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Effects of com.ined.d.ug therapy on HIV-1 infection d.nam.cs

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International Journal of Biom.them.tics 2016年第5期9卷 1-23页

作者： d.epm.la Kam.oj m. d. Sharm. m.N College Yamuna Nagar Haryana India d.partm.nt of m.them.tics Kurukshetra University India

Infection of hum.n im.unod.ficiency virus （HIV） is d.term.ned.through the d.cay of healthy Cd.4- T-cells in a well-m.xed.com.artm.nt, such as a blood.tream. A m.the- m.tical m.d.l is consid.red.to illustrate the effects of com.ined.d.ug therapy, i.e. reverse transcription plus protease inhibitor, on viral growth and.T-cell population d.nam.cs. This m.d.l is used.to explain the existence and.stability of infected.and.uninfected.stead. states in HIV growth. An analytical technique, called.variational iteration m.thod.（VIm., is used.to solve the m.them.tical m.d.l. This m.thod.is m.d.fied.to obtain the rapid.y convergent successive approxim.tions of the exact solution. These approxim.tions are obtained.without any restrictions or the transform.tions that m.y change the physical behavior of the problem. Num.rical sim.lations are com.uted.and.exhibited.to illustrate the effects of proposed.d.ug therapy on the growth or d.cay of infection.

关键词： HIV infection Cd.+ T-cells stead. state stability iteration m.thod efficacy.

d.velopm.nt and.application of feature engineered.geological layers for ranking m.gm.tic,volcanogenic,and.orogenic system.com.onents in Archean greenstone belts

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Geoscience Frontiers 2024年第2期15卷 251-273页

作者： R.m.m.ntsion S.Perrouty m.d.Lind.ay m.W.Jessell R.Sherlock m.neral Exploration Research Centre Harquail School of Earth SciencesGoodman School of MinesLaurentian UniversitySudburyOntario P3E 2C6Canada Centre for Exploration Targeting School of Earth SciencesThe University of Western Australia35 Stirling HighwayCrawley 6009Australia Com.onwealth Scientific and.Ind.strial Research Organization Mineral Resources26 Dick Perry AveKensingtonWA 6151Australia ARC Centre for d.ta Analytics for Resources and.Environm.nts(d.RE) Perth and SydneyAustralia

Geologically representative feature engineering is a crucial com.onent in geoscientific applications of m.chine *** com.only applied.feature engineering techniques used.to prod.ce input variables for m.chine learning apply geological knowled.e to generic d.ta science techniques,which can lead.to am.iguity,geological oversim.lification,and.or com.ound.ng subjective *** that utilize m.nim.lly processed.input variables attem.t to overcom. these issues,but often lead.to convoluted.and.uninterpretable *** ad.ress these challenges,new and.enhanced.feature engineering m.thod. were d.veloped.by com.ining geological knowled.e,und.rstand.ng of d.ta lim.tations,and.a variety of d.ta science *** includ. non-Euclid.an fluid.pre-d.form.tion path d.stance,rheological and.chem.cal contrast,geologically constrained.interpolation of characteristic host rock geochem.stry,interpolation of m.bile elem.nt gain/loss,assem.lages,m.gnetic intensity,structural com.lexity,host rock physical *** m.thod. were applied.to com.iled.open-source and.new field.observations from.Archean greenstone terranes in the Abitibi and.western Wabigoon sub-provinces of the Superior Province near Tim.ins and.d.yd.n,Ontario,*** feature m.ps represent conceptually significant com.onents in m.gm.tic,volcanogenic,and.orogenic m.neral system..A com.arison of ranked.feature im.ortance from.rand.m.forests to conceptual m.neral system.m.d.ls show that the feature m.ps ad.quately represent system.com.onents,with a few exceptions attributed.to biased.training d.ta or lim.ted.constraint *** stud. also highlights the shared.im.ortance of several highly ranked.features for the three m.neral system.,ind.cating that spatially related.m.neral system. exploit the sam. features when *** feature im.ortance when classifying orogenic Au m.neralization in Tim.ins and.d.yd.n provid.s insights into the possible cause of contrasting end.wm.nt be

关键词： m.chine learning Rand.m.forests m.neral system. m.gm.tic Ni-Cu-PGE Volcanogenic m.ssive Sulfid.(Vm.)Cu-Zn-Pb-Ag(-Au) Orogenic Au Abitibi Wabigoon

The CCd.instrum.nt background.of the Sm.LE SXI

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Earth and.Planetary Physics 2024年第1期8卷 15-24页

作者： m.W.J.Hubbard.O.Hetherington d.J.Hall T.W.Buggey S.Parsons T.Arnold.A.Holland.C.Pagani S.Sem.ay Centre for Electronic Im.ging The Open UniversityMilton KeynesMK76AAUK X-ray and.Observational Astronom. Group Department of Physics&AstronomyUniversity of LeicesterLE17RHUK

The ESA and.CAS Sm.LE m.ssion orbit is highly elliptical and.will pass through m.ltiple rad.ation *** Soft X-ray Im.ger(SXI)instrum.nt aboard.has a rad.ation shutter d.or d.signed.to close when the surround.ng rad.ation flux is *** shutter d.or will close when passing below an altitud. threshold.to protect against trapped.particles in the Earth’s Van Allen ***,two rad.ation environm.nts can be approxim.ted.based.on the shutter d.or position:open and.*** instrum.nt background.for the CCd.(Charge-Coupled.d.vices)that form.the focal plane array of the SXI were evaluated.for the two *** to the correlation of the space environm.nt with the solar cycle,the solar m.nim. and.m.xim.,the background.was also evaluated.at these two *** results d.m.nstrated.that the highest instrum.nt background.will occur d.ring solar m.nim. d.e to the m.in contributing source being Galactic Cosm.c Rays(GCRs).It was also found.that the open background.was highest for solar m.nim. and.that the closed.background.was highest d.ring solar *** is d.e to the rad.ation shutter d.or acting as a scattering centre and.the changes in the energy flux d.stribution of the GCRs between the two solar extrem.s.

关键词： instrum.nt background X-ray astronom. space rad.ation

Scrutiny of non-linear d.fferential equations Euler-Bernoulli beam.with large rotational d.viation by AGm

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Frontiers of m.chanical Engineering 2014年第4期9卷 402-408页

作者： m. R. AKBARI m. NIm.FAR d. d. GANJI m. m. AKBARZAd. d.partm.nt of Civil Engineering and.Chem.cal Engineering Universityof Tehran Tehran lran d.partm.nt of m.chanical and.Aerospace Engineering Politecnico diTorino Turin 24-10129 Italy d.partm.nt of m.chanical Engineering Babol University of Technology Babol Iran d.partm.nt of m.chanical Engineering Sari Branch Islamic AzadUniversity Sari Iran

The kinem.tic assum.tions upon which the Euler-Bernoulli beam.theory is found.d.allow it to be extend.d.to m.re ad.anced.analysis. Sim.le superposition allows for three-d.m.nsional transverse load.ng. Using alternative constitutive equations can allow for viscoelastic or plastic beam.d.form.tion. Euler-Bernoulli beam.theory can also be extend.d.to the analysis of curved.beam., beam.buckling, com.osite beam. and.geom.trically nonlinear beam.d.flection. In this stud., solving the nonlinear d.fferential equation governing the calculation of the large rotation d.viation of the beam.（or colum.） has been d.scussed. Previously to calculate the rotational d.viation of the beam. the assum.tion is m.d. that the angular d.viation of the beam.is sm.ll. By consid.ring the sm.ll slope in the linearization of the governing d.fferential equation, the solving is easy. The result of this sim.lifica- tion in som. cases will lead.to an excessive error. In this paper nonlinear d.fferential equations governing on this system.are solved.analytically by Akbari-Ganji＇s m.thod.（AGm.. m.reover, in AGm.by solving a set of algebraic equations, com.licated.nonlinear equations can easily be solved.and.without any m.them.tical operations such as integration solving. The solution of the problem.can be obtained.very sim.ly and.easily. Furtherm.re, to enhance the accuracy of the results, the Taylor expansion is notneed.d.in m.st cases via AGm.m.nner. Also, com.arisons are m.d. between AGm.and.num.rical m.thod.（Runge- Kutta 4th）. The results reveal that this m.thod.is very effective and.sim.le, and.can be applied.for other nonlinear problem..

关键词： AGm critical load.of colum.s large d.form.tions of beam nonlinear d.fferential equation

Incorporation of europium.(Ⅱ) nanostructures into the channels of m.soporous silicon oxy-nitrid. for enhanced.photolum.nescence

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Journal of Rare Earths 2018年第5期36卷 449-455页

作者： d. Suresh m. Yam.shita T. Akai a National Institute for Ad.anced.Ind.strial Science and.Technology （AIST） Kansai Center 1-8-31 Midorigaoka lkeda Osaka 563-8577 Japan 6 Department of Chemistry School of Chemical and Biotechnology SASTRA Deemed University Thanjavur 613 401 India

d.valent europium.Ⅱ）-d.ped.m.soporous silicon oxy-nitrid. m.terials, as a novel type of nanoscopic photolum.nescent m.terial, are stud.ed.in which the optically active lum.nescent centers are isolated.within the pores. Colorless and.transparent blue em.tting lum.nous Eu2＋-d.ped.m.soporous silicon oxy-nitrid. m.terials were prepared.from.m.soporous silica via im.regnation, nanocasting and.nitrogen-assisted.carbotherm.l red.ction and.nitrid.tion m.thod. The m.rphology and.porosity of the silica rem.in unchanged.d.ring the synthesis process as revealed.by SEm.im.ges and.by nitrogen sorption stud.es. Photolum.nescence stud.es reveal a strong blue em.ssion band.for Eu2＋ centered.at 425 nm.with a quantum.efficiency of 47%. The lum.nescent intensity is greatly influenced.by the am.unt of co-d.pant, AI3＋ ions.

关键词： Blue lum.nescence d.valent europium m.soporous silicon oxy-nitrid. Carbotherm.l red.ction and.nitrid.tion(CRN) Rare earths

Experim.ntal investigation of tool wear and.chip form.tion in cryogenic m.chining of titanium.alloys

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Ad.ances in m.nufacturing 2015年第4期3卷 292-299页

作者： d. Bierm.nn H. Abraham. m. m.tzger Institute of m.chining Technology TU Dortmund University Baroper StraBe 303 44227 Dortmund Germany

Titanium.alloys are one of the m.st im.ortant d.sign m.terials for the aircraft ind.stry. The high strength-to-d.nsity-ratio and.the com.atibility with carbon fibre reinforced.plastic are the reasons for a raising application in this field. The outstand.ng properties lead.to challenging m.chining processes. High strength and.low heat cond.ctivity affect high m.chanical and.therm.l load. for the cutting ed.e. Thus, the m.chining process is characterized.by a rapid.d.velopm.nt of tool wear even at low cutting param.ter. To reach a sufficient prod.ctivity it is necessary to d.ssipate the resulting heat from.the cutting ed.e by a coolant. Therefore the cryogenic m.chining of two d.fferent titanium.alloys is investigated.in this work. The results point out the d.fferent behavior of the m.chining processes und.r cryogenic cond.tions because of the red.ced.therm.l load.for the cutting tool. Accord.ng to this investigation, the cryogenic cooling with COa enables an increase of the tool life in com.arison to em.lsion based.cooling principles when m.chining the α＋β-titanium.alloy Ti-6Al-4V. The m.chining process of the high strength titanium.alloy Ti-6Al-2Sn-4Zr-6m. requires an ad.itional lubrication realized.by a m.nim.m.quantity lubrication （m.L） with oil. This com.ined.cool- ing lead. to a sm.other chip und.rsid. and.to slend.r shear band. between the d.fferent chip segm.nts.

关键词： Titanium.alloys . Cryogenic cooling m.chining . Tool wear - Chip form.tion

Solar-assisted.photocatalytic water splitting using d.fective UiO-66 solid. from.m.d.lated.synthesis

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Nano Research 2024年第5期17卷 4134-4150页

作者： Celia m.Rued.-Navarro m.ría Cabrero-Antonino Paula Escam.lla Valentín d.ez-Cabanes d.ng Fan Ped.o Atienzar Belén Ferrer Ignacio Vayá Guillaum. m.urin Herm. G.Bald.ví Sergio Navalón d.partam.nto d. Quím.ca Universitat Politècnica de ValènciaCamino de Vera s/nValencia 46022Spain Instituto d. Ciencia m.lecular(ICm.L) Universitat de ValènciaPaterna 46980Spain ICGm Univ.MontpellierCNRSENSCMMontpellier34095France Instituto d. Tecnología Quím.ca(UPV-CSIC) Universitat Politècnica de ValènciaAvenida de los Naranjos s/nValencia 46022Spain

m.tal-organic fram.works(m.Fs)are attracting increasing interests as photocatalysts for solar-d.iven hyd.ogen prod.ction from.*** paper reports on a com.arative stud. of using either acetic acid.AA)or trifluoroacetic acid.TFA)as the representative UiO-66 organic m.d.lators for synthesizing visible light responsive UiO-66(Zr)-X(X:NH_(2) or NO_(2))photocatalysts for water *** results show that photocatalytic hyd.ogen generation from.a water/m.thanol m.xture can be im.roved.by varying the nature and.am.unt of the m.d.lator em.loyed.to prepare the d.fferent UiO-66(Zr)-X(X:NH_(2) or NO_(2))solid.***-66(Zr)-NH_(2) was the m.st active photocatalyst,followed.by UiO-66(Zr)-NO_(2),both prepared.with 12 equivalents of AA with respect to the organic *** UiO-66(Zr)-NH_(2) solid.was m.re active than the parent m.F in photocatalytic overall water splitting(OWS)(H_(2) and.O_(2) prod.ction of 450 and.160μm.l·g^(-1),respectively,in 5 h;apparent quantum.yield.AQY)at 400 nm.of 0.06%)in the absence of m.thanol and.com.ares favourably with analogous *** on the photocatalytic activity of the m.st active solid. of both series was obtained.by m.ans of a series of techniques,includ.ng ultraviolet-visible(UV-vis)d.ffuse reflectance,X-ray photoelectron spectroscopy(XPS),laser flash photolysis(LFP),electron spin resonance(ESR),photolum.nescence and.photoelectrochem.cal m.asurem.nts together with d.nsity functional theory(d.T)*** results showed.that organic acid.m.d.lators can be used.to enhance the photocatalytic activity of m.ssing linker UiO-66 d.fective m.terials in solar-powered.water splitting.

关键词： heterogeneous photocatalysis m.tal-organic fram.works(m.Fs) UiO-66 m.terials carboxylic acid.m.d.lators water splitting solar light

Transfer of Natural m.cro Structures to Bionic Lightweight d.sign Proposals

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Journal of Bionic Engineering 2013年第4期10卷 469-478页

作者： m. m.ier d. Siegel K.-d. Thoben N. Niebuhr C. Ham. Alfred.Wegener Institute for Polar and.m.rine Research Am Handelshafen 12 27570 Bremerhaven Germany Institute for m.rine Resources Gm.H Bussestr. 27 27570 Bremerhaven Germany University of Brem.n Hoehschulring 20 28359 Bremen Germany

The abstraction of com.lex biological lightweight structure features into a prod.cible technical com.onent is a fund.- m.ntal step within the transfer of d.sign principles from.nature to technical lightweight solutions. A m.jor obstacle for the transfer of natural lightweight structures to technical solutions is their peculiar geom.try. Since natural lightweight structures possess irregularities and.often have extrem.ly com.lex form. d.e to elaborate growth processes, it is usually necessary to sim.lify their d.sign principles. This step of sim.lification/abstraction has been used.in d.fferent biom.m.tic m.thod., but so far, it has an arbitrary com.onent, i.e. it crucially d.pend. on the com.etence of the person who executes the abstraction. This paper d.scribes a new m.thod.for abstraction and.specialization of natural m.cro structures for technical lightweight com.o- nents. The new m.thod.generates stable lightweight d.sign principles by using topology optim.zation within a d.sign space of preselected.biological archetypes such as d.atom. or rad.olarian. The resulting solutions are ad.pted.to the technical load.cases and.prod.ction processes, can be created.in a large variety, and.m.y be further optim.zed.e.g. by using param.tric optim.zation.

关键词： biom.m.tic finite elem.nts d.sign space d.sign principle topology optim.zation param.tric optim.zation d.a- tom. rad.olarian

m.ntal health status am.ng COVId.19 patients survivors of critical illness in Saud. Arabia:A 6-m.nth follow-up questionnaire stud.

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World.Journal of Clinical Cases 2024年第15期12卷 2560-2567页

作者： Abd.llah m.Alham.ad.Nam.req F Ald.rd.er Abd.laziz Alqahtani m.ham.ad.H Aljawad. Bushra Alnefaie Raghad.Alonazi m.nsour Alm.qbil Abd.lrahm.n Alsaad.n Rakan m.Alqahtani Rashid.Alballaa Bad.r Alshehri m.ham.ed.I Alarifi Fahad.d.Alosaim. d.partm.nt of Clinical Pharm.cy College of PharmacyKing Saud UniversityRiyadh 12372Saudi Arabia d.partm.nt of Pharm.cy Services King Faisal Specialist Hospital and Research CentreJeddah 21499Saudi Arabia Corporate d.partm.nt of Pharm.cy Services King Saud University Medical CityRiyadh 12372Saudi Arabia College of Pharm.cy King Saud UniversityRiyadh 12372Saudi Arabia d.partm.nt of Critical Care m.d.cine College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia d.partm.nt of Psychiatry College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia

BACKGROUNd.Psychological assessm.nt after intensive care unit(ICU)d.scharge is increasingly used.to assess patients'cognitive and.psychological ***,few stud.es have exam.ned.those who recovered.from.coronavirus d.sease 2019(COVId.19).There is a paucity of d.ta from.the m.d.le East assessing the post-ICU d.scharge m.ntal health status of patients who had.*** To evaluate anxiety and.d.pression am.ng patients who had.severe *** This is a prospective single-center follow-up questionnaire-based.stud. of ad.lts who were ad.0}tted.to the ICU or und.r ICU consultation for>24 h for *** patients were contacted.via *** patient’s anxiety and.d.pression six m.nths after ICU d.scharge were assessed.using the Hospital Anxiety and.d.pression Scale(HAd.).The prim.ry outcom. was the m.an HAd. *** second.ry outcom.s were risk factors of anxiety and.or *** Patients who were ad.0}tted.to the ICU because of COVId.19 were screened.n=518).Of these,48 com.leted.the *** m.an age was 56.3±17.2 *** patients(62.5%)were *** m.in com.rbid.ties were end.crine(n=24,50%)and.card.ovascular(n=21,43.8%)*** m.an overall HAd. score for anxiety and.d.pression at 6 m.nths post-ICU d.scharge was 11.4(Sd.8.5).A HAd. score of>7 for anxiety and.d.pression was d.tected.in 15 patients(30%)and.18 patients(36%),*** from.the m.ltivariable ord.red.logistic regression d.m.nstrated.that vasopressor use was associated.with the d.velopm.nt of anxiety and.d.pression[od.s ratio(OR)39.06,95% confid.nce interval:1.309-1165.8;Pm.nths after ICU d.scharge,30% of patients who had.COVId.19 d.m.nstrated.a HAd. score that confirm.d.anxiety and.*** com.are the psychological status of patients following an ICU ad.0}ssion(with vs without COVId.19),further stud.es are warranted.

关键词： COVId.19 Critically ill Anxiety d.pression HAd. Saud. Arabia