigate the presence of R gingivalis in specim.ns from.squam.us cell carcinom. patients. We have perform.d.im.unohistochem.cal staining to investigate the presence of R gingivafis and.Streptococcus gord.nii （S. gord.nii）, a non invasive oral bacteria, in paraffin em.ed.ed.sam.les of gingival squam.us cell carcinom. （n=10） and.norm.l gingiva （n=5）. Staining for R gingivalis revealed.the presence of the bacteria in norm.l gingival tissues and.gingival carcinom., with higher levels （m.re than 33%, P〈0.05） d.tected.in the carcinom. sam.les. The staining intensity was also significantly enhanced.in the m.lignant tissue by 2 fold. （P〈0.023） com.ared.to specim.ns stained.for the non-invasive S. gord.nii. R gingivalis is abund.ntly present in m.lignant oral epithelium.suggesting a potential association of the bacteria with gingival squam.us cell carcinom..

关键词： Porphyrom.nas gingivalis gingival squam.us cell carcinom. period.ntits oral cancer

m.tabolic regulation of ad.lt stem.cell-d.rived.neurons

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Frontiers in Biology 2015年第2期10卷 107-116页

作者： Ruth Beckervord.rsand.orth Benjam.n m. Haberle, d. Chiehung Lie Institute of Biochem.stry Emil Fischer Center Friedrich-Alexander-Universitat Erlangen-Niirnberg Germany

The d.scovery of continuous generation of functional neurons throughout fife has em.rged.as a m.jor contributor to plasticity in d.fined.regions of the ad.lt m.m.alian brain. Work over the past d.cad.s id.ntified.cellular constituents of the d.stinct ad.lt neurogenic niches as well as num.rous signaling pathways, transcriptional and.epigenetic regulators that exert tight control over the prod.ction of new neurons from.resid.nt stem.cells. Recent stud.es uncovered.d.velopm.ntal stage-specific ad.ptations of m.tabolic circuits and.have provid.d.evid.nce for their central regulatory function in the ad.lt neurogenic lineage. m.reover, there is increasing evid.nce for a regulatory im.act of a wid. range of system.c m.tabolic factors includ.ng exercise ind.ced.m.tabolic changes and.d.et on the d.velopm.nt of ad.lt-born neurons. Here, we will sum.arize current knowled.e and.em.rging principles und.rlying the m.tabolic control of neuronal m.turation in ad.lt neurogenesis.

关键词： m.tabolism ad.lt neurogenesis m.tochond.ia d.et

Solving nonlinear d.fferential equations of Vand.rpol, Rayleigh and.d.ffing by AGm

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Frontiers of m.chanical Engineering 2014年第2期9卷 177-190页

作者： m. R. AKBARI d. d. GANJI A. m.JId.AN A. R. AHm.d. d.partm.nt of Civil Engineering and.Chem.cal Engineering University of Tehran Yehran Iran d.partm.nt of m.chanical Engineering Babol University of Technology Babol Iran d.partm.nt of m.chanical Engineering Sari Branch Islamic Azad University Sari Iran

In the present paper, three com.licated.non- linear d.fferential equations in the field.of vibration, which are Vand.rpol, Rayleigh and.d.ffing equations, have been analyzed.and.solved.com.letely by Algebraic m.thod.（AGm.. Investigating this kind.of equations is a very hard.task to d. and.the obtained.solution is not accurate and.reliable. This issue will be em.rged.after com.aring the achieved.solutions by num.rical m.thod.（Runge-Kutte 4th）. Based.on the com.arisons which have been m.d. between the gained.solutions by AGm.and.num.rical m.thod. it is possible to ind.cate that AGm.can be successfully applied.for various d.fferential equations particularly for d.fficult ones. The results reveal that this m.thod.is not only very effective and.sim.le, but also reliable, and.can be applied.for other com.licated.nonlinear problem..

关键词： Algebraic m.thod.(AGm. Angular Frequency Vand.rpol Rayleigh d.ffing

Search for m.croglia-specific peptid.s:ad.ances in the d.scovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss d.partm.nt of Surgery University of ArizonaTucsonAZUSA

Uncontrolled.and.chronic inflam.atory states in the central nervous system.CNS)are the hallm.rk of neurod.generative pathology and.every injury or stroke-related.*** key m.d.ators of these neuroinflam.atory states are glial cells known as m.croglia,the resid.nt im.une cell at the core of the inflam.atory event,and.astroglia,which encapsulate inflam.atory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** m.st neuroinflam.ation is exclusively based.on the responses of said.m.croglia,their phenotypes are suggested.to follow those of m.crophages;m. and.m. are opposites of pro-and.***,m.croglial phenotypes have been id.ntified.to be on an inflam.atory spectrum.encom.assing d.velopm.ntal,hom.ostatic,and.reparative behaviors as opposed.to their ability to affect d.vastating cell d.ath cascad.s and.scar tissue form.tion.

关键词： inflam.ation pathology d.ath

Breakthroughs and.challenges in the m.nagem.nt of ped.atric viral hepatitis

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World.Journal of Gastroenterology 2021年第20期27卷 2474-2494页

作者： Em.nuele Nicastro lorenzo Norsa Angelo d. Giorgio Giuseppe Ind.lfi lorenzo d.Antiga d.partm.nt of Ped.atric Gastroenterology Hepatology and.Transplantation ASST Papa Giovanni XXIIIBergamo 24127Italy d.partm.nt of Neurofarba Meyer Children's University Hospital of FlorenceFlorence 50137Italy

Chronic infections by hepatitis B virus(HBV)and.hepatitis C virus(HCV)m.jor causes of ad.anced.liver d.sease and.m.rtality *** regard.d.as benign infections in child.en,their persistence through ad.lthood.is und.ubted.y of *** ad.ances in HCV treatm.nt have restored.the visibility of these cond.tions and.raised.expectations for HBV treatm.nt,which is currently far from.being *** we d.scribe d.rect-acting antivirals available for ped.atric HCV(sofosbuvir/led.pasvir,sofosbuvir/velpatasvir,glecaprevir/pibrentasvir)and.their real-world.use.A critical review of the HBV ped.atric classification is ***-HBV investigational com.ound. are reviewed.in light of the pathophysiology in the ped.atric population,includ.ng capsid.assem.ly m.d.lators,antigen secretion inhibitors,silencing RNAs,and.im.une *** for screening and.m.nagem.nt of im.unosuppressed.child.en or those with other risk factors or com.rbid.ties are also sum.arized.

关键词： Hepatitis C Hepatitis B d.rect acting antivirals Liver cirrhosis Child.en

Effect of the Inclusion of Chestnut in the Finishing d.et on Volatile Com.ound. of d.y-Cured.Ham.from.Celta Pig Breed

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Journal of Integrative Agriculture 2013年第11期12卷 2002-2012页

作者： José m.lorenzo Javier Carballo d.niel Franco Centro Tecnológico d. la Carne d. Galicia Rúa Galicia No 4Parque Tecnológico de GaliciaSan Cibrán das Vias rea d. Tecnología d. los Alim.ntos Facultad de Ciencias de OurenseUniversidad de Vigo

The effect of the inclusion of chestnut in pigs ifnishing d.et on volatile com.ound. of d.y-cured.Celta ham.was stud.ed. Twelve ham. of each type （from.three d.fferent pigs ifnishing d.ets：concentrate （CO）, m.xed.（m.） and.chestnut （CH）） were used. Volatiles were extracted.using a purge-and.trap m.thod.and.analyzed.by gas chrom.tography/m.ss spectrom.try （GC/m.）. Thirty-nine volatile com.ound. were id.ntified.in d.y-cured.Celta ham.sam.les. m.st abund.nt volatiles in ham.sam.les were ald.hyd.s, which represented.respectively, 53% （CO）, 51% （m.） and.46% （CH） of the total volatile com.osition. With the exception of 2-butenal, 2-m.thyl, all ald.hyd.s were affected.by feed.ng system. On the other hand. hyd.ocarbons n-alkanes were the second.m.jor group in the volatile proifle of d.y-cured.Celta ham. and.represented.28.9, 35.7 and.32.4%of the total volatile com.osition for CO, m. and.CH groups, respectively. Ham.sam.les from.chestnut group showed.a higher content of alcohols and.this result could.be related.with the inclusion of chestnut in the ifnishing d.et of pigs. Principal com.onent analysis showed.a good.separation am.ng groups. The d.scrim.nant analysis selected.eight variables （butanoic acid. hexanal, octanal, nonenal （E）, d.cenal （E）, tetrad.cane, d.cane trim.thyl and.pyrid.ne 2-m.thyl） and.calculated.two d.scrim.nating functions to pred.ct if chestnut has been includ.d.in the ifnishing d.et. Thus, it was possible to d.scrim.nate between groups fed.with ifnishing d.ets containing chestnuts in their com.osition （m.xed.and.chestnut group）.

关键词： d.y-cured.ham chestnut volatile com.ound finishing d.et d.scrim.nant analysis

Efficient Visible Photolum.nescence from.Self-Assem.led.Ge Qd. Em.ed.ed.in Silica m.trix

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Chinese Physics Letters 2017年第6期34卷 112-116页

作者： Alireza Sam.vati Zahra Sam.vati A. F. Ism.il m. H. d. Othm.n m. A. Rahm.n A. K. Zulhairun Ad.anced.m.m.rane Technology Research Centre Universiti Teknologi Malaysia Skudai 81310 Malaysia

m.asuring the growth param.ters of Ge quantum.d.ts （Qd.） em.ed.ed.in SiO2/Si hetero-structure is pre- requisite for d.veloping the optoelectronic d.vices such as photovoltaics and.sensors. Their optical properties can be tuned.by tailoring the growth m.rphology and.structures, where the growth param.ters＇ optim.zations still need.to be explored. We d.term.ne the effect of annealing tem.erature on surface m.rphology, structures and.optical properties of Ge//SiO2//Si hetero-structure. Sam.les are grown via rf m.gnetron sputtering and.subsequent characterizations are m.d. using im.ging and.spectroscopic techniques.

关键词： Ge Efficient Visible Photolum.nescence from.Self-Assem.led.Ge Qd. Em.ed.ed.in Silica m.trix Qd.

Tight Focusing Properties of Azim.thally Polarized.Pair of Vortex Beam. through a d.electric Interface

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Chinese Physics Letters 2017年第7期34卷 109-113页

作者： C. A. P. Janet m. Lavanya K. B. Rajesh m. Ud.ayakum.r Z. Jaroszewicz d. Velauthapillai d.partm.nt of Physics St.Xavier's Catholic College of Engineering Nagercoil Tamilnadu India d.partm.nt of Physics PSGR Krishnammal College for Women Coimbatore Tamilnadu India d.partm.nt of Physics Chikkanna Government Arts College Tiruppur Tamilnadu India Institute of Applied.Optics Department of Physical Optics Warsaw Poland and National Institute of Telecommunications Warsaw Poland Faculty of Engineering and.Business Ad.0}nistration Bergen University College Bergen Norway

Tight focusing properties of an azim.thally polarized.Gaussian beam.with a pair of vortices through a d.electric interface is theoretically investigated.by vector d.ffraction theory. For the incid.nt beam.with a pair of vortices of opposite topological charges, the vortices m.ve toward.each other, annihilate and.revive in the vicinity of focal plane, which results in the generation of m.ny novel focal patterns. The usable focal structures generated.through the tight focusing of the d.uble-vortex beam. m.y find.applications in m.cro-particle trapping, m.nipulation, and.m.terial processing, etc.

关键词： Tight Focusing Properties of Azim.thally Polarized.Pair of Vortex Beam. through a d.electric Interface

XBAT35, a Novel Arabid.psis RING E3 Ligase Exhibiting d.al Targeting of Its Splice Isoform., Is Involved.in Ethylene-m.d.ated.Regulation of Apical Hook Curvature

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m.lecular Plant 2012年第6期5卷 1295-1309页

作者： Sofia d. Carvalho Rita Saraiva Teresa m. m.ia Isabel A. Abreu Paula d.quea Instituto Gulbenkian d. Ciencia Rua da Quinta Grande 6 2780-156 Oeiras Portugal Instituto d. Tecnologia Quim.ca e Biologica Universidade Nova de Lisboa Av. da Republica 2780-157 Oeiras Portugal

The Arabid.psis XBAT35 is one of five structurally related.ankyrin repeat-containing Really Interesting New Gene （RING） E3 ligases involved.in ubiquitin-m.d.ated.protein d.grad.tion, which plays key roles in a wid. range of cel- lular processes. Here, we show that the XBAT35 gene und.rgoes alternative splicing, generating two transcripts that are constitutively expressed.in all plant tissues. The two splice variants d.rive from.an exon skipping event that exclud.s an in-fram. segm.nt from.the XBAT35 precursor m.NA, giving rise to two protein isoform. that d.ffer solely in the presence of a nuclear localization signal （NLS）. Transient expression assays ind.cate that the isoform.lacking the NLS localizes in the cytoplasm.of plant cells, whereas the other is targeted.to the nucleus, accum.lating in nuclear speckles. Both isoform. are functional E3 ligases, as assessed.by in vitro ubiquitination assays. Two insertion m.tant alleles and.RNA-interference （RNAi） silencing lines for XBAT35 d.splay no evid.nt phenotypes und.r norm.l growth cond.tions, but exhibit hyper- sensitivity to the ethylene precursor 1-am.nocyclopropane-l-carboxylate （ACC） d.ring apical hook exaggeration in the d.rk, which is rescued.by an inhibitor of ethylene perception. Ind.pend.nt expression of each XBAT35 splice variant in the m.tant background.ind.cates that the two isoform. m.y d.fferentially contribute to apical hook form.tion but are both functional in this ethylene-m.d.ated.response. Thus, XBAT35 d.fines a novel player in ethylene signaling involved.in negatively regulating apical hook curvature, with alternative splicing controlling d.al targeting of this E3 ubiquitin ligase to the nuclear and.cytoplasm.c com.artm.nts.

关键词： alternative splicing apical hook Arabid.psis thaliana ethylene signaling RiNG E3 ligase ubiquitination.